Cited by 364Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

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Distinct Roles for Cellular Retinoic Acid-binding Proteins I and II in Regulating Signaling by Retinoic Acid

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Dong, Diane, Ruuska, Sarah E., Levinthal, David J., Noy, Noa·1999·Journal of Biological Chemistry

DOI 10.1074/jbc.274.34.23695

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Abstract

The pleiotropic effects of retinoic acid (RA) in mammalian cells are mediated by two classes of proteins: the retinoic acid receptors (RAR) and cellular retinoic acid-binding proteins (CRABP-I and CRABP-II). Here we show that expression of CRABP-II, but not CRABP-I, markedly enhanced RAR-mediated transcriptional activation of a reporter gene in COS-7 cells. The equilibrium dissociation constants of complexes of CRABP-I or CRABP-II with RA were found to differ by 2-fold. It is thus unlikely that the distinct effects of the two proteins on transactivation stem from differential ligand-binding affinities. The mechanisms by which RA transfers from the CRABPs to RAR were thus investigated directly. The rate constant for movement of RA from CRABP-II, but not from CRABP-I, to RAR strongly depended on the concentration of the acceptor. The data suggest that transfer of RA from CRABP-I to RAR involves dissociation of the ligand from the binding protein, followed by association with the receptor. In contrast, movement of RA from CRABP-II to the receptor is facilitated by a mechanism that involves direct interactions between CRABP-II and RAR. These findings reveal a striking functional difference between CRABP-I and CRABP-II, and point at a novel mechanism by which the transcriptional activity of RA can be regulated by CRABP-II.

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Principles of Fluorescence Spectroscopy
Lakowicz, J. R. (1999) · Springer eBooks · doi:10.1007/978-1-4757-3061-6 · Cited by 26,948
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
Principles of fluorescence spectroscopy
Steiner, R. F. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90125-8 · Cited by 1,006
Vitamin A in Health and Disease
Blomhoff, R. (1994) · CRC Press eBooks · doi:10.1201/9781482277562 · Cited by 597
The retinoids; Biology, chemistry, and medicine
Kaster, P. (1994) · Biochimie · doi:10.1016/0300-9084(94)90131-7 · Cited by 468
Binding Affinities of Retinol and Related Compounds to Retinol Binding Proteins
Cogan, U., Kopelman, M., Mokady, S., & Shinitzky, M. (1976) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1976.tb10390.x · Cited by 381
Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells.
Boylan, J. F., & Gudas, L. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.112.5.965 · Cited by 325
The level of CRABP-I expression influences the amounts and types of all-trans-retinoic acid metabolites in F9 teratocarcinoma stem cells.
Boylan, J. F., & Gudas, L. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36635-9 · Cited by 239
Transfer of retinoic acid from its complex with cellular retinoic acid-binding protein to the nucleus
Takase, S., Ong, D. E., & Chytil, F. (1986) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(86)90591-6 · Cited by 171
The cellular retinoic acid binding protein I is dispensable.
Gorry, P., Lufkin, T., Dierich, A., Rochette‐Egly, C., Décimo, D., Dollé, P., Mark, M. P., Durand, B., & Chambon, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9032 · Cited by 135

Show all 29 references

Research works printed but not linked: 4

Vo, 1998, Anticancer Res., 18, 217
Kersten, 1995, Proc. Natl. Acad. Sci. U. S. A., 96, 10014
Jing, 1997, Cancer Res., 57, 1668
Zheng, 1996, Endocrinology, 137, 5028, 10.1210/endo.137.11.8895377 · DOI

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Ghaffari, H., & Petzold, L. R. (2018) · Theoretical Biology and Medical Modelling · doi:10.1186/s12976-018-0088-7 · Cited by 21
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Redfern, C. P. F. (2020) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2020.02.002 · Cited by 23
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Lane, M. A., Xu, J., Wilen, E. W., Sylvester, R., Derguini, F., & Gudas, L. J. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.09.010 · Cited by 21
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Sahab, Z. J., Man, Y., Semaan, S. M., Newcomer, R. G., Byers, S. W., & Sang, Q. A. (2010) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9338-8 · Cited by 20
Non-classical Transcriptional Activity of Retinoic Acid
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Lee, S. J., Jeon, H. B., Lee, J. H., Yoo, J. S., Chun, J., & Yoo, Y. J. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00243-1 · Cited by 20
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Bami, M., Episkopou, V., Gavalas, A., & Gouti, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020197 · Cited by 18
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Kim, D. J., Kim, W. J., Lim, M., Hong, Y., Lee, S., Hong, S., Heo, J., Lee, H.-Y., & Han, S. (2018) · Journal of Korean Medical Science · doi:10.3346/jkms.2018.33.e178 · Cited by 18
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Hughes, C. S., Chin‐Aleong, J., & Kocher, H. M. (2020) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2020.151557 · Cited by 18
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Santori, F. R. (2015) · European Journal of Immunology · doi:10.1002/eji.201545712 · Cited by 18
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Long term vitamin A restriction improves meat quality parameters and modifies gene expression in Iberian pigs1
Ayuso, M., Fernández, A., Isabel, B., Rey, A. I., Benítez, R., Daza, A., López-Bote, C. J., & Óvilo, C. (2015) · Journal of Animal Science · doi:10.2527/jas.2014-8573 · Cited by 18
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Xu, L., Feng, Z., Sinha, D. K., Ducos, B., Ebenstein, Y., Tadmor, A. D., Gauron, C., Saux, T. L., Lin, S., Weiss, S., et al. (2012) · Development · doi:10.1242/dev.077776 · Cited by 17
A microarray screen for direct targets of Zic1 identifies an aquaporin gene, aqp‐3b, expressed in the neural folds
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Authors: Dong, D., Ruuska, S. E., Levinthal, D. J., & Noy, N.
Affiliations: Cornell University (US)
Corresponding author: Noy, Noa
ORCID: Ruuska, Sarah E.
Levinthal, David J.
Noy, Noa
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-08
Volume: 274
Issue: 34
Pages: 23695-23698
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.274.34.23695
OpenAlex: W2001068122
Cited by: 362
References: 29
Citations by year: 2026: 5 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 16 · 2018: 4 · 2017: 15 · 2016: 19 · 2015: 18 · 2014: 20 · 2013: 17 · 2012: 15
FWCI: 3.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7738 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 68150, R01CA068150)
National Institute of Diabetes and Digestive and Kidney Diseases (5-T32-DK07158, T32DK007158)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: retinoic acid, cellular retinoic acid-binding protein I, CRABP2, retinoic acid receptor, ligand transfer, transcriptional activation, ligand dissociation, protein-protein interaction, ligand binding affinity
MeSH terms: Animals, Tretinoin, Transcriptional Activation, Receptors, Retinoic Acid, COS Cells

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Distinct Roles for Cellular Retinoic Acid-binding Proteins I and II in Regulating Signaling by Retinoic Acid

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