Cited by 364Retinoids in leukemia and cellular processesPeroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

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Distinct Roles for Cellular Retinoic Acid-binding Proteins I and II in Regulating Signaling by Retinoic Acid

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Dong, Diane, Ruuska, Sarah E., Levinthal, David J., Noy, Noa·1999·Journal of Biological Chemistry

DOI 10.1074/jbc.274.34.23695

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Abstract

The pleiotropic effects of retinoic acid (RA) in mammalian cells are mediated by two classes of proteins: the retinoic acid receptors (RAR) and cellular retinoic acid-binding proteins (CRABP-I and CRABP-II). Here we show that expression of CRABP-II, but not CRABP-I, markedly enhanced RAR-mediated transcriptional activation of a reporter gene in COS-7 cells. The equilibrium dissociation constants of complexes of CRABP-I or CRABP-II with RA were found to differ by 2-fold. It is thus unlikely that the distinct effects of the two proteins on transactivation stem from differential ligand-binding affinities. The mechanisms by which RA transfers from the CRABPs to RAR were thus investigated directly. The rate constant for movement of RA from CRABP-II, but not from CRABP-I, to RAR strongly depended on the concentration of the acceptor. The data suggest that transfer of RA from CRABP-I to RAR involves dissociation of the ligand from the binding protein, followed by association with the receptor. In contrast, movement of RA from CRABP-II to the receptor is facilitated by a mechanism that involves direct interactions between CRABP-II and RAR. These findings reveal a striking functional difference between CRABP-I and CRABP-II, and point at a novel mechanism by which the transcriptional activity of RA can be regulated by CRABP-II.

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Authors: Dong, D., Ruuska, S. E., Levinthal, D. J., & Noy, N.
Affiliations: Cornell University (US)
Corresponding author: Noy, Noa
ORCID: Ruuska, Sarah E.
Levinthal, David J.
Noy, Noa
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-08
Volume: 274
Issue: 34
Pages: 23695-23698
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.274.34.23695
OpenAlex: W2001068122
Cited by: 362
References: 29
Citations by year: 2026: 5 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 14 · 2019: 16 · 2018: 4 · 2017: 15 · 2016: 19 · 2015: 18 · 2014: 20 · 2013: 17 · 2012: 15
FWCI: 3.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7738 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 68150, R01CA068150)
National Institute of Diabetes and Digestive and Kidney Diseases (5-T32-DK07158, T32DK007158)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: retinoic acid, cellular retinoic acid-binding protein I, CRABP2, retinoic acid receptor, ligand transfer, transcriptional activation, ligand dissociation, protein-protein interaction, ligand binding affinity
MeSH terms: Animals, Tretinoin, Transcriptional Activation, Receptors, Retinoic Acid, COS Cells

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Distinct Roles for Cellular Retinoic Acid-binding Proteins I and II in Regulating Signaling by Retinoic Acid

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