The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases
Open accessAbstract
The intracellular generation of reactive oxygen species, together with the thioredoxin and glutathione systems, is thought to participate in redox signaling in mammalian cells. The activity of thioredoxin is dependent on the redox status of thioredoxin reductase (TR), the activity of which in turn is dependent on a selenocysteine residue. Two mammalian TR isozymes (TR2 and TR3), in addition to that previously characterized (TR1), have now been identified in humans and mice. All three TR isozymes contain a selenocysteine residue that is located in the penultimate position at the carboxyl terminus and which is encoded by a UGA codon. The generation of reactive oxygen species in a human carcinoma cell line was shown to result in both the oxidation of the selenocysteine in TR1 and a subsequent increase in the expression of this enzyme. These observations identify the carboxyl-terminal selenocysteine of TR1 as a cellular redox sensor and support an essential role for mammalian TR isozymes in redox-regulated cell signaling.
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Cited by
Selenium, selenoproteins and human health: a review
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Metadata
- Authors
- Sun, Q.-A., Wu, Y., Zappacosta, F., Jeang, K.-T., Lee, B. J., Hatfield, D. L., & Gladyshev, V. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 274
- Issue
- 35
- Pages
- 24522-24530
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2092317255
- Cited by
- 323
- References
- 47
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sun, Q.-A., Wu, Y., Zappacosta, F., Jeang, K.-T., Lee, B. J., Hatfield, D. L., & Gladyshev, V. N. (1999). Redox Regulation of Cell Signaling by Selenocysteine in Mammalian Thioredoxin Reductases. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.35.24522
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
