Oxygen radicals and signaling

Finkel, Toren

doi:10.1016/s0955-0674(98)80147-6

Cited by 1,170Redox biology and oxidative stressNitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Oxygen radicals and signaling

Finkel, Toren·1998·Current Opinion in Cell Biology

DOI 10.1016/s0955-0674(98)80147-6

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Abstract

Recent evidence suggests that reactive oxygen species, such as superoxide anions and hydrogen peroxide, function as intracellular second messengers. This review will discuss the progress in understanding the intracellular pathways leading from ligand stimulation to the generation of oxidants, as well as some of the increasing number of cellular processes that appear to be subject to redox regulation.

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In healthy situations, the generation of ROS by eNOS, mitochondria, or XO is limited.
“In healthy situations, the generation of ROS by eNOS, mitochondria, or XO is limited, and in the case of mitochondria, it is probably more related to signaling pathways (289, 290).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [289]
In healthy situations, mitochondrial ROS generation is probably more related to signaling pathways.
“In healthy situations, the generation of ROS by eNOS, mitochondria, or XO is limited, and in the case of mitochondria, it is probably more related to signaling pathways (289, 290).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [289]

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Authors: Finkel, T.
Affiliations: National Institutes of Health (US)
Corresponding author: Finkel, Toren
ORCID: Finkel, Toren
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 1998-04
Volume: 10
Issue: 2
Pages: 248-253
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/s0955-0674(98)80147-6
OpenAlex: W2081748503
Cited by: 1,170
References: 54
Citations by year: 2026: 4 · 2025: 13 · 2024: 26 · 2023: 8 · 2022: 26 · 2021: 29 · 2020: 17 · 2019: 25 · 2018: 25 · 2017: 33 · 2016: 20 · 2015: 35 · 2014: 44 · 2013: 41 · 2012: 45
FWCI: 4.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords: reactive oxygen species, oxygen free radicals, superoxide, hydrogen peroxide, second messengers, redox signaling, redox regulation, intracellular signaling, oxidant production
MeSH terms: Animals, Humans, Models, Biological, Signal Transduction, Reactive Oxygen Species

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