The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-κB and p53 Signaling
Open accessAbstract
Transcriptional coactivators may function as nuclear integrators by coordinating diverse signaling events. Here we show that the p65 (RelA) component of nuclear factor-kappaB (NF-kappaB) and p53 mutually repress each other's ability to activate transcription. Additionally, tumor necrosis factor-activated NF-kappaB is inhibited by UV light-induced p53. Both p65 and p53 depend upon the coactivator CREB-binding protein (CBP) for maximal activity. Increased levels of the coactivator relieve p53-mediated repression of NF-kappaB activity and p65-mediated repression of p53-dependent gene expression. Nuclear competition for limiting amounts of CBP provides a novel mechanism for altering the balance between the expression of NF-kappaB-dependent proliferation or survival genes and p53-dependent genes involved in cell cycle arrest and apoptosis.
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Cites
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
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Definition of a consensus binding site for p53
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Cited by
Control of apoptosis by Rel/NF-κB transcription factors
Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,204
The diverse and complex roles of NF-κB subunits in cancer
Perkins, N. D. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3204 · Cited by 852
Regulation of intercellular adhesion molecule-1 (CD54) gene expression
Roebuck, K. A., & Finnegan, A. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.6.876 · Cited by 560
Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
Meylan, E., Dooley, A. L., Feldser, D. M., Shen, L., Turk, E., Ouyang, C., & Jacks, T. (2009) · Nature · doi:10.1038/nature08462 · Cited by 517
New Insights into the Role of Nuclear Factor-κB in Cell Growth Regulation
Chen, F., Castranova, V., & Shi, X. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61708-7 · Cited by 473
Metadata
- Authors
- Wadgaonkar, R., Phelps, K. M., Haque, Z., Williams, A. J., Silverman, E. S., & Collins, T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 4
- Pages
- 1879-1882
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1969044500
- Cited by
- 192
- References
- 5
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wadgaonkar, R., Phelps, K. M., Haque, Z., Williams, A. J., Silverman, E. S., & Collins, T. (1999). CREB-binding Protein Is a Nuclear Integrator of Nuclear Factor-κB and p53 Signaling. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.4.1879
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