The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Long Patch Base Excision Repair with Purified Human Proteins
Open accessAbstract
Among the different base excision repair pathways known, the long patch base excision repair of apurinic/apyrimidinic sites is an important mechanism that requires proliferating cell nuclear antigen. We have reconstituted this pathway using purified human proteins. Our data indicated that efficient repair is dependent on six components including AP endonuclease, replication factor C, proliferating cell nuclear antigen, DNA polymerases delta or epsilon, flap endonuclease 1, and DNA ligase I. Fine mapping of the nucleotide replacement events showed that repair patches extended up to a maximum of 10 nucleotides 3' to the lesion. However, almost 70% of the repair synthesis was confined to 2-4-nucleotide patches and DNA ligase I appeared to be responsible for limiting the repair patch length. Moreover, both proliferating cell nuclear antigen and flap endonuclease 1 are required for the production and ligation of long patch repair intermediates suggesting an important role of this complex in both excision and resynthesis steps.
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Fortini, P., Pascucci, B., Parlanti, E., Sobol, R. W., Wilson, S. H., & Dogliotti, E. (1998) · Biochemistry · doi:10.1021/bi972999h · Cited by 232
Self-citationProliferating Cell Nuclear Antigen Facilitates Excision in Long-patch Base Excision Repair
Gary, R., Kim, K., Cornelius, H. L., Park, M. S., & Matsumoto, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.4354 · Cited by 170
Cited by
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LINDAHL, T., & BARNES, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.127 · Cited by 714
FORTINI, P., & DOGLIOTTI, E. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.10.008 · Cited by 318
Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine
van Loon, B., Markkanen, E., & Hübscher, U. (2010) · DNA Repair · doi:10.1016/j.dnarep.2010.03.004 · Cited by 309
Self-citationCoordination of dual incision and repair synthesis in human nucleotide excision repair
Staresincic, L., Fagbemi, A. F., Enzlin, J. H., Gourdin, A. M., Wijgers, N., Dunand‐Sauthier, I., Giglia‐Mari, G., Clarkson, S. G., Vermeulen, W., & Schärer, O. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.49 · Cited by 287
Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes
Pavlov, Y. I., Shcherbakova, P. V., & Rogozin, I. B. (2006) · International Review of Cytology · doi:10.1016/s0074-7696(06)55002-8 · Cited by 123
Metadata
- Authors
- Pascucci, B., Stucki, M., Jónsson, Z. O., Dogliotti, E., & Hübscher, U.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 274
- Issue
- 47
- Pages
- 33696-33702
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1577831872
- Cited by
- 204
- References
- 2
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Pascucci, B., Stucki, M., Jónsson, Z. O., Dogliotti, E., & Hübscher, U. (1999). Long Patch Base Excision Repair with Purified Human Proteins. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.47.33696
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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