The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4
Open accessAbstract
HER4 is a member of the epidermal growth factor receptor family and has an essential function in heart and neural development. Identification of two HER4 isoforms, HER4 JM-a and JM-b, which differ in their extracellular juxtamembrane region and in their susceptibility to cleavage after phorbol ester stimulation, showed that the juxtamembrane region of the receptor is critical for proteolysis. We now demonstrate that phorbol ester and pervanadate are effective stimuli for HER4 JM-a processing and that the HER4 JM-b isoform does not undergo cleavage in response to any of the stimuli studied. We also show that HER4 JM-a is not cleaved in cells lacking the metalloprotease tumor necrosis factor-alpha-converting enzyme (TACE) and that reexpression of TACE in these cells restores constitutive and regulated processing of HER4 JM-a. Moreover, we show that the sequence specific to the HER4 JM-a juxtamembrane region is sufficient to confer susceptibility to phorbol 12-myristate 13-acetate-induced cleavage of the HER2 receptor. In conclusion, we provide evidence that TACE is essential for the regulated shedding of the HER4 JM-a receptor.
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Cites
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An Essential Role for Ectodomain Shedding in Mammalian Development
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Self-citationCloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α
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Cited by
EDWARDS, D., HANDSLEY, M., & PENNINGTON, C. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.001 · Cited by 1,161
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
Matthews, V., Schuster, B., Schütze, S., Bussmeyer, I., Ludwig, A., Hundhausen, C., Sadowski, T., Saftig, P., Hartmann, D., Kallen, K.-J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210584200 · Cited by 390
Tumor necrosis factor-α converting enzyme
Black, R. A. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00097-8 · Cited by 346
May, P., Reddy, Y. K., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201979200 · Cited by 260
Metadata
- Authors
- Rio, C., Buxbaum, J. D., Peschon, J. J., & Corfas, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 275
- Issue
- 14
- Pages
- 10379-10387
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2074320983
- Cited by
- 309
- References
- 54
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4. https://app.cochat.ai/papers/10.1074/jbc.275.14.10379
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- Rio, C., Buxbaum, J. D., Peschon, J. J., & Corfas, G. (2000). Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.14.10379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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