Tumor necrosis factor-α converting enzyme

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149 · see citing works

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

Moss, M. L., Jin, S.-L. C., Milla, M. E., Burkhart, W., Carter, H. L., Chen, W., Clay, W. C., Didsbury, J. R., Hassler, D. F., Hoffman, C. R., et al. (1997) · Nature · doi:10.1038/385733a0 · Cited by 1,611 · see citing works

An Essential Role for Ectodomain Shedding in Mammalian Development

Peschon, J. J., Slack, J. L., Reddy, P., Stocking, K. L., Sunnarborg, S. W., Lee, D. C., Russell, W. E., Castner, B. J., Johnson, R. S., Fitzner, J. N., et al. (1998) · Science · doi:10.1126/science.282.5392.1281 · Cited by 1,606 · see citing works

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., & Fahrenholz, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3922 · Cited by 1,132 · see citing works

A Novel Proteolytic Cleavage Involved in Notch Signaling

Brou, C., Logeat, F., Gupta-Rossi, N., Chable-Bessia, C., Bail, O. L., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., & Israël, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80417-7 · Cited by 1,089 · see citing works

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

Buxbaum, J. D., Liu, K.-N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., & Black, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.27765 · Cited by 933 · see citing works

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

Stöcker, W., Grams, F., Reinemer, P., Bode, W., Baumann, U., Gomis‐Rüth, F. X., & McKay, D. (1995) · Protein Science · doi:10.1002/pro.5560040502 · Cited by 725 · see citing works

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

Garton, K. J., Gough, P. J., Blobel, C., Murphy, G., Greaves, D. R., Dempsey, P. J., & Raines, E. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106434200 · Cited by 639 · see citing works

Membrane protein secretases

Hooper, N. M., Karran, E. H., & Turner, A. J. (1997) · Biochemical Journal · doi:10.1042/bj3210265 · Cited by 613 · see citing works

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

Amour, A., Slocombe, P. M., Webster, A., Butler, M., Knight, C. G., Smith, B. J., Stephens, P. E., Shelley, C., Hutton, M., Knäuper, V., et al. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01031-x · Cited by 609 · see citing works

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

Mohler, K. M., Sleath, P. R., Fitzner, J. N., Cerretti, D. P., Alderson, M. R., Kerwar, S. S., Torranee, D. S., Otten-Evans, C., Greenstreet, T. A., Weerawarna, K., et al. (1994) · Nature · doi:10.1038/370218a0 · Cited by 588 · see citing works

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

McGeehan, G. M., Becherer, J. D., Bast, R. C., Boyer, C. M., CHAMPION, B. R., Connolly, K. M., Conway, J. G., Furdon, P. J., Karp, S. E., Kidao, S., et al. (1994) · Nature · doi:10.1038/370558a0 · Cited by 561 · see citing works

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

Schlöndorff, J. S., & Blobel, C. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.21.3603 · Cited by 545 · see citing works

Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme

Reddy, P., Slack, J. L., Davis, R., Cerretti, D. P., Kozlosky, C. J., Blanton, R. A., Shows, D. M., Peschon, J. J., & Black, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14608 · Cited by 501 · see citing works

Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability

Sunnarborg, S. W., Hinkle, C. L., Stevenson, M. C., Russell, W. E., Raska, C. S., Peschon, J. J., Castner, B. J., GERHART, M. J., Paxton, R. J., Black, R. A., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112050200 · Cited by 413 · see citing works

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

Maskos, K., Fernandez-Catalan, C., Huber, R., Bourenkov, G. P., Bartunik, H. D., Ellestad, G. A., Reddy, P., Wolfson, M. F., Rauch, C. T., Castner, B. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3408 · Cited by 387 · see citing works

Intracellular maturation and localization of the tumour necrosis factor α convertase (TACE)

Schlöndorff, J. S., Becherer, J. D., & Blobel, C. (2000) · Biochemical Journal · doi:10.1042/bj3470131 · Cited by 357 · see citing works

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

Roghani, M., Becherer, J. D., Moss, M. L., Atherton, R. E., Erdjument‐Bromage, H., Arribas, J., Blackburn, K., Weskamp, G., Tempst, P., & Blobel, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3531 · Cited by 315 · see citing works

Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4

Río, C., Buxbaum, J. D., Peschon, J. J., & Corfas, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.14.10379 · Cited by 309 · see citing works

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

Dong, J., Opresko, L. K., Dempsey, P. J., Lauffenburger, D. A., Coffey, R. J., & Wiley, H. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6235 · Cited by 263 · see citing works

Ectodomain shedding of TGF‐α and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

Fan, H., & Derynck, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.24.6962 · Cited by 243 · see citing works

Stimulation-induced Down-regulation of Tumor Necrosis Factor-α Converting Enzyme

Doedens, J. R., & Black, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14598 · Cited by 167 · see citing works

Shedding of interleukin‐6 receptor and tumor necrosis factor α

Althoff, K., Reddy, P., Voltz, N., Rose‐John, S., & Müllberg, J. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01278.x · Cited by 162 · see citing works

Differential Shedding of Transmembrane Neuregulin Isoforms by the Tumor Necrosis Factor-α-Converting Enzyme

Montero, J. C., Yuste, L., Dı́az-Rodrı́guez, E., Esparı́s-Ogando, A., & Pandiella, A. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0896 · Cited by 162 · see citing works

TACE and other ADAM proteases as targets for drug discovery

Moss, M. L., White, J. M., Lambert, M. H., & Andrews, R. C. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)01738-x · Cited by 156 · see citing works

TNF-α-Converting Enzyme Cleaves the Macrophage Colony-Stimulating Factor Receptor in Macrophages Undergoing Activation

Rovida, E., Paccagnini, A., Rosso, M. D., Peschon, J. J., & Sbarba, P. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1583 · Cited by 149 · see citing works

Tumor Necrosis Factor-α Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation*

Zhang, Y., Jiang, J., Black, R. A., Baumann, G. P., & Frank, S. J. (2000) · Endocrinology · doi:10.1210/endo.141.12.7858 · Cited by 140 · see citing works

Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types

Howard, L., Lu, X., MITCHELL, S., Griffiths, S. A., & Glynn, P. (1996) · Biochemical Journal · doi:10.1042/bj3170045 · Cited by 122 · see citing works

A Proteomic Approach for the Identification of Cell-surface Proteins Shed by Metalloproteases

Guo, L., Eisenman, J. R., Mahimkar, R., Peschon, J. J., Paxton, R. J., Black, R. A., & Johnson, R. S. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m100020-mcp200 · Cited by 96 · see citing works

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

Black, R. A., Durie, F. H., Otten-Evans, C., Miller, R., Slack, J. L., Lynch, D. H., Castner, B. J., Mohler, K. M., GERHART, M. J., Johnson, R. S., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1186 · Cited by 73 · see citing works

Regulation of Membrane Metalloproteolytic Cleavage of L-selectin (CD62L) by the Epidermal Growth Factor Domain

Zhao, L., Shey, M. R., Farnsworth, M., & Dailey, M. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103748200 · Cited by 68 · see citing works

A Continuous Fluorimetric Assay for Tumor Necrosis Factor-α Converting Enzyme

Jin, G., Huang, X., Black, R. A., Wolfson, M. F., Rauch, C. T., McGregor, H., Ellestad, G. A., & Cowling, R. A. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5549 · Cited by 66 · see citing works

Further evidence for a common mechanism for shedding of cell surface proteins

Müllberg, J., Rauch, C. T., Wolfson, M. F., Castner, B. J., Fitzner, J. N., Otten-Evans, C., Mohler, K. M., Cosman, D. J., & Black, R. A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(96)01480-9 · Cited by 59 · see citing works

The therapeutic potential of small molecule TACE inhibitors

Nelson, F. C., & Zask, A. (1999) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.8.4.383 · Cited by 50 · see citing works

Expression and Purification of Correctly Processed, Active Human TACE Catalytic Domain inSaccharomyces cerevisiae

Clarke, H. R. G., Wolfson, M. F., Rauch, C. T., Castner, B. J., Huang, C.-P., GERHART, M. J., Johnson, R. S., Cerretti, D. P., Paxton, R. J., Price, V. L., et al. (1998) · Protein Expression and Purification · doi:10.1006/prep.1998.0861 · Cited by 25 · see citing works

The many roles of chemokines and chemokine receptors in inflammation

Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523 · see citing works

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works

Microglia, seen from the CX3CR1 angle

Wolf, Y., Yona, S., Kim, K.-W., & Jung, S. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00026 · Cited by 316 · see citing works

Selected biomarkers of depression: what are the effects of cytokines and inflammation

Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299 · see citing works

Stimulated Shedding of Vascular Cell Adhesion Molecule 1 (VCAM-1) Is Mediated by Tumor Necrosis Factor-α-converting Enzyme (ADAM 17)

Garton, K. J., Gough, P. J., Philalay, J., Wille, P. T., Blobel, C. P., Whitehead, R. H., Dempsey, P. J., & Raines, E. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305877200 · Cited by 282 · see citing works

mGluR1/5-Dependent Long-Term Depression Requires the Regulated Ectodomain Cleavage of Neuronal Pentraxin NPR by TACE

Cho, R. W., Park, J. M., Wolff, S. B. E., Xu, D., Hopf, C., Kim, J.-A., Reddy, R. C., Petralia, R. S., Perin, M. S., Linden, D. J., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.010 · Cited by 125 · see citing works

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works

Enhancement of long-term depression by soluble amyloid β protein in rat hippocampus is mediated by metabotropic glutamate receptor and involves activation of p38MAPK, STEP and caspase-3

Chen, X., Lin, R., Chang, L., Xu, S., Wei, X., Zhang, J., Wang, C., Anwyl, R., & Wang, Q. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.054 · Cited by 93 · see citing works

Loss of tau rescues inflammation-mediated neurodegeneration

Maphis, N., Xu, G., Kokiko-Cochran, O. N., Cardona, A. E., Ransohoff, R. M., Lamb, B. T., & Bhaskar, K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00196 · Cited by 91 · see citing works

Sub-acute restraint stress progressively increases oxidative/nitrosative stress and inflammatory markers while transiently upregulating antioxidant gene expression in the rat hippocampus

Chen, H.-J. C., Lee, J. K., Yip, T., Sernia, C., Lavidis, N. A., & Spiers, J. G. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.11.007 · Cited by 22 · see citing works

Molecular cloning and functional characterization of a snake venom metalloprotease

Jeon, O., & Kim, D. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00525.x · Cited by 47 · see citing works

Functional roles of the two distinct domains of halysase, a snake venom metalloprotease, to inhibit human platelet aggregation

You, W., Jang, Y.-J., Chung, K., Jeon, O., & Kim, D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.083 · Cited by 23 · see citing works

A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems

Xu, J., Mukerjee, S., Silva-Alves, C. R. A., Carvalho‐Galvão, A., Cruz, J. C., Balarini, C. M., Braga, V. A., Lazartigues, E. D., & França-Silva, M. S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00469 · Cited by 62 · see citing works

The Role of CD9 in Regulating TNF-α-Induced Expression of A Disintegrin and Metalloprotease 17 (ADAM17) in Aortic Endothelial Cells

Hamdan, D. (2019) · TSpace (University of Toronto)

Structural Characterization of the Ectodomain of a Disintegrin and Metalloproteinase-22 (ADAM22), a Neural Adhesion Receptor Instead of Metalloproteinase

Liu, H., Shim, A. H.-R., & He, X. L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014258 · Cited by 68 · see citing works