The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity
Open accessAbstract
GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1). Human and mouse sequence (86.2% identical amino acids) comprise 12 putative membrane-spanning helices and several conserved motifs (sugar transporter signatures), which have previously been shown to be essential for transport activity, e.g. GRK in loop 2, PETPR in loop 6, QQLSGVN in helix 7, DRAGRR in loop 8, GWGPIPW in helix 10, and PETKG in the C-terminal tail. An expressed sequence tag (STS A005N15) corresponding with the 3'-untranslated region of GLUT8 has previously been mapped to human chromosome 9. COS-7 cells transfected with GLUT8 cDNA expressed a 42-kDa protein exhibiting specific, glucose-inhibitable cytochalasin B binding (K(D) = 56.6 +/- 18 nm) and reconstitutable glucose transport activity (8.1 +/- 1. 4 nmol/(mg protein x 10 s) versus 1.1 +/- 0.1 in control transfections). In human tissues, a 2.4-kilobase pair transcript was predominantly found in testis, but not in testicular carcinoma. Lower amounts of the mRNA were detected in most other tissues including skeletal muscle, heart, small intestine, and brain. GLUT8 mRNA was found in testis from adult, but not from prepubertal rats; its expression in human testis was suppressed by estrogen treatment. It is concluded that GLUT8 is a sugar transport facilitator with glucose transport activity and a hormonally regulated testicular function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,887
Sequence and Structure of a Human Glucose Transporter
Mueckler, M., Caruso, C., Baldwin, S. A., Panico, M., Blench, I., Morris, H. R., Allard, W. J., Lienhard, G. E., & Lodish, H. F. (1985) · Science · doi:10.1126/science.3839598 · Cited by 1,547
A graphic method for the determination and presentation of binding parameters in a complex system
Rosenthal, H. E. (1967) · Analytical Biochemistry · doi:10.1016/0003-2697(67)90297-7 · Cited by 1,512
Cushman, S. W., & Wardzala, L. J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85561-8 · Cited by 1,086
A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport
Marger, M. D., & Saier, M. H. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90081-w · Cited by 948
Molecular cloning and characterization of an insulin-regulatable glucose transporter
James, D. E., Strube, M., & Muecdler, M. (1989) · Nature · doi:10.1038/338083a0 · Cited by 903
Molecular Biology of Mammalian Glucose Transporters
Bell, G. I., Kayano, T., Buse, J. B., Burant, C. F., Takeda, J., Lin, D., Fukumoto, H., & Seino, S. (1990) · Diabetes Care · doi:10.2337/diacare.13.3.198 · Cited by 853
Thorens, B., Sarkar, H. K., Kaback, H. R., & Lodish, H. F. (1988) · Cell · doi:10.1016/0092-8674(88)90051-7 · Cited by 786
The glucose transporter family: structure, function and tissue-specific expression
Gould, G. W., & Holman, G. D. (1993) · Biochemical Journal · doi:10.1042/bj2950329 · Cited by 785
Drug excretion mediated by a new prototype of polyspecific transporter
Gründemann, D., Gorboulev, V., Gambaryan, S., Veyhl, M., & Koepsell, H. (1994) · Nature · doi:10.1038/372549a0 · Cited by 643
Cited by
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
Macheda, M. L., Rogers, S., & Best, J. D. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20166 · Cited by 1,229
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
Wood, I. S., & Trayhurn, P. (2003) · British Journal of Nutrition · doi:10.1079/bjn2002763 · Cited by 889
Carbohydrates in fish nutrition: effects on growth, glucose metabolism and hepatic enzymes
HEMRE, G.-I., MOMMSEN, T. P., & KROGDAHL, Å. (2002) · Aquaculture Nutrition · doi:10.1046/j.1365-2095.2002.00200.x · Cited by 888
Metadata
- Authors
- Doege, H., Schürmann, A., Bahrenberg, G., Brauers, A., & Joost, H.-G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 275
- Issue
- 21
- Pages
- 16275-16280
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2008257508
- Cited by
- 258
- References
- 33
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity. https://app.cochat.ai/papers/10.1074/jbc.275.21.16275
- The paper
- Doege, H., Schürmann, A., Bahrenberg, G., Brauers, A., & Joost, H.-G. (2000). GLUT8, a Novel Member of the Sugar Transport Facilitator Family with Glucose Transport Activity. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.21.16275
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
