Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
Open accessAbstract
The number of known glucose transporters has expanded considerably over the past 2 years. At least three, and up to six, Na+-dependent glucose transporters (SGLT1–SGLT6; gene name SLC5A) have been identified. Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1–GLUT12 and HMIT; gene name SLC2A) are now recognised. These various transporters exhibit different substrate specificities, kinetic properties and tissue expression profiles. The number of distinct gene products, together with the presence of several different transporters in certain tissues and cells (for example, GLUT1, GLUT4, GLUT5, GLUT8, GLUT12 and HMIT in white adipose tissue), indicates that glucose delivery into cells is a process of considerable complexity.
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GLUT-1 is the main expressed GLUT in red blood cell membrane and is not insulin dependent.
“It could be explained by the fact that GLUT-1 is the main expressed GLUT in red blood cell (RBC) membrane which is not insulin dependent [22,110]; thus, insulin resistance would not affect FDG uptake in RBCs.”
From Effect of blood glucose level on standardized uptake value (SUV) in 18F-FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements (2019) · cites this paper as [22]
The Class I facilitative transporters section says GLUT1 is expressed particularly in erythrocytes, while the Perspective calls GLUT1 a constitutive transporter and distinguishes it from insulin-responsive GLUT4. The paper does not establish that GLUT1 is the main GLUT in the red-blood-cell membrane. (LLM, conf=0.82)
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- Authors
- Wood, I. S., & Trayhurn, P.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Wood, I. Stuart
- ORCID
- Trayhurn, Paul
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2003-01
- Volume
- 89
- Issue
- 1
- Pages
- 3-9
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2135514341
- Cited by
- 889
- References
- 52
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 29 · 2023: 20 · 2022: 35 · 2021: 38 · 2020: 49 · 2019: 42 · 2018: 48 · 2017: 44 · 2016: 48 · 2015: 34 · 2014: 55 · 2013: 37 · 2012: 46
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucose transporters, sodium-glucose cotransporter, Na+-dependent glucose transport, substrate specificity, transport kinetics, tissue expression, white adipose tissue, GLUT4, GLUT5, GLUT8, GLUT12
- MeSH terms
- Adipose Tissue, Biological Transport, Active, Diabetes Mellitus, Type 2, Glucose, Humans, Monosaccharide Transport Proteins, Muscles
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