The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Targeted Disruption of the Mouse 3-Phosphoglycerate Dehydrogenase Gene Causes Severe Neurodevelopmental Defects and Results in Embryonic Lethality
Open accessAbstract
D-3-Phosphoglycerate dehydrogenase (Phgdh; EC 1.1.1.95) is the first committed enzyme of L-serine biosynthesis in the phosphorylated pathway. To determine the physiological importance of Phgdh-dependent L-serine biosynthesis in vivo, we generated Phgdh-deficient mice using targeted gene disruption in embryonic stem cells. The absence of Phgdh led to a drastic reduction of L-serine metabolites such as phosphatidyl-L-serine and sphingolipids. Phgdh null embryos have small bodies with abnormalities in selected tissues and died after days post-coitum 13.5. Striking abnormalities were evident in the central nervous system in which the Phgdh null mutation culminated in hypoplasia of the telencephalon, diencephalon, and mesencephalon; in particular, the olfactory bulbs, ganglionic eminence, and cerebellum appeared as indistinct structures. These observations demonstrate that the Phgdh-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis.
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“However, inhibitors of PHGDH might have a limited therapeutic index, as de novo serine synthesis has an important physiological role in the central nervous system (Furuya, 2008) and PHGDH-deficient mice exhibit severe brain morphogenesis defects (Yoshida et al., 2004).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Yoshida et al., 2004
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“Therefore, as further confirmed by the early embryonic lethality observed in Phgdh (cid:4) / (cid:4) homozygous knock-out mice (Yoshida et al., 2004), this short cytosolic pathway is crucial to guarantee the correct brain functioning.”
Pagliano, P., Salzano, F., D’Amore, C., Spera, A. M., Conti, V., Folliero, V., Franci, G., & Ascione, T. (2025) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2025.2534056 · Cited by 2
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“Mice with a PGDH gene deletion and human patients with a mutation in the PPSB gene show reduced serine levels in the brain and blood, respectively, indicating the involvement of PPSB in mammalian serine biosynthesis [17,18].”
BackgroundPannexin 1 regulates ventricular zone neuronal development
Wicki‐Stordeur, L. E. (2015) · UVic’s Research and Learning Repository (University of Victoria) · Cited by 2
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“For instance, deficiency of the two a-KG associated enzymes Psat1 and Phgdh, which are upregulated in RPs, have been reported in microcephaly, psychomotor retardation and epilepsy (Acuna-Hidalgo et al., 2014; Sharma & Prasad, 2017; Yoshida et al., 2003).”
BackgroundD-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transportPreprint
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Additional file 6 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480131
Additional file 7 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480134
Additional file 5 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480128
Additional file 8 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480137
D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transportPreprint
Suzuki, M., Adachi, K., Wiriyasermukul, P., Fukumura, M., Tamura, R., Hirano, Y., Aizawa, Y., Miyamoto, T., Taniguchi, S., Toda, M., et al. (2025) · eLife · doi:10.7554/elife.108562
Additional file 4 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480125
Additional file 1 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480116
Additional file 2 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480119
Additional file 3 of PHGDH supports liver ceramide synthesis and sustains lipid homeostasis
Kang, Y. P., Falzone, A., Liu, M., González‐Sánchez, P., Choi, B.-H., Coloff, J. L., Saller, J. J., Karreth, F. A., & DeNicola, G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12480122
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“Gene Ontology (GO) analysis on the differentially expressed genes (DEGs) in the RNA-seq data revealed that DEGs upregulated at pH 6.8 were enriched in pathways related to stress and immune responses, such as CR2 29,30 , TCF7 31 – 33 ,and IL32 34 ;whereasDEGsupregulatedatpH7.”
Influentialᴅ-serine suppresses one-carbon metabolism by competing with mitochondrial ʟ-serine transportPreprint
Suzuki, M., Adachi, K., Wiriyasermukul, P., Fukumura, M., Tamura, R., Hirano, Y., Aizawa, Y., Miyamoto, T., Taniguchi, S., Toda, M., et al. (2026) · eLife · doi:10.7554/elife.108562.2
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Marchant, M. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.19389875
D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transportPreprint
Suzuki, M., Adachi, K., Wiriyasermukul, P., Fukumura, M., Tamura, R., Hirano, Y., Aizawa, Y., Miyamoto, T., Taniguchi, S., Toda, M., et al. (2026) · eLife · doi:10.7554/elife.108562.3
Metadata
- Authors
- Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., & Hirabayashi, Y.
- Affiliations
- RIKEN (JP)
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Hokkaido University (JP)
- Utsunomiya University (JP)
- Corresponding author
- Furuya, Shigeki
- Hirabayashi, Yoshio
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 279
- Issue
- 5
- Pages
- 3573-3577
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2097895708
- Cited by
- 161
- References
- 25
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 13 · 2020: 15 · 2019: 4 · 2018: 11 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 4 · 2013: 3 · 2012: 8
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- 3-phosphoglycerate dehydrogenase, PHGDH, L-serine biosynthesis, embryonic lethality, neurodevelopmental defects, brain morphogenesis, sphingolipids, olfactory bulb hypoplasia, ganglionic eminence, cerebellum, telencephalon, diencephalon, midbrain
- MeSH terms
- Alleles, Animals, Brain, Carbohydrate Dehydrogenases, Cytosol, Exons, Heterozygote, Immunohistochemistry, Introns, Liver, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Fluorescence, Mutation, Nervous System, Phenotype, Phosphorylation, Serine, Stem Cells, Time Factors, Blotting, Southern, Blotting, Western, Polymerase Chain Reaction, Phosphoglycerate Dehydrogenase, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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