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Sperm Motility Is Dependent on a Unique Isoform of the Na,K-ATPase
Open accessAbstract
The Na,K-ATPase, a member of the P-type ATPases, is composed of two subunits, alpha and beta, and is responsible for translocating Na(+) out of the cell and K(+) into the cell using the energy of hydrolysis of one molecule of ATP. The electrochemical gradient it generates is necessary for many cellular functions, including establishment of the plasma membrane potential and transport of sugars and ions in and out of the cell. Families of isoforms for both the alpha and beta subunits have been identified, and specific functional roles for individual isoforms are just beginning to emerge. The alpha4 isoform is the most recently identified Na, K-ATPase alpha isoform, and its expression has been found only in testis. Here we show that expression of the alpha4 isoform in testis is localized to spermatozoa and that inhibition of this isoform alone eliminates sperm motility. These data describe for the first time a biological function for the alpha4 isoform of the Na,K-ATPase, revealing a critical role for this isoform in sperm motility.
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Keilin's Respiratory Chain Concept and Its Chemiosmotic Consequences
Mitchell, P. (1979) · Science · doi:10.1126/science.388618 · Cited by 738
Cited by
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Richards, J. G., Semple, J. W., Bystriansky, J. S., & Schulte, P. M. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00701 · Cited by 358
Brosh, Jr. (2001) · The EMBO Journal · doi:10.1093/emboj/20.20.5791 · Cited by 260
Johnson, K. R., Gagnon, L. H., & Chang, B. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9632-0 · Cited by 19
Metadata
- Authors
- Woo, A. L., James, P. F., & Lingrel, J. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 275
- Issue
- 27
- Pages
- 20693-20699
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2090850018
- Cited by
- 167
- References
- 1
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Woo, A. L., James, P. F., & Lingrel, J. B. (2000). Sperm Motility Is Dependent on a Unique Isoform of the Na,K-ATPase. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m002323200
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