The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF
Open accessAbstract
The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues. NPFF specifically bound to NPFF1 (K(d) = 1.13 nm) and NPFF2 (K(d) = 0.37 nm), and both receptors were activated by NPFF in a variety of heterologous expression systems. The localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports a role for NPFF in pain modulation. Among the receptors with the highest amino acid sequence homology to NPFF1 and NPFF2 are members of the orexin, NPY, and cholecystokinin families, which have been implicated in feeding. These similarities together with the finding that BIBP3226, an anorexigenic Y1 receptor ligand, also binds to NPFF1 suggest a potential role for NPFF1 in feeding. The identification of NPFF1 and NPFF2 will help delineate their roles in these and other physiological functions.
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Cloned Human and Rat Galanin GALR3 Receptors
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Self-citationReceptor for the Pain Modulatory Neuropeptides FF and AF Is an Orphan G Protein-coupled Receptor
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Neuropeptide FF, pain and analgesia
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Gene for Pain Modulatory Neuropeptide NPFF: Induction in Spinal Cord by Noxious Stimuli
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Cited by
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
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Orphan G-protein-coupled receptors and natural ligand discovery
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Neuropeptide Y receptors: how to get subtype selectivity
Pedragosa-Badia, X., Stichel, J., & Beck-Sickinger, A. G. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00005 · Cited by 191
Metadata
- Authors
- Bonini, J. A., Jones, K. A., Adham, N., Forray, C., Artymyshyn, R., Durkin, M. M., Smith, K. E., Tamm, J. A., Boteju, L. W., Lakhlani, P. P., Raddatz, R., Yao, W.-J., Ogozalek, K. L., Boyle, N., Kouranova, E. V., Quan, Y., Vaysse, P. J., Wetzel, J. M., Branchek, T. A., Gerald, C., & Borowsky, B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 275
- Issue
- 50
- Pages
- 39324-39331
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2142793823
- Cited by
- 428
- References
- 28
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bonini, J. A., Jones, K. A., Adham, N., Forray, C., Artymyshyn, R., Durkin, M. M., Smith, K. E., Tamm, J. A., Boteju, L. W., Lakhlani, P. P., Raddatz, R., Yao, W.-J., Ogozalek, K. L., Boyle, N., Kouranova, E. V., Quan, Y., Vaysse, P. J., Wetzel, J. M., Branchek, T. A., . . . Borowsky, B. (2000). Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m004385200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
