Do Modulators of the Mitochondrial KATP Channel Change the Function of Mitochondria in Situ?
Open accessAbstract
Pharmacological opening of mitochondrial cardiac ATP-sensitive potassium (K(ATP)) channels has the chance to be a promising but still controversial cardioprotective mechanism. Physiological roles of mitochondrial K(ATP) channels in the myocardium remain unclear. We studied the effects of diazoxide, a specific opener of these channels, on the function of rat mitochondria in situ in saponin-permeabilized fibers using an ionic medium that mimics the cytosol. In the presence of NADH-producing substrates (malate + glutamate), neither 100 microm diazoxide nor 100 microm glibenclamide (a K(ATP) channel blocker) changed the mitochondrial respiration in the absence or presence of ADP. Because the K(ATP) channel function could be modified by changes in adenine nucleotide concentrations near the mitochondria, we studied the effects of diazoxide and glibenclamide on the functional activity of mitochondrial kinases. Both diazoxide and glibenclamide did not change the in situ ADP sensitivity in the presence or absence of creatine (apparent K(m) values for ADP were, respectively, 59 +/- 9 and 379 +/- 45 microm). Similarly, stimulation of the mitochondrial respiration with AMP in the presence of ATP due to adenylate kinase activity was not affected by the modulators of K(ATP) channels. However, when succinate was used as substrate, diazoxide significantly inhibited basal respiration by 22% and maximal respiration by 24%. Thus, at a cardioprotective dose, the main functional effect of diazoxide depends on respiratory substrates and seems not to be related to K(ATP) channel activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Diazoxide inhibits complex II, while the KATP channel antagonist 5-HD can be metabolized by mitochondrial β-oxidation.
“Diazoxide inhibits complex II [128,129,147], while the K ATP channel antagonist 5-HD can be metabolized by the ß-oxidation pathway of the mitochondria [148][149][150].”
From Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning (2013) · cites this paper as [147]
Cites
ATP-regulated K+ channels in cardiac muscle
Noma, A. (1983) · Nature · doi:10.1038/305147a0 · Cited by 2,341 · see citing works
Cardioprotective Effect of Diazoxide and Its Interaction With Mitochondrial ATP-Sensitive K+Channels
Garlid, K., Pauček, P., Yarov-Yarovoy, V. M., Murray, H. N., Darbenzio, R. B., DʼAlonzo, A. J., Lodge, N. J., Smith, M. A., & Grover, G. J. (1997) · Circulation Research · doi:10.1161/01.res.81.6.1072 · Cited by 1,019 · see citing works
Mitochondrial ATP-Dependent Potassium Channels
Liu, Y., Sato, T., O'Rourke, B. P., & Marbán, E. (1998) · Circulation · doi:10.1161/01.cir.97.24.2463 · Cited by 816 · see citing works
ATP-sensitive K+ channel in the mitochondrial inner membrane
Inoue, I., Nagase, H., Kishi, K., & Higuti, T. (1991) · Nature · doi:10.1038/352244a0 · Cited by 751 · see citing works
Sarcolemmal Versus Mitochondrial ATP-Sensitive K+Channels and Myocardial Preconditioning
Gross, G. J., & Fryer, R. M. (1999) · Circulation Research · doi:10.1161/01.res.84.9.973 · Cited by 478 · see citing works
The Mitochondrial K Channel as a Receptor for Potassium Channel Openers
Garlid, K., Pauček, P., Yarov-Yarovoy, V. M., Sun, X., & Schindler, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.8796 · Cited by 445 · see citing works
Modulation of Mitochondrial ATP-Dependent K+Channels by Protein Kinase C
Sato, T., O'Rourke, B. P., & Marbán, E. (1998) · Circulation Research · doi:10.1161/01.res.83.1.110 · Cited by 366 · see citing works
Veksler, V., Kuznetsov, A. V., Sharov, V. G., Kapelko, V. I., & Saks, V. A. (1987) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(87)90174-5 · Cited by 360 · see citing works
Self-citationPauček, P., Mironova, G. D., Mahdi, F., Beavis, A. D., Woldegiorgis, G., & Garlid, K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35717-x · Cited by 357 · see citing works
ATP‐sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria
Holmuhamedov, E., Wang, L., & Terzic, A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0347m.x · Cited by 346 · see citing works
Yao, Z., & Gross, G. J. (1994) · Circulation · doi:10.1161/01.cir.89.4.1769 · Cited by 256 · see citing works
State-dependent Inhibition of the Mitochondrial KATP Channel by Glyburide and 5-Hydroxydecanoate
Jabůrek, M., Yarov-Yarovoy, V. M., Pauček, P., & Garlid, K. (1998) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57796-1 · Cited by 254 · see citing works
Cation transport in mitochondria — The potassium cycle
Garlid, K. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00061-8 · Cited by 205 · see citing works
Wang, Y., Hirai, K., & Ashraf, M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.731 · Cited by 198 · see citing works
Muscle Creatine Kinase-deficient Mice
Veksler, V., Kuznetsov, A. V., Anflous, K., Matéo, P., van Deursen, J., Wieringa, B., & Ventura‐Clapier, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19921 · Cited by 185 · see citing works
Self-citationSignal Transduction in Ischemic Preconditioning:
Baines, C. P., Cohen, M. V., & Downey, J. M. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00251.x · Cited by 152 · see citing works
Takashi, E., Wang, Y., & Ashraf, M. (1999) · Circulation Research · doi:10.1161/01.res.85.12.1146 · Cited by 151 · see citing works
Phosphotransfer reactions in the regulation of ATP‐sensitive K + channels
Dzeja, P. P., & Terzic, A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.7.523 · Cited by 147 · see citing works
Grover, G. J., DʼAlonzo, A. J., Parham, C. S., & Darbenzio, R. B. (1995) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199507000-00023 · Cited by 145 · see citing works
Jovanović, A., Jovanović, S., Lorenz, E., & Terzic, A. (1998) · Circulation · doi:10.1161/01.cir.98.15.1548 · Cited by 119 · see citing works
Direct effects of diazoxide on mitochondria in pancreatic B‐cells and on isolated liver mitochondria
Grimmsmann, T., & Rustenbeck, I. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701663 · Cited by 117 · see citing works
Is the chemical gate of connexins voltage sensitive? Behavior of Cx32 wild-type and mutant channels
Peracchia, C., Wang, X. G., & Peracchia, L. L. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.6.c1361 · Cited by 79 · see citing works
Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide—I
Schäfer, G., Portenhauser, R., & Trolp, R. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90358-3 · Cited by 52 · see citing works
THE EFFECTS OF DIAZOXIDE AND BENZOTHIADIAZINE DIURETICS UPON PHOSPHODIESTERASE
Moore, P. F. (1968) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1968.tb19050.x · Cited by 49 · see citing works
Regulation of mitochondrial KATP channel by redox agents
Sm, G., Skarga, Y. Y., Mironova, G. D., & Marinov, B. S. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00179-0 · Cited by 45 · see citing works
Binding of diazoxide and other benzothiadiazines to human albumin
Sellers, E. M., & Koch‐Weser, J. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90620-0 · Cited by 30 · see citing works
Blockade of the ATP-sensitive Potassium Channel by Taurine in Rabbit Ventricular Myocytes
Han, J. (1996) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1996.0197 · Cited by 29 · see citing works
Ribalet, B., Mirell, C. J., Johnson, D. G., & Levin, S. R. (1996) · The Journal of General Physiology · doi:10.1085/jgp.107.2.231 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondria in health and disease: perspectives on a new mitochondrial biology
Duchen, M. R. (2004) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.03.001 · Cited by 723 · see citing works
Evidence for Mitochondrial K + Channels and Their Role in Cardioprotection
O'Rourke, B. P. (2004) · Circulation Research · doi:10.1161/01.res.0000117583.66950.43 · Cited by 444 · see citing works
Garlid, K., Santos, P. D. D., Xie, Z., Costa, A. D. T., & Pauček, P. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(03)00109-9 · Cited by 332 · see citing works
KATP channels and myocardial preconditioning: an update
Gross, G. J., & Peart, J. N. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00421.2003 · Cited by 324 · see citing works
K<sub>ATP</sub> channel‐independent targets of diazoxide and 5‐hydroxydecanoate in the heart
Hanley, P. J., Mickel, M., Löffler, M., Brandt, U., & Daut, J. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.023960 · Cited by 320 · see citing works
Preconditioning protects by inhibiting the mitochondrial permeability transition
Hausenloy, D. J., Yellon, D. M., Mani-Babu, S., & Duchen, M. R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00678.2003 · Cited by 263 · see citing works
Mechanisms by which opening the mitochondrial ATP- sensitive K+channel protects the ischemic heart
Santos, P. D. D., Kowaltowski, A. J., Laclau, M. N., Seetharaman, S., Pauček, P., Boudina, S., Thambo, J., Tariosse, L., & Garlid, K. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00034.2002 · Cited by 221 · see citing works
HANLEY, P., & DAUT, J. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.04.002 · Cited by 218 · see citing works
Lim, K. H. H., Javadov, S. A., Das, M., Clarke, S. J., Suleiman, M. S., & Halestrap, A. P. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.031484 · Cited by 219 · see citing works
Dröse, S. (2013) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.01.004 · Cited by 201 · see citing works
The direct physiological effects of mitoKATPopening on heart mitochondria
Costa, A. D. T., Quinlan, C. L., Andrukhiv, A., West, I. C., Jabůrek, M., & Garlid, K. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00794.2005 · Cited by 195 · see citing works
Özcan, C., Bienengraeber, M., Dzeja, P. P., & Terzic, A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00552.2001 · Cited by 195 · see citing works
Mitochondrial potassium channels
Szewczyk, A. M., Jarmuszkiewicz, W., & Kunz, W. S. (2009) · IUBMB Life · doi:10.1002/iub.155 · Cited by 181 · see citing works
Kôrge, P., Honda, H. M., & Weiss, J. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052713199 · Cited by 177 · see citing works
Mitochondria and Ca2+ signaling: old guests, new functions
Graier, W. F., Frieden, M., & Malli, R. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0296-1 · Cited by 160 · see citing works
Heinen, A., Camara, A. K. S., Aldakkak, M., Rhodes, S. S., Riess, M. L., & Stowe, D. F. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00215.2006 · Cited by 127 · see citing works
Ralph, S. J., Moreno-Sánchez, R., Neuzil, J., & Rodríguez-Enríquez, S. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0566-7 · Cited by 126 · see citing works
Carroll, R. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00330-3 · Cited by 122 · see citing works
Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection
Dzeja, P. P., Bast, P., Özcan, C., Valverde, A. M., Holmuhamedov, E., Wylen, D. G. L. V., & Terzic, A. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00847.2002 · Cited by 104 · see citing works
Mitochondria and reperfusion injury
Lisa, F. D., Canton, M., Menabò, R., Dodoni, G., & Bernardi, P. (2003) · Basic Research in Cardiology · doi:10.1007/s00395-003-0415-x · Cited by 103 · see citing works
Budas, G. R., Jovanovic, S., Crawford, R. M., & Jovanović, A. (2004) · The FASEB Journal · doi:10.1096/fj.04-1602fje · Cited by 92 · see citing works
Hanley, P. J., Dröse, S., Brandt, U., Lareau, R. A., Banerjee, A. L., Srivastava, D. K., Banaszak, L. J., Barycki, J. J., Veldhoven, P. P. V., & Daut, J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.073932 · Cited by 88 · see citing works
Singh, H. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00041-5 · Cited by 86 · see citing works
The mitochondrial permeability transition pore (PTP) — An example of multiple molecular exaptation?
Vianello, A., Casolo, V., Petrussa, E., Peresson, C., Patui, S., Bertolini, A. M., Passamonti, S., Braidot, E., & Zancani, M. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.06.620 · Cited by 83 · see citing works
Rousou, A. J., Ericsson, M., Federman, M., Levitsky, S., & McCully, J. D. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00338.2004 · Cited by 83 · see citing works
Mitochondrial potassium channels: From pharmacology to function
Szewczyk, A. M., Skalska, J., Głąb, M., Kulawiak, B., Malińska, D., Koszela-Piotrowska, I., & Kunz, W. S. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.002 · Cited by 81 · see citing works
Differential Actions of Cardioprotective Agents on the Mitochondrial Death Pathway
Akao, M., O'Rourke, B. P., Kusuoka, H., Teshima, Y., Jones, S. P., & Marbán, E. (2003) · Circulation Research · doi:10.1161/01.res.0000051862.16691.f9 · Cited by 81 · see citing works
Lawrence, C., Billups, B., Rodrigo, G. C., & Standen, N. B. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704289 · Cited by 76 · see citing works
Nagy, K. A., Kis, B., Rajapakse, N. C., Bari, F., & Busija, D. W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20120 · Cited by 67 · see citing works
The Mitochondrial Potassium Cycle
Garlid, K., & Pauček, P. (2001) · IUBMB Life · doi:10.1080/15216540152845948 · Cited by 59 · see citing works
Minners, J., Lacerda, L., Yellon, D. M., Opie, L. H., McLeod, C. J., & Sack, M. N. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9066-6 · Cited by 49 · see citing works
Shneyvays, V., Leshem, D., Zinman, T., Mamedova, L. K., Jacobson, K. A., & Shainberg, A. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01157.2004 · Cited by 47 · see citing works
Brustovetsky, T., Shalbuyeva, N., & Brustovetsky, N. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.091199 · Cited by 46 · see citing works
Pelloux, S., Robillard, J. M., Ferrera, R., Bilbaut, A., Ojeda, C., Saks, V. A., Ovize, M., & Tourneur, Y. (2005) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2005.06.009 · Cited by 45 · see citing works
Adebiyi, A., McNally, E. M., & Jaggar, J. H. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.048165 · Cited by 42 · see citing works
Kôrge, P., Honda, H. M., & Weiss, J. N. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01296.2004 · Cited by 36 · see citing works
Matsuzaki, S., Szweda, P. A., Szweda, L. I., & Humphries, K. M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.008 · Cited by 35 · see citing works
Holmuhamedov, E., Özcan, C., Jahangir, A., & Terzic, A. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1010894427373 · Cited by 34 · see citing works
Minners, J. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00337-7 · Cited by 30 · see citing works
Kopustinskienė, D. M., Toleikis, A., & Saris, N.-E. L. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1023746103401 · Cited by 30 · see citing works
Diazoxide and Pinacidil Uncouple Pyruvate–Malate-Induced Mitochondrial Respiration
Kopustinskienė, D. M., Jovaisiene, J., Liobikas, J., & Toleikis, A. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1013870704002 · Cited by 27 · see citing works
Jilkina, O., Kuzio, B., Grover, G. J., & Kupriyanov, V. V. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1524 · Cited by 24 · see citing works
The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats
Merdžo, I., Rutkai, I., Tokes, T., Sure, V. N. L. R., Katakam, P. V. G., & Busija, D. W. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00964.2015 · Cited by 22 · see citing works
Mitochondrial KATPChannels: Probing Molecular Identity and Pharmacology
Terzic, A., Dzeja, P. P., & Holmuhamedov, E. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1256 · Cited by 22 · see citing works
Liu, B., Zhu, X., Chen, C., Hu, K., Swartz, H. M., Chen, Y., & He, G. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0283-2 · Cited by 21 · see citing works
SUR1 As a New Therapeutic Target for Pulmonary Arterial Hypertension
Ribeuz, H. L., Masson, B., Capuano, V., Dutheil, M., Gooroochurn, H., Boët, A., Ghigna, M., de Montpréville, V., Girerd, B., Lambert, M., et al. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0180oc · Cited by 20 · see citing works
Kopustinskienė, D. M., Liobikas, J., Škėmienė, K., Malinauskas, F., & Toleikis, A. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000276552 · Cited by 20 · see citing works
Role of endogenous nitric oxide in classic preconditioning in rat hearts
Prendes, M. G. M., González, M. J., Savino, E. A., & Varela, A. (2006) · Regulatory Peptides · doi:10.1016/j.regpep.2006.10.015 · Cited by 19 · see citing works
Pasdois, P., Beauvoit, B. P., Tariosse, L., Jaspard‐Vinassa, B., Bonoron‐Adèle, S., & Santos, P. D. D. (2006) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-006-9016-3 · Cited by 16 · see citing works
Sarcolemmal KATP channels in ageing
Jovanović, A. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2003.10.001 · Cited by 14 · see citing works
Reinhardt, R., Manaenko, A., Pissarek, M., Wagner, A., & Illés, P. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00102-4 · Cited by 12 · see citing works
Ageing, gender and cardiac sarcolemmal KATP channels
Jovanović, A. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.12.0004 · Cited by 9 · see citing works
Gross, G. J. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704965 · Cited by 8 · see citing works
Baumann, P., Poitry, S., Roatti, A., & Baertschi, A. J. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00393.2002 · Cited by 8 · see citing works
Reinhardt, R., Manaenko, A., Guenther, A., Franke, H., Dickel, T., de Arriba, S. G., Muench, G. W., Schneider, D., Wagner, A., & Illés, P. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00053-6 · Cited by 6 · see citing works
Inhibitory effect of glybenclamide on mitochondrial chloride channels from rat heart
Komínková, V., Ondriaš, K., & Tomaskova, Z. S. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.024 · Cited by 5 · see citing works
Cardioprotection by preconditioning: KATP channels, metabolism, or both?
Standen, N. B. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.025601 · Cited by 4 · see citing works
Hanley, P. J., & Daut, J. (2005) · Cited by 1 · see citing works
Ojeda, C., Joseph, P., Saks, V. A., Piriou, V., & Tourneur, Y. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009882.61557.a7 · Cited by 1 · see citing works
Shalaby, A. (2013) · Tampere University Institutional Repository (Tampere University)
- Authors
- Ovide-Bordeaux, S., Ventura-Clapier, R., & Veksler, V.
- Affiliations
- Université Paris-Sud (FR)
- Corresponding author
- Veksler, Vladimir
- ORCID
- Veksler, Vladimir
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 275
- Issue
- 47
- Pages
- 37291-37295
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1989633392
- Cited by
- 60
- References
- 28
- Citations by year
- 2022: 1 · 2016: 1 · 2013: 3 · 2012: 1
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- mitochondrial ATP-sensitive potassium channel, diazoxide, glibenclamide, mitochondrial respiration, cardioprotection, adenine nucleotides, adenylate kinase, succinic acid, ADP sensitivity, respiratory substrates
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Animals, Creatine Kinase, Diazoxide, Glyburide, Hypoglycemic Agents, Male, Mitochondria, Oxygen Consumption, Potassium Channels, Rats, Wistar, ATP-Binding Cassette Transporters, Potassium Channels, Inwardly Rectifying, Rats, KATP Channels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
