The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The ERK Signaling Cascade Inhibits Gonadotropin-stimulated Steroidogenesis
Open accessAbstract
The response of granulosa cells to luteinizing hormone (LH) and follicle-stimulating hormone (FSH) is mediated mainly by cAMP/protein kinase A (PKA) signaling. Notably, the activity of the extracellular signal-regulated kinase (ERK) signaling cascade is elevated in response to these stimuli as well. We studied the involvement of the ERK cascade in LH- and FSH-induced steroidogenesis in two granulosa-derived cell lines, rLHR-4 and rFSHR-17, respectively. We found that stimulation of these cells with the appropriate gonadotropin induced ERK activation as well as progesterone production downstream of PKA. Inhibition of ERK activity enhanced gonadotropin-stimulated progesterone production, which was correlated with increased expression of the steroidogenic acute regulatory protein (StAR), a key regulator of progesterone synthesis. Therefore, it is likely that gonadotropin-stimulated progesterone formation is regulated by a pathway that includes PKA and StAR, and this process is down-regulated by ERK, due to attenuation of StAR expression. Our results suggest that activation of PKA signaling by gonadotropins not only induces steroidogenesis but also activates down-regulation machinery involving the ERK cascade. The activation of ERK by gonadotropins as well as by other agents may be a key mechanism for the modulation of gonadotropin-induced steroidogenesis.
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Cites
DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis
Zazopoulos, E., Lalli, E., Stocco, D. M., & Sassone-Corsi, P. (1997) · Nature · doi:10.1038/36899 · Cited by 433
Phosphorylation of the Nuclear Receptor SF-1 Modulates Cofactor Recruitment
Hammer, G. D., Krylova, I., Zhang, Y., Darimont, B. D., Simpson, K., Weigel, N. L., & Ingraham, H. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80480-3 · Cited by 375
Hanukoglu, I., Suh, B. S., Himmelhoch, S., & Amsterdam, A. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.4.1373 · Cited by 81
Self-citation
Cited by
The ERK Cascade: Distinct Functions within Various Subcellular Organelles
Wortzel, I., & Seger, R. (2011) · Genes & Cancer · doi:10.1177/1947601911407328 · Cited by 563
Self-citationStocco, D. M., Wang, X., Jo, Y., & Manna, P. R. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0532 · Cited by 538
Molecular mechanisms of ovulation: co-ordination through the cumulus complex
Russell, D. L., & Robker, R. L. (2007) · Human Reproduction Update · doi:10.1093/humupd/dml062 · Cited by 431
Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells
Moore, R. K., Otsuka, F., & Shimasaki, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207362200 · Cited by 326
Martin, L. J., Boucher, N., Brousseau, C., & Tremblay, J. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0370 · Cited by 141
Metadata
- Authors
- Seger, R., Hanoch, T., Rosenberg, R., Dantes, A., Merz, W. E., Strauss, J. F., & Amsterdam, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 276
- Issue
- 17
- Pages
- 13957-13964
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1599163395
- Cited by
- 233
- References
- 3
- FWCI
- 25.46
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- hybrid
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