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SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting
Open accessAbstract
SUMO-1 is a small ubiquitin-related modifier that is covalently linked to many cellular protein targets. Proteins modified by SUMO-1 and the SUMO-1-activating and -conjugating enzymes are located predominantly in the nucleus. Here we define a transferable sequence containing the PsiKXE motif, where Psi represents a large hydrophobic amino acid, that confers the ability to be SUMO-1-modified on proteins to which it is linked. Whereas addition of short sequences from p53 and IkappaBalpha, containing the PsiKXE motif, to a carrier protein is sufficient for modification in vitro, modification in vivo requires the additional presence of a nuclear localization signal. Thus, protein substrates must be targeted to the nucleus to undergo SUMO-1 conjugation.
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Citations
Cited by
Perkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674
GPS-SUMO: a tool for the prediction of sumoylation sites and SUMO-interaction motifs
Zhao, Q., Xie, Y., Zheng, Y., Jiang, S., Liu, W., Mu, W., Liu, Z., Zhao, Y., Xue, Y., & Ren, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku383 · Cited by 522
A comprehensive compilation of SUMO proteomics
Hendriks, I. A., & Vertegaal, A. C. O. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.81 · Cited by 514
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation
Hendriks, I. A., Lyon, D., Young, C., Jensen, L. J., Vertegaal, A. C. O., & Nielsen, M. L. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3366 · Cited by 382
Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318
Metadata
- Authors
- Rodriguez, M. S., Dargemont, C., & Hay, R. T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-04
- Volume
- 276
- Issue
- 16
- Pages
- 12654-12659
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1991189921
- Cited by
- 744
- References
- 0
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rodriguez, M. S., Dargemont, C., & Hay, R. T. (2001). SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m009476200
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