Reciprocal Phosphorylation and Regulation of Endothelial Nitric-oxide Synthase in Response to Bradykinin Stimulation

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Dimmeler, S., Fleming, I., Fisslthaler, B., Hermann, C., Busse, R., & Zeiher, A. M. (1999) · Nature · doi:10.1038/21224 · Cited by 3,591

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248

Nitric oxide: an endogenous modulator of leukocyte adhesion.

Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K. X., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,616

Okadaic acid: a new probe for the study of cellular regulation

Cohen, P., Holmes, C. F. B., & Tsukitani, Y. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90192-e · Cited by 1,373

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

Papapetropoulos, A., García‐Cardeña, G., Madri, J. A., & Sessa, W. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119868 · Cited by 1,195

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11367.x · Cited by 1,158

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

Coffer, P. J., Jin, J., & Woodgett, J. R. (1998) · Biochemical Journal · doi:10.1042/bj3350001 · Cited by 1,064

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

Boulanger, C. M., & Lüscher, T. F. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114477 · Cited by 1,044

Coordinated Endothelial Nitric Oxide Synthase Activation by Translocation and Phosphorylation Determines Flow-Induced Nitric Oxide Production in Resistance Vessels

Figueroa, X. F., González, D. R., Puebla, M., Acevedo, J. P., Rojas‐Líbano, D., Durán, W. N., & Borić, M. P. (2013) · Journal of Vascular Research · doi:10.1159/000355301 · Cited by 30

Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling

Gill, R. M., Braz, J. C., Jin, N., Etgen, G. J., & Shen, W. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00831.2006 · Cited by 30

Renal Autocrine and Paracrine Signaling: A Story of Self-protection

Leipziger, J., & Prætorius, H. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00014.2019 · Cited by 28

Phosphorylation of Neuronal and Endothelial Nitric Oxide Synthase in the Kidney with High and Low Salt Diets

Mount, P. F., Fraser, S. A., Watanabe, Y., Lane, N., Katsis, F., Chen, Z., Kemp, B. E., & Power, D. A. (2005) · Nephron Physiology · doi:10.1159/000089092 · Cited by 29

Cyclin-Dependent Kinase 5 Phosphorylates Endothelial Nitric Oxide Synthase at Serine 116

Cho, D., Seo, J., Park, J., Jo, C., Choi, Y. J., Soh, J., & Jo, I. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.140210 · Cited by 29

Nanocurcumin and arginine entrapped injectable chitosan hydrogel for restoration of hypoxia induced endothelial dysfunction

Mohandas, A., & Jayakumar, R. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.205 · Cited by 28

Beneficial effect of the oligomerized polyphenol oligonol on high glucose‐induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

Zhang, X., Yokoo, H., Nishioka, H., Fujii, H., Matsuda, N., Hayashi, T., & Hattori, Y. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00594.x · Cited by 28

α-Tocopherol Amplifies Phosphorylation of Endothelial Nitric Oxide Synthase at Serine 1177 and its Short-Chain Derivative Trolox Stabilizes Tetrahydrobiopterin

Heller, R., Hecker, M., Stahmann, N., Thiele, J. J., Werner‐Felmayer, G., & Werner, E. R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.017 · Cited by 28

Inhibition of MEK/ERK1/2 signalling alters endothelial nitric oxide synthase activity in an agonist-dependent manner

Cale, J. M., & Bird, I. M. (2006) · Biochemical Journal · doi:10.1042/bj20060371 · Cited by 28

Solution Structure of Calmodulin Bound to the Target Peptide of Endothelial Nitric Oxide Synthase Phosphorylated at Thr495

Piazza, M. J., Taiakina, V., Guillemette, S. R., Guillemette, J. G., & Dieckmann, T. (2014) · Biochemistry · doi:10.1021/bi401466s · Cited by 28

Chronic Ethanol Exposure Stimulates Endothelial Cell Nitric Oxide Production through PI-3 Kinase-and hsp90-dependent Mechanisms

Polikandriotis, J. A., Rupnow, H. L., & Hart, C. M. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000187597.62590.a4 · Cited by 28

Detection of nitric oxide production in cell cultures by luciferin–luciferase chemiluminescence

Woldman, Y. Y., Eubank, T. D., Mock, A. J., Stevens, N. C., Varadharaj, S., Turco, J., Gavrilin, M. A., Branchini, B. R., & Khramtsov, V. V. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.001 · Cited by 27

Alpha1-adrenergic-mediated eNOS phosphorylation in intact arteries

Looft‐Wilson, R. C., Todd, S. E., Araj, C. A., Mutchler, S. M., & Goodell, C. R. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.09.003 · Cited by 27

Phylogenesis of constitutively formed nitric oxide in non-mammals

Toda, N., & Ayajiki, K. (2006) · Springer eBooks · doi:10.1007/112_0601 · Cited by 27

Expression of endothelial nitric oxide synthase traffic inducer in the placentas of women with pre‐eclampsia

Xiang, W., Chen, H., Xu, X., Zhang, M., & Jiang, R. (2005) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2004.12.041 · Cited by 27

Regional and Global Protective Effects of Tissue Kallikrein Gene Delivery to the Peri-Infarct Myocardium

Spillmann, F., Graiani, G., Linthout, S. V., Meloni, M., Campesi, I., Lagrasta, C. A. M., Westermann, D., Tschöpe, C., Quaini, F., Emanueli, C., et al. (2006) · Regenerative Medicine · doi:10.2217/17460751.1.2.235 · Cited by 27

Posttranslational regulation of NO synthase activity in the renal medulla of diabetic rats

Lee, D. L., Sasser, J. M., Hobbs, J. L., Boriskie, A., Pollock, D. M., Carmines, P. K., & Pollock, J. S. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00127.2004 · Cited by 27

Platelet Activating Factor-Induced Ceramide Micro-Domains Drive Endothelial NOS Activation and Contribute to Barrier Dysfunction

Predescu, S. A., Knezevic, I. I., Bardita, C., Neamu, R. F., Brovcovych, V., & Predescu, D. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075846 · Cited by 26

Agonist-specific differences in mechanisms mediating eNOS-dependent pial arteriolar dilation in rats

Xu, H.-L., Feinstein, D. L., Santizo, R. A., Koenig, H. M., & Pelligrino, D. A. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2002.282.1.h237 · Cited by 25

Post-Translational Inactivation of Endothelial Nitric Oxide Synthase in the Transgenic Sickle Cell Mouse Penis

Musicki, B., Champion, H. C., Hsu, L. L.-Y., Bivalacqua, T. J., & Burnett, A. L. “. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02123.x · Cited by 24

Effects of different statins on endothelial nitric oxide synthase and AKT phosphorylation in endothelial cells

Wang, J., Xu, Z., Kitajima, I., & Wang, Z. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2007.10.034 · Cited by 24

Dissociation of endothelial nitric oxide synthase phosphorylation and activity in uterine artery endothelial cells

Cale, J. M., & Bird, I. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00942.2005 · Cited by 23

Comparative effects of sirolimus and cyclosporin on conduit arteries endothelial function in kidney recipients

Joannidès, R., Étienne, I., Iacob, M., de Ligny, B. H., Barbier, S., Bellien, J., Lebranchu, Y., Thuillez, C., & Godin, M. (2010) · Transplant International · doi:10.1111/j.1432-2277.2010.01122.x · Cited by 23

Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells

Rust, N. M., Papa, M. P., Scovino, A. M., da Silva, M. M. C., Calzavara-Silva, C. E., Marques, E. T. D. A., Peçanha, L. M. T., Scharfstein, J., & Arruda, L. B. (2012) · Virology · doi:10.1016/j.virol.2011.10.003 · Cited by 22

L-Arginine and immune modulation: A pharmacological perspective on inflammation and autoimmune disorders

Dimeji, I. Y., Abass, K. S., Audu, N. M., & Adekola, S. A. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177615 · Cited by 26

PI3K signaling in arterial diseases: Non redundant functions of the PI3K isoforms

Lupieri, A., Smirnova, N. F., Malet, N., Gayral, S., & Laffargue, M. (2015) · Advances in Biological Regulation · doi:10.1016/j.jbior.2015.06.002 · Cited by 25

Plasma kallikrein-bradykinin pathway promotes circulatory nitric oxide metabolite availability during hypoxia

Padhy, G., Gangwar, A., Sharma, M., Himashree, G., Singh, K. P., Bhaumik, G., Bhargava, K., & Sethy, N. K. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.02.009 · Cited by 22

PP2B-dependent NO production in the medullary thick ascending limb during diabetes

Foster, J. M., Carmines, P. K., & Pollock, J. S. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90760.2008 · Cited by 22

Cadmium attenuates bradykinin-driven nitric oxide production by interplaying with the localization pattern of endothelial nitric oxide synthase

Majumder, S., Gupta, R., Reddy, H., Sinha, S., Muley, A., Kolluru, G. K., & Chatterjee, S. (2009) · Biochemistry and Cell Biology · doi:10.1139/o09-018 · Cited by 21

A bronchial epithelium-derived factor reduces pulmonary vascular tone in the newborn rat

Belik, J., Pan, J., Jankov, R. P., & Tanswell, A. K. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01004.2003 · Cited by 21

Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production

Batori, R. K., Bécsi, B., Nagy, D., Kónya, Z., Hegedűs, C., Bordán, Z., Verin, A. D., Lontay, B., & Erdődi, F. (2017) · Scientific Reports · doi:10.1038/srep44698 · Cited by 24

Endostatin induces acute endothelial nitric oxide and prostacyclin release

Li, C., Harris, M. B., Venema, V. J., & Venema, R. C. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.055 · Cited by 21

Kallikrein–Kinin System in Neovascularization

Bäder, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.184549 · Cited by 21

Signature of microsatellite instability, KRAS and BRAF gene mutations in German patients with locally advanced rectal adenocarcinoma before and after neoadjuvant 5-FU radiochemotherapy.

Demes, M. C., Scheil-Bertram, S., Bartsch, H., & Fisseler‐Eckhoff, A. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2078-6891.2013.012 · Cited by 20

Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function

Haines, R. J., Corbin, K. D., Pendleton, L. C., Meininger, C. J., & Eichler, D. C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.074 · Cited by 20

NAD(P)H:Quinone Oxidoreductase 1 Activation Reduces Blood Pressure Through Regulation of Endothelial Nitric Oxide Synthase Acetylation in Spontaneously Hypertensive Rats

Kim, Y. H., Hwang, J. H., Kim, K., Noh, J., Gang, G.-T., Seo, Y., Nam, K., Kwak, T., Lee, H. G., & Lee, C.-H. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu116 · Cited by 20

Endothelial nitric oxide synthase uncoupling and microvascular dysfunction in the mesentery of mice deficient in α-galactosidase A

Kang, J. J., Shu, L., Park, J. L., Shayman, J. A., & Bodary, P. F. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00185.2013 · Cited by 20

Nitric Oxide Production Modulates Cyclosporin A-Induced Distal Renal Tubular Acidosis in the Rat

Tsuruoka, S., Schwartz, G. J., Wakaumi, M., Nishiki, K., Yamamoto, H., Purkerson, J. M., & Fujimura, A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.048207 · Cited by 20

Reversal of SIN ‐1‐induced e NOS dysfunction by the spin trap, DMPO , in bovine aortic endothelial cells via e NOS phosphorylation

Das, A. K., Gopalakrishnan, B., Druhan, L. J., Wang, T., Pascali, F. D., Rockenbauer, A., Racoma, I. O., Varadharaj, S., Zweier, J. L., Cardounel, A. J., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12572 · Cited by 19

Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway

Thai, T., Zhong, F., Dang, L., Chan, E., Ku, J., Malle, E., Geczy, C. L., Keaney, J. F., & Thomas, S. R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.12.448 · Cited by 20

Regulation of vascular function by RCAN1 (ADAPT78)

Riper, D. A. V., Jayakumar, L., Latchana, N., Bhoiwala, D. L., Mitchell, A. N., Valenti, J. W., & Crawford, D. R. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.029 · Cited by 19

Rosiglitazone preserves pulmonary vascular function in lambs with increased pulmonary blood flow

Oishi, P. E., Sharma, S., Datar, S. A., Kumar, S., Aggarwal, S., Lü, Q., Raff, G. W., Azakie, A., Hsu, J., Sajti, E., et al. (2012) · Pediatric Research · doi:10.1038/pr.2012.149 · Cited by 19

The pathophysiology of preeclampsia in view of the two-stage model

Alasztics, B., Kukor, Z., Pánczél, Z., & Valent, S. (2012) · Orvosi Hetilap · doi:10.1556/oh.2012.29415 · Cited by 19

Retinoic acid decreases nitric oxide production in endothelial cells: a role of phosphorylation of endothelial nitric oxide synthase at Ser1179

Cho, D., Choi, Y. J., Jo, S. A., Nam, J., Jung, S., & Jo, I. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.099 · Cited by 18

Les récepteurs de la bradykinine : de nouveaux rôles physiopathologiques

Bascands, J., Schanstra, J. P., Couture, R., & Girolami, J. (2003) · médecine/sciences · doi:10.1051/medsci/200319111093 · Cited by 18

A case of acute respiratory distress syndrome responsive to methylene blue during a carcinoid crisis

van Diepen, S., Sobey, A., Lewanczuk, R. Z., Singh, G., Sidhu, S., Zibdawi, M., & Mullen, J. C. (2013) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-013-0026-4 · Cited by 18

Pravastatin induces NO synthesis by enhancing microsomal arginine uptake in healthy and preeclamptic placentas

Pánczél, Z., Kukor, Z., Supák, D., Kovács, B. G., Kecskeméti, A., Czizel, R., Djurecz, M., Alasztics, B., Csomó, K. B., Hrabák, A., et al. (2019) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-019-2507-0 · Cited by 17

The role of NO-cGMP pathway inhibition in vascular endothelial-dependent smooth muscle relaxation disorder of AT1-AA positive rats: protective effects of adiponectin

Wang, Z., Wu, Y., Zhang, S., Zhao, Y., Yin, X., Wang, W., Ma, X., & Liu, H. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.02.006 · Cited by 17

Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation

Ruan, L., Torres, C. M., Buffett, R. J., Kennard, S., Fulton, D. J., & Venema, R. C. (2013) · Vascular Pharmacology · doi:10.1016/j.vph.2013.05.004 · Cited by 17

Proliferation of regulatory mechanisms for eNOS: an emerging role for the cytoskeleton

Skidgel, R. A. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00045.2002 · Cited by 17

Molecular modeling and simulation of the human eNOS reductase domain, an enzyme involved in the release of vascular nitric oxide

Devika, N. T., Amresh, P., Hassan, M. I., & Ali, B. M. J. (2014) · Journal of Molecular Modeling · doi:10.1007/s00894-014-2470-7 · Cited by 16

Arsenite Acutely Decreases Nitric Oxide Production via the ROS—Protein Phosphatase 1—Endothelial Nitric Oxide Synthase-Thr 497 Signaling Cascade

Seo, J., Lee, J. Y., Sung, M.-S., Byun, C. J., Cho, D., Lee, H.-J., Park, J., Cho, H.-S., Cho, S.-J., & Jo, I. (2014) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2014.106 · Cited by 16

Somatostatin modulates PI3K-Akt, eNOS and NHE activity in the ciliary epithelium

Ghosh, S., Choritz, L., Geibel, J. P., & Coca‐Prados, M. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.05.002 · Cited by 16

Tiger nut ( Cyperus esculentus L.) supplemented diet modulate key biochemical indices relevant to erectile function in male rats

Olabiyi, A. A., Oboh, G., Akinyemi, A. J., Ademiluyi, A. O., Boligon, A. A., & de Campos, M. M. A. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.04.022 · Cited by 16

Intrauterine growth restriction-induced deleterious adaptations in endothelial progenitor cells: possible mechanism to impair endothelial function

Oliveira, V., de Souza, L. V., Fernandes, T. M., S., S. D., de Carvalho, M. H. C., Akamine, E. H., Michelini, L. C., de Oliveira, E. M., & Franco, M. D. C. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000484 · Cited by 16

Direct Interaction of the Cell Division Cycle 37 Homolog Inhibits Endothelial Nitric Oxide Synthase Activity

Harris, M. B., Bartoli, M., Sood, S. G., Matts, R. L., & Venema, R. C. (2006) · Circulation Research · doi:10.1161/01.res.0000203564.54250.0b · Cited by 16

Moringa oleifera Seeds Improve Aging-Related Endothelial Dysfunction in Wistar Rats

Randriamboavonjy, J. I., Heurtebise, S., Pacaud, P., Loirand, G., & Tesse, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2567198 · Cited by 15

Novel Pannexin‐1‐Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO‐Dependent Relaxation

Lillo, M. A., Gaete, P. S., Puebla, M., Burboa, P. C., Poblete, I. M., & Figueroa, X. F. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2678134 · Cited by 15

Bradykinin Mediates Phosphorylation of eNOS in Odontoblasts

Korkmaz, Y., Bloch, W., Steinritz, D., Baumann, M. A., Addicks, K., Schneider, K., & Raab, W. H.-M. (2006) · Journal of Dental Research · doi:10.1177/154405910608500611 · Cited by 15

Insulin signaling in the vasculature

Begum, N. (2003) · Frontiers in bioscience · doi:10.2741/1146 · Cited by 15

A review of current progress in gene and stem cell therapy for erectile dysfunction

Gür, S., Kadowitz, P. J., & Hellstrom, W. J. G. (2008) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.8.10.1521 · Cited by 14

Effect of melatonin on inflammatory response to prolonged exercise

Souissi, A., Souissi, N., Dabboubi, R., & Souissi, N. (2018) · Biological Rhythm Research · doi:10.1080/09291016.2018.1543638 · Cited by 13

Natural Product Extract of Dicksonia sellowiana Induces Endothelium-Dependent Relaxations by a Redox-Sensitive Src- and Akt-Dependent Activation of eNOS in Porcine Coronary Arteries

Rattmann, Y. D., Anselm, E., Kim, J. H., Dal-Ros, S., Auger, C., Miguel, O. G., Santos, A. R. S., Chataigneau, T., & Schini‐Kerth, V. B. (2012) · Journal of Vascular Research · doi:10.1159/000336647 · Cited by 13

Simvastatin reverses cardiac hypertrophy caused by disruption of the bradykinin 2 receptorPresented in part at the American College of Cardiology meeting March 2003 in Orlando, USA, and the Society for Pediatric Research meeting May 2007 in Toronto, Canada.

Osorio, J. C., Cheema, F. H., Martens, T. P., Mahmut, N., Kinnear, C., Gonzalez, A. M. D., Bonney, W. J., Homma, S., Liao, J. K., & Mital, S. R. (2008) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y08-068 · Cited by 13

Relationship between Endothelial Nitric Oxide Synthase, Insulin Resistance and Macrovascular Disease in Patients with Acute Myocardial Infarction

Li, J., Yang, Z., Wu, S., & Kong, J. (2012) · Journal of International Medical Research · doi:10.1177/147323001204000232 · Cited by 13

Angiotensin II-induced hypertension blunts thick ascending limb NO production by reducing NO synthase 3 expression and enhancing threonine 495 phosphorylation

Ramseyer, V. D., Gonzalez‐Vicente, A., Carretero, O. A., & Garvin, J. L. (2014) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00279.2014 · Cited by 12

Dihydroxyeicosatrienoic Acid, a Metabolite of Epoxyeicosatrienoic Acids Upregulates Endothelial Nitric Oxide Synthase Expression Through Transcription: Mechanism of Vascular Endothelial Function Protection

Zuo, D., Pi, Q., Shi, Y., Luo, S., & Xia, Y. (2021) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-021-00978-x · Cited by 12

15-hydroxyeicosatetraenoic acid depressed endothelial nitric oxide synthase activity in pulmonary artery.

Ye, H., Bi, H.-R., Lu, C., Tang, X., & Zhu, D. (2005) · PubMed · Cited by 12

The N-terminal portion of autoinhibitory element modulates human endothelial nitric-oxide synthase activity through coordinated controls of phosphorylation at Thr495 and Ser1177

Wu, P., Chen, B.-R., Hsieh, C.-C., Lin, W.-C., Wu, K. K., Hwu, Y., & Chen, P. (2014) · Bioscience Reports · doi:10.1042/bsr20140079 · Cited by 12

Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for SHP‐1 phosphatase

Patel, B., SHARIFI, M., MILWARD, A. D., Oberprieler, N. G., Gibbins, J. M., Parkin, S., & Naseem, K. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02160.x · Cited by 12

Lack of involvement of extracellular signal-regulated kinase (ERK) in the agonist-induced endothelial nitric oxide synthesis

Schmidt, K., Gibraeil, H. D., & Mayer, B. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00936-4 · Cited by 12

G-Protein-Coupled Receptors in Chronic Kidney Disease Induced by Hypertension and Diabetes

Tang, H., Li, K., Shi, Z., & Wu, J. (2025) · Cells · doi:10.3390/cells14100729 · Cited by 11

TRPC channel-derived calcium fluxes differentially regulate ATP and flow-induced activation of eNOS

Muzorewa, T. T., Buerk, D. G., Jaron, D., & Barbee, K. A. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.03.005 · Cited by 11

Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving cerebral collateral blood flow

Kemps, H., Dessy, C., Dumas, L., Sonveaux, P., Alders, L., Broeckhoven, J. V., Font, L. P., Lambrichts, S. M. P., Foulquier, S., Hendrix, S., et al. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221084410 · Cited by 10

Genetically increased angiotensin I-converting enzyme alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice

Chollet, C., Placier, S., Chatziantoniou, C., Hus-Citharel, A., Caron, N., Roussel, R., Alhenc‐Gelas, F., & Bouby, N. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00356.2017 · Cited by 11

Acute-on-chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries through enhanced PKA, PI3K/AKT and cGMP signalling pathways

Caracuel, L., Sastre, E., Llévenes, P., Prieto, I., Funes, T., Aller, M., Árias, J., Balfagón, G., & Blanco‐Rivero, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-43513-y · Cited by 11

Multiple myeloma in a murine syngeneic model:modulation of growth and angiogenesis by a monoclonal antibody to kininogen

Sáinz, I. M., Isordia‐Salas, I., Espinola, R. G., Long, W. K., Pixley, R. A., & Colman, R. W. (2005) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-005-0068-8 · Cited by 11

Adipocytokine, progranulin, augments acetylcholine‐induced nitric oxide‐mediated relaxation through the increases of cGMP production in rat isolated mesenteric artery

Kazama, K., Hoshino, K., Kodama, T., Okada, M., & Yamawaki, H. (2016) · Acta Physiologica · doi:10.1111/apha.12739 · Cited by 10

Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways

Song, W., Yuan, Y., Tan, X.-H., Gu, Y., Zeng, J., Song, W.-D., Xin, Z.-C., Fang, D., & Guan, R. (2022) · PeerJ · doi:10.7717/peerj.14192 · Cited by 10

Tetrahydrobiopterin paradoxically mediates cardiac oxidative stress and mitigates ethanol-evoked cardiac dysfunction in conscious female rats

Yao, F., & Abdel‐Rahman, A. A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174406 · Cited by 10

Phosphorylation of argininosuccinate synthase by protein kinase A

Corbin, K. D., Pendleton, L. C., Solomonson, L. P., & Eichler, D. C. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.056 · Cited by 10

Remodelling of Membrane Rafts Expression in Lung Cells as an Early Sign of Mechanotransduction-Signalling in Pulmonary Edema

Palestini, P., Botto, L., Rivolta, I., & Miserocchi, G. (2011) · Journal of Lipids · doi:10.1155/2011/695369 · Cited by 10

Simvastatin increases the activity of endothelial nitric oxide synthase via enhancing phosphorylation

Li, X., Wang, P., Xu, X., Wang, Y., Xia, Y., & Wang, D. W. (2009) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-009-0304-0 · Cited by 10

Engineering nitric oxide synthase chimeras to function as NO dioxygenases

Wang, Z., Haque, M. M., Binder, K. E., Sharma, M., Wei, C., & Stuehr, D. J. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.03.002 · Cited by 11

Contact System Activation in Plasma from Dengue Patients Might Harness Endothelial Virus Replication through the Signaling of Bradykinin Receptors

Coelho, S. V. A., Rust, N. M., Vellasco, L., Papa, M. P., Pereira, A., Palazzo, M., Juliano, M. A., da Costa, S. M., Alves, A. M. B., Cordeiro, M. T., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14010056 · Cited by 10

Bases moleculares da glomerulopatia diabética

Lagranha, C. J., Fiorino, P., Casarini, D. E., Schaan, B. D., & Irigoyen, M. C. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000600003 · Cited by 10

PFKFB3 Connects Glycolytic Metabolism with Endothelial Dysfunction in Human and Rodent Obesity

Batori, R. K., Bordán, Z., Padgett, C. A., Huo, Y., Chen, F., Atawia, R. T., Lucas, R., Ushio‐Fukai, M., Fukai, T., de Chantemèle, E. J. B., et al. (2025) · Antioxidants · doi:10.3390/antiox14020172 · Cited by 9

Inflammation of the Human Dental Pulp Induces Phosphorylation of eNOS at Thr495 in Blood Vessels

Erdek, Ö., Bloch, W., Rink, S., Roggendorf, H. C., Uzun, S., Meul, B., Koch, M., Neugebauer, J., Deschner, J., & Korkmaz, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10071586 · Cited by 9

Influence of Race, Gender, Age, and Diabetes on the Skin Circulation

PETROFSKY, J. S., & Bains, G. S. (2009) · Springer eBooks · doi:10.1007/978-3-540-89656-2_61 · Cited by 9

Effects of epoxyeicosatrienoic acids on levels of eNOS phosphorylation and relevant signaling transduction path-ways involved

Chen, R. (2005) · Science in China Series C Life Sciences · doi:10.1360/062004-36 · Cited by 9

Desensitization of endothelial nitric oxide synthase by receptor agonists

Wagner, S., Groschner, K., Mayer, B., & Schmidt, K. (2002) · Biochemical Journal · doi:10.1042/bj20011178 · Cited by 9

H2O2 Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling

Thengchaisri, N., Kuo, L., & Hein, T. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010489 · Cited by 8

Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1

Yegambaram, M., Kumar, S., Wu, X., Lü, Q., Sun, X., Flores, A. G., Meadows, M. L., Barman, S. A., Fulton, D. J., Wang, T., et al. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.08.004 · Cited by 8

The kallikrein–kinin system in diabetic kidney disease

Liu, W., Stanton, R. C., & Zhang, Z. (2017) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000344 · Cited by 8

Intermittent hypoxia changes the interaction of the kinin–VEGF system and impairs myocardial angiogenesis in the hypertrophic heart

Visniauskas, B., Perry, J. C., Gomes, G. N., Nogueira‐Pedro, A., Paredes‐Gamero, E. J., Tufik, S. B., & Chagas, J. R. (2021) · Physiological Reports · doi:10.14814/phy2.14863 · Cited by 8

Coordinated regulation of endothelial calcium signaling and shear stress-induced nitric oxide production by PKCβ and PKCη

Muzorewa, T. T., Buerk, D. G., Jaron, D., & Barbee, K. A. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110125 · Cited by 8

Pancreatic kininogenase improves erectile function in streptozotocin-induced type 2 diabetic rats with erectile dysfunction

Chen, Y., Dai, Y., Chen, G.-T., Yang, B., Chen, J., Zhang, Z., Zhu, L., Jiang, H., & Yu, W. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_23_18 · Cited by 8

Exogenous Pancreatic Kallikrein Improves Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetes

Wu, M., Yang, Y.-P., Wang, M., Zeng, F., Li, Q., Liu, W., Guo, S.-Z., He, M., Wang, Y., Huang, J., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00855 · Cited by 9

Biology of Nitric Oxide Synthases

Fleming, I. (2008) · Comprehensive physiology · doi:10.1002/cphy.cp020403 · Cited by 7

The stroke risk gene Foxf2 maintains brain endothelial cell function via Tie2 signaling

Völgyi, K., González-Gallego, J., Müller, S. A., Todorov, M. I., Şeker, F. B., Frerich, S., Cernilogar, F. M., Schröger, L., Malik, R., Cao, J., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02136-5 · Cited by 8

Identification of Regulatory Sites of Phosphorylation of the Bovine Endothelial Nitric-oxide Synthase at Serine 617 and Serine 635

Michell, B. J., Harris, M. B., Chen, Z.-P., Ju, H., Venema, V. J., Blackstone, M. A., Huang, W., Venema, R. C., & Kemp, B. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205144200 · Cited by 212

Phosphorylation of Thr(495) regulates Ca(21)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res 2001; 88:E68–E75

Fleming, I., Fißlthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2016)

Phosphorylation of Thr 495 Regulates Ca 2+ /Calmodulin-Dependent Endothelial Nitric Oxide Synthase Activity

Fleming, I., Fisslthaler, B., Dimmeler, S., Kemp, B. E., & Busse, R. (2001) · Circulation Research · doi:10.1161/hh1101.092677 · Cited by 770

Rapid increase in endothelial nitric oxide production by bradykinin is mediated by protein kinase A signaling pathway

Bae, S. W., Kim, H. S., Nam, Y., Park, Y. S., Jo, S. A., & Jo, I. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01086-6 · Cited by 106

Bradykinin-regulated Interactions of the Mitogen-activated Protein Kinase Pathway with the Endothelial Nitric-oxide Synthase

Bernier, S. G., Haldar, S. M., & Michel, T. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005116200 · Cited by 190