The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Krüppel-like Factor 4 (Gut-enriched Krüppel-like Factor) Inhibits Cell Proliferation by Blocking G1/S Progression of the Cell Cycle
Open accessAbstract
Krüppel-like factor 4 (KLF4) is an epithelial cell-enriched, zinc finger-containing transcription factor, the expression of which is associated with growth arrest. Previous studies show that constitutive expression of KLF4 inhibits DNA synthesis but the manner by which KLF4 exerts this effect is unclear. In the present study, we developed a system in which expression of KLF4 is controlled by a promoter that is induced upon treatment of cells containing the receptors for the insect hormone, ecdysone, with ponasterone A, an ecdysone analogue. The rate of proliferation of a stably transfected colon cancer cell line, RKO, was significantly decreased following addition of ponasterone A when compared with untreated cells. Flow cytometric analyses indicated that the inducible expression of KLF4 caused a block in the G(1)/S phase of the cell cycle. A similar block was observed when ecdysone receptor-containing RKO cells were infected with a replication-defective recombinant adenovirus containing an inducible KLF4 and treated with ponasterone A. Results of these studies provide evidence that the inhibitory effect of KLF4 on cell proliferation is mainly exerted at the G(1)/S boundary of the cell cycle.
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Citations
Cites
The biology of the mammalian Krüppel-like family of transcription factors
Dang, D. T., Pevsner, J., & Yang, V. W. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00059-5 · Cited by 458
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Cited by
Katz, J. P., Perreault, N., Goldstein, B. G., Lee, C. S., Labosky, P. A., Yang, V. W., & Kaestner, K. H. (2002) · Development · doi:10.1242/dev.129.11.2619 · Cited by 594
Self-citationKrüppel-like factor 4 (KLF4): What we currently know
Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 523
Self-citationTelomere dysfunction provokes regional amplification and deletion in cancer genomes
O'Hagan, R. C., Chang, S., Maser, R. S., Mohan, R., Artandi, S. E., Chin, L., & DePinho, R. A. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00094-6 · Cited by 246
Chen, W.-C., Lin, H.-H., & Tang, M.-J. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.05.019 · Cited by 58
Ray-Jones, H., Duffus, K., McGovern, A., Martin, P., Shi, C., Hankinson, J., Gough, O., Yarwood, A., Morris, A. P., Adamson, A., et al. (2020) · BMC Biology · doi:10.1186/s12915-020-00779-3 · Cited by 31
Metadata
- Authors
- Chen, X., Johns, D. C., Geiman, D. E., Marban, E., Dang, D. T., Hamlin, G., Sun, R., & Yang, V. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 276
- Issue
- 32
- Pages
- 30423-30428
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2028405970
- Cited by
- 266
- References
- 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Chen, X., Johns, D. C., Geiman, D. E., Marban, E., Dang, D. T., Hamlin, G., Sun, R., & Yang, V. W. (2001). Krüppel-like Factor 4 (Gut-enriched Krüppel-like Factor) Inhibits Cell Proliferation by Blocking G1/S Progression of the Cell Cycle. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m101194200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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