The biology of the mammalian Krüppel-like family of transcription factors

Dang, Duyen T.; Pevsner, Jonathan; Yang, Vincent W.

doi:10.1016/s1357-2725(00)00059-5

Cited by 460Kruppel-like factors researchGenomics and Chromatin DynamicsConnective Tissue Growth Factor Research

The biology of the mammalian Krüppel-like family of transcription factors

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Dang, Duyen T., Pevsner, Jonathan, Yang, Vincent W.·2000·The International Journal of Biochemistry & Cell Biology

DOI 10.1016/s1357-2725(00)00059-5PMC PMC2754176

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Abstract

Recent advances in molecular cloning have led to the identification of a large number of mammalian zinc finger-containing transcription factors that exhibit homology to the Drosophila melanogaster protein, Krüppel. Although the amino acid sequences in the zinc finger domains of these Krüppel-like factors (KLFs) are closely related to one another, the regions outside the zinc fingers of the proteins are usually unique. KLFs display seemingly different and broad biological properties with each functioning as an activator of transcription, a repressor or both. This review article provides a current phylogenetic classification of the identified KLFs to date. More importantly, the currently known biological activities of the KLFs in regulating transcription, cell proliferation, differentiation and development are summarized and compared. Further characterization of this interesting protein family should provide additional insights into the their respective regulatory role in various important biological processes.

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ZNF681 contains a classical C2H2 (Kruppel) zinc finger motif and functions as an activator and repressor of transcription, regulating proliferation, differentiation, and development.
“Zinc finger protein 681 contains a classical C 2 H 2 (Kruppel) zinc finger motif and functions as an activator and repressor of transcription, regulating proliferation, differentiation, and development.38,49”
From Altered genome-wide methylation in endometriosis (2014) · cites this paper as [38]

The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902 · see citing works
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
Mitchell, P. J., & Tjian, R. (1989) · Science · doi:10.1126/science.2667136 · Cited by 3,046 · see citing works
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500 · see citing works
Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
Miller, J., McLachlan, A., & Klug, A. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03825.x · Cited by 2,476 · see citing works
The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
Berg, J. M., & Shi, Y. (1996) · Science · doi:10.1126/science.271.5252.1081 · Cited by 1,930 · see citing works
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698 · see citing works
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
Kadonaga, J. T., Carner, K., Masiarz, F. R., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90594-0 · Cited by 1,614 · see citing works
The Sp-family of transcription factors
Suske, G. (1999) · Gene · doi:10.1016/s0378-1119(99)00357-1 · Cited by 1,112 · see citing works
Stimulation of GAL4 Derivative Binding to Nucleosomal DNA by the Yeast SWI/SNF Complex
Côté, J., Quinn, J., Workman, J. L., & Peterson, C. L. (1994) · Science · doi:10.1126/science.8016655 · Cited by 861 · see citing works
Klf4 is a transcription factor required for establishing the barrier function of the skin
Segre, J. A., Bauer, C., & Fuchs, E. V. (1999) · Nature Genetics · doi:10.1038/11926 · Cited by 793 · see citing works
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex
Kwon, H., Imbalzano, A. N., Khavari, P. A., Kingston, R. E., & Green, M. R. (1994) · Nature · doi:10.1038/370477a0 · Cited by 780 · see citing works
A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.
Christy, B. A., Lau, L. F., & Nathans, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7857 · Cited by 734 · see citing works
A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†
Miller, I. J., & Bieker, J. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2776-2786.1993 · Cited by 719 · see citing works
Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1.
Oberhammer, F., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W., & Schulte‐Hermann, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5408 · Cited by 669 · see citing works
Identification and Characterization of a Gene Encoding a Gut-enriched Krüppel-like Factor Expressed during Growth Arrest
Shields, J. M., Christy, R. J., & Yang, V. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.20009 · Cited by 652 · see citing works
Self-citation
DNA methylation: past, present and future directions
Robertson, K. D., & Jones, P. A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.461 · Cited by 609 · see citing works
Histone acetylases and deacetylases in cell proliferation
Kouzarides, T. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80006-9 · Cited by 602 · see citing works
Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
Parkins, A. C., Sharpe, A. H., & Orkin, S. H. (1995) · Nature · doi:10.1038/375318a0 · Cited by 599 · see citing works
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors
Philipsen, S., & Suske, G. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.2991 · Cited by 595 · see citing works
Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
Winston, F., & Carlson, M. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90300-s · Cited by 574 · see citing works
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
Nuez, B., Michalovich, D., Bygrave, A. E., Ploemacher, R., & Grosveld, F. G. (1995) · Nature · doi:10.1038/375316a0 · Cited by 550 · see citing works
Protein motifs 5. Zinc fingers.
Klug, A., & Schwabe, J. W. R. (1995) · PubMed · Cited by 546 · see citing works
Zinc fingers
Klug, A., & Schwabe, J. W. R. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.8.7768350 · Cited by 524 · see citing works
Guidelines for Human Gene Nomenclature
Wain, H., Bruford, E. A., Lovering, R. C., Lush, M. J., Wright, M. W., & Povey, S. (2002) · Genomics · doi:10.1006/geno.2002.6748 · Cited by 501 · see citing works
Zif268 protein–DNA complex refined at 1.6å: a model system for understanding zinc finger–DNA interactions
Elrod-Erickson, M., Rould, M. A., Nekludova, L., & Pabo, C. O. (1996) · Structure · doi:10.1016/s0969-2126(96)00125-6 · Cited by 421 · see citing works
LKLF: A Transcriptional Regulator of Single-Positive T Cell Quiescence and Survival
Kuo, C. T., Veselits, M., & Leiden, J. M. (1997) · Science · doi:10.1126/science.277.5334.1986 · Cited by 419 · see citing works
The primary structure of transcription factor TFIIIA has 12 consecutive repeats
Brown, R. S., Sander, C., & Argos, P. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80723-7 · Cited by 417 · see citing works
A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene
Schuh, R., Aicher, W. K., Gaul, U., Côté, S., Preiss, A., Maier, D., Seifert, E., Nauber, U., Schröder, C., Kemler, R., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90817-2 · Cited by 410 · see citing works
The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesisPreprint
Kuo, C. T., Veselits, M., Barton, K., Lu, M. M., Clendenin, C. J., & Leiden, J. M. (1997) · Genes & Development · doi:10.1101/gad.11.22.2996 · Cited by 369 · see citing works
Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene
Imataka, H., Sogawa, K., Yasumoto, K., Kikuchi, Y., Sasano, K., Kobayashi, A., Hayami, M., & Fujii‐Kuriyama, Y. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05451.x · Cited by 348 · see citing works
Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases
Zhang, W., & Bieker, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9855 · Cited by 342 · see citing works
The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter
Zhang, W., Geiman, D. E., Shields, J. M., Dang, D. T., Mahatan, C. S., Kaestner, K. H., Biggs, J. R., Kraft, A. S., & Yang, V. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000062200 · Cited by 327 · see citing works
Self-citation
Cloning and characterization of mCtBP2, a co‐repressor that associates with basic Krüppel‐like factor and other mammalian transcriptional regulators
Turner, J., & Crossley, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5129 · Cited by 315 · see citing works
A Gene for a Novel Zinc-finger Protein Expressed in Differentiated Epithelial Cells and Transiently in Certain Mesenchymal Cells
Garrett‐Sinha, L. A., Eberspaecher, H., Seldin, M. F., & Crombrugghe, B. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31384 · Cited by 313 · see citing works
A SWI/SNF–Related Chromatin Remodeling Complex, E-RC1, Is Required for Tissue-Specific Transcriptional Regulation by EKLF In Vitro
Armstrong, J. A., Bieker, J. J., & Emerson, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81785-7 · Cited by 303 · see citing works
Mammalian Krüppel-like transcription factors: more than just a pretty finger
Turner, J. J. O., & Crossley, M. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01406-1 · Cited by 294 · see citing works
Identification of a novel TGF-β-regulated gene encoding a putative zinc finger protein in human osteoblasts
Subramaniam, M., Harris, S. A., Oursler, M. J., Rasmussen, K., Riggs, B. L., & Spelsberg, T. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.23.4907 · Cited by 264 · see citing works
Isolation of a Gene Encoding a Functional Zinc Finger Protein Homologous to Erythroid Krüppel-Like Factor: Identification of a New Multigene Family
Anderson, K. P., Kern, C. B., Crable, S. C., & Lingrel, J. B. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.5957 · Cited by 262 · see citing works
Transcriptional Activation of Transforming Growth Factor β1 and Its Receptors by the Kruppel-like Factor Zf9/Core Promoter-binding Protein and Sp1
Kim, Y.-S., Ratziu, V., Choi, S.-G., Lalazar, A., Theiss, G., Dang, Q., Kim, S., & Friedman, S. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33750 · Cited by 249 · see citing works
Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells.
Tachibana, I., Imoto, M., Adjei, P. N., Gores, G. J., Subramaniam, M., Spelsberg, T. C., & Urrutia, R. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119418 · Cited by 241 · see citing works
Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis
Ratziu, V., Lalazar, A., Wong, L., Dang, Q., Collins, C. C., Shaulian, E., Jensen, S., & Friedman, S. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9500 · Cited by 240 · see citing works
Hepatocyte apoptosis: Is transforming growth factor-B1 the kiss of death? Oberhammer FA, Pavelka M, Sharma S, Tietenbacher R, Purchio AF, Bursch W, Schulte-Hermann R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc Natl Acad Sci USA 1992;89:5408–5412
Fausto, N. (1993) · Hepatology · doi:10.1016/0270-9139(93)90250-q · Cited by 229 · see citing works
Target Detection Assay (TDA): a versatile procedure to determine DNA blinding sites as demonstrated on SP1 protein
Thiesen, H., & Bach, C. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.11.3203 · Cited by 229 · see citing works
Gut-enriched Kruppel-like factor represses cyclin D1 promoter activity through Sp1 motif
Shie, J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.15.2969 · Cited by 223 · see citing works
Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells
Crossley, M., Whitelaw, E., Perkins, A., Williams, G., Fujiwara, Y., & Orkin, S. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1695 · Cited by 222 · see citing works
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes.
Lømo, J., Blomhoff, H. K., Beiske, K., Stokke, T., & Smeland, E. B. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.4.1634 · Cited by 203 · see citing works
Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene Switching
Donze, D., Townes, T. M., & Bieker, J. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.4.1955 · Cited by 203 · see citing works
The role of EKLF in human beta-globin gene competition.Preprint
Wijgerde, M., Gribnau, J. H., Trimborn, T., Nuez, B., Philipsen, S., Grosveld, F. G., & Fraser, P. (1996) · Genes & Development · doi:10.1101/gad.10.22.2894 · Cited by 203 · see citing works
Zinc Fingers in Caenorhabditis elegans : Finding Families and Probing Pathways
Clarke, N. D., & Berg, J. M. (1998) · Science · doi:10.1126/science.282.5396.2018 · Cited by 198 · see citing works
cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2
Sogawa, K., Imataka, H., Yamasaki, Y., Kusume, H., Abe, H., & Fujii‐Kuriyama, Y. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.7.1527 · Cited by 195 · see citing works
Molecular Cloning and Characterization of TIEG2Reveals a New Subfamily of Transforming Growth Factor-β-inducible Sp1-like Zinc Finger-encoding Genes Involved in the Regulation of Cell Growth
Cook, T. A., Gebelein, B. A., Mesa, K., Mladek, A. C., & Urrutia, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.40.25929 · Cited by 189 · see citing works
Human EZF, a Krüppel-like Zinc Finger Protein, Is Expressed in Vascular Endothelial Cells and Contains Transcriptional Activation and Repression Domains
Yet, S., McA'Nulty, M. M., Folta, S. C., Yen, H.-W., Yoshizumi, M., Hsieh, C.-M., Layne, M. D., Chin, M. T., Wang, H., Perrella, M. A., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.1026 · Cited by 188 · see citing works
Expression of early growth response genes in human prostate cancer.
Eid, M. A., Kumar, M. V., Iczkowski, K. A., Bostwick, D. G., & Tindall, D. J. (1998) · PubMed · Cited by 186 · see citing works
Identification of the DNA sequence that interacts with the gut-enriched Kruppel-like factor
Shields, J. M. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.3.796 · Cited by 179 · see citing works
Hepatic stellate cells
Ankoma‐Sey, V., & Friedman, S. L. (1998) · Springer eBooks · doi:10.1007/978-94-011-4932-7_20 · Cited by 173 · see citing works
A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells
Conkright, M. D. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.5.1263 · Cited by 162 · see citing works
Human Kruppel-like Factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription
van Vliet, J., Turner, J., & Crossley, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.9.1955 · Cited by 158 · see citing works
The transforming growth factor β1-inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress
Ribeiro, A. C., Bronk, S. F., Roberts, P. J., Urrutia, R. A., & Gores, G. J. (1999) · Hepatology · doi:10.1002/hep.510300620 · Cited by 158 · see citing works
Expression of the Transcription Factor Lung Kruppel-Like Factor Is Regulated by Cytokines and Correlates with Survival of Memory T Cells In Vitro and In Vivo
Schober, S. L., Kuo, C. T., Schluns, K. S., Lefrançois, L., Leiden, J. M., & Jameson, S. C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3662 · Cited by 139 · see citing works
A Novel Human Zinc Finger Protein That Interacts with the Core Promoter Element of a TATA Box-less Gene
Koritschoner, N. P., Bocco, J. L., Panzetta-Dutari, G. M., Dumur, C. I., Flury, A., & Patrito, L. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9573 · Cited by 138 · see citing works
Loss of LKLF Function Results in Embryonic Lethality in Mice
Wani, M. A., Means, R. T., & Lingrel, J. B. (1998) · Transgenic Research · doi:10.1023/a:1008809809843 · Cited by 137 · see citing works
BTEB2, a Kruppel-Like Transcription Factor, Regulates Expression of the SMemb/Nonmuscle Myosin Heavy Chain B (SMemb/NMHC-B) Gene
Watanabe, N., Kurabayashi, M., Shimomura, Y., Kawai‐Kowase, K., Hoshino, Y.-I., Manabe, I., Watanabe, M., Aikawa, M., Kuro‐o, M., Suzuki, T., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.2.182 · Cited by 136 · see citing works
Two Potent Nuclear Localization Signals in the Gut-enriched Krüppel-like Factor Define a Subfamily of Closely Related Krüppel Proteins
Shields, J. M., & Yang, V. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18504 · Cited by 133 · see citing works
Self-citation
High-resolution localization of 69 potential human zinc finger protein genes: A number are clustered
Hoovers, J. M. N., Mannens, M. M. A. M., John, R. M., Bliek, J., van Heyningen, V., Porteous, D. J., Leschot, N. J., Westerveld, A., & Little, P. (1992) · Genomics · doi:10.1016/0888-7543(92)90372-y · Cited by 133 · see citing works
Basic Transcription Element-binding Protein (BTEB) Is a Thyroid Hormone-regulated Gene in the Developing Central Nervous System
Denver, R. J., Ouellet, L., Furling, D., Kobayashi, A., Fujii‐Kuriyama, Y., & Puymirat, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23128 · Cited by 128 · see citing works
The Gut-enriched Krüppel-like Factor Suppresses the Activity of the CYP1A1 Promoter in an Sp1-dependent Fashion
Zhang, W., Shields, J. M., Sogawa, K., Fujii‐Kuriyama, Y., & Yang, V. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17917 · Cited by 127 · see citing works
Self-citation
Transactivation and growth suppression by the gut-enriched Kruppel-like factor (Kruppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction
Geiman, D. E. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.5.1106 · Cited by 126 · see citing works
Cloning the cDNA for a New Human Zinc Finger Protein Defines a Group of Closely Related Krüppel-like Transcription Factors
Matsumoto, N., Laub, F., Aldabe, R., Zhang, W., Ramirez, F., Yoshida, T., & Terada, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28229 · Cited by 124 · see citing works
Three Conserved Transcriptional Repressor Domains Are a Defining Feature of the TIEG Subfamily of Sp1-like Zinc Finger Proteins
Cook, T. A., Gebelein, B. A., Belal, M., Mesa, K., & Urrutia, R. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29500 · Cited by 123 · see citing works
The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1
Brembeck, F. H., & Rustgi, A. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004013200 · Cited by 120 · see citing works
Transcriptional Regulation of the CLC-K1 Promoter by myc-Associated Zinc Finger Protein and Kidney-Enriched Krüppel-Like Factor, a Novel Zinc Finger Repressor
Uchida, S., Tanaka, Y., Ito, H., Saito-Ohara, F., Inazawa, J., Yokoyama, K. K., Sasaki, S., & Marumo, F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7319-7331.2000 · Cited by 120 · see citing works
The Erythroid Krüppel-Like Factor Transactivation Domain is a Critical Component for Cell-Specific Inducibility of a β-Globin Promoter
Bieker, J. J., & Southwood, C. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.852 · Cited by 119 · see citing works
Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines.
Hsing, A. Y., Kadomatsu, K., Bonham, M. J. D., & Danielpour, D. (1996) · PubMed · Cited by 115 · see citing works
Transcriptional activation of urokinase by the Krüppel-like factor Zf9/COPEB activates latent TGF-beta1 in vascular endothelial cells.
Kojima, S., Hayashi, S., Shimokado, K., Suzuki, Y., Shimada, J., Crippa, M. P., & Friedman, S. L. (2000) · PubMed · Cited by 114 · see citing works
Lung Kruppel-like Factor, a Zinc Finger Transcription Factor, Is Essential for Normal Lung Development
Wani, M. A., Wert, S. E., & Lingrel, J. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21180 · Cited by 113 · see citing works
Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II
Meisner, H. M., & Czech, M. (1991) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(91)90076-b · Cited by 110 · see citing works
Expression of the gut‐enriched Krüppel‐like factor gene during development and intestinal tumorigenesis
Ton-That, H., Kaestner, K. H., Shields, J. M., Mahatanankoon, C. S., & Yang, V. W. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01465-8 · Cited by 108 · see citing works
Self-citation
Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny
Southwood, C. M., Downs, K. M., & Bieker, J. J. (1996) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199607)206:3 · Cited by 108 · see citing works
RFLAT-1
Song, A., Chen, Y.-F., Thamatrakoln, K., Storm, T. A., & Krensky, A. M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80010-2 · Cited by 105 · see citing works
Regulation of CYP1A1 expression
Fujii‐Kuriyama, Y., Imataka, H., Sogawa, K., Yasumoto, K., & Kikuchi, Y. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.2.1537460 · Cited by 105 · see citing works
NOMENCLATURE
White, J. A., McALPINE, P. J., Antonarakis, S. E., Cann, H. M., Eppig, J. T., Frazer, K. S., Frézal, J., Lancet, D., Nahmias, J. A., Pearson, P. L., et al. (1997) · Genomics · doi:10.1006/geno.1997.4979 · Cited by 102 · see citing works
Expression of type XIV collagen in developing chicken tendons: Association with assembly and growth of collagen fibrils
Young, B. B., Gordon, M. K., & Birk, D. E. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200004)217:4 · Cited by 100 · see citing works
A zinc‐finger transcription factor induced by TGF‐β promotes apoptotic cell death in epithelial Mv1Lu cells
Chalaux, E., López‐Rovira, T., Rosa, J. L., Pons, G., Boxer, L. M., Bartrons, R., & Ventura, F. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01051-0 · Cited by 99 · see citing works
Characterization of an early growth response gene, which encodes a zinc finger transcription factor, potentially involved in cell cycle regulation
Blok, L. J., Grossmann, M. E., Perry, J. E., & Tindall, D. J. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.11.8584037 · Cited by 99 · see citing works
Decreased expression of the gut‐enriched Krüppel‐like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients
Dang, D. T., Bachman, K. E., Mahatan, C. S., Dang, L. H., Giardiello, F. M., & Yang, V. W. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01727-0 · Cited by 98 · see citing works
Self-citation
Transcriptional Activation of the Zinc Finger Transcription Factor BTEB2 Gene by Egr-1 Through Mitogen-Activated Protein Kinase Pathways in Vascular Smooth Muscle Cells
Kawai‐Kowase, K., Kurabayashi, M., Hoshino, Y., Ohyama, Y., & Nagai, R. (1999) · Circulation Research · doi:10.1161/01.res.85.9.787 · Cited by 98 · see citing works
A Novel cis-Acting DNA Element Required for a High Level of Inducible Expression of the Rat P-450c Gene
Yanagida, A., Sogawa, K., Yasumoto, K., & Fujii-Kuriyama, Y. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.4.1470 · Cited by 91 · see citing works
Transcriptional regulation of the AP-2α promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor
Imhof, A., Schuierer, M., Werner, O., Moser, M., Roth, C., Bauer, R., & Buettner, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.194 · Cited by 90 · see citing works
Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)
Bieker, J. J. (1996) · DNA and Cell Biology · doi:10.1089/dna.1996.15.347 · Cited by 84 · see citing works
Transactivation of the Human Keratin 4 and Epstein-Barr Virus ED-L2 Promoters by Gut-enriched Krüppel-like Factor
Jenkins, T. D., Opitz, O. G., Okano, J., & Rustgi, A. K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10747 · Cited by 84 · see citing works
The DNA Binding Protein BTEB Mediates Acetaldehyde-Induced, Jun N-Terminal Kinase-Dependent αI(I) Collagen Gene Expression in Rat Hepatic Stellate Cells
Chen, A., & Davis, B. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2818-2826.2000 · Cited by 83 · see citing works
Discrimination Among Potential Activators of the β-Globin CACCC Element by Correlation of Binding and Transcriptional Properties
Hartzog, G. A., & Myers, R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.44-56.1993 · Cited by 80 · see citing works
Estrogen Regulation of a Transforming Growth Factor-β Inducible Early Gene That Inhibits Deoxyribonucleic Acid Synthesis in Human Osteoblasts*
Tau, K. R., Hefferan, T. E., Waters, K. M., Robinson, J. A., Subramaniam, M., Riggs, B. L., & Spelsberg, T. C. (1998) · Endocrinology · doi:10.1210/endo.139.3.5830 · Cited by 80 · see citing works
TIEG proteins join the Smads as TGF-β-regulated transcription factors that control pancreatic cell growth
Cook, T. A., & Urrutia, R. A. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.4.g513 · Cited by 80 · see citing works
The Krüppel‐like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact
Okano, J., Opitz, O. G., Nakagawa, H., Jenkins, T. D., Friedman, S. L., & Rustgi, A. K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01468-x · Cited by 77 · see citing works
Characterization of the structure and regulation of the murine gene encoding gut-enriched Kruppel-like factor (Kruppel-like factor 4)
Mahatan, C. S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.23.4562 · Cited by 74 · see citing works
Erythroid Krüppel‐like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter‐ and intramolecular interactions.
Chen, X., & Bieker, J. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00975.x · Cited by 67 · see citing works
Basic Krüppel-like factor functions within a network of interacting haematopoietic transcription factors
Turner, J. J. O., & Crossley, M. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00067-9 · Cited by 66 · see citing works
Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1 -Deficient Embryonic Stem Cells by Using a Knock-in Strategy
Okuda, T., Takeda, K., Fujita, Y., Nishimura, M., Yagyu, S., Yoshida, M., Akira, S., Downing, J. R., & Abe, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.319-328.2000 · Cited by 66 · see citing works
Regulation of Erythroid Krüppel-like Factor (EKLF) Transcriptional Activity by Phosphorylation of a Protein Kinase Casein Kinase II Site within Its Interaction Domain
Ouyang, L., Chen, X., & Bieker, J. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23019 · Cited by 65 · see citing works
Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter
Shi, H. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.24.4807 · Cited by 65 · see citing works
Up‐regulation of gut‐enriched krüppel‐like factor by interferon‐γ in human colon carcinoma cells
Chen, Z. Y., Shie, J., & Tseng, C. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01764-6 · Cited by 63 · see citing works
Erythroid Kruppel like factor: from fishing expedition to gourmet meal
Perkins, A. C. (1999) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(99)00083-7 · Cited by 61 · see citing works
Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos
Perkins, A. C., Peterson, K. R., Stamatoyannopoulos, G., Witkowska, H. E., & Orkin, S. H. (2000) · Blood · doi:10.1182/blood.v95.5.1827.004k10_1827_1833 · Cited by 55 · see citing works
GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk
Panigada, M., Porcellini, S., Sutti, F., Doneda, L., Pozzoli, O., Consalez, G. G., Guttinger, M., & Grassi, F. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00237-8 · Cited by 54 · see citing works
Effects of gonadal and adrenal androgens in a novel androgen-responsive human osteoblastic cell line
Hofbauer, L. C., Hicok, K. C., & Khosla, S. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19981001)71:1 · Cited by 54 · see citing works
Genomic Structure and DNA Binding Properties of the Human Zinc Finger Transcriptional Repressor AP-2rep (KLF12)
Roth, C. T., Schuierer, M. M., Günther, K., & Buettner, R. (2000) · Genomics · doi:10.1006/geno.1999.6084 · Cited by 53 · see citing works
Cell-specific Transcription of Leukotriene C4Synthase Involves a Kruppel-like Transcription Factor and Sp1
Zhao, J.-L., Austen, K. F., & LAM, B. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8903 · Cited by 52 · see citing works
Comparison of DNA-Binding Properties between BTEB and Sp11
Sogawa, K., Kikuchi, Y., Imataka, H., & Fujii‐Kuriyama, Y. (1993) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124224 · Cited by 49 · see citing works
cDNA Isolation, Genomic Structure, Regulation, and Chromosomal Localization of Human Lung Kruppel-like Factor
Wani, M. A., Conkright, M. D., Jeffries, S., Hughes, M., & Lingrel, J. B. (1999) · Genomics · doi:10.1006/geno.1999.5888 · Cited by 41 · see citing works
Trans-Activation Functions of the Sp-Related Nuclear Factor, Basic Transcription Element-Binding Protein, and Progesterone Receptor in Endometrial Epithelial Cells
Simmen, R. C. M., Chung, T. E., Imataka, H., Michel, F. J., Badinga, L., & Simmen, F. A. (1999) · Endocrinology · doi:10.1210/endo.140.6.6625 · Cited by 41 · see citing works
Isolation and Initial Characterization of GBF, a Novel DNA-Binding Zinc Finger Protein That Binds to the GC-Rich Binding Sites of the HIV-1 Promoter
Suzuki, T., Yamamoto, T., Kurabayashi, M., Nagai, R., Yazaki, Y., & Horikoshi, M. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022124 · Cited by 39 · see citing works
Hepatic Stellate Cells
Weiskirchen, R., & Friedman, S. L. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3207-9 · Cited by 38 · see citing works
Eukaryotic Transcription Factors: Identification, Characterization and Functions
Yang, V. W. (1998) · Journal of Nutrition · doi:10.1093/jn/128.11.2045 · Cited by 36 · see citing works
Self-citation
Characterization of the mouse TGFβ-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts
Fautsch, M. P., Vrabel, A. M., Rickard, D. J., Subramaniam, M., Spelsberg, T. C., & Wieben, E. D. (1998) · Mammalian Genome · doi:10.1007/s003359900878 · Cited by 35 · see citing works
Analysis of Functional Domains of a GC Box-Binding Protein, BTEB1
Kobayashi, A., Sogawa, K., Imataka, H., & Fujii-Kuriyama, Y. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124727 · Cited by 31 · see citing works
Erythroid Krüppel-like factor is recruited to the CACCC box in the β-globin promoter but not to the CACCC box in the γ-globin promoter: The role of the neighboring promoter elements
Lee, J.-S., Ngo, H., Kim, D., & Chung, J. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040476297 · Cited by 31 · see citing works
Estrogen Regulation of a Transforming Growth Factor- Inducible Early Gene That Inhibits Deoxyribonucleic Acid Synthesis in Human Osteoblasts
Tau, K. R. (1998) · Endocrinology · doi:10.1210/en.139.3.1346 · Cited by 25 · see citing works
cDNA cloning and expression analysis of mouse zf9, a Krüppel-like transcription factor gene that is induced by adipogenic hormonal stimulation in 3T3-L1 cells
Inuzuka, H., Wakao, H., Masuho, Y., Muramatsu, M.-A., Tojo, H., & Nanbu-Wakao, R. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00161-x · Cited by 24 · see citing works
Cell-type Expression, Immunolocalization, and Deoxyribonucleic Acid-binding Activity of Basic Transcription Element Binding Transcription Factor, an Sp-related Family Member, in Porcine Endometrium of Pregnancy1
Wang, Y., Michel, F. J., Wing, A., Simmen, F. A., & Simmen, R. C. M. (1997) · Biology of Reproduction · doi:10.1095/biolreprod57.4.707 · Cited by 21 · see citing works
Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein
Ohe, N., Yamasaki, Y., Sogawa, K., Inazawa, J., Ariyama, T., Oshimura, M., & Fujii‐Kuriyama, Y. (1993) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01233255 · Cited by 20 · see citing works
The Role of Sp Family Members, Basic Krupple-Like Factor, and E Box Factors in the Basal and IFN-γ Regulated Expression of the Human Complement C4 Promoter
Ulgiati, D., Subrata, L. S., & Abraham, L. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.300 · Cited by 19 · see citing works
Interaction of melittin with a human lymphoblastoid cell line, HMy2
Weston, K. M., & Raison, R. L. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980201)68:2 · Cited by 19 · see citing works
A Novel cis-Acting DNA Element Required for a High Level of Inducible Expression of the Rat P-450c Gene
Yanagida, A., Sogawa, K., Yasumoto, K., & Fujii‐Kuriyama, Y. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.4.1470-1475.1990 · Cited by 17 · see citing works

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Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2007) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,781 · see citing works
Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
Black, A. R., Black, J. D., & Azizkhan‐Clifford, J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1111 · Cited by 1,049 · see citing works
Kruppel-Like Factor 15 Modulates Renal Interstitial Fibrosis by ERK/MAPK and JNK/MAPK Pathways Regulation
Gao, X., Wu, G., Gu, X., Fu, L., & Mei, C. (2013) · Kidney & Blood Pressure Research · doi:10.1159/000355743 · Cited by 1,036 · see citing works
Sp1- and Krüppel-like transcription factors.
Kaczynski, J., Cook, T. A., & Urrutia, R. A. (2003) · Genome biology · doi:10.1186/gb-2003-4-2-206 · Cited by 976 · see citing works
Krüppel-like Factors: Three Fingers in Many Pies
Bieker, J. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100043200 · Cited by 604 · see citing works
Kruppel-like factor 2 regulates thymocyte and T-cell migration
Carlson, C. M., Endrizzi, B. T., Wu, J., Ding, X., Weinreich, M. A., Walsh, E. R., Wani, M. A., Lingrel, J. B., Hogquist, K. A., & Jameson, S. C. (2006) · Nature · doi:10.1038/nature04882 · Cited by 593 · see citing works
KLF4, p21 and context-dependent opposing forces in cancer
Rowland, B. D., & Peeper, D. S. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1780 · Cited by 548 · see citing works
Krüppel-like factor 4 (KLF4): What we currently know
Ghaleb, A. M., & Yang, V. W. (2017) · Gene · doi:10.1016/j.gene.2017.02.025 · Cited by 516 · see citing works
Self-citation
Aryl hydrocarbon receptor and intestinal immunity
Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 530 · see citing works
Gene Expression in Fibroblasts and Fibrosis
Manabe, I., Shindo, T., & Nagai, R. (2002) · Circulation Research · doi:10.1161/01.res.0000046452.67724.b8 · Cited by 508 · see citing works
Transcriptional Control of Dendritic Cell Development
Murphy, T. L., Grajales‐Reyes, G. E., Wu, X., Tussiwand, R., Briseño, C. G., Iwata, A., Kretzer, N. M., Durai, V., & MURPHY, K. M. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120204 · Cited by 484 · see citing works
Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses
Tussiwand, R., Everts, B., Grajales‐Reyes, G. E., Kretzer, N. M., Iwata, A., Bagaitkar, J., Wu, X., Wong, R., Anderson, D. A., Murphy, T. L., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.017 · Cited by 439 · see citing works
Role of Kruppel-Like Transcription Factors in Endothelial Biology
Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 414 · see citing works
A Single-Cell Transcriptomic Atlas of Human Skin Aging
Zou, Z., Long, X., Zhao, Q., Zheng, Y., Song, M., Ma, S., Jing, Y., Wang, S., He, Y., Esteban, C. R., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2020.11.002 · Cited by 402 · see citing works
Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
Shindo, T., Manabe, I., Fukushima, Y., Tobe, K., Aizawa, K., Miyamoto, S., Kawai‐Kowase, K., Moriyama, N., Imai, Y., Kawakami, H., et al. (2002) · Nature Medicine · doi:10.1038/nm738 · Cited by 394 · see citing works
Krüppel-like transcription factors: A functional family
Pearson, R. C. M., Fleetwood, J., Eaton, S. A., Crossley, M., & Bao, S. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.07.018 · Cited by 378 · see citing works
Transcriptional Regulation of Adipogenesis
de Sá, P. M., Richard, A. J., Hang, H., & Stephens, J. M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160022 · Cited by 395 · see citing works
Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis
Mori, T., Sakaue, H., Iguchi, H., Gomi, H., Okada, Y., Takashima, Y., Nakamura, K., Nakamura, T., Yamauchi, T., Kubota, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410515200 · Cited by 340 · see citing works
Sp1: Emerging roles—Beyond constitutive activation of TATA-less housekeeping genes
Wierstra, I. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.03.074 · Cited by 337 · see citing works
Adipogenesis
Sarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328 · see citing works
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Small, K. S., Grundberg, E., Soranzo, N., Ahmadi, K. R., Spector, T. D., Shin, S., Deloukas, P., Hedman, Å. K., Lindgren, C. M., McCarthy, M. I., et al. (2011) · Nature Genetics · doi:10.1038/ng.833 · Cited by 319 · see citing works
Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation
Ghaleb, A. M., Nandan, M. O., Chanchevalap, S., Dalton, W. B., Hisamuddin, I. M., & Yang, V. W. (2005) · Cell Research · doi:10.1038/sj.cr.7290271 · Cited by 308 · see citing works
Self-citation
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer
Zhao, W., Hisamuddin, I. M., Nandan, M. O., Babbin, B. A., Lamb, N. E., & Yang, V. W. (2004) · Oncogene · doi:10.1038/sj.onc.1207067 · Cited by 306 · see citing works
Self-citation
Kruppel-like Factor 4 Is a Mediator of Proinflammatory Signaling in Macrophages
Feinberg, M. W., Cao, Z., Wara, A. K., Lebedeva, M. A., SenBanerjee, S., & Jain, M. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509378200 · Cited by 295 · see citing works
Transcriptional networks and chromatin remodeling controlling adipogenesis
Siersbæk, R., Nielsen, R., & Mandrup, S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.10.001 · Cited by 278 · see citing works
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
Dong, J., & Chen, C. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0045-z · Cited by 270 · see citing works
Krüppel-like Factor 4 (Gut-enriched Krüppel-like Factor) Inhibits Cell Proliferation by Blocking G1/S Progression of the Cell Cycle
Chen, X., Johns, D. C., Geiman, D. E., Marbán, E., Dang, D. T., Hamlin, G., Sun, R., & Yang, V. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101194200 · Cited by 267 · see citing works
Self-citation
Krüppel-like Factor 4 Mediates p53-dependent G1/S Cell Cycle Arrest in Response to DNA Damage
Yoon, H. S., Chen, X., & Yang, V. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211027200 · Cited by 266 · see citing works
Self-citation
The diverse functions of Krüppel‐like factors 4 and 5 in epithelial biology and pathobiology
McConnell, B. B., Ghaleb, A. M., Nandan, M. O., & Yang, V. W. (2007) · BioEssays · doi:10.1002/bies.20581 · Cited by 258 · see citing works
Self-citation
Cancer Stem Cell Hierarchy in Glioblastoma Multiforme
Bradshaw, A., Wickremsekera, A., Tan, S. T., Peng, L., Davis, P. F., & Itinteang, T. (2016) · Frontiers in Surgery · doi:10.3389/fsurg.2016.00021 · Cited by 255 · see citing works
Permeability barrier dysfunction in transgenic mice overexpressing claudin 6
Turksen, K., & Troy, T.-C. (2002) · Development · doi:10.1242/dev.129.7.1775 · Cited by 230 · see citing works
Emerging role of KLF4 in human gastrointestinal cancer
Wei, D., Kanai, M., Huang, S., & Xie, K. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi243 · Cited by 224 · see citing works
Transcriptional Profiling of Krüppel-like Factor 4 Reveals a Function in Cell Cycle Regulation and Epithelial Differentiation
Chen, X., Whitney, E. M., Gao, S. Y., & Yang, V. W. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01449-3 · Cited by 215 · see citing works
Self-citation
Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns
Sebzda, E., Zou, Z., Lee, J. S., Wang, T., & Kahn, M. L. (2008) · Nature Immunology · doi:10.1038/ni1565 · Cited by 205 · see citing works
Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications
Omole, A. E., & Fakoya, A. O. J. (2018) · PeerJ · doi:10.7717/peerj.4370 · Cited by 207 · see citing works
The family feud: turning off Sp1 by Sp1-like KLF proteins
Lomberk, G. A., & Urrutia, R. A. (2005) · Biochemical Journal · doi:10.1042/bj20051234 · Cited by 204 · see citing works
A Conserved α-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A
Zhang, J., Moncrieffe, M. C., Kaczynski, J., Ellenrieder, V., Prendergast, F. G., & Urrutia, R. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5041-5049.2001 · Cited by 187 · see citing works
Krϋppel-like factors (KLFs) in renal physiology and disease
Rane, M. J., Zhao, Y., & Cai, L. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.021 · Cited by 179 · see citing works
Transcriptional activation of endoglin and transforming growth factor-β signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury
Botella, L. M., Sánchez-Elsner, T., Sanz-Rodrı́guez, F., Kojima, S., Shimada, J., Guerrero-Esteo, M., Cooreman, M. P., Ratziu, V., Langa, C., Vary, C., et al. (2002) · Blood · doi:10.1182/blood.v100.12.4001 · Cited by 175 · see citing works
Recruitment of Serum Response Factor and Hyperacetylation of Histones at Smooth Muscle–Specific Regulatory Regions During Differentiation of a Novel P19-Derived In Vitro Smooth Muscle Differentiation System
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Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications
Zhang, L., Meng, X. L., Zhu, X., Yang, D., Chen, R., Jiang, Y., & Xu, T. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1021-3 · Cited by 170 · see citing works
Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition
Small, K. S., Todorčević, M., Civelek, M., El-Sayed Moustafa, J. S., Wang, X., Simon, M. M., Fernandez-Tajes, J., Mahajan, A., Horikoshi, M., Hugill, A., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0088-x · Cited by 168 · see citing works
Krüppel-like Factor 4 Inhibits Epithelial-to-Mesenchymal Transition through Regulation of E-cadherin Gene Expression
Yori, J. L., Johnson, E., Zhou, G., Jain, M. K., & Keri, R. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.114546 · Cited by 159 · see citing works
Transcription Factor KLF7 Is Important for Neuronal Morphogenesis in Selected Regions of the Nervous System
Laub, F., Lei, L., Sumiyoshi, H., Kajimura, D., Dragomir, C. L., Smaldone, S., Puché, A. C., Petros, T. J., Mason, C. A., Parada, L. F., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5699-5711.2005 · Cited by 151 · see citing works
Intestinal-enriched Krüppel-like Factor (Krüppel-like Factor 5) Is a Positive Regulator of Cellular Proliferation
Sun, R., Chen, X., & Yang, V. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000870200 · Cited by 151 · see citing works
Self-citation
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Chen, C., Benjamin, M. S., Sun, X., Otto, K. B., Guo, P., Dong, X., Bao, Y., Zhou, Z., Cheng, X., Simons, J. W., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21533 · Cited by 145 · see citing works
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DiFeo, A. V., Martignetti, J. A., & Narla, G. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.11.001 · Cited by 136 · see citing works
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Self-citation
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Ravasi, T., Huber, T., Zavolan, M., Forrest, A. R. R., Gaasterland, T., Grimmond, S. M., RIKEN GER Group, Members, G., & Hume, D. A. (2003) · Genome Research · doi:10.1101/gr.949803 · Cited by 103 · see citing works
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Self-citation
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The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media
Adelman, C. A., Chattopadhyay, S., & Bieker, J. J. (2002) · Development · doi:10.1242/dev.129.2.539 · Cited by 94 · see citing works
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Memon, A., & Lee, W. K. (2018) · Cancers · doi:10.3390/cancers10060161 · Cited by 90 · see citing works
Krüppel‐like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras‐mediated transformation
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Funnell, A. P. W., Maloney, C., Thompson, L. J., Keys, J. R., Tallack, M. R., Perkins, A. C., & Crossley, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01658-06 · Cited by 88 · see citing works
Transcriptomic analysis of developmental features of Bombyx mori wing disc during metamorphosis
Ou, J., Deng, H., Zheng, S.-C., Huang, L., Feng, Q.-L., & Liu, L. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-820 · Cited by 89 · see citing works
Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator–activated receptor γ agonists in colon cancer cells
Chintharlapalli, S. R., Papineni, S., Jutooru, I., MCALEES, A. J., & Safe, S. H. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0022 · Cited by 88 · see citing works
Krüppel-Like Factor 5 Is Important for Maintenance of Crypt Architecture and Barrier Function in Mouse Intestine
McConnell, B. B., Kim, S. S., Ke, Y., Ghaleb, A. M., Takeda, N., Manabe, I., Nusrat, A., Nagai, R., & Yang, V. W. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.086 · Cited by 88 · see citing works
Self-citation
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells
Nandan, M., & Yang, V. W. (2009) · Histology and Histopathology · doi:10.14670/hh-24.1343 · Cited by 98 · see citing works
Self-citation
IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors
Ahmed, M., & Gaffen, S. L. (2013) · Cytokine · doi:10.1016/j.cyto.2012.12.007 · Cited by 87 · see citing works
KLF15 negatively regulates estrogen-induced epithelial cell proliferation by inhibition of DNA replication licensing
Ray, S., & Pollard, J. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118515109 · Cited by 85 · see citing works
Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy
Gao, Y., Ding, Y., Chen, H., Chen, H., & Zhou, J. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150302105052 · Cited by 83 · see citing works
An Emerging Role for Krüppel-Like Factors in Vascular Biology
Feinberg, M. W., Lin, Z., Fisch, S., & Jain, M. K. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.06.005 · Cited by 83 · see citing works
Altered genome-wide methylation in endometriosis
Naqvi, H., Ilagan, Y., Krikun, G., & Taylor, H. S. (2014) · Reproductive Sciences · doi:10.1177/1933719114532841 · Cited by 82 · see citing works
Role of Notch signaling in colon homeostasis and carcinogenesis
Miyamoto, S., & Rosenberg, D. W. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02049.x · Cited by 80 · see citing works

Authors: Dang, D. T., Pevsner, J., & Yang, V. W.
Affiliations: Johns Hopkins University (US)
Kennedy Krieger Institute (US)
Corresponding author: Yang, Vincent W.
ORCID: Pevsner, Jonathan
Yang, Vincent W.
Venue: The International Journal of Biochemistry & Cell Biology
Publisher: Elsevier BV
Published: 2000-12
Volume: 32
Issue: 11-12
Pages: 1103-1121
ISSN: 1357-2725 (ISSN-L)
DOI: 10.1016/s1357-2725(00)00059-5
PMC: PMC2754176
OpenAlex: W2133383018
Cited by: 458
References: 126
Citations by year: 2026: 6 · 2025: 8 · 2024: 16 · 2023: 22 · 2022: 7 · 2021: 12 · 2020: 15 · 2019: 17 · 2018: 29 · 2017: 16 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 21 · 2012: 18
FWCI: 1.18
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 385 d)
Locations: The International Journal of Biochemistry & Cell Biology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (CA 84197, R01CA084197)
National Institute of Diabetes and Digestive and Kidney Diseases (F32DK010020, DK 52230, DK10020, R01DK052230)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Keywords: Krüppel-like factors, zinc finger transcription factor, transcriptional regulation, transcriptional activator, transcriptional repressor, phylogenetic classification, cell proliferation, cell differentiation, development (biology)
MeSH terms: Animals, DNA-Binding Proteins, Humans, Mammals, Phylogeny, Repressor Proteins, Transcription Factors, Transcription, Genetic, Zinc Fingers, Kruppel-Like Transcription Factors

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The biology of the mammalian Krüppel-like family of transcription factors

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