The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design
Open accessAbstract
Cysteine proteases of the papain superfamily are implicated in a number of cellular processes and are important virulence factors in the pathogenesis of parasitic disease. These enzymes have therefore emerged as promising targets for antiparasitic drugs. We report the crystal structures of three major parasite cysteine proteases, cruzain, falcipain-3, and the first reported structure of rhodesain, in complex with a class of potent, small molecule, cysteine protease inhibitors, the vinyl sulfones. These data, in conjunction with comparative inhibition kinetics, provide insight into the molecular mechanisms that drive cysteine protease inhibition by vinyl sulfones, the binding specificity of these important proteases and the potential of vinyl sulfones as antiparasitic drugs.
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Pharmacological Inhibitors of the NLRP3 Inflammasome
Zahid, A., Li, B., Kombe, A. J. K., Jin, T., & Tao, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02538 · Cited by 671
Metadata
- Authors
- Kerr, I. D., Lee, J. H., Farady, C. J., Marion, R., Rickert, M., Sajid, M., Pandey, K. C., Caffrey, C. R., Legac, J., Hansell, E., McKerrow, J. H., Craik, C. S., Rosenthal, P. J., & Brinen, L. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 284
- Issue
- 38
- Pages
- 25697-25703
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2143287044
- Cited by
- 294
- References
- 44
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kerr, I. D., Lee, J. H., Farady, C. J., Marion, R., Rickert, M., Sajid, M., Pandey, K. C., Caffrey, C. R., Legac, J., Hansell, E., McKerrow, J. H., Craik, C. S., Rosenthal, P. J., & Brinen, L. S. (2009). Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m109.014340
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
