Mechanical Regulation of the Proangiogenic Factor CCN1/CYR61 Gene Requires the Combined Activities of MRTF-A and CREB-binding Protein Histone Acetyltransferase

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,262

Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease

Owens, G. K., Kumar, M. S., & Wamhoff, B. R. (2004) · Physiological Reviews · doi:10.1152/physrev.00041.2003 · Cited by 3,472

HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

Yang, X.-J., & Seto, E. (2007) · Oncogene · doi:10.1038/sj.onc.1210599 · Cited by 940

Activation of Cardiac Gene Expression by Myocardin, a Transcriptional Cofactor for Serum Response Factor

Wang, D.-Z., Chang, P. S., Wang, Z., Sutherland, L. B., Richardson, J. A., Small, E. M., Krieg, P. A., & Olson, E. N. (2001) · Cell · doi:10.1016/s0092-8674(01)00404-4 · Cited by 898

Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL

Vartiainen, M., Guettler, S., Larijani, B., & Treisman, R. (2007) · Science · doi:10.1126/science.1141084 · Cited by 672

The CCN Family of Angiogenic Regulators: The Integrin Connection

Lau, L. F., & Lam, S. C.-T. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4456 · Cited by 645

Actin' together: serum response factor, its cofactors and the link to signal transduction.

Posern, G., & Treisman, R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.09.008 · Cited by 560

Functions and mechanisms of action of CCN matricellular proteins

Chen, C.-C., & Lau, L. F. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.07.025 · Cited by 549

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

Han, J., Lee, J., Jiang, Y., Li, Z., Feng, L., & Ulevitch, R. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2886 · Cited by 512

CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

Babic, A. M., Kireeva, M. L., Kolesnikova, T. V., & Lau, L. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6355 · Cited by 495

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998

Linking actin dynamics and gene transcription to drive cellular motile functions

Olson, E. N., & Nordheim, A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2890 · Cited by 958

Revisiting the matricellular concept

Murphy-Ullrich, J. E., & Sage, E. H. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.07.005 · Cited by 401

CCN1/CYR61: the very model of a modern matricellular protein

Lau, L. F. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0778-3 · Cited by 338

Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development

Xiao, Y., Hill, M. C., Zhang, M., Martin, T. J., Morikawa, Y., Wang, S., Moise, A. R., Wythe, J. D., & Martin, J. F. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.03.019 · Cited by 181

G Protein–Coupled Receptor and RhoA-Stimulated Transcriptional Responses: Links to Inflammation, Differentiation, and Cell Proliferation

Yu, O. M., & Brown, J. H. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.097857 · Cited by 123

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

Fang, F., Yang, Y., Yuan, Z., Gao, Y., Zhou, J., Chen, Q., & Xu, Y. (2011) · Circulation Research · doi:10.1161/circresaha.111.240655 · Cited by 104

Megakaryocytic Leukemia 1 Bridges Epigenetic Activation of NADPH Oxidase in Macrophages to Cardiac Ischemia-Reperfusion Injury

Yu, L., Yang, G., Zhang, X., Wang, P., Weng, X., Yang, Y., Li, Z., Fang, M., Xu, Y., Sun, A., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.035377 · Cited by 101

Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G Protein-Coupled Receptor- and RhoA-Mediated Transcriptional Regulation and Cell Proliferation

Yu, O. M., Miyamoto, S., & Brown, J. H. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00772-15 · Cited by 97

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2

Hinkel, R., Trenkwalder, T., Petersen, B., Husada, W., Gesenhues, F., Lee, S., Hannappel, E., Bock-Marquette, I., Theisen, D., Leitner, L., et al. (2014) · Nature Communications · doi:10.1038/ncomms4970 · Cited by 93

Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging

Fedintsev, A., & Moskalev, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101097 · Cited by 72

Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription

Tsou, P., Haak, A. J., Khanna, D., & Neubig, R. R. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00060.2014 · Cited by 85

Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system

Yoshida, T., & Aoki, H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00283 · Cited by 81

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

Yu, L., Weng, X., Liang, P., Dai, X., Wu, X.-Y., Xu, H., Fang, M., Fang, F., & Xu, Y. (2014) · Journal of Cell Science · doi:10.1242/jcs.152314 · Cited by 81

Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor-A signaling pathway

Wang, N., Zhang, R., Wang, S., Zhang, C., Mao, L., Zhuang, C.-Y., Tang, Y.-Y., Luo, X., Zhou, H., & Zhang, T. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.04.021 · Cited by 78

Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy

Weng, X., Yu, L., Peng, L., Chen, D., Cheng, X. F., Yang, Y., Li, L., Zhang, T., Zhou, B., Wu, X., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.11.009 · Cited by 74

Atherosclerosis and the Capillary Network; Pathophysiology and Potential Therapeutic Strategies

Ziegler, T., Rahman, F. A., Jurisch, V., & Kupatt, C. (2019) · Cells · doi:10.3390/cells9010050 · Cited by 80

Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells

Tian, W., Hao, C., Fan, Z., Weng, X., Qin, H., Wu, X., Fang, M., Chen, Q., Shen, A., & Xu, Y. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.07.029 · Cited by 73

MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Yu, L., Fang, F., Dai, X. J., Xu, H., Qi, X., Fang, M., & Xu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00301-w · Cited by 71

MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription

Cheng, X., Yang, Y., Fan, Z., Yu, L., Bai, H., Zhou, B., Wu, X., Xu, H., Fang, M., Shen, A., et al. (2015) · Oncogene · doi:10.1038/onc.2015.14 · Cited by 68

The transcriptional regulator megakaryoblastic leukemia‐1 mediates serum response factor‐independent activation of tenascin‐C transcription by mechanical stress

Asparuhova, M. B., Ferralli, J., Chiquet, M., & Chiquet‐Ehrismann, R. (2011) · The FASEB Journal · doi:10.1096/fj.11-187310 · Cited by 67

Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cells

Milone, M. R., Pucci, B., Bruzzese, F., Carbone, C., Piro, G., Costantini, S., Capone, F., Leone, A., Gennaro, E. D., Caraglia, M., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.165 · Cited by 65

Eyeing the Cyr61/CTGF/NOV (CCN) group of genes in development and diseases: highlights of their structural likenesses and functional dissimilarities

Krupska, I., Bruford, E. A., & Chaqour, B. (2015) · Human Genomics · doi:10.1186/s40246-015-0046-y · Cited by 63

Megakaryoblastic leukemia protein-1 (MKL1): Increasing evidence for an involvement in cancer progression and metastasis

Scharenberg, M. A., Chiquet‐Ehrismann, R., & Asparuhova, M. B. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.014 · Cited by 60

Force-induced Myofibroblast Differentiation through Collagen Receptors Is Dependent on Mammalian Diaphanous (mDia)

Chan, M. W. C., Chaudary, F., Lee, W., Copeland, J. W. R., & McCulloch, C. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075218 · Cited by 60

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

Kircher, P., Hermanns, C., Nossek, M., Drexler, M. K., Grosse, R., Fischer, M., Sarikas, A., Penkava, J., Lewis, T. C., Prywes, R., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aad2959 · Cited by 58

Shape-Induced Terminal Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation

Connelly, J. T., Mishra, A., Gautrot, J. E., & Watt, F. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027259 · Cited by 54

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

Tian, W., Fan, Z., Li, J., Hao, C., Li, M., Xu, H., Wu, X., Zhou, B., Zhang, L., Fang, M., et al. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.12.005 · Cited by 54

Megakaryocytic leukemia 1 (MKL1) ties the epigenetic machinery to hypoxia-induced transactivation of endothelin-1

Yang, Y., Chen, D., Yuan, Z., Fang, F., Cheng, X. F., Xia, J., Fang, M., Xu, Y., & Gao, Y. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt311 · Cited by 52

Revisited and Revised: Is RhoA Always a Villain in Cardiac Pathophysiology?

Miyamoto, S., Re, D. P. D., Xiang, S. Y., Zhao, X., Florholmen, G., & Brown, J. H. (2010) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-010-9192-8 · Cited by 51

Connective Tissue Growth Factor Regulates Retinal Neovascularization through p53 Protein-dependent Transactivation of the Matrix Metalloproteinase (MMP)-2 Gene

Chintala, H., Liu, H., Parmar, R., Kamalska, M., Kim, Y. J., Lovett, D., Grant, M. B., & Chaqour, B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386565 · Cited by 43

The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1

Muehlich, S., Hampl, V., Khalid, S., Singer, S., Frank, N., Breuhahn, K., Gudermann, T. W., & Prywes, R. (2011) · Oncogene · doi:10.1038/onc.2011.560 · Cited by 52

Megakaryocytic Leukemia 1 Directs a Histone H3 Lysine 4 Methyltransferase Complex to Regulate Hypoxic Pulmonary Hypertension

Chen, D., Yang, Y., Cheng, X. F., Fang, F., Xu, G., Yuan, Z., Xia, J., Kong, H., Xie, W., Wang, H., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.114.04585 · Cited by 47

MRTF-A steers an epigenetic complex to activate endothelin-induced pro-inflammatory transcription in vascular smooth muscle cells

Yang, Y., Cheng, X. F., Tian, W., Zhou, B., Wu, X., Xu, H., Fang, F., Fang, M., & Xu, Y. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku776 · Cited by 48

Functional MicroRNA Library Screening Identifies the HypoxaMiR MiR-24 as a Potent Regulator of Smooth Muscle Cell Proliferation and Vascularization

Fiedler, J., Stoehr, A., Gupta, S. K., Hartmann, D., Holzmann, A., Just, A., Hansen, A., Hilfiker‐Kleiner, D., Eschenhagen, T., & Thum, T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5418 · Cited by 47

Ablation of serum response factor in hepatic stellate cells attenuates liver fibrosis

Kong, M., Hong, W., Shao, Y., Lv, F., Fan, Z., Li, P., Xu, Y., & Guo, J. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01831-8 · Cited by 47

Cyr61, a Matricellular Protein, Is Needed for Dendritic Arborization of Hippocampal Neurons

Malik, A. R., Urbańska, M., Góźdź, A., Swiech, L. J., Nagalski, A., Perycz, M., Błażejczyk, M., & Jaworski, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.411629 · Cited by 45

MRTF-A and STAT3 synergistically promote breast cancer cell migration

Liao, X., Wang, N., Liu, L., Li, Z., Xing, W., Zhao, D., Sun, X., Hu, P., Dong, J., & Zhang, T. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.07.023 · Cited by 47

Sphingosine 1–phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells

Wang, W., Hind, T., Lam, B. W. S., & Herr, D. R. (2019) · The FASEB Journal · doi:10.1096/fj.201801635r · Cited by 39

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic Retinopathy

Hasan, A., Pokeza, N., Shaw, L., Lee, H.-S., Lazzaro, D., Chintala, H., Rosenbaum, D., Grant, M. B., & Chaqour, B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198689 · Cited by 39

MRTFs‐ master regulators of EMT

Gasparics, Á., & Sebe, A. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24544 · Cited by 37

CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy

Di, Y., ZHANG, Y., Nie, Q.-Z., & Chen, X. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2371 · Cited by 37

Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection

Zhao, X., Ding, E., Yu, O. M., Xiang, S. Y., Tan‐Sah, V. P., Yung, B. S., Hedgpeth, J., Neubig, R. R., Lau, L. F., Brown, J. H., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.07.017 · Cited by 37

Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy

Lee, S., Elaskandrany, M., Lau, L. F., Lazzaro, D. R., Grant, M. B., & Chaqour, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-01585-8 · Cited by 35

Double null cells reveal that CBP and p300 are dispensable for p53 targetsp21andMdm2but variably required for target genes of other signaling pathways

Kasper, L. H., Thomas, M. C., Zambetti, G. P., & Brindle, P. K. (2011) · Cell Cycle · doi:10.4161/cc.10.2.14542 · Cited by 34

Myocardin-related Transcription Factor Regulates Nox4 Protein Expression

Rozycki, M., Bialik, J. F., Speight, P., Dan, Q., Knudsen, T. E., Szeto, S. G., Yuen, D. A., Szászi, K., Pedersen, S. F., & Kapùs, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.674606 · Cited by 34

Cysteine‐rich protein 61 (CCN1) and connective tissue growth factor (CCN2) at the crosshairs of ocular neovascular and fibrovascular disease therapy

Yan, L., & Chaqour, B. (2013) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-013-0206-6 · Cited by 35

A non-autonomous role of MKL1 in the activation of hepatic stellate cells

Li, Z., Li, P., Lu, Y., Sun, D., Zhang, X., & Xu, Y. (2019) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2019.03.001 · Cited by 32

Eyeing the Extracellular Matrix in Vascular Development and Microvascular Diseases and Bridging the Divide between Vascular Mechanics and Function

Chaqour, B., & Karrasch, C. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103487 · Cited by 32

Cellular diversity of the somatosensory cortical map plasticity

Kole, K., Scheenen, W. J. J. M., Tiesinga, P. H. E., & Celikel, T. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.015 · Cited by 30

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells

Zhang, Z., Chen, B., Zhu, Y., Zhang, T., Zhang, X., Yuan, Y., & Xu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.664375 · Cited by 26

Transcriptional regulation of endothelial dysfunction in atherosclerosis: an epigenetic perspective

Xu, Y. (2014) · Journal of Biomedical Research · doi:10.7555/jbr.27.20130055 · Cited by 26

CCN1–Yes-Associated Protein Feedback Loop Regulates Physiological and Pathological Angiogenesis

Lee, S., Ahad, A., Luu, M., Moon, S., Caesar, J., Cardoso, W. V., Grant, M. B., & Chaqour, B. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00107-19 · Cited by 26

Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells

Shu, X.-Z., Zhang, L., Zhang, R., Zhang, C., He, H., Zhou, H., Wang, N., & Zhang, T. (2015) · Gene · doi:10.1016/j.gene.2015.02.076 · Cited by 24

Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress

Honjo, T., Kubota, S., Kamioka, H., Sugawara, Y., Ishihara, Y., Yamashiro, T., Takigawa, M., & Takano‐Yamamoto, T. (2012) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-012-0177-z · Cited by 23

Nucleocytoplasmic shuttling: a common theme in mechanotransduction

Sharili, A. S., & Connelly, J. T. (2014) · Biochemical Society Transactions · doi:10.1042/bst20130286 · Cited by 22

Mechanism of irradiation‐induced mammary cancer metastasis: A role for SAP‐dependent Mkl1 signaling

Asparuhova, M. B., Secondini, C., Rüegg, C., & Chiquet‐Ehrismann, R. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.04.003 · Cited by 22

Valproic Acid-Induced CCN1 Promotes Osteogenic Differentiation by Increasing CCN1 Protein Stability through HDAC1 Inhibition in Tonsil-Derived Mesenchymal Stem Cells

Yu, Y., Oh, S.-Y., Kim, H. Y., Choi, J.-Y., Jo, S. A., & Jo, I. (2022) · Cells · doi:10.3390/cells11030534 · Cited by 22

TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells

Chen, G., Chen, X., Sukumar, A. N., Gao, B., Curley, J., Schnaper, H. W., Ingram, A. J., & Krepinsky, J. C. (2013) · Journal of Cell Science · doi:10.1242/jcs.126714 · Cited by 20

Changes and related factors of blood CCN1 levels in diabetic patients

Xiang, Z., Chen, S., Qin, X., Lin, S., Xu, Y., Lu, L., & Zou, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1131993 · Cited by 23

cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1

Duggirala, A., Kimura, T. E., Sala‐Newby, G. B., Johnson, J. L., Wu, Y., Newby, A. C., & Bond, M. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.11.012 · Cited by 20

MKL 1 is an epigenetic mediator of TNF ‐α‐induced proinflammatory transcription in macrophages by interacting with ASH 2

Song, M., Fang, F., Dai, X. J., Yu, L., Fang, M., & Xu, Y. (2017) · FEBS Letters · doi:10.1002/1873-3468.12601 · Cited by 20

Cortical Granule Distribution and Expression Pattern of Genes Regulating Cellular Component Size, Morphogenesis, and Potential to Differentiation are Related to Oocyte Developmental Competence and Maturational Capacity In Vivo and In Vitro

Kulus, M., Kranc, W., Ješeta, M., Sujka‐Kordowska, P., Konwerska, A., Ciesiółka, S., Celichowski, P., Moncrieff, L., Kocherova, I., Józkowiak, M., et al. (2020) · Genes · doi:10.3390/genes11070815 · Cited by 17

Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells

Zhang, R., Wang, N., Zhang, M., Zhang, L., Guo, Z., Luo, X., Zhou, H., He, H., & Zhang, T. (2015) · Stem Cells International · doi:10.1155/2015/534758 · Cited by 16

Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs

Castaldi, A., Chesini, G. P., Taylor, A. E., Sussman, M. A., Brown, J. H., & Purcell, N. H. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.04.006 · Cited by 16

MRTF‐A regulates myoblast commitment to differentiation by targeting PAX7 during muscle regeneration

Song, R., Zhao, S., Xu, Y., Hu, J., Ke, S., Li, F., Tian, G., Zheng, X., Li, J., Gu, L., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16820 · Cited by 17

Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF–CREB-binding site

Herndon, C. A., Ankenbruck, N., Lester, B. E., Bailey, J., & Fromm, L. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.01.001 · Cited by 16

Myocardin-Related Transcription Factor A Mediates LPS-Induced iNOS Transactivation

Lin, L., Zhang, Q., Fan, H., Zhao, H., & Yang, Y. (2020) · Inflammation · doi:10.1007/s10753-020-01213-0 · Cited by 14

Astrocyte CCN1 stabilizes neural circuits in the adult brain

Sancho, L., Boisvert, M., Eddy, T., Burgado, J., Contreras, M., Labarta-Bajo, L., Wang, E., Tatsumi, L., & Allen, N. J. (2025) · Nature · doi:10.1038/s41586-025-09770-w · Cited by 17

CYR61 delivery promotes angiogenesis during bone fracture repair

Lang, A., Eastburn, E. A., Younesi, M., Nijsure, M. P., Siciliano, C., Haran, A. P., Panebianco, C. J., Seidl, E., Tang, R., Alsberg, E., et al. (2025) · npj Regenerative Medicine · doi:10.1038/s41536-025-00398-y · Cited by 15

CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH

Zhao, G., Kim, E. W., Jiang, J., Bhoot, C., Charles, K. R., Baek, J., Mohan, S., Adams, J. S., Tetradis, S., & Lyons, K. M. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4128 · Cited by 13

The regulation and functions of the matricellular CCN proteins induced by shear stress

Wang, Y.-K., Weng, H.-K., & Mo, F. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00760-z · Cited by 12

The Erk MAP kinase pathway is activated at muscle spindles and is required for induction of the muscle spindle‐specific gene Egr3 by neuregulin1

Herndon, C. A., Ankenbruck, N., & Fromm, L. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23293 · Cited by 12

Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity

Morrell, E. D., Grazioli, S., Hung, C. F., Kajikawa, O., Harju-Baker, S., Stapleton, R. D., Gharib, S. A., Amado‐Rodríguez, L., Albaiceta, G. M., Wurfel, M. M., et al. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00073.2020 · Cited by 13

Sphingosine-1-Phosphate Attenuates Lipopolysaccharide-Induced Pericyte Loss via Activation of Rho-A and MRTF-A

Rahman, F. A., d’Almeida, S., Zhang, T., Asadi, M., Bozoglu, T. M., Bongiovanni, D., von Scheidt, M., Dietzel, S., Schwedhelm, E., Hinkel, R., et al. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1716844 · Cited by 12

Deciphering the dynamics: Exploring the impact of mechanical forces on histone acetylation

Cai, J., Deng, Y., Min, Z., Li, C., Zhao, Z., & Jing, D. (2024) · The FASEB Journal · doi:10.1096/fj.202400907rr · Cited by 11

Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization

Ziegler, T., Kraus, M., Husada, W., Gesenhues, F., Jiang, Q., Pinkenburg, O., Trenkwalder, T., Laugwitz, K., le Noble, F. A. C., Weber, C., et al. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.013 · Cited by 11

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation

Mattingly, M. L., Ruple, B. A., Sexton, C. L., Godwin, J. S., McIntosh, M. C., Smith, M. A., Plotkin, D. L., Michel, J. M., Anglin, D. A., Kontos, N. J., et al. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1281702 · Cited by 10

The role of myocardin-related transcription factor-A in Aβ 25–35 induced neuron apoptosis and synapse injury

Zhang, Y., Pan, H.-Y., Hu, X., Cao, X., Wang, J., Min, Z.-L., Xu, S., Xiao, W., Yuan, Q., Li, N., et al. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.003 · Cited by 11

Mitogen-Activated Protein Kinase Phosphatase-1 Promotes Neovascularization and Angiogenic Gene Expression

Boerckel, J. D., Chandrasekharan, U. M., Waitkus, M. S., Tillmaand, E. G., Bartlett, R. S., & DiCorleto, P. E. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303403 · Cited by 11

SRF depletion in early life contributes to social interaction deficits in the adulthood

Roszkowska, M., Krysiak, A., Majchrowicz, L., Nader, K., Beroun, A., Michaluk, P., Pękała, M., Jaworski, J., Kondrakiewicz, L., Puścian, A., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04291-5 · Cited by 9

Potential epigenetic molecular regulatory networks in ocular neovascularization

Hu, Q., Zhang, X., Sun, M., Jiang, B., Zhang, Z., & Sun, D. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.970224 · Cited by 10

Inhibition of the Myocardin-Related Transcription Factor Pathway Increases Efficacy of Trametinib in NRAS-Mutant Melanoma Cell Lines

Appleton, K. M., Palsuledesai, C. C., Misek, S. A., Blake, M. K., Zagorski, J. W., Gallo, K. A., Dexheimer, T. S., & Neubig, R. R. (2021) · Cancers · doi:10.3390/cancers13092012 · Cited by 10

Intrahepatic upregulation of MRTF-A signaling contributes to increased hepatic vascular resistance in cirrhotic rats with portal hypertension

Zheng, L., Qin, J., Sun, L., Gui, L., Zhang, C., Huang, Y., Deng, W., Huang, A., Sun, D., & Luo, M. (2016) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2016.11.010 · Cited by 9

Translational Aspects of Adeno-Associated Virus–Mediated Cardiac Gene Therapy

Ziegler, T., Ishikawa, K., Hinkel, R., & Kupatt, C. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.229 · Cited by 9

Correlations Between CCN1 Immunoexpression and Myocardial Histologic Lesions in Sudden Cardiac Death

Papetta, A., Gakiopoulou, H., Agapitos, E. B., Patsouris, E., & Lazaris, A. C. (2013) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e31828d69b5 · Cited by 8

Major Histocompatibility Complex Class II Transactivator Inhibits Cysteine-rich 61 Expression in Osteoblastic Cells and Its Implication in the Pathogenesis of Periapical Lesions

Lee, Y., Lin, S., Hong, C., Wang, J., Yang, H., Lai, E. H., Chen, M.-H., & Kok, S. (2010) · Journal of Endodontics · doi:10.1016/j.joen.2010.03.009 · Cited by 8

Thymosinβ4 Improves Differentiation and Vascularization of EHTs

Ziegler, T., Hinkel, R., Stoehr, A., Thomas Eschenhagen, A., Laugwitz, K., le Noble, F. A. C., David, R., Hansen, A., & Kupatt, C. (2017) · Stem Cells International · doi:10.1155/2017/6848271 · Cited by 8

Dissection of mechanoresponse elements in promoter sites of the mechanoresponsive CYR61 gene

Seefried, L., Müller-Deubert, S. M., Krug, M., Youssef, A., Schütze, N., Ignatius, A. A., Jakob, F. J., & Ebert, R. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.031 · Cited by 8

Current status and future direction of mechanotransduction mechanisms: Perspectives from cell membrane to nucleus

Shi, Y., Yue, J., Wang, Z., He, S., & Sa, G. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152524 · Cited by 6

Atomic Force Microscopy-Based Measurements of Retinal Microvessel Stiffness in Mice with Endothelial-Specific Deletion of CCN1

Chaqour, B., Grant, M. B., Lau, L. F., Wang, B., Urbanski, M. M., & Melendez‐Vasquez, C. V. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2744-0_22 · Cited by 6

Genetic modification of corneal neovascularization in Dstn corn1 mice

Kawakami-Schulz, S. V., Sattler, S. G., Doebley, A.-L., Ikeda, A., & Ikeda, S. (2013) · Mammalian Genome · doi:10.1007/s00335-013-9468-9 · Cited by 5

CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells

Dou, Q., Feng, H., Sun, L., Xu, X., & Cui, M. (2016) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0559 · Cited by 5

CCN1 expression is regulated by mechanical stimuli in tendons

Leong, N. L., Greskovich, K. E., Blommer, J. M., & Jiang, J. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.04.058 · Cited by 5

Knockdown SENP1 Suppressed the Angiogenic Potential of Mesenchymal Stem Cells by Impacting CXCR4-Regulated MRTF-A SUMOylation and CCN1 Expression

Zhang, R., Liu, Q., Lyu, C., Gao, X., & Ma, W. (2023) · Biomedicines · doi:10.3390/biomedicines11030914 · Cited by 3

Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis

Shirure, V. S., Sewell-Loftin, M. K., Lam, S. F., Todd, T. D., Hwang, P. Y., & George, S. C. (2017) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-60511-1_7 · Cited by 3

CCN1 as an emerging key regulator in sensitive skin and skin aging: Mechanisms and therapeutic potential

Kang, L., Wang, S., Zhang, Z., Liu, Y., Li, S., Geng, L., Cai, S., Wu, Y. X., Ye, L., Li, D., et al. (2025) · Journal of Dermatologic Science and Cosmetic Technology · doi:10.1016/j.jdsct.2025.100129 · Cited by 2

Spontaneous urinary bladder regeneration after subtotal cystectomy increases YAP/WWTR1 signaling and downstream BDNF expression: Implications for smooth muscle injury responses

AITKEN, K. J., Yadav, P., Sidler, M., Thanabalasingam, T., Ahmed, T., Aggarwal, P., Yip, S. T., Jeffrey, N., Jiang, J., Siebenaller, A. R., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287205 · Cited by 1

The CCN Genes as the “Master” Regulators of Angiogenesis, Vasculogenesis, Fibrogenesis and Cell Differentiation/Fate Specification in Mechanical Force-Driven Developmental Processes and Pathological Events

Hanna, M., & Chaqour, B. (2010) · Springer eBooks · doi:10.1007/978-90-481-3779-4_5

Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways

Han, J., Macarak, E. J., Rosenbloom, J., Chung, K. C., & Chaqour, B. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03723.x · Cited by 82

Stretch-inducible Expression of the Angiogenic Factor CCN1 in Vascular Smooth Muscle Cells Is Mediated by Egr-1

Grote, K., Bavendiek, U., Grothusen, C., Flach, I., Hilfiker-Kleiner, D., Drexler, H., & Schieffer, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406532200 · Cited by 52

Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins

Chaqour, B., & Goppelt‐Struebe, M. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05360.x · Cited by 189

GPCRs are regulators of MRTF‐A and YAP mediated CCN1 expression (1066.4)

Yu, O. M., Miyamoto, S., & Brown, J. H. (2014) · The FASEB Journal · doi:10.1096/fasebj.28.1_supplement.1066.4

Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis

Yang, R., Amir, J., Liu, H., & Chaqour, B. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90291.2008 · Cited by 54