Lau, Lester F.

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.

Sun, H., Charles, C. H., Lau, L. F., & Tonks, N. K. (1993) · Cell

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 1,156

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology

Connective Tissue Growth Factor ResearchWound Healing and Treatments

Cited by 998

Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc.

Lau, L. F., & Nathans, D. (1987) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingGenomics and Chromatin Dynamics

Cited by 856

Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.

Lau, L. F., & Nathans, D. (1985) · The EMBO Journal

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 567

Functions and mechanisms of action of CCN matricellular proteins

Chen, C.-C., & Lau, L. F. (2009) · The International Journal of Biochemistry & Cell Biology

Connective Tissue Growth Factor ResearchBone and Dental Protein Studies

Cited by 549

CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

Babic, A. M., Kireeva, M. L., Kolesnikova, T. V., & Lau, L. F. (1998) · Proceedings of the National Academy of Sciences

Angiogenesis and VEGF in CancerConnective Tissue Growth Factor Research

Cited by 495

CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity

Mo, F.-E., Muntean, A. G., Chen, C.-C., Stolz, D. B., Watkins, S. C., & Lau, L. F. (2002) · Molecular and Cellular Biology

Connective Tissue Growth Factor ResearchPregnancy and preeclampsia studies

Cited by 416

Cyr61, a Product of a Growth Factor-Inducible Immediate-Early Gene, Promotes Cell Proliferation, Migration, and Adhesion

Kireeva, M. L., Mo, F.-E., Yang, G. P., & Lau, L. F. (1996) · Molecular and Cellular Biology

Connective Tissue Growth Factor ResearchFibroblast Growth Factor Research

Cited by 341

CCN1/CYR61: the very model of a modern matricellular protein

Lau, L. F. (2011) · Cellular and Molecular Life Sciences

Connective Tissue Growth Factor ResearchBone and Dental Protein Studies

Cited by 338

Fructose stimulated de novo lipogenesis is promoted by inflammation

Todoric, J., Di Caro, G., Reibe, S., Henstridge, D. C., Green, C. R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., et al. (2020) · Nature Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 328

Expression of cyr61, a growth factor-inducible immediate-early gene.

O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology

Connective Tissue Growth Factor ResearchSignaling Pathways in Disease

Cited by 310

The Angiogenic Factors Cyr61 and Connective Tissue Growth Factor Induce Adhesive Signaling in Primary Human Skin Fibroblasts

Chen, C.-C., Chen, N., & Lau, L. F. (2001) · Journal of Biological Chemistry

Connective Tissue Growth Factor ResearchCell Adhesion Molecules Research

Cited by 305

The Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts

Chen, C.-C., Mo, F.-E., & Lau, L. F. (2001) · Journal of Biological Chemistry

Connective Tissue Growth Factor ResearchWound Healing and Treatments

Cited by 300

Matricellular Protein CCN1 Promotes Regression of Liver Fibrosis through Induction of Cellular Senescence in Hepatic Myofibroblasts

Kim, K.-H., Chen, C.-C., Monzon, R. I., & Lau, L. F. (2013) · Molecular and Cellular Biology

Liver physiology and pathologyConnective Tissue Growth Factor Research

Cited by 261

Cellular senescence controls fibrosis in wound healing

Jun, J.-I., & Lau, L. F. (2010) · Aging

Wound Healing and TreatmentsConnective Tissue Growth Factor Research

Cited by 255

Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins αvβ3 and α6β1 in Human Umbilical Vein Endothelial Cells

Leu, S.-J., Lam, S. C.-T., & Lau, L. F. (2002) · Journal of Biological Chemistry

Connective Tissue Growth Factor ResearchCell Adhesion Molecules Research

Cited by 247

Identification of integrin αMβ2 as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions

Schober, J. M., Chen, N., Grzeszkiewicz, T. M., Jovanovic, I., Emeson, E. E., Ugarova, T. P., Ye, R. D., Lau, L. F., & Lam, S. C.-T. (2002) · Blood

Cell Adhesion Molecules ResearchConnective Tissue Growth Factor Research

Cited by 242

Activation-dependent Adhesion of Human Platelets to Cyr61 and Fisp12/Mouse Connective Tissue Growth Factor Is Mediated through Integrin αIIbβ3

Jedsadayanmata, A., Chen, C.-C., Kireeva, M. L., Lau, L. F., & Lam, S. C.-T. (1999) · Journal of Biological Chemistry

Platelet Disorders and TreatmentsCell Adhesion Molecules Research

Cited by 204

Adhesion of Human Umbilical Vein Endothelial Cells to the Immediate-Early Gene Product Cyr61 Is Mediated through Integrin αvβ3

Kireeva, M. L., Lam, S. C.-T., & Lau, L. F. (1998) · Journal of Biological Chemistry

Cell Adhesion Molecules ResearchConnective Tissue Growth Factor Research

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Adhesion of Human Skin Fibroblasts to Cyr61 Is Mediated through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans

Chen, N., Chen, C.-C., & Lau, L. F. (2000) · Journal of Biological Chemistry

Connective Tissue Growth Factor ResearchCell Adhesion Molecules Research

Cited by 195

The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing

Jun, J.-I., Kim, K.-H., & Lau, L. F. (2015) · Nature Communications

Wound Healing and TreatmentsConnective Tissue Growth Factor Research

Cited by 173

Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages

Bai, T., Chen, C.-C., & Lau, L. F. (2010) · The Journal of Immunology

Connective Tissue Growth Factor ResearchSignaling Pathways in Disease

Cited by 173

CYR61 Stimulates Human Skin Fibroblast Migration through Integrin αvβ5 and Enhances Mitogenesis through Integrin αvβ3, Independent of Its Carboxyl-terminal Domain

Grzeszkiewicz, T. M., Kirschling, D. J., Chen, N., & Lau, L. F. (2001) · Journal of Biological Chemistry

Connective Tissue Growth Factor ResearchCell Adhesion Molecules Research

Cited by 162

Cyr61, Product of a Growth Factor-Inducible Immediate-Early Gene, Regulates Chondrogenesis in Mouse Limb Bud Mesenchymal Cells

Wong, M., Kireeva, M. L., Kolesnikova, T. V., & Lau, L. F. (1997) · Developmental Biology

Osteoarthritis Treatment and MechanismsConnective Tissue Growth Factor Research

Cited by 155