Transforming Growth Factor-β1 (TGF-β1) Induces Human Osteoclast Apoptosis by Up-regulating Bim

Osteoclast differentiation and activation

Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670 · see citing works

Smad transcription factorsPreprint

Massagué, J., Seoane, J., & Wotton, D. (2005) · Genes & Development · doi:10.1101/gad.1350705 · Cited by 2,432 · see citing works

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β

Hughes, D. E., Dai, A., Tiffee, J. C., Li, H. H., Mundy, G. R., & Boyce, B. F. (1996) · Nature Medicine · doi:10.1038/nm1096-1132 · Cited by 813 · see citing works

TGF‐β receptor‐activated p38 MAP kinase mediates Smad‐independent TGF‐β responses

Yu, L., DeRouen, M. C., & Zhang, Y. E. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf366 · Cited by 721 · see citing works

Transforming Growth Factor-β1 to the Bone

Janssens, K., ten Dijke, P., Janssens, S., & Van Hul, W. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0001 · Cited by 710 · see citing works

Molecular Biology of Bone Metastasis

Kingsley, L. A., Fournier, P. G. J., Chirgwin, J. M., & Guise, T. A. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0234 · Cited by 437 · see citing works

Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-β: implications for carcinogenesis

Javelaud, D., & Mauviel, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208928 · Cited by 400 · see citing works

Drugs Used to Treat Osteoporosis: The Critical Need for a Uniform Nomenclature Based on Their Action on Bone Remodeling

Riggs, B. L., & PARFITT, A. M. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041114 · Cited by 379 · see citing works

TGF‐β signaling: A tale of two responses

Rahimi, R. A., & Leof, E. B. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21501 · Cited by 371 · see citing works

p38 MAP kinase: a convergence point in cancer therapy

Olson, J. M., & Hallahan, A. R. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.007 · Cited by 335 · see citing works

Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells

Takai, H., Kanematsu, M., Yano, K., Tsuda, E., Higashio, K., Ikeda, K., Watanabe, K., & Yamada, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27091 · Cited by 299 · see citing works

Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures.

Chenu, C., Pfeilschifter, J., Mundy, G. R., & Roodman, G. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5683 · Cited by 295 · see citing works

Transforming Growth Factor-β-induced Apoptosis Is Mediated by Smad-dependent Expression of GADD45b through p38 Activation

Yoo, J., Ghiassi, M., Jirmanova, L., Balliet, A. G., Hoffman‐Liebermann, B., Fornace, A. J., Liebermann, D. A., Böttinger, E. P., & Roberts, A. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307869200 · Cited by 261 · see citing works

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3‐only Bcl‐2 family member Bim

Akiyama, T., Bouillet, P., Miyazaki, T., Kadono, Y., Chikuda, H., Chung, U., Fukuda, A., Hikita, A., Seto, H., Okada, T., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg635 · Cited by 241 · see citing works

Dual role for TGF-?1 in apoptosis

Sánchez‐Capelo, A. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.11.002 · Cited by 228 · see citing works

Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Edlund, S., Bu, S., Schuster, N., Aspenström, P., Heuchel, R. L., Heldin, N., ten Dijke, P., Heldin, C., & Landström, M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-03-0037 · Cited by 227 · see citing works

A role for TGFβ1 in osteoclast differentiation and survival

Fuller, K., Lean, J. M., Bayley, K. E., Wani, M. R., & Chambers, T. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.13.2445 · Cited by 199 · see citing works

Pharmacologic Inhibition of the TGF-β Type I Receptor Kinase Has Anabolic and Anti-Catabolic Effects on Bone

Mohammad, K. S., Chen, C. G., Balooch, G., Stebbins, E. G., McKenna, C. R., Davis, H., Niewolna, M., Peng, X., Nguyen, D. H., Ionova-Martin, S. S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005275 · Cited by 179 · see citing works

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

Gingery, A., Bradley, E. W., Pederson, L. G., Ruan, M. M., Horwood, N. J., & Oursler, M. J. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.006 · Cited by 175 · see citing works

X-linked Inhibitor of Apoptosis Protein Functions as a Cofactor in Transforming Growth Factor-β Signaling

Reffey, S. B., Würthner, J., Parks, W. T., Roberts, A. B., & Duckett, C. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100331200 · Cited by 147 · see citing works

Transforming Growth Factor-β Controls Human Osteoclastogenesis through the p38 MAPK and Regulation of RANK Expression

Karsdal, M. A., Hjorth, P., Henriksen, K., Kirkegaard, T., Nielsen, K. L., Lou, H., Delaissé, J., & Foged, N. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303905200 · Cited by 137 · see citing works

Upregulation of two BH3-only proteins, Bmf and Bim, during TGFβ-induced apoptosis

Ramjaun, A. R., Tomlinson, S., Eddaoudi, A., & Downward, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209852 · Cited by 131 · see citing works

The p38 MAPK stress pathway as a tumor suppressor or more?

Loesch, M. (2008) · Frontiers in bioscience · doi:10.2741/2951 · Cited by 115 · see citing works

Transforming Growth Factor β-Dependent Sequential Activation of Smad, Bim, and Caspase-9 Mediates Physiological Apoptosis in Gastric Epithelial Cells

Ohgushi, M., Kuroki, S., Fukamachi, H., O’Reilly, L. A., Kuida, K., Strasser, A., & Yonehara, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10017-10028.2005 · Cited by 102 · see citing works

Smad3 Potentiates Transforming Growth Factor β (TGFβ)-induced Apoptosis and Expression of the BH3-only Protein Bim in WEHI 231 B Lymphocytes

Wildey, G. M., Patil, S. D., & Howe, P. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211958200 · Cited by 97 · see citing works

TGFβ‐mediated BIM expression and apoptosis are regulated through SMAD3‐dependent expression of the MAPK phosphatase MKP2

Ramesh, S., Qi, X., Wildey, G. M., Robinson, J., Molkentin, J. D., Letterio, J. J., & Howe, P. H. (2008) · EMBO Reports · doi:10.1038/embor.2008.158 · Cited by 87 · see citing works

Transforming Growth Factor-β-induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway

Karsdal, M. A., Fjording, M. S., Foged, N. T., Delaissé, J.-M., & Lochter, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008738200 · Cited by 81 · see citing works

Induction of p53 and Bax during TGF-beta 1 initiated apoptosis in rat liver epithelial cells.

Teramoto, T., Kiss, A., & Thorgeirsson, S. (1998) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1006/bbrc.1998.9411 · Cited by 68 · see citing works

Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis

Roux, S., Lambert-Comeau, P., Saint-Pierre, C., Lépine, M., Sawan, B., & Parent, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.092 · Cited by 67 · see citing works

Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway

Chamoux, E., Houde, N., L'Ériger, K., & Roux, S. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21430 · Cited by 65 · see citing works

Identification of the gene transcription and apoptosis mediated by TGF‐β‐Smad2/3‐Smad4 signaling

Yu, J., Zhang, L., Chen, A., Xiang, G., Wang, Y., Wu, J., Mitchelson, K. R., Cheng, J., & Zhou, Y. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21325 · Cited by 59 · see citing works

The death receptor DR5 is involved in TRAIL-mediated human osteoclast apoptosis

Colucci, S. C., Brunetti, G., Cantatore, F. P., Oranger, A., Mori, G., Pignataro, P., Tamma, R., Grassi, F. R., Zallone, A. Z., & Grano, M. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0095-3 · Cited by 58 · see citing works

Gene expression of transforming growth factor-beta 1 and its type II receptor in giant cell tumors of bone. Possible involvement in osteoclast-like cell migration.

Zheng, M., Fan, Y., Wysocki, S. J., Lau, A. T., Robertson, T., Beilharz, M. W., Wood, D., & Papadimitriou, J. M. (1994) · PubMed Central · Cited by 54 · see citing works

Osteopetrosis-like phenotype in latent TGF-β binding protein 3 deficient mice

Dabovic, B., Levasseur, R., Zambuto, L., Chen, Y., Karsenty, G., & Rifkin, D. B. (2005) · Bone · doi:10.1016/j.bone.2005.02.021 · Cited by 52 · see citing works

Transforming growth factor-β enables NFATc1 expression during osteoclastogenesis

Fox, S. W., Evans, K. E., & Lovibond, A. C. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.120 · Cited by 35 · see citing works

Effects of transforming growth factor‐β on long‐term human cord blood monocyte cultures

Orcel, P., Bielakoff, J., & de Vernejoul, M. C. (1990) · Journal of Cellular Physiology · doi:10.1002/jcp.1041420211 · Cited by 15 · see citing works

TRAIL Is Involved in Human Osteoclast Apoptosis

Brunetti, G., Oranger, A., Mori, G., Tamma, R., Benedetto, A. D., Pignataro, P., Grassi, F. R., Zallone, A. Z., Grano, M., & Colucci, S. C. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.011 · Cited by 13 · see citing works

TGF-β Isoform and Receptor Expression in Giant Cell Tumor and Giant Cell Lesions of Bone

Franchi, A., Benvenuti, S., Masi, L., Malentacchi, C., Arganini, L., Brandi, M. L., & Santucci, M. (2001) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200106000-00010 · Cited by 9 · see citing works

Untitled work

Good (1996) · doi:10.1002/(sici)1097-4652(199609)168:3

Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement

Siddiqui, J. A., & Partridge, N. C. (2016) · Physiology · doi:10.1152/physiol.00061.2014 · Cited by 546 · see citing works

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

Wu, M., Wu, S., Chen, W., & Li, Y.-P. (2024) · Cell Research · doi:10.1038/s41422-023-00918-9 · Cited by 445 · see citing works

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

Lee, K., Seo, I., Choi, M. H., & Jeong, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103004 · Cited by 251 · see citing works

Regulation of Bim in Health and Disease

Sionov, R. V., Vlahopoulos, S., & Granot, Z. (2015) · Oncotarget · doi:10.18632/oncotarget.5492 · Cited by 225 · see citing works

Targeting polymer therapeutics to bone

Low, S. A., & Kopec̆ek, J. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.012 · Cited by 158 · see citing works

Cytokine-mediated immunomodulation of osteoclastogenesis

Zhou, P., Zheng, T., & Zhao, B. (2022) · Bone · doi:10.1016/j.bone.2022.116540 · Cited by 144 · see citing works

Can platelet-rich plasma (PRP) improve bone healing? A comparison between the theory and experimental outcomes

Malhotra, A., Pelletier, M. H., Yu, Y. Y., & Walsh, W. R. (2012) · Archives of Orthopaedic and Trauma Surgery · doi:10.1007/s00402-012-1641-1 · Cited by 130 · see citing works

Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions

Jann, J., Gascon, S., Roux, S., & Faucheux, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207597 · Cited by 129 · see citing works

New Insights Into Osteoclast Biology

McDonald, M. M., Kim, A. S., Mulholland, B. S., & Rauner, M. (2021) · JBMR Plus · doi:10.1002/jbm4.10539 · Cited by 116 · see citing works

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Wu, Z., Li, W., Jiang, K., Lin, Z., Qian, C., Wu, M., Xia, Y., Li, N., Zhang, H., Xiao, H.-X., et al. (2024) · MedComm · doi:10.1002/mco2.657 · Cited by 115 · see citing works

TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

Xia, Y., Inoue, K., Du, Y., Baker, S. J., Reddy, E. P., Greenblatt, M. B., & Zhao, B. (2022) · Nature Communications · doi:10.1038/s41467-022-31475-1 · Cited by 110 · see citing works

Molecular signaling mechanisms behind polyphenol-induced bone anabolism

Torre, E. (2017) · Phytochemistry Reviews · doi:10.1007/s11101-017-9529-x · Cited by 104 · see citing works

The Rising Era of “Immunoporosis”: Role of Immune System in the Pathophysiology of Osteoporosis

Srivastava, R., & Sapra, L. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s351918 · Cited by 79 · see citing works

Mechanisms of Spontaneous Resolution of Acute Gouty Inflammation

Steiger, S., & Harper, J. L. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0392-5 · Cited by 71 · see citing works

Inhibition of HIF Prolyl Hydroxylase-2 Blocks Tumor Growth in Mice through the Antiproliferative Activity of TGFβ

Ameln, A. K., Muschter, A., Mamlouk, S., Kalucka, J. M., Prade, I., Franke, K., Rezaei, M., Poitz, D. M., Breier, G., & Wielockx, B. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3838 · Cited by 70 · see citing works

The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells

Jagani, Z., Wiederschain, D., Loo, A. T., He, D., Mosher, R. E., Fordjour, P., Monahan, J. E., Morrissey, M., Yao, Y.-M., Christoph Lengauer, C., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4229 · Cited by 70 · see citing works

Genetics in Endocrinology: Autosomal dominant osteopetrosis revisited: lessons from recent studies

Bollerslev, J., Henriksen, K., Nielsen, M. F., Brixen, K., & Hul, W. V. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0136 · Cited by 69 · see citing works

The adaptor protein p62/SQSTM1 in osteoclast signaling pathways

McManus, S., & Roux, S. (2012) · Journal of Molecular Signaling · doi:10.1186/1750-2187-7-1 · Cited by 68 · see citing works

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Cash, T. P., Gruber, J. J., Hartman, T. R., Henske, E. P., & Simon, M. C. (2011) · Oncogene · doi:10.1038/onc.2010.628 · Cited by 59 · see citing works

Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species

Li, M., Chen, X., Yan, J., Zhou, L., Wang, Y., He, F., Lin, J., Zhu, C., Pan, G., Yu, J., et al. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.003 · Cited by 51 · see citing works

The Molecular Mechanisms of Regulatory T Cell Immunosuppression

Pandiyan, P., Zheng, L., & Lenardo, M. J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00060 · Cited by 50 · see citing works

A dual role of TGF-β in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling

Lee, B., Oh, Y., Jo, S., Kim, T., & Ji, J. D. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.12.003 · Cited by 50 · see citing works

Effects of LLLT in combination with bisphosphonate on bone healing in critical size defects: a histological and histometric study in rat calvaria

Garcia, V. G., da Conceição, J. M., Fernandes, L. A., de Almeida, J. M., Nagata, M. J. H., Bosco, Á. F., & Theodoro, L. H. (2012) · Lasers in Medical Science · doi:10.1007/s10103-012-1068-5 · Cited by 50 · see citing works

Positive and negative regulators of osteoclast apoptosis

Soysa, N. S., & Alles, N. (2019) · Bone Reports · doi:10.1016/j.bonr.2019.100225 · Cited by 49 · see citing works

A mechanobiological model of orthodontic tooth movement

Schepdael, A. V., Sloten, J. V., & Geris, L. (2012) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-012-0396-5 · Cited by 48 · see citing works

General analysis of mathematical models for bone remodeling

Zumsande, M., Stiefs, D., Siegmund, S., & Groß, T. (2010) · Bone · doi:10.1016/j.bone.2010.12.010 · Cited by 47 · see citing works

Transforming Growth Factor β1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression

Zhao, H., Zhang, J., Shao, H., Liu, J., Jin, M., Chen, J., & Huang, Y. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2303 · Cited by 44 · see citing works

C5aR1 interacts with TLR 2 in osteoblasts and stimulates the osteoclast‐inducing chemokine CXCL 10

Mödinger, Y., Rapp, A. E., Pázmándi, J., Vikman, A., Holzmann, K., Haffner‐Luntzer, M., Huber-Lang, M. S., & Ignatius, A. A. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13873 · Cited by 41 · see citing works

The Effects of TGF-β Signaling on Cancer Cells and Cancer Stem Cells in the Bone Microenvironment

Futakuchi, M., Lami, K., Tachibana, Y., Yamamoto, Y., Furukawa, M., & Fukuoka, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205117 · Cited by 40 · see citing works

Platelet‐rich plasma impairs osteoclast generation from human precursors of peripheral blood

Cenni, E., Avnet, S., Fotia, C., Salerno, M., & Baldini, N. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21073 · Cited by 39 · see citing works

Erratum to: Transforming Growth Factor b1/Smad4 Signaling Affects Osteoclast Differentiation via Regulation of miR-155 Expression

Zhao, H., Zhang, J., Shao, H., Liu, J., Jin, M., Chen, J., & Huang, Y. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.1303 · Cited by 38 · see citing works

Role of TGF-β in a Mouse Model of High Turnover Renal Osteodystrophy

Liu, S., Song, W., Boulanger, J., Tang, W., Sabbagh, Y., Kelley, B., Gotschall, R. R., Ryan, S., Phillips, L. A., Malley, K., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2120 · Cited by 35 · see citing works

MicroRNAs Are Critical Regulators of Osteoclast Differentiation

Hrdlicka, H. C., Lee, S., & Delany, A. M. (2019) · Current Molecular Biology Reports · doi:10.1007/s40610-019-0116-3 · Cited by 35 · see citing works

S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells

Tong, D., Qu, H., Meng, X., Jiang, Y., LIU, D., Ye, S., CHEN, H., Jin, Y., Fu, S., & Geng, J. (2014) · Oncology Reports · doi:10.3892/or.2014.3295 · Cited by 32 · see citing works

Different Effects of Fluoride Exposure on the Three Major Bone Cell Types

Jiang, N., Guo, F., Sun, B., Zhang, X., & Xu, H. J. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01684-9 · Cited by 29 · see citing works

Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures

Fowler, T. W., Kamalakar, A., Akel, N. S., Kurten, R. C., Suva, L. J., & Gaddy, D. (2015) · Journal of Cell Science · doi:10.1242/jcs.157834 · Cited by 28 · see citing works

The balance between helper T 17 and regulatory T cells in osteoimmunology and relevant research progress on bone tissue engineering

Zhu, S.-Y., Zhou, J., & Xie, Z.-G. (2024) · Immunity, Inflammation and Disease · doi:10.1002/iid3.70011 · Cited by 24 · see citing works

Characterization and Identification of Subpopulations of Mononuclear Preosteoclasts Induced by TNF-α in Combination with TGF-β in Rats

Matsubara, R., Kukita, T., Ichigi, Y., Takigawa, I., Qu, P., Funakubo, N., Miyamoto, H., Nonaka, K., & Kukita, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047930 · Cited by 20 · see citing works

Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption

Shang, N., & Wu, J. (2019) · Nutrients · doi:10.3390/nu11092254 · Cited by 23 · see citing works

Gene expression profile in osteoclasts from patients with Paget's disease of bone

Michou, L., Chamoux, E., Couture, J., Morissette, J., Brown, J. P., & Roux, S. (2009) · Bone · doi:10.1016/j.bone.2009.11.012 · Cited by 23 · see citing works

Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis

Hussein, O., Tiedemann, K., & Komarova, S. V. (2010) · Bone · doi:10.1016/j.bone.2010.09.006 · Cited by 21 · see citing works

Immunology of Gut-Bone Signaling

Collins, F. L., Schepper, J. D., Rios‐Arce, N. D., Steury, M. D., Kang, H. J., Mallin, H., Schoenherr, D. T., Camfield, G., Chishti, S., McCabe, L. R., et al. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_5 · Cited by 21 · see citing works

Anti-osteopontin monoclonal antibody prevents ovariectomy-induced osteoporosis in mice by promotion of osteoclast apoptosis

Zhang, B., Dai, J., Wang, H., Wei, H., Zhao, J., Guo, Y., & Fan, K. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.149 · Cited by 21 · see citing works

Role of rhBMP-7, Fibronectin, And Type I Collagen in Dental Implant Osseointegration Process: An Initial Pilot Study on Minipig Animals

Schierano, G., Canuto, R. A., von Degerfeld, M. M., Navone, R., Peirone, B., Preti, G., & Muzio, G. (2021) · Materials · doi:10.3390/ma14092185 · Cited by 20 · see citing works

Prostaglandin D2 induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways

Li, Y., Haroun, S., Parent, J., & de Brum-Fernandes, A. J. (2013) · Bone · doi:10.1016/j.bone.2013.12.011 · Cited by 20 · see citing works

Prostaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway

Li, Y., Durand, M., Jacob, M. C. L., Hogan, P., McManus, S., Roux, S., & de Brum-Fernandes, A. J. (2012) · Bone · doi:10.1016/j.bone.2012.06.003 · Cited by 19 · see citing works

Mathematical Model of Bone Remodeling Captures the Antiresorptive and Anabolic Actions of Various Therapies

ROSS, D. S., Mehta, K., & Cabal, A. (2016) · Bulletin of Mathematical Biology · doi:10.1007/s11538-016-0229-2 · Cited by 18 · see citing works

Bim: Guardian of Tissue Homeostasis and Critical Regulator of the Immune System, Tumorigenesis and Bone Biology

Akiyama, T., & Tanaka, S. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0126-1 · Cited by 17 · see citing works

Modeling osteoporosis to design and optimize pharmacological therapies comprising multiple drug types

Jörg, D. J., Fuertinger, D. H., Cherif, A., Bushinsky, D. A., Mermelstein, A., Raimann, J. G., & Kotanko, P. (2022) · eLife · doi:10.7554/elife.76228 · Cited by 15 · see citing works

Coordination of Osteoblastogenesis and Osteoclastogenesis by the Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Matrix To Promote Bone Regeneration

Wu, H. C., Yin, G., Pu, X., Wang, J., Liao, X., & Huang, Z. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00264 · Cited by 15 · see citing works

Unraveling the Molecular Mechanisms of Osteoarthritis: The Potential of Polyphenols as Therapeutic Agents

Rahaman, S. N., Lishadevi, M., & Anandasadagopan, S. K. (2025) · Phytotherapy Research · doi:10.1002/ptr.8455 · Cited by 15 · see citing works

Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing

Baratchart, E., Lo, C.-H., Lynch, C., & Basanta, D. (2021) · bioRxiv · doi:10.1371/journal.pcbi.1009839 · Cited by 14 · see citing works

Modulation of tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptors in a human osteoclast model in vitro

McManus, S., Chamoux, E., Bisson, M., & Roux, S. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0662-5 · Cited by 14 · see citing works

The usefulness of an autologous blood clot combined with gelatin for regeneration of periodontal tissue

Kabashima, H., Sakai, T., Mizobe, K., Nakamuta, H., Kurita, K., & Terada, Y. (2013) · Journal of Oral Science · doi:10.2334/josnusd.55.363 · Cited by 13 · see citing works

Opposite Function of ERα and ERβ in Controlling 17β-Estradiol-mediated Osteogenesis in Osteoblasts

Wang, Y., Li, M., Zhang, H., Tang, M., Guo, C., Deng, A., Chen, Y., & Xiao, L. (2016) · Archives of Medical Research · doi:10.1016/j.arcmed.2016.07.002 · Cited by 11 · see citing works

Autologous platelet-rich plasma therapy — a promising method for tissue repair/ /regeneration in many medical fields

Piszczorowicz, Ł., Król, D., & Dyląg, S. (2020) · Journal of Transfusion Medicine · doi:10.5603/jtm.2020.0004 · Cited by 11 · see citing works

The Role of Oral and Gut Microbiota in Bone Health: Insights from Bacterial Extracellular Vesicles

Liang, P., Chen, X., Su, Z., Luo, Y., Wang, T., Jiang, L., Guo, L., & Luo, T. (2025) · Microorganisms · doi:10.3390/microorganisms13102254 · Cited by 10 · see citing works

Excessive mechanical stress induced temporomandibular joint osteoarthritis via osteoclasts‐mediated osteogenic differentiation of BMSCs

Wang, L., Tian, Y., Liu, M., He, Z., Xiao, Y., Yuan, X. H., & Zhang, Q. (2022) · Journal of Oral Rehabilitation · doi:10.1111/joor.13360 · Cited by 8 · see citing works

Association of SMAD2 polymorphisms with bone mineral density in postmenopausal Korean women

Kim, B., Hwang, J. Y., Han, B. G., Lee, J., Lee, J., Park, E. K., Lee, S. H., Chung, Y. E., Kim, G. S., Kim, S.-Y., et al. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1450-8 · Cited by 8 · see citing works

Gap junctional communication is involved in differentiation of osteoclasts from bone marrow and peripheral blood monocytes

Kylmäoja, E., Nakamura, M., Kokkonen, H. E., Ronkainen, V., Lehenkari, P. P., & Tuukkanen, J. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00621 · Cited by 8 · see citing works

Effects of TGF‑β1 on the migration and morphology of RAW264.7 cells in vitro

Ueta, M., Takaoka, K., Yamamura, M., Maeda, H., Tamaoka, J., Nakano, Y., Noguchi, K., & Kishimoto, H. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10662 · Cited by 7 · see citing works

Serum IL-6 and TGF-β1 concentrations as diagnostic biomarkers in elderly male patients with osteoporosis

Chen, Z., Yang, G., Su, W., He, S., & Wang, Y.-W. (2024) · European Spine Journal · doi:10.1007/s00586-024-08553-7 · Cited by 6 · see citing works

Identification of 8-(2-methyl phenyl)-9H-benzo[f]indeno[2,1-c]quinolin-9-one (C-5635020) as a novel and selective TGFβ RII kinase inhibitor for breast cancer therapy

Shahrani, M. M. A., Abohassan, M., Alshahrani, M. Y., Gahtani, R. M., & Rajagopalan, P. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151225 · Cited by 6 · see citing works

Extracellular Signal-Regulated Kinases Play Essential but Contrasting Roles in Osteoclast Differentiation

Kim, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015342 · Cited by 6 · see citing works

A novel role for TGF-β1 in bone remodeling

Nishimura, R. (2009) · IBMS BoneKEy · doi:10.1138/20090409 · Cited by 5 · see citing works

Aberrant Bone Homeostasis in AML Is Associated with Activated Oncogenic FLT3-Dependent Cytokine Networks

Bär, I., Ast, V., Meyer, D., König, R., Rauner, M., Hofbauer, L. C., & Müller, J. P. (2020) · Cells · doi:10.3390/cells9112443 · Cited by 5 · see citing works

Postmenopausal Osteoporosis: A Mini Review

Shuai, Y., Zhang, Z., Guo, T., Yang, R., Lei, J., & Liu, W. (2019) · EMJ Rheumatology · doi:10.33590/emjrheumatol/10311765 · Cited by 5 · see citing works

Bone remodeling features in elderly and senile patients with the proximal femur fractures after hip replacement

Хвисюк, О. М., Babalian, V. O., PAVLOV, S. B., & Pavlova, G. B. (2020) · Wiadomości Lekarskie · doi:10.36740/wlek202002110 · Cited by 4 · see citing works

The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone

Carroll, M., Alliston, T. N., & Dole, N. S. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00802-w · Cited by 4 · see citing works

MODEL-BASED ANALYSIS OF IGF-1 EFFECT ON OSTEOBLAST AND OSTEOCLAST REGULATION IN BONE TURNOVER

Lee, W., & Okos, M. R. (2016) · Journal of Biological Systems · doi:10.1142/s0218339016500042 · Cited by 4 · see citing works

Extension of Generalized Modeling and Application to Problems from Cell Biology

Zumsande, M. (2011) · Qucosa (Saxon State and University Library Dresden) · Cited by 3 · see citing works

WITHDRAWN: Inorganic Pyrophosphate Promotes Osteoclastogenic Commitment and Survival of Bone Marrow Derived Monocytes mediated by Egr-1 up-regulation and MITF phosphorylationPreprint

Abdelmagid, S. M., Zajac, A. L., Salhab, I., & Nah, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.01.321976 · Cited by 3 · see citing works

Osteoclasts

Ross, F. P. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10018-6 · Cited by 2 · see citing works

Development of Novel Models for Studying Osteoclasts

Thudium, C. S. (2014) · Lund University Publications (Lund University) · Cited by 2 · see citing works

The Potential Role of Integrin Regulation by Par6 in TGF-beta-induced Apoptosis

Avery-Cooper, G. (2011) · The Atrium (University of Guelph)

The Molecular Mechanisms of Regulatory T cell Immunosuppression

(2013) · Frontiers research topics · doi:10.3389/978-2-88919-093-5

Clinical and basic research papers – October 2009

Ferrari, S., Seeman, E., Deng, H., Little, D. G., & Matsumoto, T. (2009) · IBMS BoneKEy · doi:10.1138/20090398

Immune features of the bone remodelling after the hip arthroplasty in elderly and senile patients with proximal femur fractures

Babalian, V. O., Pavlov, S., & Khvysyuk, О. (2020) · ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS · doi:10.15674/0030-59872020188-98

A mechanistic model for genetic regulation of postmenopausal bone lossPreprint

Rattsev, I., Gabhann, F. M., Hertz, D. L., & Taylor, C. O. (2026) · medRxiv · doi:10.64898/2026.06.04.26354968

Transforming Growth Factor-β Coordinately Induces Suppressor of Cytokine Signaling 3 and Leukemia Inhibitory Factor to Suppress Osteoclast Apoptosis

Ruan, M. M., Pederson, L. G., Bradley, E. W., Bamberger, A., & Oursler, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-0813 · Cited by 38 · see citing works

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

Gingery, A., Bradley, E. W., Pederson, L. G., Ruan, M. M., Horwood, N. J., & Oursler, M. J. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.006 · Cited by 175 · see citing works

Bone Morphogenetic Protein-2 Promotes Osteoblast Apoptosis through a Smad-independent, Protein Kinase C-dependent Signaling Pathway

Haÿ, E., Lemonnier, J., Fromigué, O., & Marie, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011265200 · Cited by 171 · see citing works

A dual role of TGF-β in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling

Lee, B., Oh, Y., Jo, S., Kim, T., & Ji, J. D. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.12.003 · Cited by 50 · see citing works

TGFβ1 Regulates Human RANKL-Induced Osteoclastogenesis via Suppression of NFATc1 Expression

Tokunaga, T., Mokuda, S., Kohno, H., Yukawa, K., Kuranobu, T., Oi, K., Yoshida, Y., Hirata, S., & Sugiyama, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030800 · Cited by 36 · see citing works