The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53
Open accessAbstract
The tumor suppressor p53 is regulated by numerous post-translational modifications. Lysine methylation has recently emerged as a key post-translational modification that alters the activity of p53. Here, we describe a novel lysine methylation site in p53 that is carried out by two homologous histone methyltransferases, G9a and Glp. G9a and Glp specifically methylate p53 at Lys(373), resulting mainly in dimethylation. During DNA damage, the overall level of p53 modified at Lys(373)me2 does not increase, despite the dramatic increase in total p53, indicating that Lys(373)me2 correlates with inactive p53. Further, reduction of G9a and/or Glp levels leads to a larger population of apoptotic cells. Examination of the Oncomine data base shows that G9a and Glp are overexpressed in various cancers compared with corresponding normal tissues, suggesting that they are putative oncogenes. These data reveal a new methylation site within p53 mediated by the methylases G9a and Glp and indicate that G9a is a potential inhibitory target for cancer treatment.
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Cites
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Toledo, F., & Wahl, G. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc2012 · Cited by 1,286
Post-translational modification of p53 in tumorigenesis
Bode, A. M., & Dong, Z. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1455 · Cited by 1,270
Feng, L., Lin, T., Uranishi, H., Gu, W., & Xu, Y. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5389-5395.2005 · Cited by 236
Research works printed but not linked: 15
- Prives, 2001, Cell, 107, 815, 10.1016/S0092-8674(01)00619-5 · DOI
- Huang, 2008, Curr. Opin. Genet. Dev., 18, 152, 10.1016/j.gde.2008.01.012 · DOI · Paper page
- Schotta, 2004, Genes Dev., 18, 1251, 10.1101/gad.300704 · DOI · Paper page
- Huang, 2006, Nature, 444, 629, 10.1038/nature05287 · DOI · Paper page
- Chuikov, 2004, Nature, 432, 353, 10.1038/nature03117 · DOI · Paper page
- Shi, 2007, Mol. Cell, 27, 636, 10.1016/j.molcel.2007.07.012 · DOI · Paper page
- Lysachirskaia, 2008, J. Biol. Chem., 283, 34660, 10.1074/jbc.M806020200 · DOI
- Huang, 2007, Nature, 449, 105, 10.1038/nature06092 · DOI · Paper page
- Tachibana, 2002, Genes Dev., 16, 1779, 10.1101/gad.989402 · DOI · Paper page
- Tachibana, 2005, Genes Dev., 19, 815, 10.1101/gad.1284005 · DOI · Paper page
- Rhodes, 2004, Neoplasia, 6, 1, 10.1016/S1476-5586(04)80047-2 · DOI · Paper page
- Lysrummel, 2005, Proc. Natl. Acad. Sci. U.S.A., 102, 10188, 10.1073/pnas.0503068102 · DOI · Paper page
- Tang, 2008, Cell, 133, 612, 10.1016/j.cell.2008.03.025 · DOI · Paper page
- Schulte, 2009, Cancer Res., 69, 2065, 10.1158/0008-5472.CAN-08-1735 · DOI · Paper page
- Lysahl, 2006, Cancer Res., 66, 11341, 10.1158/0008-5472.CAN-06-1570 · DOI · Paper page
Cited by
The multiple mechanisms that regulate p53 activity and cell fate
Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129
SET for life: biochemical activities and biological functions of SET domain-containing proteins
Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.004 · Cited by 314
Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
Sweis, R. F., Pliushchev, M., Brown, P. J., Guo, J., Li, F., Maag, D., Petros, A. M., Soni, N. B., Tse, C., Vedadi, M., et al. (2014) · ACS Medicinal Chemistry Letters · doi:10.1021/ml400496h · Cited by 193
Liu, M., Thomas, S. L., DeWitt, A. K., Zhou, W., Madaj, Z. B., Ohtani, H., Baylin, S. B., Liang, G., & Jones, P. A. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3953 · Cited by 127
Jayaram, H., Hoelper, D., Jain, S. U., Cantone, N., Lundgren, S. M., Poy, F., Allis, C. D., Cummings, R., Bellon, S., & Lewis, P. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605523113 · Cited by 92
Metadata
- Authors
- Huang, J., Dorsey, J., Chuikov, S., Zhang, X., Jenuwein, T., Reinberg, D., & Berger, S. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 285
- Issue
- 13
- Pages
- 9636-9641
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2086180957
- Cited by
- 383
- References
- 3
- FWCI
- 10.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 3949 d)
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- Huang, J., Dorsey, J., Chuikov, S., Zhang, X., Jenuwein, T., Reinberg, D., & Berger, S. L. (2010). G9a and Glp Methylate Lysine 373 in the Tumor Suppressor p53. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m109.062588
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