Angiopoietin-2 Stimulation of Endothelial Cells Induces αvβ3 Integrin Internalization and Degradation

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570 · see citing works

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,831 · see citing works

Environmental sensing through focal adhesions

Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543 · see citing works

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262 · see citing works

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821 · see citing works

Role of integrins in cell invasion and migration

Hood, J. D., & Cheresh, D. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc727 · Cited by 1,781 · see citing works

Endothelial Cell Migration During Angiogenesis

Lamalice, L., Bœuf, F. L., & Huot, J. (2007) · Circulation Research · doi:10.1161/01.res.0000259593.07661.1e · Cited by 1,486 · see citing works

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,460 · see citing works

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985 · see citing works

Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933 · see citing works

Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor‐2

Soldi, R., Mitola, S. M. F., Strasly, M., Defilippi, P., Tarone, G., & Bussolino, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.882 · Cited by 627 · see citing works

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

Abedi, H., & Zachary, I. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15442 · Cited by 468 · see citing works

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

Saharinen, P., Eklund, L., Miettinen, J., Wirkkala, R., Anisimov, A., Winderlich, M., Nottebaum, A., Vestweber, D., Deutsch, U., Koh, G. Y., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1715 · Cited by 415 · see citing works

Multiple connections link FAK to cell motility and invasion

Schlaepfer, D. D., & Mitra, S. K. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.12.002 · Cited by 415 · see citing works

The role of the Angiopoietins in vascular morphogenesis

Thomas, M., & Augustin, H. G. (2009) · Angiogenesis · doi:10.1007/s10456-009-9147-3 · Cited by 407 · see citing works

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

Fukuhara, S., Sako, K., Minami, T., Noda, K., Kim, H. Z., Kodama, T., Shibuya, M., Takakura, N., Koh, G. Y., & Mochizuki, N. (2008) · Nature Cell Biology · doi:10.1038/ncb1714 · Cited by 386 · see citing works

The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

Scharpfenecker, M., Fiedler, U., Reiss, Y., & Augustin, H. G. (2005) · Journal of Cell Science · doi:10.1242/jcs.01653 · Cited by 382 · see citing works

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases

Marmor, M. D., & Yarden, Y. (2004) · Oncogene · doi:10.1038/sj.onc.1207390 · Cited by 382 · see citing works

PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading

Roberts, M. S., Barry, S. T., Woods, A. J., van der Sluijs, P., & Norman, J. C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00442-0 · Cited by 348 · see citing works

Decreased angiogenesis and arthritic disease in rabbits treated with an αvβ3 antagonist

Storgard, C. M., Stupack, D. G., Jonczyk, A., Goodman, S. L., Fox, R. I., & Cheresh, D. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3756 · Cited by 310 · see citing works

An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization

Drake, C. J., Cheresh, D. A., & Little, C. D. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.7.2655 · Cited by 307 · see citing works

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain

Borges, E., Jan, Y., & Ruoslahti, E. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007040200 · Cited by 293 · see citing works

Signaling by integrin receptors

Kumar, C. C. (1998) · Oncogene · doi:10.1038/sj.onc.1202172 · Cited by 288 · see citing works

Direct Cell Adhesion to the Angiopoietins Mediated by Integrins

Carlson, T. R., Feng, Y., Maisonpierre, P. C., Mrksich, M., & Morla, A. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100282200 · Cited by 265 · see citing works

Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397

Hamadi, A., Bouali, M., Dontenwill, M., Stoeckel, H., Takeda, K., & Rondé, P. (2005) · Journal of Cell Science · doi:10.1242/jcs.02565 · Cited by 257 · see citing works

Complementary Actions of Inhibitors of Angiopoietin-2 and VEGF on Tumor Angiogenesis and Growth

Hashizume, H., Falcón, B. L., Kuroda, T., Bałuk, P., Coxon, A., Yu, D., BREADY, J. V., Oliner, J. D., & McDonald, D. M. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1977 · Cited by 252 · see citing works

Angiopoietin-2 Levels Are Associated with Disease Progression in Metastatic Malignant Melanoma

Helfrich, I., Edler, L., Sucker, A., Thomas, M., Christian, S., Schadendorf, D., & Augustin, H. G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1615 · Cited by 201 · see citing works

Angiopoietin-2 Stimulates Breast Cancer Metastasis through the α5β1 Integrin-Mediated Pathway

Imanishi, Y., Hu, B., Jarzynka, M. J., Guo, P., Elishaev, E., Bar-Joseph, I., & Cheng, S.-Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4100 · Cited by 190 · see citing works

Integrin traffic

Pellinen, T. S., & Ivaska, J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03216 · Cited by 189 · see citing works

Stable interaction between α5β1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1

Cascone, I., Napione, L., Maniero, F., Serini, G., & Bussolino, F. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507082 · Cited by 179 · see citing works

Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

Nasarre, P., Thomas, M., Kruse, K., Helfrich, I., Wolter, V., Deppermann, C., Schadendorf, D., Thurston, G., Fiedler, U., & Augustin, H. G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3030 · Cited by 177 · see citing works

Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the αvβ1 Integrin and Focal Adhesion Kinase Signaling Pathway

Hu, B., Jarzynka, M. J., Guo, P., Imanishi, Y., Schlaepfer, D. D., & Cheng, S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1149 · Cited by 172 · see citing works

Del1 Induces Integrin Signaling and Angiogenesis by Ligation of αVβ3

Penta, K., Varner, J. A., Liaw, L., Hidai, C., Schatzman, R., & Quertermous, T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11101 · Cited by 153 · see citing works

Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase

Avraham, H. K., Lee, T.-H., Koh, Y., Kim, T., Jiang, S., Sussman, M. A., Samarel, A. M., & Avraham, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301253200 · Cited by 152 · see citing works

The sperm outer dense fiber protein is the 10th member of the superfamily of mammalian small stress proteins

Fontaine, J., Rest, J. S., Welsh, M. J., & Benndorf, R. (2003) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2003)8 · Cited by 145 · see citing works

The Integrin Antagonist Cilengitide Activates αVβ3, Disrupts VE-Cadherin Localization at Cell Junctions and Enhances Permeability in Endothelial Cells

Alghisi, G. C., Ponsonnet, L., & Rüegg, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004449 · Cited by 129 · see citing works

Endothelial focal adhesions and barrier function

Wu, M. H. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.096537 · Cited by 127 · see citing works

Angiopoietin-2 Impairs Revascularization After Limb Ischemia

Reiss, Y., Droste, J., Heil, M., Tribulova, S., Schmidt, M. H. H., Schaper, W. K. A., Dumont, D., & Plate, K. H. (2007) · Circulation Research · doi:10.1161/circresaha.106.143594 · Cited by 111 · see citing works

Roles of Integrins in Tumor Angiogenesis and Lymphangiogenesis

Garmy-Susini, B. H., & Varner, J. A. (2008) · Lymphatic Research and Biology · doi:10.1089/lrb.2008.1011 · Cited by 95 · see citing works

Inhibition of angiogenesis in vitro and in vivo: comparison of the relative activities of triflavin, an Arg-Gly-Asp-containing peptide and anti-αvβ3 integrin monoclonal antibody

Sheu, J., Yen, M., Kan, Y.-C., Hung, W.-C., Chang, P.-T., & Luk, H. (1997) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(97)00057-3 · Cited by 91 · see citing works

PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser‐910: Dissociation from Tyr‐397 phosphorylation and requirement for ERK activation

Hunger‐Glaser, I., Fan, R. S., Perez‐Salazar, E., & Rozengurt, E. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20018 · Cited by 84 · see citing works

Besides adhesion: new perspectives of integrin functions in angiogenesis

Serini, G., Napione, L., Arese, M., & Bussolino, F. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn045 · Cited by 58 · see citing works

Increased recycling of α5β1 integrins by lung endothelial cells in response to tumor necrosis factor

Gao, B., Curtis, T. M., Blumenstock, F. A., Minnear, F. L., & Saba, T. M. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.2.247 · Cited by 34 · see citing works

Association of Ang-2 with Integrin β2 Controls Ang-2/PDGF-BB-Dependent Upregulation of Human Peripheral Blood Monocyte Fibrinolysis

Bezuidenhout, L. M., Zilla, P., & Davies, N. H. (2009) · Inflammation · doi:10.1007/s10753-009-9148-9 · Cited by 17 · see citing works

Angiopoietins in angiogenesis

Fagiani, E., & Christofori, G. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.08.018 · Cited by 676 · see citing works

Role of Angiopoietin-2 in Vascular Physiology and Pathophysiology

Akwii, R. G., Sajib, M. S., Zahra, F. T., & Mikelis, C. M. (2019) · Cells · doi:10.3390/cells8050471 · Cited by 552 · see citing works

Endothelial von Willebrand factor regulates angiogenesis

Starke, R. D., Ferraro, F., Paschalaki, K. E., Dryden, N. H., McKinnon, T. A. J., Sutton, R. E., Payne, E. M., Haskard, D. O., Hughes, A. D., Cutler, D. F., et al. (2010) · Blood · doi:10.1182/blood-2010-01-264507 · Cited by 511 · see citing works

Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

Felcht, M., Luck, R., Schering, A., Seidel, P., Srivastava, K., Hu, J., Bartol, A., Kienast, Y., Vettel, C., Loos, E. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58832 · Cited by 479 · see citing works

The effects of sepsis on endothelium and clinical implications

Dolmatova, E. V., Wang, K., Mandavilli, R., & Griendling, K. K. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa070 · Cited by 324 · see citing works

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Hakanpaa, L., Sipila, T., Leppanen, V.-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K., & Saharinen, P. (2015) · Nature Communications · doi:10.1038/ncomms6962 · Cited by 287 · see citing works

Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

Ivaska, J., & Heino, J. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154017 · Cited by 279 · see citing works

Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems

Eklund, L., Kangas, J., & Saharinen, P. (2016) · Clinical Science · doi:10.1042/cs20160129 · Cited by 206 · see citing works

Angiopoietin-2: An Attractive Target for Improved Antiangiogenic Tumor Therapy

Gerald, D., Chintharlapalli, S. R., Augustin, H. G., & Benjamin, L. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4697 · Cited by 202 · see citing works

Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy

Kienast, Y., Klein, C., Scheuer, W., Raemsch, R., Lorenzon, E., Bernicke, D., Herting, F., Yu, S., The, H. H., Martarello, L., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0081 · Cited by 201 · see citing works

Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy

Gacche, R. N., & Meshram, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.002 · Cited by 195 · see citing works

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

Ziegler, T., Horstkotte, J., Schwab, C., Pfetsch, V., Weinmann, K., Dietzel, S., Rohwedder, I., Hinkel, R., Groß, L., Lee, S.-M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66549 · Cited by 191 · see citing works

Angiopoietin-2 Is Critical for Cytokine-Induced Vascular Leakage

Benest, A. V., Kruse, K., Savant, S., Thomas, M., Laib, A. M., Loos, E. K., Fiedler, U., & Augustin, H. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070459 · Cited by 178 · see citing works

Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma

Huang, R., & Rofstad, E. K. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0763-x · Cited by 180 · see citing works

Receptor Tyrosine Kinase-Mediated AngiogenesisPreprint

Jeltsch, M., Leppänen, V., Saharinen, P., & Alitalo, K. K. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009183 · Cited by 171 · see citing works

Macrophage regulation of tumor angiogenesis: Implications for cancer therapy

Squadrito, M. L., & Palma, M. D. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.04.005 · Cited by 170 · see citing works

Angiopoietin 2 Induces Pericyte Apoptosis via α3β1 Integrin Signaling in Diabetic Retinopathy

Park, S. W., Yun, J.-H., Kim, J. H., Kim, K.-W., Cho, C., & Kim, J. H. (2014) · Diabetes · doi:10.2337/db13-1942 · Cited by 155 · see citing works

Cellular and molecular regulation of vascular permeability

Goddard, L. M., & Iruela‐Arispe, M. L. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-09-0678 · Cited by 150 · see citing works

Vascular leak in sepsis: physiological basis and potential therapeutic advances

McMullan, R. R., McAuley, D. F., O’Kane, C. M., & Silversides, J. A. (2024) · Critical Care · doi:10.1186/s13054-024-04875-6 · Cited by 135 · see citing works

Angiogenesis-Related Pathways in the Pathogenesis of Ovarian Cancer

Gavalas, N. G., Liontos, M., Trachana, S. P., Bagratuni, T., Arapinis, C., Liacos, C., Dimopoulos, M. A., & Bamias, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815885 · Cited by 133 · see citing works

Integrin-Dependent Cell–Matrix Adhesion in Endothelial Health and Disease

Aman, J., & Margadant, C. (2023) · Circulation Research · doi:10.1161/circresaha.122.322332 · Cited by 127 · see citing works

THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES

Heier, J. S., Singh, R. P., Wykoff, C. C., Csaky, K. G., Lai, T. Y. Y., Loewenstein, A., Schlottmann, P. G., Paris, L. P., Westenskow, P. D., & Quezada-Ruiz, C. (2020) · Retina · doi:10.1097/iae.0000000000003003 · Cited by 118 · see citing works

VON WILLEBRAND FACTOR, ANGIODYSPLASIA AND ANGIOGENESIS

RANDI, A. M., Laffan, M., & Starke, R. D. (2013) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2013.060 · Cited by 103 · see citing works

Tie2 Expression on Macrophages Is Required for Blood Vessel Reconstruction and Tumor Relapse after Chemotherapy

Chen, L., Li, J., Wang, F., Dai, C., Wu, F., Liu, X., Li, T., Glauben, R., Zhang, Y., Nie, G., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1114 · Cited by 106 · see citing works

Angiopoietin-2 TIEs Up Macrophages in Tumor Angiogenesis

Palma, M. D., & Naldini, L. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0171 · Cited by 101 · see citing works

microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements

Paping, A., Weghake, E., Brüggemann, K., Engbers, A., Brinkmann, B., Kemper, B., Seggewiß, J., Stock, C. M., Ebnet, K., Kiesel, L., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143993 · Cited by 95 · see citing works

p130Cas: A key signalling node in health and disease

Barrett, A., Pellet-Many, C., Zachary, I. C., Evans, I. M., & Frankel, P. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.12.019 · Cited by 93 · see citing works

Exosomes derived from human macrophages suppress endothelial cell migration by controlling integrin trafficking

Lee, H., Kim, Y. H., & Kim, D. (2013) · European Journal of Immunology · doi:10.1002/eji.201343660 · Cited by 86 · see citing works

Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration

Hove, I. V., Hu, T., Beets, K., Bergen, T. V., Etienne, I., Stitt, A. W., Vermassen, E., & Feyen, J. H. M. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100966 · Cited by 79 · see citing works

Platelet‐Activation Mechanisms and Vascular Remodeling

Rubenstein, D. A., & Yin, W. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170049 · Cited by 75 · see citing works

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity

Rivera, L. B., & Brekken, R. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011143 · Cited by 72 · see citing works

Molecular Regulation of Sprouting Angiogenesis

Duran, C. L., Howell, D. W., Dave, J. M., Smith, R. L., Torrie, M. E., Essner, J. J., & Bayless, K. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160048 · Cited by 76 · see citing works

The yin, the yang, and the Angiopoietin-1

Saharinen, P., & Alitalo, K. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58196 · Cited by 62 · see citing works

Angiopoietin-1 enhances skeletal muscle regeneration in mice

Mofarrahi, M., McClung, J. M., Kontos, C. D., Davis, E. C., Tappuni, B., Moroz, N., Pickett, A., Huck, L., Harel, S., Danialou, G., et al. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00267.2014 · Cited by 58 · see citing works

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861

Pedrosa, A., Bodrug, N., Gómez-Escudero, J., Carter, E. P., Reynolds, L. E., Georgiou, P. N., Fernandez, I., Lees, D. M., Kostourou, V., Alexopoulou, A. N., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3934 · Cited by 57 · see citing works

The Manifold Cellular Functions of von Willebrand Factor

Mojzisch, A., & Brehm, M. A. (2021) · Cells · doi:10.3390/cells10092351 · Cited by 54 · see citing works

Regulation of signaling interactions and receptor endocytosis in growing blood vessels

Pitulescu, M. E., & Adams, R. H. (2014) · Cell Adhesion & Migration · doi:10.4161/19336918.2014.970010 · Cited by 53 · see citing works

The roles of ADAMTS in angiogenesis and cancer

Sun, Y., Huang, J., & Yang, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-3461-8 · Cited by 53 · see citing works

Late endosomal and lysosomal trafficking during integrin‐mediated cell migration and invasion

Rainero, E., & Norman, J. C. (2013) · BioEssays · doi:10.1002/bies.201200160 · Cited by 53 · see citing works

Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration

Schaefer, A., Nethe, M., & Hordijk, P. L. (2012) · Biochemical Journal · doi:10.1042/bj20111815 · Cited by 50 · see citing works

Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice

Langlois, B., Belozertseva, E., Parlakian, A., Bourhim, M., Gao-Li, J., Blanc, J., Tian, L., Coletti, D., Labat, C., Ramdame-Cherif, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12024-z · Cited by 51 · see citing works

Substrate stiffness directs diverging vascular fates

Wong, L., Kumar, A., Gabela-Zuniga, B., Chua, J., Singh, G., Happe, C. L., Engler, A. J., Fan, Y., & McCloskey, K. E. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.07.030 · Cited by 47 · see citing works

Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy

Huang, Y., Xia, J., Zheng, J., Geng, B., Liu, P., Yu, F., Liu, B., Zhang, H., Xu, M., Ye, P., et al. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0374-9 · Cited by 45 · see citing works

Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass

Clajus, C., Lukasz, A., David, S., Hertel, B., Lichtinghagen, R., Parikh, S. M., Simon, A., Ismail, I., Haller, H., & Kümpers, P. (2012) · Cytokine · doi:10.1016/j.cyto.2012.04.002 · Cited by 44 · see citing works

Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components

Sheng, X., Zhang, C., Zhao, J., Xu, J., Zhang, P., Ding, Q., & Zhang, J. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01269-7 · Cited by 50 · see citing works

Intracellular trafficking of integrins in cancer cells

Onodera, Y., Nam, J., & Sabe, H. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.05.007 · Cited by 42 · see citing works

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin

Dalton, A. C., Shlamkovich, T., Papo, N., & Barton, W. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163732 · Cited by 41 · see citing works

Review of the endothelial pathogenic mechanism of TIE2-related venous malformation

Du, Z., Zheng, J., Zhang, Z., & Wang, Y. (2017) · Journal of Vascular Surgery Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2017.05.001 · Cited by 41 · see citing works

Gln-362 of Angiopoietin-2 Mediates Migration of Tumor and Endothelial Cells through Association with α5β1 Integrin

Lee, H. S., Oh, S. J., Lee, K.-H., Lee, Y.-S., Ko, E., Kim, K. E., Kim, H.-C., Kim, S., Song, P. H., Kim, Y.-I., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.572594 · Cited by 36 · see citing works

Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells

Arunmanee, W., Ecoy, G. A. U., Khine, H. E. E., Duangkaew, M., Prompetchara, E., Pithi Chanvorachote, B., & Chaotham, C. (2020) · Molecules · doi:10.3390/molecules25040816 · Cited by 36 · see citing works

Abnormal angiogenesis in blood outgrowth endothelial cells derived from von Willebrand disease patients

Selvam, S. N., Casey, L. J., Bowman, M. L., Hawke, L. G., Longmore, A., Mewburn, J. D., Ormiston, M. L., Archer, S. L., Maurice, D. H., & James, P. (2017) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000635 · Cited by 35 · see citing works

Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science

Selvam, S. N., & James, P. (2017) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0037-1599145 · Cited by 35 · see citing works

Signaling Network Map of Endothelial TEK Tyrosine Kinase

Khan, A. A., Sandhya, V. K., Singh, P., Parthasarathy, D., Kumar, A., Advani, J., Gattu, R., Ranjit, D. V., Vaidyanathan, R., Mathur, P. P., et al. (2014) · Journal of Signal Transduction · doi:10.1155/2014/173026 · Cited by 34 · see citing works

Angiogenesis in malignant melanoma

Felcht, M., & Thomas, M. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12580 · Cited by 34 · see citing works

Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

Akwii, R. G., Sajib, M. S., Zahra, F. T., Tullar, P., Zabet‐Moghaddam, M., Zheng, Y., Gutkind, J. S., Doçi, C. L., & Mikelis, C. M. (2022) · Angiogenesis · doi:10.1007/s10456-022-09831-y · Cited by 30 · see citing works

Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors

Kiss, E. A., & Saharinen, P. (2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2_4 · Cited by 28 · see citing works

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Schillemans, M., Kat, M., Westeneng, J., Gangaev, A., Hofman, M., Nota, B., van Alphen, F. P. J., de Boer, M., van den Biggelaar, M., Margadant, C., et al. (2019) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12242 · Cited by 26 · see citing works

Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation

Kesler, C. T., Pereira, E. R., Cui, C. H., Nelson, G. M., Masuck, D. J., Baish, J. W., & Padera, T. P. (2015) · The FASEB Journal · doi:10.1096/fj.14-268920 · Cited by 23 · see citing works

Chemosensitizing activity of peptide from Lentinus squarrosulus (Mont.) on cisplatin-induced apoptosis in human lung cancer cells

Khine, H. E. E., Ecoy, G. A. U., Roytrakul, S., Phaonakrop, N., Pornputtapong, N., Prompetchara, E., Pithi Chanvorachote, B., & Chaotham, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-83606-1 · Cited by 20 · see citing works

Vanucizumab mode of action: Serial biomarkers in plasma, tumor, and skin-wound-healing biopsies

Heil, F., Babitzki, G., Julien-Laferrière, A., Ooi, C.-H., Hidalgo, M. M., Massard, C., Martinez‐García, M., Tourneau, C. L., Kockx, M. M., Gerber, P. A., et al. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100984 · Cited by 19 · see citing works

Cooperation between AlphavBeta3 integrin and the fibroblast growth factor receptor enhances proliferation of Hox-overexpressing acute myeloid leukemia cells

Shah, C. A., Bei, L., Wang, H., Altman, J. K., Platanias, L. C., & Eklund, E. A. (2016) · Oncotarget · doi:10.18632/oncotarget.10189 · Cited by 18 · see citing works

Antithrombotic therapy in ventricular assist device (VAD) management: From ancient beliefs to updated evidence. A narrative review

Morici, N., Varrenti, M., Brunelli, D., Perna, E., Cipriani, M., Ammirati, E., Frigerio, M., Cattaneo, M., & Oliva, F. G. (2018) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2018.06.005 · Cited by 18 · see citing works

Angiopoietin 2 stimulates trophoblast invasion via a mechanism associated with JNK signaling

Hou, H., Ning, F., Zhang, J. Y., Lu, Q., Zhang, M., Wu, P., Chen, M., & Lash, G. E. (2021) · Molecular Human Reproduction · doi:10.1093/molehr/gaab014 · Cited by 17 · see citing works

Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma

Solecki, G. M., Osswald, M., Weber, D., Glock, M., Ratliff, M., Müller, H., Krieter, O., Kienast, Y., Wick, W., & Winkler, F. (2019) · Cancers · doi:10.3390/cancers11030314 · Cited by 17 · see citing works

A systems biology model of junctional localization and downstream signaling of the Ang–Tie signaling pathway

Zhang, Y., Kontos, C. D., Annex, B. H., & Popel, A. S. (2021) · npj Systems Biology and Applications · doi:10.1038/s41540-021-00194-6 · Cited by 16 · see citing works

Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

Shlamkovich, T., Aharon, L., Koslawsky, D., Einav, Y., & Papo, N. (2018) · BMC Biology · doi:10.1186/s12915-018-0557-9 · Cited by 16 · see citing works

The TIE Receptor Family

Saharinen, P., Jeltsch, M., Santoyo, M. M., Leppänen, V., & Alitalo, K. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-11888-8_16 · Cited by 16 · see citing works

New insights into the non-hemostatic role of von Willebrand factor in endothelial protection

Agostini, S., & Lionetti, V. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0126 · Cited by 15 · see citing works

Tumor Angiogenesis

(2019) · Springer eBooks · doi:10.1007/978-3-319-33673-2 · Cited by 15 · see citing works

Effects of amelogenins on angiogenesis-associated processes of endothelial cells

Almqvist, S., Kleinman, H. K., Werthén, M., Thomsen, P., & Ågren, M. S. (2011) · Journal of Wound Care · doi:10.12968/jowc.2011.20.2.68 · Cited by 14 · see citing works

Special considerations in GI bleeding in VWD patients

Chornenki, N. L. J., Ocran, E., & James, P. (2022) · Hematology · doi:10.1182/hematology.2022000390 · Cited by 14 · see citing works

Source of angiopoietin-2 in the sera of women during pregnancy

Woolnough, C., Wang, Y., Kan, C. Y., Morris, J. M., Tasevski, V., & Ashton, A. W. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.08.003 · Cited by 13 · see citing works

Emerging roles for ubiquitin in adenovirus cell entry

Marvin, S. A., & Wiethoff, C. M. (2012) · Biology of the Cell · doi:10.1111/boc.201100096 · Cited by 12 · see citing works

C16 Peptide Promotes Vascular Growth and Reduces Inflammation in a Neuromyelitis Optica Model

Chen, H., Fu, X., Jiang, J., & Han, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01373 · Cited by 13 · see citing works

Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium

Pierce, R. W., Shabanova, V., Canarie, M. F., Pinto, M., Silva, Y. S. D., Bhandari, V., & Giuliano, J. S. (2018) · Shock · doi:10.1097/shk.0000000000001172 · Cited by 15 · see citing works

Association of Low Tumor Endothelial Cell pY397–Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer

Roy-Luzarraga, M., Abdel-Fatah, T. M. A., Reynolds, L. E., Clear, A. J., Taylor, J. G., Gribben, J. G., Chan, S. Y. T., Jones, J. L., & Hodivala‐Dilke, K. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19304 · Cited by 12 · see citing works

Platelet‐Activation Mechanisms and Vascular Remodeling

Rubenstein, D. A., & Yin, W. B. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00037.x · Cited by 11 · see citing works

Angiopoietins in the bone marrow microenvironment of acute lymphoblastic leukemia

Karakurt, N., Aksu, T., Köksal, Y., Yaralı, N., Tunç, B., Uçkan, D., & Özgüner, M. (2016) · Hematology · doi:10.1080/10245332.2015.1125078 · Cited by 11 · see citing works

UV radiation induces the release of angiopoietin‐2 from dermal microvascular endothelial cells

Navid, F., Kolbe, L., Stäb, F., Korff, T., & Neufang, G. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01416.x · Cited by 11 · see citing works

Aggressive primary cutaneous B‐cell lymphomas show increased Angiopoietin‐2‐induced angiogenesis

Teichert, M., Stumpf, C., Booken, N., Wobser, M., Nashan, D., Hallermann, C., Mogler, C., Müller, F. M., Becker, J. C., Moritz, R. K. C., et al. (2015) · Experimental Dermatology · doi:10.1111/exd.12688 · Cited by 9 · see citing works

Angiopoietin-2 impairs collateral artery growth associated with the suppression of the infiltration of macrophages in mouse hindlimb ischaemia

Tan, X., Yan, K., Ren, M., Chen, N., Li, Y., Deng, X., Wang, L., Li, R., Luo, M., Liu, Y., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1055-x · Cited by 7 · see citing works

Switching Roles─Exploring Concentration-Dependent Agonistic versus Antagonistic Behavior of Integrin Ligands

Ludwig, B. S., Krautkremer, N., Tomassi, S., Maro, S. D., Leva, F. S. D., Benge, A., Nieberler, M., Kessler, H., Marinelli, L., Kossatz, S., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02111 · Cited by 7 · see citing works

Gastrointestinal bleeding in von Willebrand patients: special diagnostic and management considerations

Ocran, E., Chornenki, N. L. J., Bowman, M. L., Sholzberg, M., & James, P. D. (2023) · Expert Review of Hematology · doi:10.1080/17474086.2023.2221846 · Cited by 6 · see citing works

Anti-angiogenic Targets: Angiopoietin and Angiopoietin-Receptors

Kiss, E. A., & Saharinen, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-31215-6_4-1 · Cited by 5 · see citing works

Molecular Regulation of Sprouting Angiogenesis

Duran, C. L., Howell, D. W., Dave, J. M., Smith, R. L., Torrie, M. E., Essner, J. J., & Bayless, K. J. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00003.x · Cited by 4 · see citing works

A hitchhiker's guide through the COVID-19 galaxy

Felsenstein, S., & Reiff, A. O. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108849 · Cited by 4 · see citing works

Angiogenese beim malignen Melanom

Felcht, M., & Thomas, M. (2015) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.12580_suppl · Cited by 2 · see citing works

Dissecting the Phospho-Regulatory Landscape of Protein Kinase N1 (PKN1) and Its Downstream Signaling: Functional Insights into the Activity-Dependent and Disease-Relevant Phosphosites

Kammarambath, S. R., Dcunha, L., Gopalakrishnan, A. P., Gautam, Y. S., Basha, F. A., Shivamurthy, P. B., Madar, I. H., & Raju, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052137 · Cited by 1 · see citing works

The Significance of Angiopoietin Valency in Vascular Health and Disease

Zhao, Y. T., Ehnes, D. D., Mathieu, J., & Ruohola‐Baker, H. (2026) · Cells · doi:10.3390/cells15090820 · Cited by 1 · see citing works

Cellular and Molecular Mechanisms Involved in Breaching of the Blood–Brian Barrier by Circulating Breast Cancer Cells

Avraham, H. K., Jiang, S., Wang, L., Fu, Y., & Avraham, S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5647-6_12 · Cited by 1 · see citing works

Evading Innate and Adaptive Immunity During Adenovirus Cell Entry

Marvin, S. A. (2013) · Loyola eCommons (Loyola University of Chicago) · Cited by 1 · see citing works

Von Willebrand factor regulation of angiogenesis and vascular integrity: implications for gastrointestinal angiodysplasia and beyond

RANDI, A. M., & Castaman, G. (2024) · doi:10.1002/9781119419525.ch25 · Cited by 1 · see citing works

Von Willebrand Factor Deficiency Impairs Vascular Morphogenesis via Angiopoietin-2: Relevance for Gut AngiodysplasiaPreprint

Constantinescu‐Bercu, A., Smith, K. E., Wong, S. Y., Ballerini, M., Nastro, A., Wiggins, B. G., Pirri, D., Li, A. K. C., Evers, J., Tsiamita, O., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.09.675051 · Cited by 1 · see citing works

Angiopoietin-1 and -2 in Infectious Diseases associated with Endothelial Cell Dysfunction

Page, A. V., & Liles, W. C. (2012) · TSpace (University of Toronto)

Control of vascular integrity via endothelial growth factor and integrin cell adhesion receptor pathways

Hakanpää, L. (2020) · Työväentutkimus Vuosikirja

TIE

Saharinen, P., & Holopainen, T. (2014) · Springer eBooks · doi:10.1007/978-1-4614-6613-0_18-3

Cell-Matrix Adhesion Proteinsin the Regulation of Endothelial Permeability

Antohe, F. (2013) · CRC Press eBooks · doi:10.1201/b15421-9

TIE

Saharinen, P., & Holopainen, T. (2017) · Springer eBooks · doi:10.1007/978-1-4419-0717-2_18

Elevated plasma Ang2/Tie2 ratio as a diagnostic and prognostic biomarker for sepsis in leukemia patients

Yang, S., Wang, R. X., Li, H., Chen, X., Zhai, J., Huang, M., 陈添彬, Huang, M., & Jiang, L. (2026) · Cytokine · doi:10.1016/j.cyto.2026.157118

Régulation dépendante du contexte de la morphogenèse et de l’intégrité capillaire par angiopoietin-like 4

Liabotis, A. (2018) · theses.fr (ABES) · doi:10.70675/52bcdc87z9aedz40abz9459z9019f91b56fe

Molecular mechanisms of Angiopoietin-2-mediated destabilisation of the vascular endothelium

Thomas, M. (2008) · FreiDok plus (Universitätsbibliothek Freiburg)

Regulation of Tie2 by angiopoietin-1 and angiopoietin-2 in endothelial cells.

Bogdanovic, E. (2009) · Library and Archives Canada (Government of Canada) · Cited by 1 · see citing works

Endothelial destabilization by angiopoietin-2 via integrin β1 activation

Hakanpaa, L., Sipila, T., Leppanen, V.-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K., & Saharinen, P. (2015) · Nature Communications · doi:10.1038/ncomms6962 · Cited by 287 · see citing works

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

Yuan, H. T., Khankin, E. V., Karumanchi, S. A., & Parikh, S. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01472-08 · Cited by 374 · see citing works

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin

Dalton, A. C., Shlamkovich, T., Papo, N., & Barton, W. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163732 · Cited by 41 · see citing works