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Cited by 104

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Human Serotonin 5-HT4 Receptor Regulates Secretion of Non-amyloidogenic Precursor Protein

Robert, Sylvain J., Zugaza, José L., Fischmeister, Rodolphe, Gardier, Alain M., Lezoualc'h, Frank·2001·Journal of Biological Chemistry
DOI 10.1074/jbc.m109008200
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Crossref · 10.1074/jbc.m109008200

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  • Activation of serotonin receptors reduces Aβ production in vitro.

    “Activation of serotonin receptors has been shown to reduce Aβ production in vitro; treatment with serotonin or receptor agonists activates intracellular signaling cascades and increases levels of the α-secretase product sAPP-α (10–12).”

    From An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice (2014) · cites this paper as [12]

    In “Effect of 5-HT4 Receptor Activation on Aβ Production” (page not supplied), the authors report no effect of serotonin on Aβ production in their CHO-cell experiment. The Discussion likewise says that receptor stimulation did not change secreted Aβ levels, although it increased sAPPα secretion. (LLM, conf=0.93)

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  • Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer's disease (AD).

    “Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD).”

    From An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice (2014) · cites this paper as [12]

    In “Effect of 5-HT4 Receptor Activation on Aβ Production,” the authors report no effect of serotonin on Aβ production in CHO cells compared with untreated controls, contrary to the claimed in vitro suppression. The provided passages do not report Aβ suppression in animal models of AD. (LLM, conf=0.88)

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Metadata

Authors
Robert, S. J., Zugaza, J. L., Fischmeister, R., Gardier, A. M., & Lezoualc'h, F.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2001-11
Volume
276
Issue
48
Pages
44881-44888
ISSN
0021-9258
DOI
10.1074/jbc.m109008200
Cited by
104
References
3
Language
en
Licence

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