Conformational States of Human Rat Sarcoma (Ras) Protein Complexed with Its Natural Ligand GTP and Their Role for Effector Interaction and GTP Hydrolysis

Cited by (149)

Items 101–149 of 149

1. Tumor-derived RHOA mutants interact with effectors in the GDP-bound state
   Yuan Lin, Theresa A. Ramelot, Simge Senyuz, Attila Gürsoy, Hyunbum Jang, Ruth Nussinov, Özlem Keskin, Yi Zheng · 2024 · Nature Communications
2. Targeting the “undruggable” RAS - new strategies - new hope?
   Britta Mörchen, Oleksandr Shkura, Raphael Stoll, Iris Helfrich · 2019 · Cancer Drug Resistance
3. Conformational States of ADP Ribosylation Factor 1 Complexed with Different Guanosine Triphosphates As Studied by 31P NMR Spectroscopy
   Tanja Meierhofer, Maren Eberhardt, Michael Spoerner · 2011 · Biochemistry
4. Differentiating the pre-hydrolysis states of wild-type and A59G mutant HRas: An insight through MD simulations
   Neeru Sharma, Uddhavesh Sonavane, Rajendra Joshi · 2017 · Computational Biology and Chemistry
5. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models
   Anjelika Gasilina, Gurdat Premnauth, Purujit N. Gurjar, Jacek Biesiada, Shailaja Hegde, David Milewski, Gang Ma, Tanya V. Kalin, Edward J. Merino, Jarek Meller et al. · 2020 · PLoS ONE
6. Probing binding and allosteric mechanisms of the KRAS interactions with monobodies and affimer proteins: ensemble-based mutational profiling and thermodynamic analysis of binding energetics and allostery reveal diversity of functional hotspots and cryptic pockets linked by conserved communication network
   Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Guang Hu, Gennady M. Verkhivker · 2025 · Physical Chemistry Chemical Physics
7. Predicting X‐ray solution scattering from flexible macromolecules
   Hao Zhou, Hugo Guterres, Carla Mattos, Lee Makowski · 2018 · Protein Science
8. Atomic-level mechanisms of abnormal activation in NRAS oncogenes from two-dimensional free energy landscapes
   Zheyao Hu, Jordi Martı́ · 2024 · Nanoscale
9. GAP positions catalytic H-Ras residue Q61 for GTP hydrolysis in molecular dynamics simulations, complicating chemical rescue of Ras deactivation
   Lara A. Patel, Timothy J. Waybright, Andrew G. Stephen, Chris Neale · 2023 · Computational Biology and Chemistry
10. Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein
    Shigeyuki Matsumoto, Haruka Taniguchi‐Tamura, Mitsugu Araki, Takashi Kawamura, Ryo Miyamoto, Chiemi Tsuda, Fumi Shima, Takashi Kumasaka, Yasushi Okuno, Tohru Kataoka · 2021 · Biochemical and Biophysical Research Communications
11. NMR analysis of the backbone dynamics of the small GTP ase Rheb and its interaction with the regulatory protein FKBP 38
    Maristella De Cicco, L. Kiss, Sonja A. Dames · 2017 · FEBS Letters
12. Advances in NMR Methods to Identify Allosteric Sites and Allosteric Ligands
    Hazem Abdelkarim, Ben Hitchinson, Avik Banerjee, Vadim Gaponenko · 2019 · Advances in experimental medicine and biology
13. Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of the Founding RAS Gene Family Members
    Panagiotis G. Adamopoulos, Panagiotis Tsiakanikas, Michaela A. Boti, Andreas Scorilas · 2021 · International Journal of Molecular Sciences
14. Structural Dynamics of Rho GTPases
    Yuan Lin, Yi Zheng · 2024 · Journal of Molecular Biology
15. Discovery of Small Molecule NSC290956 as a Therapeutic Agent for KRas Mutant Non-Small-Cell Lung Cancer
    Jiaxin Zhang, Zuojia Liu, Wenjing Zhao, Xunzhe Yin, Xiliang Zheng, Chuanbo Liu, Jin Wang, Erkang Wang · 2022 · Frontiers in Pharmacology
16. A Comparative CEST NMR Study of Slow Conformational Dynamics of Small GTPases Complexed with GTP and GTP Analogues
    Dong Long, Christopher B. Marshall, Guillaume Bouvignies, Mohammad T. Mazhab‐Jafari, Matthew James Smith, Mitsuhiko Ikura, Lewis E. Kay · 2013 · Angewandte Chemie
17. Backbone assignment and secondary structure of Rnd1, an unusual Rho family small GTPase
    Shufen Cao, Xi’an Mao, Deli Liu, Matthias Buck · 2012 · Biomolecular NMR Assignments
18. Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody
    Oscar Jungholm, Carolina L. Trkulja, Martin Moche, Sreesha P. Srinivasa, Maria-Nefeli Christakopoulou, Max Davidson, Anna Reymer, Kent E. Jardemark, Rafaela L Fogaça, Anaswara Ashok et al. · 2024 · Scientific Reports
19. Lipid- and substrate-induced conformational and dynamic changes in a glycosyltransferase involved in E. coli LPS synthesis revealed by 19F and 31P NMR
    Joan Patrick, Pontus Pettersson, Lena Mäler · 2023 · Biochimica et Biophysica Acta (BBA) - Biomembranes
20. An Updated Review on KRAS Mutation in Lung Cancer (NSCLC) and Its Effects on Human Health
    Subhrojyoti Ghosh, Tiyasa Bhuniya, Anuvab Dey, Madhurima Koley, Preeti Roy, Aishi Bera, Debarshi Gol, Ankita Chowdhury, Rajanyaa Chowdhury, Shinjini Sen · 2023 · Applied Biochemistry and Biotechnology
21. High Pressure Promotes Binding of the Allosteric Inhibitor Zn2+‐Cyclen in Crystals of Activated H‐Ras
    Éric Girard, Pedro Lopes, Michael Spoerner, Anne‐Claire Dhaussy, T. Prangé, Hans Robert Kalbitzer, N. Colloc’h · 2024 · Chemistry - A European Journal
22. Two Small Molecules, ZCL278 and AZA197 Show Promise in Influencing Protein Interactions Involving the Ras-Related Protein Cell division cycle 42 [Cdc42] to Modulate Its Oncogenic Potential
    Djamali Muhoza, Paul D. Adams · 2017 · Open Journal of Biophysics
23. How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational Investigations
    Lin Frank Song, Dana Rabara, Semiha Kevser Bali, Jun Pei, Edmond Y. Lau, Daniel A. Kirshner, Felice C. Lightstone, Frank McCormick, Andrew G. Stephen, Yue Yang · 2025 · Journal of Chemical Information and Modeling
24. Impact of KRAS-G12 Mutations on the KRAS-GTP Bound Conformational Dynamics: Structure, Free Energy Barriers and Drugging Pockets
    Zheyao Hu, Zigan Sha, Jordi Martı́, Shujuan Guo, Sheng‐ce Tao · 2026 · JACS Au
25. Molecular Dynamics Investigation into the Stability of KRas and CRaf Multimeric Complexes
    Chongli Geng, Juan Zeng, Xianming Deng, Fei Xia, Xin Xu · 2025 · The Journal of Physical Chemistry B
26. Millisecond Allosteric Dynamics of Activated Ras Reproduced with a Slowly Hydrolyzable GTP Analogue
    Xiaomin Chen, Hexuan Gao, Dong Long · 2020 · ChemBioChem
27. Path Sampling Simulations Reveal How the Q61L Mutation Alters the Dynamics of KRas
    Sander Roet, Ferry Hooft, Peter G. Bolhuis, David W. H. Swenson, Jocelyne Vreede · 2022 · The Journal of Physical Chemistry B
28. Structure and Function of the mTOR Activator Rheb
    Christopher B. Marshall, Mohammad T. Mazhab‐Jafari, Vuk Stambolic, Mitsuhiko Ikura · 2014 · Springer eBooks
29. Monitoring Dynamics of Large Membrane Proteins by 19 F Paramagnetic Longitudinal Relaxation: Domain Movement in a Glutamate Transporter Homolog
    Yun T. Huang, Xiaoyu Wang, Guohua Lv, Asghar M. Razavi, Gerard H. M. Huysmans, Harel Weinstein, Clay Bracken, David Eliezer, Olga Boudker · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
30. Isoform-Specific Destabilization of the Active Site Reveals Molecular Mechanism of Intrinsic Activation of KRas G13D
    Christian William Johnson, Yi-Jang Lin, Derion F Reid, Jillian A. Parker, Patrick S. Dischinger, Carrie R. Graveel, Spiro Pavlopoulos, Matthew R. Steensma, Kevin M. Haigis, Carla Mattos · 2019 · SSRN Electronic Journal
31. NMR 1H, 13C, and 15N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation
    Alok Kumar Sharma, Marco Tonelli, Marcin D. Dyba, William Gillette, Dominic Esposito, Dwight V. Nissley, Frank P. McCormick, Anna E. Maciag · 2025 · Biomolecular NMR Assignments
32. Ensemble-Based Binding Free Energy Profiling and Network Analysis of the KRAS Interactions with DARPin Proteins Targeting Distinct Binding Sites: Revealing Molecular Determinants and Universal Architecture of Regulatory Hotspots and Allosteric Binding
    Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker · 2025 · Biomolecules
33. Investigating the effects of cysteine-118 oxidation on G12D KRas structure and dynamics: insights from MD simulations
    Shimaa Salamh, Abdallah Sayyed–Ahmad · 2023 · Journal of Biomolecular Structure and Dynamics
34. Considerations Around Structure-Based Drug Discovery for KRAS Using DOCK
    Mayukh Chakrabarti, Y. Stanley Tan, Trent E. Balius · 2024 · Methods in molecular biology
35. Turbo Analytics: Applications of Big Data and HPC in Drug Discovery
    Rajendra Joshi, Uddhavesh Sonavane, Vinod Jani, Amit Saxena, Shruti Koulgi, Mallikarjunachari Uppuladinne V N, Neeru Sharma, Sandeep Surendra Malviya, E P Ramakrishnan, Vivek Gavane et al. · 2019 · Challenges and advances in computational chemistry and physics
36. Extending the Lifetime of Native GTP‐Bound Ras for Site‐Resolved NMR Measurements: Quantifying the Allosteric Dynamics
    Xiaomin Chen, Haijie Yao, Hui Wang, Yunyun Mao, Dan Liu, Dong Long · 2019 · Angewandte Chemie
37. Combined computational and solution scattering methods to study the dynamical properties of Ras
    Guterres · 2018 · Digital Repository Service (Northeastern University)
38. A Conserved Architecture of Allosteric Communications and Regulatory Hotspots in the KRAS Complexes with Diverse Binding Proteins Controls Mechanisms of Effector Mimicry and Allosteric Modulation : Atomistic Revelations from Molecular Simulations and Mutational Scanning of Binding Energetics and Allostery
    Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
39. Structural Analysis of Active Site Conformations in Ras and Rap1 GTPases.
    Genevieve Anne Holzapfel · 2011 · NCSU Libraries Repository (North Carolina State University Libraries)
40. Using genetics to identify epigenetic and signal transduction targets in cancer
    Joydeep Bhadury · 2016 · Gothenburg University Publications Electronic Archive (Gothenburg University)
41. Structural Analysis of Ras Bound to Raf Kinase and Implications of Ras Allosteric Site
    Susan Fetics · 2012 · NCSU Libraries Repository (North Carolina State University Libraries)
42. Targeting Protein-Protein Interactions in Small GTPases
    Jiahui Liu, Ning Kang, Yaxue Zhao, Mingyan Zhu · 2018 · Springer eBooks
43. The most oncogenic Ras isoform
    Jillian A. Parker · 2017 · Digital Repository Service (Northeastern University)
44. Path sampling simulations reveal how the Q61L mutation restricts the dynamics of KRas
    Sander Roet, Ferry Hooft, Peter G. Bolhuis, David W.H. Swenson, Jocelyne Vreede · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
45. The structural basis of allosteric communication networks of Ras GTPases and their oncogenic mutants
    Alicia Yvette Volmar · 2020 · Digital Repository Service (Northeastern University)
46. Allosteric interactions in KRas and HRas: studies of KRas/Calmodulin and HRas/Raf-RBD
    Monica Ojeda · 2023 · Digital Repository Service (Northeastern University)
47. Path sampling simulations reveal how the Q61L mutation restricts the dynamics of KRas
    Jocelyne Vreede, Sander Roet, Swenson, David · 2020 · Universiteit van Amsterdam
48. The Neomorphic Chemistry of KRAS Autophosphorylation Is Dynamically Regulated by Active Site Conformation
    Christian William Johnson, Rofiat Oladimeji, Eve O’Donohue, Kevin M. Haigis · 2026 · ACS Chemical Biology
49. Virtual Screening and Molecular Docking of Natural Compounds as Selective Inhibitors of Mutant NRAS in Melanoma
    Vijay Baladhye, Nayanika Das · 2026 · International Journal of Chemistry and Technology