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Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.

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Ras/Rap effector specificity determined by charge reversal

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Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF6 and Members of the Ras Subfamily

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Transformation Efficiency of RasQ61 Mutants Linked to Structural Features of the Switch Regions in the Presence of Raf

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Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes

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Structural and biochemical analysis of Ras‐effector signaling via RalGDS

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Fundamental Link between Folding States and Functional States of Proteins

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Structure of the G60A Mutant of Ras

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Perturbation of the conformational equilibria in Ras by selective mutations as studied by ³¹P NMR spectroscopy

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Indirect Referencing of31P and19F NMR Spectra

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Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42

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Solution Structure of the Ras Binding Domain of the Protein Kinase Byr2 from Schizosaccharomyces pombe

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A novel mechanism for the modulation of the Ras-effector interaction by small molecules

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Solution Structure and Dynamics of the Small GTPase RalB in Its Active Conformation: Significance for Effector Protein Binding

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Conformational States of the Nuclear GTP-Binding Protein Ran and Its Complexes with the Exchange Factor RCC1 and the Effector Protein RanBP1

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Surface Change of Ras Enabling Effector Binding Monitored in Real Time at Atomic Resolution

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Solid-state 31P NMR Spectroscopy of Microcrystals of the Ras Protein and its Effector Loop Mutants: Comparison Between Crystalline and Solution State

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Observation of slow dynamic exchange processes in RAS protein crystals by 31P solid state NMR spectroscopy

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31P-NMR spectra of the Ha-ras p21. Nucleotide complexes

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NMR in Medicine and Biology: Structure Determination, Tomography, In Vivo Spectroscopy

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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

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Ras Conformational Ensembles, Allostery, and Signaling

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The current understanding of KRAS protein structure and dynamics

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Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

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GTP-Dependent K-Ras Dimerization

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Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis

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Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations

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Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects

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Binding hotspots on K-ras: Consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis

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The Role of Magnesium for Geometry and Charge in GTP Hydrolysis, Revealed by Quantum Mechanics/Molecular Mechanics Simulations

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Metal–Bis(2‐picolyl)amine Complexes as State 1(T) Inhibitors of Activated Ras Protein

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An engineered protein antagonist of K-Ras/B-Raf interaction

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Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras

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“Pathway drug cocktail”: targeting Ras signaling based on structural pathways

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Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog

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The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic MutantsPreprint

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KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non–Small Cell Lung Cancer

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Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

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The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling

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Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants: Interaction Patterns in Ras Oncogenic Mutants

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KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation

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Aggregation of Lipid-Anchored Full-Length H-Ras in Lipid Bilayers: Simulations with the MARTINI Force Field

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Clinical Outcome With Platinum-Based Chemotherapy in Patients With Advanced Nonsquamous EGFR Wild-Type Non–Small-Cell Lung Cancer Segregated According to KRAS Mutation Status

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DRoP: A Water Analysis Program Identifies Ras-GTP-Specific Pathway of Communication between Membrane-Interacting Regions and the Active Site

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Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

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Plasma membrane regulates Ras signaling networks

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Exploring major signaling cascades in melanomagenesis: a rationale route for targetted skin cancer therapy

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Specific Substates of Ras To Interact with GAPs and Effectors: Revealed by Theoretical Simulations and FTIR Experiments

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Detailed Structure of the H2PO4––Guanosine Diphosphate Intermediate in Ras-GAP Decoded from FTIR Experiments by Biomolecular Simulations

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The Allosteric Switch and Conformational States in Ras GTPase Affected by Small Molecules

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The Structure of the G Domain of the Ras Superfamily

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The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS

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Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins

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Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy

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Inhibition of prenylated KRAS in a lipid environment

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Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR

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Biology, pathology, and therapeutic targeting of RAS

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Excited-state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants

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E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form

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Current status of the development of Ras inhibitors

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Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery

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Conformational Features of Ras: Key Hydrogen-Bonding Interactions of Gln61 in the Intermediate State during GTP Hydrolysis

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Conformational Fluctuations in GTP-Bound K-Ras: A Metadynamics Perspective with Harmonic Linear Discriminant Analysis

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Dynamic conformational equilibria in the active states of KRAS and NRAS

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Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography

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Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C

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Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR

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Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells

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Regulation of GTPase function by autophosphorylation

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High Pressure NMR Methods for Characterizing Functional Substates of Proteins

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Extending the Lifetime of Native GTP‐Bound Ras for Site‐Resolved NMR Measurements: Quantifying the Allosteric Dynamics

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Elucidating the Mode of Action of a Typical Ras State 1(T) Inhibitor

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The Renaissance of Ras

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Cu2+-cyclen as Probe to Identify Conformational States in Guanine Nucleotide Binding Proteins

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The protonation states of GTP and GppNHp in Ras proteins

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Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring

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State 1(T) Inhibitors of Activated Ras

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Structural basis for LZTR1 recognition of RAS GTPases for degradation

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Markov State Models Reconcile Conformational Plasticity of GTPase with Its Substrate Binding Event

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Orthogonal RNA replication enables directed evolution and Darwinian adaptation in mammalian cells

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NMR-Derived Conformational Ensemble of State 1 of Activated Ras Reveals Insights into a Druggable Pocket

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Identification of functional substates of KRas during GTP hydrolysis with enhanced sampling simulations

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Direct Observation of Membrane-Associated H-Ras in the Native Cellular Environment by In-Cell 19F-NMR Spectroscopy

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Unveiling the State Transition Mechanisms of Ras Proteins through Enhanced Sampling and QM/MM Simulations

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High pressure 31P NMR spectroscopy on guanine nucleotides

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Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling

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Probing the wild-type HRas activation mechanism using steered molecular dynamics, understanding the energy barrier and role of water in the activation

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Metall‐Bis(2‐picolyl)amin‐Komplexe als Zustand‐1(T)‐Inhibitoren für aktiviertes Ras‐Protein

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Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D

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Mechanisms of isoform-specific residue influence on GTP-bound HRas, KRas, and NRas

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Development of Accurate Force Fields for Mg 2+ and Triphosphate Interactions in ATP·Mg 2+ and GTP·Mg 2+ Complexes

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Insight into structural dynamics involved in activation mechanism of full length KRAS wild type and P-loop mutants

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A Modified Infrared Spectrometer with High Time Resolution and Its Application for Investigating Fast Conformational Changes of the GTPase Ras

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Interconversion of Two GDP-Bound Conformations and Their Selection in an Arf-Family Small G Protein

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Early-stage structure-based drug discovery for small GTPases by NMR spectroscopy

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The small GTPase MRAS is a broken switch

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Exploring binding and allosteric energy landscapes for the KRAS interactions with effector proteins using Markov state modeling of conformational ensembles and allosteric network modeling

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Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle

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Slow conformational dynamics of the guanine nucleotide‐binding protein Ras complexed with the GTP analogue GTPγS

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Conformational States of Ras Complexed with the GTP Analogue GppNHp or GppCH2p: Implications for the Interaction with Effector Proteins

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Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers

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Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics

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