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Purification and Characterization of the Human Elongator Complex
Open accessAbstract
Human Elongator complex was purified to virtual homogeneity from HeLa cell extracts. The purified factor can exist in two forms: a six-subunit complex, holo-Elongator, which has histone acetyltransferase activity directed against histone H3 and H4, and a three-subunit core form, which does not have histone acetyltransferase activity despite containing the catalytic Elp3 subunit. Elongator is a component of early elongation complexes formed in HeLa nuclear extracts and can interact directly with RNA polymerase II in solution. Several human homologues of the yeast Elongator subunits were identified as subunits of the human Elongator complex, including StIP1 (STAT-interacting protein 1) and IKAP (IKK complex-associated protein). Mutations in IKAP can result in the severe human disorder familial dysautonomia, raising the possibility that this disease might be due to compromised Elongator function and therefore could be a transcription disorder.
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Cited by
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Morrison, D. K., & Davis, R. J. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091942 · Cited by 786
Role of tRNA modifications in human diseases
Torres, A. G., Batlle, E., & Ribas de Pouplana, L. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.008 · Cited by 414
Ward, A. J., & Cooper, T. A. (2010) · The Journal of Pathology · doi:10.1002/path.2649 · Cited by 414
IKBKAP/ELP1 gene mutations: mechanisms of familial dysautonomia and gene-targeting therapies
Rubin, B., & Anderson, S. (2017) · The Application of Clinical Genetics · doi:10.2147/tacg.s129638 · Cited by 21
Metadata
- Authors
- Hawkes, N. A., Otero, G., Winkler, G. S., Marshall, N., Dahmus, M. E., Krappmann, D., Scheidereit, C., Thomas, C. L., Schiavo, G., Erdjument-Bromage, H., Tempst, P., & Svejstrup, J. Q.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 277
- Issue
- 4
- Pages
- 3047-3052
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2115551830
- Cited by
- 246
- References
- 0
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hawkes, N. A., Otero, G., Winkler, G. S., Marshall, N., Dahmus, M. E., Krappmann, D., Scheidereit, C., Thomas, C. L., Schiavo, G., Erdjument-Bromage, H., Tempst, P., & Svejstrup, J. Q. (2002). Purification and Characterization of the Human Elongator Complex. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m110445200
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