The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Flavohemoglobin Detoxifies Nitric Oxide in Aerobic, but Not Anaerobic, Escherichia coli
Open accessAbstract
Nitric-oxide dioxygenase (NOD) and reductase (NOR) activities of flavohemoglobin (flavoHb) have been suggested as mechanisms for NO metabolism and detoxification in a variety of microbes. Mechanisms of NO detoxification were tested in Escherichia coli using flavoHb-deficient mutants and overexpressors. flavoHb showed negligible anaerobic NOR activity and afforded no protection to the NO-sensitive aconitase or the growth of anoxic E. coli, whereas the NOD activity and the protection afforded with O(2) were substantial. A NO-inducible, O(2)-sensitive, and cyanide-resistant NOR activity efficiently metabolized NO and protected anaerobic cells from NO toxicity independent of the NOR activity of flavoHb. flavoHb possesses nitrosoglutathione and nitrite reductase activities that may account for the protection it affords against these agents. NO detoxification by flavoHb occurs most effectively via O(2)-dependent NO dioxygenation.
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Cites
Nitric oxide and mitochondrial respiration
Brown, G. C. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00025-0 · Cited by 702
Kinetics and mechanism of the oxidation of human deoxyhemoglobin by nitrites.
Doyle, M. P., Pickering, R. A., DeWeert, T. M., Hoekstra, J. W., & Pater, D. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43285-1 · Cited by 334
Nitrosative stress: Metabolic pathway involving the flavohemoglobin
Hausladen, A., Gow, A. J., & Stamler, J. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14100 · Cited by 285
Cited by
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
GARDNER, P. (2005) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.10.003 · Cited by 269
Self-citationOxidative Stress and Antioxidants—A Critical Review on In Vitro Antioxidant Assays
Kotha, R. R., Tareq, F. S., Yildiz, E., & Luthria, D. L. (2022) · Antioxidants · doi:10.3390/antiox11122388 · Cited by 259
Nitric Oxide Formation by Escherichia coli
Corker, H., & Poole, R. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303282200 · Cited by 178
Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite
Sobko, T., Reinders, C. I., Jansson, E. Å., Norin, E., Midtvedt, T., & Lundberg, J. O. (2005) · Nitric Oxide · doi:10.1016/j.niox.2005.08.002 · Cited by 160
Metadata
- Authors
- Gardner, A. M., & Gardner, P. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 277
- Issue
- 10
- Pages
- 8166-8171
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2003811454
- Cited by
- 175
- References
- 3
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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