Cited by 519Immune Response and InflammationNF-κB Signaling PathwaysInflammasome and immune disorders

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Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

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Hsu, Hsien-Yeh, Wen, Meng-Hsuan·2002·Journal of Biological Chemistry

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Abstract

Lipopolysaccharide (LPS) stimulates macrophages to release inflammatory cytokines, interleukin-1 beta (IL-1), and tumor necrosis factor (TNF). LPS-induced TNF suppresses scavenger receptor functions in macrophages (van Lenten, B. J., and Fogelman, A. M. (1992) J. Immunol. 148, 112-116), which is regulated by TNF-mediated protein kinases (Hsu, H. Y., and Twu, Y. C. (2000) J. Biol. Chem. 275, 41035-41048). To examine the molecular mechanism for LPS induction of IL-1 in macrophages, we demonstrated that LPS quickly stimulated reactive oxygen species (ROS), and 3 h later induced prointerleukin-1 beta (pro-IL-1, precursor of IL-1) production and IL-1 secretion. LPS stimulated pro-IL-1 message/protein between 3 and 10 h; however, there was a 40% reduction of pro-IL-1 in preincubation of the antioxidant, N-acetylcysteine (NAC). Moreover, NAC moderated LPS-induced IL-1 secretion partially via interleukin 1-converting enzyme. The maximal activity of LPS-induced ERK, JNK, and p38 was 12- (30 min), 5- (30 min), and 16-fold (15 min), respectively. In contrast, NAC reduced ERK activity to 60% and decreased p38 activity to the basal level, but JNK activity was induced 2-fold. Furthermore, the pharmacological antagonists LY294002, SB203580, curcumin, calphostin C, and PD98059 revealed the diverse roles of LPS-mediated protein kinases in pro-IL-1. On the other hand, NAC and diphenyleneiodonium chloride partially inhibited LPS-induced Rac activity and protein-tyrosine kinase (PTK), indicating that LPS-mediated ROS and NADPH oxidase correspond to Rac activation and IL-1 expression. Our findings establish for the first time that LPS-mediated PTK/phosphatidylinositol 3-kinase/Rac/p38 pathways play a more important role than pathways of PTK/PKC/MEK/ERK and of PTK/phosphatidylinositol 3-kinase/Rac/JNK in the regulation of pro-IL-1/IL-1. The findings also further elucidate the critical role of LPS-mediated ROS in signal transduction pathways. Our results suggest that understanding LPS-transduced signals in IL-1 induction upon the antibacterial action of macrophages should provide a therapeutic strategy for aberrant inflammatory responses leading to severe cellular injury or concurrent multiorgan septic damage.

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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1.
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,793
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647
A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes
Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J. G., et al. (1992) · Nature · doi:10.1038/356768a0 · Cited by 2,613
The stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,423
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244
The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway
Coso, O. A., Chiariello, M., Yu, J., Teramoto, H., Crespo, P., Xu, N., Miki, T., & Gutkind, J. S. (1995) · Cell · doi:10.1016/s0092-8674(05)80018-2 · Cited by 1,629
Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin
Ulevitch, R. J., & Tobias, P. S. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.002253 · Cited by 1,442
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
Marais, R., Wynne, J., & Treisman, R. (1993) · Cell · doi:10.1016/0092-8674(93)90237-k · Cited by 1,275

Flagged first, then by citations

Show all 72 references

Research works printed but not linked: 6

Gray, 1993, Mol. Cell. Biol., 13, 6678
Loppnow, 1998, Eur. Cytokine Netw., 9, 675
Devary, 1991, Mol. Cell. Biol., 11, 2804
Crawford, 1988, Cancer Res., 48, 2132
Minden, 1994, Mol. Cell. Biol., 14, 6683
Wong, 1996, Exs (Basel), 77, 321

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“, JNK, ERK1/2, and p38) in macrophages and neutrophils [23].”
Background
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Kim, D. Y., Jun, J.-H., Lee, H.-L., Woo, K. M., Ryoo, H., Kim, G.-S., Baek, J., & Han, S. (2007) · Archives of Pharmacal Research · doi:10.1007/bf02980269 · Cited by 61
“Although antioxidants can prevent expression of LPS-induced inflammatory mediators in phagocytic cells (Hsu and Wen, 2002; Kim et al., 2004; Ryan et al., 2004), other investigators have demonstrated that NAC upregulates these mediators in human chondrocytes (MathyHartert et al.”
BackgroundResultInfluential
Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells
Wang, Y., Zhang, M. X., Meng, X., Liu, F. Q., Yu, G. S., Zhang, C., Sun, T., Wang, X. P., Li, L., Wang, Y. Y., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01335.2008 · Cited by 59
“Activation of MAPK proteins is critical in the cellular responses associated with inflammatory stimuli such as LPS (10).”
Background
Inhibition of Rac activity alleviates lipopolysaccharide-induced acute pulmonary injury in mice
Yao, H., Chen, L., Xu, C., Wang, J., Chen, J., Xie, Q.-M., Wu, X., & Yan, X. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.020 · Cited by 58
“inflammatory cells [6,7,9], and accumulated evidence indicated that LPS stimulated Rac2 activation in vitro [21–25].”
Background
Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor‐κB activation in resting and activated microglial cells
Ajmone‐Cat, M. A., Simone, R. D., Nicolini, A., & Minghetti, L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01562.x · Cited by 58
“Among the other families of kinases activated by LPS (i.e. ERK, JNK), p38 plays a predominant role in modulating the synthesis of TNF-a, IL-1b and iNOS (Lee et al. 2000; Han et al. 2002; Hsu and Wen 2002), therefore representing a potential target of PS/PtdSerR elicited signals.”
Background
Toll-Interacting Protein in Resolving and Non-Resolving Inflammation
Kowalski, E., & Li, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00511 · Cited by 56
“By sharp contrast, Tollip translocates to mitochondria through its CUE domain interaction upon stimulation with super-low doses of LPS. Mitochondrial Tollip, instead, is an important facilitator for the generation of mitochondrial reactive oxygen species (ROS), which drives the expression of pro-inflammatory mediators…”
Background
Removal and killing of multispecies endodontic biofilms by N -acetylcysteine
Choi, Y., Kim, C., Moon, J.-H., & Lee, J. (2017) · Brazilian Journal of Microbiology · doi:10.1016/j.bjm.2017.04.003 · Cited by 57
Resveratrol-loaded Nanoparticles Conjugated With Kidney Injury molecule-1 As a Drug Delivery System for Potential Use in Chronic Kidney Disease
Lin, Y., Lee, Y., Hsu, Y., Chen, Y.-J., Lin, Y., Cheng, F., & Chiu, H. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0256 · Cited by 58
DNMT and HDAC inhibitors together abrogate endotoxemia mediated macrophage death by STAT3-JMJD3 signaling
Samanta, S., Zhou, Z., Rajasingh, S., Panda, A., Sampath, V., & Rajasingh, J. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.07.002 · Cited by 59
“The dose of LPS (1ug/ml) was selected based upon our previous studies as well as other studies have shown that LPS at this dose caused a significant release of ROS responsible for inflammation (Hsu and Wen, 2002).”
Method
NADH oxidase signaling induces cyclooxygenase‐2 expression during lipopolysaccharide stimulation in cardiomyocytes
Peng, T., Lu, X., & Feng, Q. (2004) · The FASEB Journal · doi:10.1096/fj.04-2289fje · Cited by 57
“Mitogen-activated protein kinases (MAPK) are sensitive to ROS, and NADPH oxidase has been demonstrated to play an important role in MAPK activation in response to LPS in macrophages (19).”
Background
Role of oxidative stress in ERK and p38 MAPK activation induced by the chemical sensitizer DNFB in a fetal skin dendritic cell line
Matos, T. J., Duarte, C. B., Gonçalo, M., & Lopes, M. C. (2005) · Immunology and Cell Biology · doi:10.1111/j.1440-1711.2005.01378.x · Cited by 57
A study on immunomodulatory mechanism of Polysaccharopeptide mediated by TLR4 signaling pathway
Wang, Z., Dong, B., Feng, Z., Yu, S., & Bao, Y. (2015) · BMC Immunology · doi:10.1186/s12865-015-0100-5 · Cited by 56
“The role of TLR4 in Gram-negative bacterial LPSmediated signaling has been studied extensively [32, 33].”
Background
MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression
Talwar, H. S., Bauerfeld, C. P., Bouhamdan, M., Farshi, P., Liu, Y., & Samavati, L. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.02.018 · Cited by 56
Reishi immuno‐modulation protein induces interleukin‐2 expression via protein kinase‐dependent signaling pathways within human T cells
Hsu, H., Hua, K., Wu, W., Hsu, J., Weng, S.-T., Lin, T., Liu, C., Hseu, R., & Huang, C. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21144 · Cited by 57
“Further, we also found that NAC and diphenyleneiodonium (DPI), an inhibitor of NADPH oxidase (Hsu and Wen, 2002), were both able to elicit a dose-dependent inhibition of IL-2 secretion within Jurkat T cells (Fig.”
BackgroundSelf-citation
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“Other preformed cytokines such as pro-IL-1 /IL-1 demonstrate a similar delayed upregulation of both protein and mRNA after inflammatory stimulus (LPS) as identified in the present study for MIF (30).”
Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells
Kim, H.-G., Yoon, D. H., Kim, C.-H., Shrestha, B., Chang, W., Lim, S., Lee, W., Han, S.-G., Lee, J.-O., Lim, M., et al. (2007) · Journal of Medicinal Food · doi:10.1089/jmf.2006.156 · Cited by 57
“21 29, 30 , 33, 34 In recent years, much of the effort has been focused on delineating the intracellular intracellular signaling cascades for MAPKs in inflammatory pathways I. obliquus has a history of use as a traditional medicine.”
Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice
Ma, Z., Kong, C., Wu, H., Song, P. K., Zhang, X., Yuan, Y., Deng, W., & Tang, Q. (2020) · Theranostics · doi:10.7150/thno.47516 · Cited by 54
Gangliosides induce autophagic cell death in astrocytes
Hwang, J., Lee, S., Lee, J. T., Kwon, T. K., Kim, D. R., Kim, H., Park, H., & Suk, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00563.x · Cited by 54
“ROS also play an important role in inflammatory signalling pathways (Hsu and Wen, 2002).”
Background
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Choi, S., Choi, H.-H., Lee, S., Ko, S.-H., You, H. J., Ye, S., & Chung, M.-H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.022 · Cited by 55
Redox Regulation of Lipopolysaccharide-mediated Sulfiredoxin Induction, Which Depends on Both AP-1 and Nrf2
Kim, H., Jung, Y., Shin, B. S., Kim, H., Song, H., Bae, S. H., Rhee, S. G., & Jeong, W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126839 · Cited by 56
Environmental enrichment cognitive neuroprotection in an experimental model of cerebral ischemia: biochemical and molecular aspects
Gonçalves, L. V., Herlinger, A. L., Ferreira, T. A. A., Coitinho, J. B., Pires, R. G. W., & Martins-Silva, C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.023 · Cited by 52
“IL-1β expression contributes to ischemic brain damage [93–95], being induced by pro-inflammatory stimuli such as bacterial and viral products, TNF (tumor necrosis factor), cell lesions and hypoxia [96].”
Efficacy of DL-α lipoic acid against systemic inflammation-induced mice: antioxidant defense system
Jesudason, E. P., Masilamoni, J. G., Walter, C. E. J., Paul, S. F. D., & Rajadas, J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9748-y · Cited by 54
“Systemic inflammation activates macrophage/monocytes, neutrophils, and phagocytes to initiate generation of proinflammatory cytokines [34] and ROS such as superoxide [35] hydrogen peroxide [36, 37].”
Background
Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression
Hua, K., Hsu, H., Chao, L. K., Chen, S., Yang, W., Hsu, J., & Wong, C. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21050 · Cited by 54
“…and modulation of TLR4 is an important early step in either EORP- (Hsu et al., 2004) or LPS-mediated signal transduction in the regulation of IL-1 gene expression (Hsu and Wen, 2002), thus we were interested in examining the effect of EORP (i.e., fraction 3, F3) upon TLR4 surface expression.”
BackgroundMethodSelf-citation
Quercetin and the ocular surface: What we know and where we are going
McKay, T. B., & Karamichos, D. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370216685187 · Cited by 52
H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells
Bourque, C., Zhang, Y., Fu, M., Racine, M., Greasley, A., Pei, Y., Wu, L., Wang, R., & Yang, G. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.11.004 · Cited by 53
Role of multidrug resistance-associated protein 1 expression in the in vitro susceptibility of rat nerve cell to unconjugated bilirubin
Falcão, A. S., Bellarosa, C., Fernandes, A. M. A., Brito, M. A., Silva, R. F. M., Tiribelli, C., & Brites, D. M. T. O. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.026 · Cited by 52
Increased extracellular heat shock protein 90α in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children
Fitrolaki, M.-D., Dimitriou, H., Venihaki, M., Katrinaki, M., Ilia, S., & Briassoulis, G. C. (2016) · Medicine · doi:10.1097/md.0000000000004651 · Cited by 52
Asymmetric cyanine as a far-red fluorescence probe for mitochondrial viscosity
Park, S. J., Shin, B. K., Lee, H. W., Song, J. M., Je, J. T., & Kim, H. M. (2019) · Dyes and Pigments · doi:10.1016/j.dyepig.2019.108080 · Cited by 52
Chitosan Nanococktails Containing Both Ceria and Superparamagnetic Iron Oxide Nanoparticles for Reactive Oxygen Species-Related Theranostics
Wu, Y., Zhang, R., Nguyen, D. H. T., Kurniawan, N. D., Moonshi, S. S., Whittaker, A. K., & Ta, H. T. (2021) · ACS Applied Nano Materials · doi:10.1021/acsanm.1c00141 · Cited by 54
Airborne endotoxin in fine particulate matter in Beijing
Guan, T., Yao, M., Wang, J., Fang, Y., Hu, S., Wang, Y., Dutta, A., Yang, J., Wu, Y., Hu, M., et al. (2014) · Atmospheric Environment · doi:10.1016/j.atmosenv.2014.08.005 · Cited by 51
Comparison of Mouse Urinary Metabolic Profiles after Exposure to the Inflammatory Stressors γ Radiation and Lipopolysaccharide
Laiakis, E. C., Hyduke, D. R., & Fornace, A. J. (2012) · Radiation Research · doi:10.1667/rr2771.1 · Cited by 52
“Although rapid induction of ROS is also attributed to LPS treatment and not only to radiation, LPS-generated ROS tend to subside and give rise to nitric oxide at later times (52), whereas radiation-generated ROS and subsequent oxidative stress are persistent (53).”
Background
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Shen, R., Yin, P., Yao, H., Chen, L., Chang, X., Li, H., & Hou, X. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s299163 · Cited by 51
Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures
Wang, T., Liu, B., Qin, L., Wilson, B. C., & Hong, J. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.10.040 · Cited by 51
“Evidence shows that ROS can also act as second messengers to activate diverse downstream signaling pathways involving protein kinase C, mitogen-activated protein kinase, and nuclear factor-nB (Hsu and Wen, 2002).”
Background
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Corsini, E., Viviani, B., Birindelli, S., Gilardi, F., Torri, A., Codecà, I., Lucchi, L., Bartesaghi, S., Galli, C. L., Marinovich, M., et al. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.07.002 · Cited by 51
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Lao, Y., Yang, K., Wang, Z., Sun, X., Zou, Q., Yu, X., Cheng, J., Tong, X., Yeh, E. T. H., Yang, J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.816769 · Cited by 51
“To date, the functional role of ROS has been observed under LPS stimulation contexts in the activation of the NLRP3 inflammasome, a pathway generating active caspase-1 and resulting in secretion of mature IL-1 (85–87), activation of the MAPK/AP-1 pathway and the production/secretion of IL-6 (84).”
BackgroundInfluential
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Wu, X., Dai, H., Xu, C., Liu, L., & Li, S. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36748 · Cited by 50
A coumarin-based TICT fluorescent probe for real-time fluorescence lifetime imaging of mitochondrial viscosity and systemic inflammation in vivo
Liang, Y., Zhao, Y., Lai, C., Zou, X., & Lin, W. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01150b · Cited by 49
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Liu, J.-Y., Yang, F., Lu, C., Yang, Y., Wen, C.-L., Hua, K., & Wu, S. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8018722 · Cited by 49
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Zhao, G., Yu, R., Deng, J., Zhao, Q., Li, Y., Joo, M., van Breemen, R. B., Christman, J. W., & Xiao, L. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.080762 · Cited by 50
Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation
Boza, P., Ayala, P., Vivar, R., Humeres, C. D., Cáceres, F. T., Muñoz, C., Garcı́a, L., Hermoso, M. A., & Dı́az-Araya, G. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.05.001 · Cited by 50
Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health
Budnik, L. T., Ádám, B., Albin, M. C., Banelli, B., Baur, X., Belpoggi, F., Bolognesi, C., Bröberg, K., Gustavsson, P., Göen, T., et al. (2018) · Journal of Occupational Medicine and Toxicology · doi:10.1186/s12995-018-0186-9 · Cited by 49
FRS 1000, an extract of red onion peel, strongly inhibits phosphodiesterase 5A (PDE 5A)
Lines, T. C., & Ono, M. (2005) · Phytomedicine · doi:10.1016/j.phymed.2004.12.001 · Cited by 49
Piceatannol attenuates D-GalN/LPS-induced hepatoxicity in mice: Involvement of ER stress, inflammation and oxidative stress
Wen, J., Lin, H., Zhao, M., Tao, L., Yang, Y., Xu, X., Jia, A., Zhang, J., & Weng, D. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.08.037 · Cited by 48
Rutin attenuates inflammatory responses induced by lipopolysaccharide in an in vitro mouse muscle cell (C2C12) model
Liu, S., Adewole, D. I., Li, Y., Sid, V., Wang, B., Karmin, O., & Yang, C. (2019) · Poultry Science · doi:10.3382/ps/pez037 · Cited by 48
Mechanisms of Dimethyl Sulfoxide Augmentation of IL-1β Production
Xing, L., & Remick, D. G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6195 · Cited by 48
“In contrast, Hsu and Wen (41) published that NAC decreased LPSinduced IL-1 production in the murine macrophage cell line J774A.1 by inhibiting ROI and modulating the ICE.”
BackgroundInfluential
Study on the Antiinflammatory Activity of Methanol Extract from Seagrass Zostera japonica
Hua, K., Hsu, H., Su, Y., Lin, I.-F., Yang, S.-S., Chen, Y.-M., & Chao, L. K. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0509658 · Cited by 47
Self-citation
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Wu, X., Dai, H., Liu, L., Xu, C., Yin, Y., Yi, J., Bielec, M., Han, Y., & Li, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.11.015 · Cited by 47
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Shum, J. K. S., Melendez, J. A., & Jeffrey, J. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205094200 · Cited by 46

Authors: Hsu, H.-Y., & Wen, M.-H.
Affiliations: National Yang Ming University (TW)
Corresponding author: Hsu, Hsien-Yeh
ORCID: Wen, Meng-Hsuan
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2002-06
Volume: 277
Issue: 25
Pages: 22131-22139
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m111883200
OpenAlex: W2016146035
Cited by: 519
References: 72
Citations by year: 2026: 13 · 2025: 17 · 2024: 20 · 2023: 21 · 2022: 21 · 2021: 27 · 2020: 22 · 2019: 23 · 2018: 25 · 2017: 33 · 2016: 27 · 2015: 21 · 2014: 18 · 2013: 19 · 2012: 14
FWCI: 7.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6719 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: lipopolysaccharide, IL-1β, reactive oxygen species, N-acetylcysteine, macrophages, Rac, p38 MAPK, JNK, ERK, phosphatidylinositol 3-kinase, tyrosine kinase, NADPH oxidase, signal transduction, inflammatory cytokines, TNF-α
MeSH terms: Animals, Carrier Proteins, Cell Line, Chromones, Curcumin, Enzyme Activation, Enzyme Inhibitors, Enzyme-Linked Immunosorbent Assay, Flavonoids, Gene Expression Regulation, Genes, Dominant, Imidazoles, Interleukin-1, Lipopolysaccharides, Macrophages, Models, Biological, Morpholines, Naphthalenes, Oxygen, Protein Binding, Pyridines, Time Factors, Transfection, Signal Transduction, Reactive Oxygen Species, rac1 GTP-Binding Protein, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, Intracellular Signaling Peptides and Proteins, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, MAP Kinase Kinase 4, Mice

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Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

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