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SUMOylation Regulates the Homologous to E6-AP Carboxyl Terminus (HECT) Ubiquitin Ligase Rsp5p

Novoselova, Tatiana Vladislavovna, Rose, Ruth-Sarah, Marks, Helen Margaret, Sullivan, James Andrew·2013·Journal of Biological Chemistry

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  • Rsp5p, the only Nedd4-family HECT-type ubiquitin ligase in yeast, exhibits reduced activity upon SUMOylation, affecting ubiquitin-mediated endocytosis of the manganese transporter Smf1p.

    “By contrast, Rsp5p as the only member of the Nedd4 family of HECT-type ubiquitin ligases in yeast exhibits reduced activity upon SUMOylation, which eventually affects ubiquitin-mediated endocytosis of the manganese transporter Smf1p (39).”

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Metadata

Authors
Novoselova, T. V., Rose, R.-S., Marks, H. M., & Sullivan, J. A.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2013-04
Volume
288
Issue
15
Pages
10308-10317
ISSN
0021-9258
Cited by
9
References
0
Language
en

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