Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples*

Tai, Leon M., Bilousova, Tina, Jungbauer, Lisa, Roeske, Stephen K., Youmans, Katherine L., Yu, Chunjiang, Poon, Wayne W., Cornwell, Lindsey B. +8 more·2013·Journal of Biological Chemistry

Cited by (166)

Items 101–166 of 166

  1. Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways
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  2. Impact of Apolipoprotein E ε4 in Alzheimer’s Disease: A Meta-Analysis of Voxel-Based Morphometry Studies
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  3. Apolipoprotein E impairs amyloid‐β fibril elongation and maturation
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  4. Increased Susceptibility of Dyslipidemic LSR+/− Mice to Amyloid Stress is Associated with Changes in Cortical Cholesterol Levels
    Anthony Pinçon, Mélanie H. Thomas, Marion Huguet, Ahmad Allouche, Julie Colin, Alain Georges, A. Derien, Marie‐Claire Lanhers, Catherine Malaplate, Thierry Oster et al. · 2015 · Journal of Alzheimer s Disease
  5. APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition
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  6. Cerebrospinal Fluid Apolipoprotein E Concentration and Severity of Cognitive Impairment in Patients With Newly Diagnosed Alzheimer’s Disease
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  7. Plasma-Enabled Carbon Nanostructures for Early Diagnosis of Neurodegenerative Diseases
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  8. Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
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  9. Differential Binding of Human ApoE Isoforms to Insulin Receptor is Associated with Aberrant Insulin Signaling in AD Brain Samples
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  10. Reduced Influence of apoE on Aβ43 Aggregation and Reduced Vascular Aβ43 Toxicity as Compared with Aβ40 and Aβ42
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  11. Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction
    Steve Zaldua, Frederick C. Damen, Rohan Pisharody, Riya Thomas, Kelly D. Fan, Giri K. Ekkurthi, Sarah B. Scheinman, Sami Alahmadi, Felecia M. Marottoli, Simon T. Alford et al. · 2020 · Heliyon
  12. Effect and Mechanism of Exogenous Melatonin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis
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  13. Enhanced self-assembly of the 7–12 sequence of amyloid-β peptide by tyrosine bromination
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  14. Genomic Characteristics of Genetic Creutzfeldt-Jakob Disease Patients with V180I Mutation and Associations with Other Neurodegenerative Disorders
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  15. Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human APOE4
    Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai · 2021 · Frontiers in Neuroscience
  16. Halogenation of the N‐Terminus Tyrosine 10 Promotes Supramolecular Stabilization of the Amyloid‐β Sequence 7–12
    Daniele Maiolo, Andrea Pizzi, Alessandro Gori, Lara Gazzera, Nicola Demitri, Alessandro Genoni, Fulvio Baggi, Fabio Moda, Giancarlo Terraneo, Francesca Baldelli Bombelli et al. · 2020 · ChemistryOpen
  17. Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE
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  18. Sex and sex hormone differences in hippocampal neurogenesis and their relevance to Alzheimer’s disease
    Bonnie H. Lee, Tanvi A. Puri, L. Galea · 2021 · Sex and Gender Differences in Alzheimer's Disease
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  20. LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice
    Sophie K. Stukas, Lita A. Freeman, Michael Lee, Anna Wilkinson, Alice Ossoli, Boris L. Vaisman, Stephen J. Demosky, Jeniffer Y. Chan, Veronica Hirsch‐Reinshagen, Alan Thomas Remaley et al. · 2014 · Journal of Lipid Research
  21. Recent Advancements in Biosensors for the Detection and Characterization of Amyloids: A Review
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  22. The Unveiling of Therapeutic Targets for Alzheimer’s Disease: An Integrative Review
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  23. Sex-specific influences of APOEε4 genotype on hippocampal neurogenesis and progenitor cells in middle-aged rats
    Bonnie H. Lee, Mel Cevizci, S. Lieblich, L. Galea · 2025 · Biology of Sex Differences
  24. RETRACTED: Injection of exogenous amyloid-β oligomers aggravated cognitive deficits, and activated necroptosis, in APP23 transgenic mice
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  25. Apolipoprotein E4 inhibits γ‐secretase activity via binding to the γ‐secretase complex
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  26. Mass‐tag barcoding for multiplexed analysis of human synaptosomes and other anuclear events
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  27. The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studies
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  28. Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies
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  29. Review Article APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease
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  30. Review of research advances in the cerebral lymphatic system and neurological disorders
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  31. Apolipoprotein E interacts with amyloid-β oligomers via positively cooperative multivalent binding
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  32. Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits
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  33. Effect of time-restricted feeding on cognitive dysfunction in Alzheimer’s disease and the role of ApoE polymorphism: protocol for a randomised controlled trial
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  34. Functions of the basal lamina and ApoE in cerebral amyloid angiopathy
    A. Juan-Palencia, Yao Yao · 2025 · Fluids and Barriers of the CNS
  35. Neurochemical Aspects of Alzheimer Disease
    A. A. Farooqui · 2016 · Springer eBooks
  36. Methods to Assess Activity and Potency of Rexinoids Using Rapid Luciferase-Based Assays: A Case Study with NEt-TMN
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  37. Protein Structure and Folding
    L. Brent Cole, Peter R. Kramer · 2015 · Elsevier eBooks
  38. Exploring the parity paradox: Differential effects on neuroplasticity and neuroinflammation by APOEe4 genotype at middle-age
    Bonnie H. Lee, Mel Cevizci, Stephanie E. Lieblich, Muna Ibrahim, Yanhua Wen, Rand S. Eid, Yvonne Lamers, Paula Duarte‐Guterman, Liisa A.M. Galea · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  39. New Thinking About the Role of an Alzheimer's Risk Gene in Amyloid Clearance
    Susan Fitzgerald · 2013 · Neurology Today
  40. Effects of acidic oligosaccharide sugar chain on amyloid oligomer-induced impairment of synaptic plasticity in rats
    Lan Yi Chang, Fushun Li, Xiaowei Chen, Shujun Xu, Chuang Wang, Hongzhuan Chen, Qinwen Wang · 2014 · Metabolic Brain Disease
  41. Methods to Generate an Array of Novel Rexinoids by SAR on a Potent Retinoid X Receptor Agonist: A Case Study with NEt-TMN
    Carl E. Wagner, Peter W. Jurutka · 2019 · Methods in molecular biology
  42. Apolipoprotein A-I Mimetic 4F Peptide Generates Amyloid Cytotoxins by Forming Hetero-oligomers with β-amyloid
    Bikash Ranjan Sahoo, Michael E. Bekier, Zichen Liu, Vojč Kocman, Andrea K. Stoddard, Gattadahalli M. Anantharamaiah, James S. Nowick, Carol A. Fierke, Yanzhuang Wang, Ayyalusamy Ramamoorthy · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  43. ApoE lipidation, not isoform, is the key modulator of Aβ interaction, uptake, and cytotoxicity
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  58. Additional file 12 of Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
    Noah R. Johnson, Athena C.-J. Wang, Christina M. Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil E. Markham, Allen, Cody, A. Ranjitha Dhanasekaran, Heidi J. Chial et al. · 2022 · Figshare
  59. Additional file 1 of Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance
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  60. Additional file 11 of Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognition
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