Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased with APOE4 and Alzheimer Disease in a Transgenic Mouse Model and Human Samples*
Tai, Leon M., Bilousova, Tina, Jungbauer, Lisa, Roeske, Stephen K., Youmans, Katherine L., Yu, Chunjiang, Poon, Wayne W., Cornwell, Lindsey B. +8 more·2013·Journal of Biological Chemistry
Cited by (166)
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- Sex and sex hormone differences in hippocampal neurogenesis and their relevance to Alzheimer’s diseaseBonnie H. Lee, Tanvi A. Puri, L. Galea · 2021 · Sex and Gender Differences in Alzheimer's Disease
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- RETRACTED: Injection of exogenous amyloid-β oligomers aggravated cognitive deficits, and activated necroptosis, in APP23 transgenic miceHyerin Yu, Ryuta Morihara, Ricardo Satoshi Ota-Elliott, Zhihong Bian, Yuting Bian, Xinran Hu, Hongming Sun, Yusuke Fukui, Koji Abe, Hiroyuki Ishiura et al. · 2023 · Brain Research · Retracted
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- Mass‐tag barcoding for multiplexed analysis of human synaptosomes and other anuclear eventsChandresh R. Gajera, Rosemary Fernandez, Kathleen S. Montine, Edward J. Fox, Dunja Mrdjen, Nadia O. Postupna, Christopher Dirk Keene, Sean C. Bendall, Thomas Jude Montine · 2021 · Cytometry Part A
- The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesMadison Bailey, Zlatomira G. Ilchovska, Akram A. Hosseini, JeYoung Jung · 2024 · medRxiv
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- Review Article APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's diseaseDaniel M. Michaelson · 2014
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- Apolipoprotein E interacts with amyloid-β oligomers via positively cooperative multivalent bindingSwagatha Ghosh, Timir Baran Sil, Sukanta Dolai, Kanchan Garai · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
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- Effect of time-restricted feeding on cognitive dysfunction in Alzheimer’s disease and the role of ApoE polymorphism: protocol for a randomised controlled trialJiao Chen, Xin Zhang, Xuhui Chen, Weiwei Yu, Mengzhen Jia, Li Zhu, Zhigang Liu, Jun Hu · 2025 · BMJ Open
- Functions of the basal lamina and ApoE in cerebral amyloid angiopathyA. Juan-Palencia, Yao Yao · 2025 · Fluids and Barriers of the CNS
- Neurochemical Aspects of Alzheimer DiseaseA. A. Farooqui · 2016 · Springer eBooks
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- Protein Structure and FoldingL. Brent Cole, Peter R. Kramer · 2015 · Elsevier eBooks
- Exploring the parity paradox: Differential effects on neuroplasticity and neuroinflammation by APOEe4 genotype at middle-ageBonnie H. Lee, Mel Cevizci, Stephanie E. Lieblich, Muna Ibrahim, Yanhua Wen, Rand S. Eid, Yvonne Lamers, Paula Duarte‐Guterman, Liisa A.M. Galea · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- New Thinking About the Role of an Alzheimer's Risk Gene in Amyloid ClearanceSusan Fitzgerald · 2013 · Neurology Today
- Effects of acidic oligosaccharide sugar chain on amyloid oligomer-induced impairment of synaptic plasticity in ratsLan Yi Chang, Fushun Li, Xiaowei Chen, Shujun Xu, Chuang Wang, Hongzhuan Chen, Qinwen Wang · 2014 · Metabolic Brain Disease
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- Apolipoprotein A-I Mimetic 4F Peptide Generates Amyloid Cytotoxins by Forming Hetero-oligomers with β-amyloidBikash Ranjan Sahoo, Michael E. Bekier, Zichen Liu, Vojč Kocman, Andrea K. Stoddard, Gattadahalli M. Anantharamaiah, James S. Nowick, Carol A. Fierke, Yanzhuang Wang, Ayyalusamy Ramamoorthy · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- ApoE lipidation, not isoform, is the key modulator of Aβ interaction, uptake, and cytotoxicityKamila Nurmakova, Gregory-Neal W Gomes, Zachary A. Levine · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and AstrocytesSofia Söllvander · 2015 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
- Review Article Alzheimer's disease biomarkers in animal models: closing the translational gapJonathan J. Sabbagh, Jefferson W. Kinney, Jeffrey L. Cummings, Lou Ruvo · 2013
- Human APOE4 affects microglial reactivity and spatial cognition in a mouse model of alzheimer's disease riskGustavo A. Rodriguez · 2014 · DigitalGeorgetown (Georgetown University Library)
- Alzheimer’s Disease Therapeutics Targeting Apolipoprotein EFan Liao, David M. Holtzman · 2016 · Elsevier eBooks
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- AXL receptor tyrosine kinase regulates Apolipoprotein E expressionWenchen Zhao · 2019 · cIRcle (University of British Columbia)
- PERFLUOROOCTANESULFONIC ACID (PFOS) AS A POTENTIAL RISK FACTOR FOR LATE-ONSET ALZHEIMER’S DISEASEVeronia Basaly · 2020
- The interactive impact of omega-3 fatty acids, APOE genotype and sex hormones on cognitionMatthew G. Pontifex · 2020 · UEA Digital Repository (University of East Anglia)
- Additional file 2 of Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearanceWeixi Feng, Yanli Zhang, Ze Wang, Hanrong Xu, Ting Wu, Charles Marshall, Junying Gao, Ming Xiao · 2020 · Figshare
- Differential Effects of Aβ Peptides on the Plasmin-Dependent Degradation of ApoE3 and ApoE4.Merc M Kemeh, Anthony J Furnelli, Noel D Lazo · 2025 · ACS Chemical Neuroscience
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- Additional file 13 of Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognitionNoah R. Johnson, Athena C.-J. Wang, Christina M. Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil E. Markham, Allen, Cody, A. Ranjitha Dhanasekaran, Heidi J. Chial et al. · 2022 · Figshare
- Additional file 1 of APOE effects on regional tau in preclinical Alzheimer’s diseaseChristina B. Young, Emily Johns, Gabriel Kennedy, Michaël E. Belloy, Philip S. Insel, Michael D. Greicius, Reisa Anne Sperling, Keith A. Johnson, Kathleen L. Poston, Elizabeth C. Mormino · 2023 · Figshare
- Additional file 12 of Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognitionNoah R. Johnson, Athena C.-J. Wang, Christina M. Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil E. Markham, Allen, Cody, A. Ranjitha Dhanasekaran, Heidi J. Chial et al. · 2022 · Figshare
- Additional file 1 of Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearanceFeng, Weixi, Zhang, Yanli, Ze Wang, Xu, Hanrong, Wu, Ting, Charles Marshall, Gao, Junying, Xiao, Ming · 2020 · Figshare
- Additional file 11 of Imipramine and olanzapine block apoE4-catalyzed polymerization of Aβ and show evidence of improving Alzheimer’s disease cognitionNoah R. Johnson, Athena C.-J. Wang, Christina M. Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil E. Markham, Allen, Cody, A. Ranjitha Dhanasekaran, Heidi J. Chial et al. · 2022 · Figshare
- Mouse models elucidating the role of apolipoprotein E in neurological conditionsEileen Ruth Samson Torres, Jacob Raber · 2025 · Elsevier eBooks
- High-density lipoprotein mimetic peptide 4F ameliorates APOE4-associated lipid dysfunction in primary and iPSC-derived astrocytes and cerebral organoidsKristina Fredriksen, Siddhi S. Joshi, Allison Chang, Ling Li · 2025 · bioRxiv
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- Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’AlzheimerLaurie Arnaud · 2021 · theses.fr (ABES)
- Regulation of Alzheimer pathology by amyloid seeds : from toxic effects to therapeutic opportunities, in mouse model of amyloidosisMarina Célestine · 2023 · theses.fr (ABES)
- Apolipoprotein E lipidation, rather than isoform identity, determines amyloid-β binding and astrocyte clearanceKamila Nurmakova, Gregory-Neal W Gomes, Zachary A. Levine · 2026 · Journal of Biological Chemistry