The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation
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eef2k encodes a calcium/calmodulin-dependent protein kinase, which phosphorylates eukaryotic elongation factor 2 (eEF2) to inhibit translational elongation.
“The eef2k encodes a calcium/calmodulin-dependent protein kinase, which phosphorylates eukaryotic elongation factor 2 (eEF2) to inhibit translational elongation34,35.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [35]
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Cites
Browne, G. J., Finn, S. G., & Proud, C. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309773200 · Cited by 353 · see citing works
A Peptide Model for Calmodulin Trapping by Calcium/Calmodulin-dependent Protein Kinase II
Putkey, J. A., & Waxham, M. N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29619 · Cited by 94 · see citing works
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Research works printed but not linked: 4
- Nairn, A. C., Bhagat, B., and Palfrey, H. C. (1985) Identification of calmod- ulin-dependent protein kinase III and its major M r 100,000 substrate in mammalian tissues. Proc. Natl. Acad. Sci. U.S.A. 82, 7939 -7943
- Ryazanov, A. G., Ward, M. D., Mendola, C. E., Pavur, K. S., Dorovkov, M. V., Wiedmann, M., Erdjument-Bromage, H., Tempst, P., Parmer, T. G., Prostko, C. R., Germino, F. J., and Hait, W. N. (1997) Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Proc. Natl. Acad. Sci. U.S.A. 94, 4884 -4889
- Schultz, J., Milpetz, F., Bork, P., and Ponting, C. P. (1998) SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl. Acad. Sci. U.S.A. 95, 5857-5864
- Dephoure, N., Zhou, C., Ville ´n, J., Beausoleil, S. A., Bakalarski, C. E., Elledge, S. J., and Gygi, S. P. (2008) A quantitative atlas of mitotic phos- phorylation. Proc. Natl. Acad. Sci. U.S.A. 105, 10762-10767
Cited by
Sorted by citations
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
Xu, B., Zhang, Y., Du, X.-F., Li, J., Zi, H.-X., Bu, J.-W., Yan, Y., Han, H., & Du, J.-L. (2017) · Cell Research · doi:10.1038/cr.2017.62 · Cited by 354 · see citing works
Liu, R., & Proud, C. G. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2015.123 · Cited by 117 · see citing works
The role of eEF2 kinase in the rapid antidepressant actions of ketamine
(2020) · Advances in Pharmacology · doi:10.1016/bs.apha.2020.04.005 · Cited by 52 · see citing works
- Authors
- Tavares, C. D. J., Ferguson, S. B., Giles, D. H., Wang, Q., Wellmann, R. M., O'Brien, J. P., Warthaka, M., Brodbelt, J. S., Ren, P., & Dalby, K. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 289
- Issue
- 34
- Pages
- 23901-23916
- ISSN
- 0021-9258
- Cited by
- 41
- References
- 2
- Language
- en
- Licence
- Funders
- National Institutes of Health (R21 GM099028, GM106137, GM59802)
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