A Peptide Model for Calmodulin Trapping by Calcium/Calmodulin-dependent Protein Kinase II

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Conformational changes of calmodulin upon Ca 2+ binding studied with a microfluidic mixer

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Synaptic memory and CaMKII

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Intracellular calmodulin availability accessed with two-photon cross-correlation

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Two-Photon Cross-Correlation Analysis of Intracellular Reactions with Variable Stoichiometry

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Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity

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A New Role for IQ Motif Proteins in Regulating Calmodulin Function

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βCaMKII Regulates Actin Assembly and Structure

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Chemical Quenched Flow Kinetic Studies Indicate an Intraholoenzyme Autophosphorylation Mechanism for Ca2+/Calmodulin-dependent Protein Kinase II

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A Mechanism for Calmodulin (CaM) Trapping by CaM-kinase II Defined by a Family of CaM-binding Peptides

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Calmodulin shuttling mediates cytonuclear signaling to trigger experience-dependent transcription and memory

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Neurogranin Alters the Structure and Calcium Binding Properties of Calmodulin

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Nanoparticle as Signaling Protein Mimic: Robust Structural and Functional Modulation of CaMKII upon Specific Binding to Fullerene C60 Nanocrystals

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Spatial Diffusivity and Availability of Intracellular Calmodulin

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Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines

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Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the α or β catalytic subunit

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PEP-19, an Intrinsically Disordered Regulator of Calmodulin Signaling

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Light scattering and transmission electron microscopy studies reveal a mechanism for calcium/calmodulin‐dependent protein kinase II self‐association

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Role of the N- and C-Lobes of Calmodulin in the Activation of Ca2+/Calmodulin-Dependent Protein Kinase II

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Acidic/IQ Motif Regulator of Calmodulin

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Switching characteristics of a model for biochemical-reaction networks describing autophosphorylation versus dephosphorylation of Ca2+/calmodulin-dependent protein kinase II

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Calcium-stimulated Autophosphorylation Site of Plant Chimeric Calcium/Calmodulin-dependent Protein Kinase

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The Molecular Mechanism of Eukaryotic Elongation Factor 2 Kinase Activation

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Thermodynamics of Calmodulin Trapping by Ca2+/Calmodulin-Dependent Protein Kinase II: Subpicomolar Kd Determined Using Competition Titration Calorimetry

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Stimulus History Alters Behavioral Responses of Neuronal Growth Cones

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Neurogranin stimulates Ca2+/calmodulin-dependent kinase II by suppressing calcineurin activity at specific calcium spike frequencies

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Vascular CaMKII: heart and brain in your arteries

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Rapid Synthesis of Cryo-ET Data for Training Deep Learning ModelsPreprint

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In Vitro Reconstitution of a CaMKII Memory Switch by an NMDA Receptor-Derived Peptide

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Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Increases Small-Conductance Ca2+-Activated K+ Current in Patients with Chronic Atrial Fibrillation

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Camguk/CASK Enhances Ether-Á-Go-Go Potassium Current by a Phosphorylation-Dependent Mechanism

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Intra- and Interdomain Effects Due to Mutation of Calcium-binding Sites in Calmodulin

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Structural Analysis and Stochastic Modelling Suggest a Mechanism for Calmodulin Trapping by CaMKII

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CaMKII autophosphorylation can occur between holoenzymes without subunit exchange

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CaM-Kinase II Dephosphorylates Thr286 by a Reversal of the Autophosphorylation Reaction

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Intrinsically Disordered PEP-19 Confers Unique Dynamic Properties to Apo and Calcium Calmodulin

Wang, X., Kleerekoper, Q., Xiong, L.-W., & Putkey, J. A. (2010) · Biochemistry · doi:10.1021/bi100500m · Cited by 16 · see citing works

Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement

Curtis, A. J., Zhu, J., Penny, C. J., & Gold, M. G. (2023) · eLife · doi:10.7554/elife.85008 · Cited by 15 · see citing works

Interaction of Calmodulin with l-Selectin at the Membrane Interface: Implication on the Regulation of l-Selectin Shedding

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Opposing Intermolecular Tuning of Ca2+ Affinity for Calmodulin by Neurogranin and CaMKII Peptides

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A model for molecular mechanisms of synaptic competition for a finite resource

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Transient Anomalous Subdiffusion: Effects of Specific and Nonspecific Probe Binding with Actin Gels

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Relative Cosolute Size Influences the Kinetics of Protein-Protein Interactions

Hoffman, L., Wang, X., Sanabria, H., Cheung, M. S., Putkey, J. A., & Waxham, M. N. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.06.043 · Cited by 12 · see citing works

FERM Domain of Moesin Desorbs the Basic-Rich Cytoplasmic Domain of l-Selectin from the Anionic Membrane Surface

Deng, W., Cho, S., & Li, R. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.06.008 · Cited by 12 · see citing works

Decoding time-varying calcium signals by the postsynaptic biochemical network

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Intermolecular Peptide Cross‐Linking by Using Diaminodicarboxylic Acids

Kamalov, M., Kaur, H., & Brimble, M. A. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201503458 · Cited by 10 · see citing works

Research progress on the role of CaMKII in heart disease.

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Binding of Nox5's EF-Hand domain to the peptides corresponding to the phosphorylatable region and regulatory inhibitory loop in its dehydrogenase domain

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Calmodulin Adopts an Extended Conformation when Interacting with L-Selectin in Membranes

Deng, W., Putkey, J. A., & Li, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062861 · Cited by 8 · see citing works

Cytoskeletal-like Filaments of Ca2+-Calmodulin-Dependent Protein Kinase II Are Formed in a Regulated and Zn2+-Dependent Manner

Hoffman, L., Li, L., Alexov, E. G., Sanabria, H., & Waxham, M. N. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00028 · Cited by 7 · see citing works

Calmodulin Binding to Connexin 35: Specializations to Function as an Electrical Synapse

Aseervatham, J., Li, X., Mitchell, C. K., Lin, Y., Heidelberger, R., & O’Brien, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176346 · Cited by 7 · see citing works

A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping

Bartol, T. M., Ordyan, M., B, T. J. S. A., Rangamani, P., & Kennedy, M. B. (2025) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2025.1547948 · Cited by 8 · see citing works

Photounbinding of Calmodulin from a Family of CaM Binding Peptides

Neumüller, K. G., Elsayad, K., Reisecker, J. M., Waxham, M. N., & Heinze, K. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014050 · Cited by 6 · see citing works

Heterogeneity in human hippocampal CaMKII transcripts reveals allosteric hub-dependent regulationPreprint

Sloutsky, R., Dziedzic, N., Dunn, M. J., Bates, R. M., Torres-Ocampo, A. P., Boopathy, S., Page, B., Weeks, J. G., Chao, L. H., & Stratton, M. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/721589 · Cited by 4 · see citing works

Training Generalized Segmentation Networks with Real and Synthetic Cryo-ET dataPreprint

Purnell, C. J., Heebner, J. E., Nguyen, L., Swulius, M. T., Hylton, R. K., Kabonick, S. G., Grillo, M. A., Grillo, S. L., Grigoryev, S. A., Heberle, F. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.31.635598 · Cited by 4 · see citing works

UV–Vis and NIR Fluorescence Spectroscopy

Patonay, G., Beckford, G., & Hanninen, P. E. (2014) · doi:10.1002/9783527654703.ch26 · Cited by 3 · see citing works

Improved Synthesis of 2-Trifluoromethyl-10-aminopropylphenothiazine: Making 2-Trifluoromethyl-10-aminopropylphenothiazine Readily Available for Calmodulin Purification

Johnson, J. W., Cain, K. W., Dunlap, T. B., & Naumiec, G. R. (2018) · ACS Omega · doi:10.1021/acsomega.8b02146 · Cited by 2 · see citing works

The critical role of the C-terminal lobe of calmodulin in activating eukaryotic elongation factor 2 kinase

Long, K. J., Browning, L. S., Piserchio, A., Isiorho, E. A., Gadallah, M. I., Douangvilay, J., Wang, E. Y., Kalugin, J. K., Brodbelt, J. S., Ghose, R., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110650 · Cited by 2 · see citing works

A spatial model of autophosphorylation of Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trappingPreprint

Bartol, T. M., Ordyan, M., B, T. J. S. A., Rangamani, P., & Kennedy, M. B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.02.578696 · Cited by 2 · see citing works

Neurogranin modulates the rate of association between calmodulin and target peptides

Putkey, J. A., Hoffman, L., Berka, V., & Wang, X. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.05.010 · Cited by 1 · see citing works

Ser500 phosphorylation acts as a conformational switch to prime eEF-2K for activation

Bohanon, A. L., Browning, L. S., Piserchio, A., Long, K. J., Jacob, S., Sammons, R. M., Tavares, C. D. J., Cho, E. J., Ghose, R., & Dalby, K. N. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111087 · Cited by 1 · see citing works

PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis

Tsong, H., Waxham, M. N., & Stavoe, A. K. (2026) · iScience · doi:10.1016/j.isci.2026.117518 · Cited by 1 · see citing works

Experiment and Simulation Reveal Residue Details for How Target Binding Tunes Calmodulin’s Calcium-Binding Properties

Nde, J., Zhang, P., Waxham, M. N., & Cheung, M. S. (2023) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.2c08734 · Cited by 1 · see citing works

Activity-Dependent Regulation of Ether á … go-go K+ Channels.

Marble, D. D. (2008) · Deep Blue (University of Michigan)

Structural studies of calcium/calmodulin dependent protein kinase II activation

Chao, L. H. (2010)

Voltage-Dependent Regulation of Intracellular Signaling by Ether À go-go K⁺Channels.

Hegle, A. P. (2007) · Deep Blue (University of Michigan)

Amplification of Switching Characteristics of Biochemical-Reaction Networks Involving Ca2+/Calmodulin-Dependent Protein Kinase II: Implication for LTP Induced by a Single Burst during the Theta Oscillation

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Identification and Characterization of a Novel Polypeptide in the CNS of Bombyx mori During Pupal - Adult Transformation

Shanavas, A., Dutta‐Gupta, A., & Murthy, R. (1997)

Memória metabólica de células beta pancreática controla a secreção de insulina e é mediada pela CaMKII

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Methods optimization for the expression and purification of human calcium calmodulin-dependent protein kinase II alpha

Bolton, S. C., Thompson, D. H., & Kinzer‐Ursem, T. L. (2024) · PLoS ONE · doi:10.1371/journal.pone.0285651

Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons

Curtis, A. J., Zhu, J., Studniarczyk, D., Church, T. W., Farrant, M., & Gold, M. G. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0795-25.2025

CaMKII generates actin bundle morphology and mechanics distinct from canonical bivalent cross-linkersPreprint

Vargas-Hernández, S., bueno, C., Syeda, M., Pham, J., Mireles, L. L., Mauro, C. M. D., Wolynes, P. G., Waxham, M. N., & Gustavsson, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.16.752118

A Mechanism for Calmodulin (CaM) Trapping by CaM-kinase II Defined by a Family of CaM-binding Peptides

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Ca2+/calmodulin-dependent protein kinase II. Identification of a regulatory autophosphorylation site adjacent to the inhibitory and calmodulin-binding domains.

Schworer, C. M., Colbran, R. J., Keefer, J. R., & Soderling, T. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68264-x · Cited by 191 · see citing works

Calcium/calmodulin-independent autophosphorylation sites of calcium/calmodulin-dependent protein kinase II. Studies on the effect of phosphorylation of threonine 305/306 and serine 314 on calmodulin binding using synthetic peptides.

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Molecular Characterization of Calmodulin Trapping by Calcium/Calmodulin-dependent Protein Kinase II

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Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II.

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