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Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P)

da Palma, Joel Ramos, Cendron, Laura, Seidah, Nabil Georges, Pasquato, Antonella, Kunz, Stefan·2016·Journal of Biological Chemistry
DOI 10.1074/jbc.m115.677757
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  • The prodomain of S1P is crucial for its folding, autoprocessing and proteolysis of substrates including SREBP2.

    “Contrasting to those in other proprotein convertases that function as an inhibitor, the prodomain of S1P is crucial for its folding, autoprocessing and proteolysis of substrates including SREBP2 (da Palma et al., 2014; da Palma et al., 2016).”

    From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as da Palma et al., 2016

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Research works printed but not linked: 36

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  8. Vincent, 2003, Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1, J. Virol, 77, 8640, 10.1128/JVI.77.16.8640-8649.2003 · DOI
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  10. Rojek, 2008, Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito, J. Virol, 82, 6045, 10.1128/JVI.02392-07 · DOI
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  14. da Palma, 2014, Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease, J. Biol. Chem, 289, 35743, 10.1074/jbc.M114.588525 · DOI · Paper page
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  16. Elagoz, 2002, Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity, J. Biol. Chem, 277, 11265, 10.1074/jbc.M109011200 · DOI · Paper page
  17. Pullikotil, 2007, The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization, J. Biol. Chem, 282, 27402, 10.1074/jbc.M703200200 · DOI
  18. Burri, 2012, Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease, J. Virol, 86, 4935, 10.1128/JVI.00024-12 · DOI
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  31. Burri, 2013, Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P), J. Virol, 87, 6406, 10.1128/JVI.00072-13 · DOI
  32. Lesage, 2000, The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function, Mol. Biol. Cell, 11, 1947, 10.1091/mbc.11.6.1947 · DOI
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Metadata

Authors
da Palma, J. R., Cendron, L., Seidah, N. G., Pasquato, A., & Kunz, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2016-01
Volume
291
Issue
5
Pages
2055-2066
ISSN
0021-9258
DOI
10.1074/jbc.m115.677757
Cited by
14
References
1
Language
en
Licence
Funders
  • Swiss National Science Foundation (31003A-135536, 310030_149746)
  • Canadian Institutes of Health Research (93792)
  • Canada Research Chairs (216684)
  • Novartis Stiftung für Medizinisch-Biologische Forschung (14B086)

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