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Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins
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S1P is synthesized as an inactive precursor and undergoes multiple processing of its N-terminal prodomain involving the catalytic triad D218/H249/S414, generating S1P-A, S1P-B'/B, and S1P-C'/C.
“S1P is synthesized as an inactive precursor whose domain organization is shown in Fig. 4C. To become mature, S1P undergoes multiple processing of the N-terminal prodomain involving the catalytic triad D218/H249/S414, generating three shortened forms designated S1P-A, S1P-B’/B and S1P-C’/C (Espenshade et al., 1999; Elagoz et al., 2002; da Palma et al., 2014).”
From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Espenshade et al., 1999
S1P cleavage at the B'/B sites is required for subsequent cleavage at the C'/C sites.
“These results are consistent with the earlier work (Espenshade et al., 1999; da Palma et al., 2014), and suggest that S1P cleavage at the B’/B sites is required for subsequent cleavage at the C’/C sites.”
From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Espenshade et al., 1999
Autoprocessing at the C'/C sites occurs in trans involving another S1P protein.
“autoprocessing at the C’/C sites is reported to occur in trans involving another S1P protein (Espenshade et al., 1999; da Palma et al., 2014)”
From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Espenshade et al., 1999
S1P-B'/B can already cleave the SREBP2 precursor and activate downstream signaling.
“Another unique aspect of S1P is that it needs not to be completely processed to become enzymatically active, as S1P-B’/B can already cleave the SREBP2 precursor and activate the downstream signaling (Espenshade et al., 1999; da Palma et al., 2014).”
From POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation (2021) · cites this paper as Espenshade et al., 1999
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Metadata
- Authors
- Espenshade, P. J., Cheng, D., Goldstein, J. L., & Brown, M. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 274
- Issue
- 32
- Pages
- 22795-22804
- ISSN
- 0021-9258
- Cited by
- 161
- References
- 0
- Language
- en
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