Nrf2 Transcription Factor Can Directly Regulate mTOR

Upstream and downstream of mTOR

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Molecular mechanisms of mTOR-mediated translational control

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Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

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Active Genes Are Tri-Methylated at K4 of Histone H3

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Growing roles for the mTOR pathway

Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,556 · see citing works

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

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Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast

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Polycomb silencing mechanisms and the management of genomic programmes

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Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Malhotra, D., Portales-Casamar, É., Singh, A., Srivastava, S., Arenillas, D. J., Happel, C., Shyr, C., Wakabayashi, N., Kensler, T. W., Wasserman, W. W., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq212 · Cited by 796 · see citing works

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryotePreprint

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Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 792 · see citing works

Protocol for the fast chromatin immunoprecipitation (ChIP) method

Nelson, J. D., Denisenko, O. N., & Bomsztyk, K. (2006) · Nature Protocols · doi:10.1038/nprot.2006.27 · Cited by 771 · see citing works

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

Li, W., Khor, T. O., Xu, C., Shen, G., Jeong, W.-S., Yu, S., & Kong, A.-N. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.017 · Cited by 738 · see citing works

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

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Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKKPreprint

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Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

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Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

Chorley, B. N., Campbell, M. R., Wang, X., Karaca, M., Sambandan, D., Bangura, F., Xue, P., Pi, J., Kleeberger, S. R., & Bell, D. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks409 · Cited by 557 · see citing works

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

Kang, M.-I., Kobayashi, A., Wakabayashi, N., Kim, S.-G., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308347100 · Cited by 536 · see citing works

Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants.

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Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Tong, K. I., Padmanabhan, B., Kobayashi, A., Shang, C., Hirotsu, Y., Yokoyama, S., & Yamamoto, M. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00753-07 · Cited by 447 · see citing works

KEAP1 E3 Ligase-Mediated Downregulation of NF-κB Signaling by Targeting IKKβ

Lee, D.-F., Kuo, H.-P., Liu, M., Chou, C.-K., Xia, W., Du, Y., Shen, J., Chen, C.-T., Huo, L., Hsu, M.-C., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.07.025 · Cited by 399 · see citing works

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

Yu, M., Li, H., Liu, Q., Liu, F., Tang, L., Li, C., Yuan, Y., Zhan, Y., Xu, W., Li, W., et al. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.01.014 · Cited by 319 · see citing works

mTOR inhibitors in cancer therapy

Zaytseva, Y. Y., Valentino, J. D., Gulhati, P., & Evers, B. M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.005 · Cited by 292 · see citing works

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance

Rushworth, S. A., Zaitseva, L., Murray, M. Y., Shah, N. M., Bowles, K. M., & MacEwan, D. J. (2012) · Blood · doi:10.1182/blood-2012-04-422121 · Cited by 290 · see citing works

EZH2 Methyltransferase and H3K27 Methylation in Breast Cancer

Yoo, K. H., & Hennighausen, L. G. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.8.59 · Cited by 260 · see citing works

Nrf2 protects against airway disorders

Cho, H., & Kleeberger, S. R. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.024 · Cited by 237 · see citing works

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

Maher, J. M., & Yamamoto, M. P. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.011 · Cited by 231 · see citing works

mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets

Watanabe, R., Liu, W., & Huang, J. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.089623 · Cited by 186 · see citing works

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

Shen, G., & Kong, A. T. (2009) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.680 · Cited by 185 · see citing works

The Absence of Nrf2 Enhances NF-B-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes

Pan, H., Wang, H., Wang, X., Zhu, L., & Mao, L. (2012) · Mediators of Inflammation · doi:10.1155/2012/217580 · Cited by 179 · see citing works

Increased glutathione synthesis through an ARE-Nrf2-dependent pathway by zinc in the RPE: implication for protection against oxidative stress.

Ha, K.-N., Chen, Y., Cai, J.-Y., & Sternberg, P. (2006) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.05-1322 · Cited by 161 · see citing works

Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers

Yamadori, T., Ishii, Y., Homma, S., Morishima, Y., Kurishima, K., Itoh, K., Yamamoto, M. P., Minami, Y., Noguchi, M., & Hizawa, N. (2012) · Oncogene · doi:10.1038/onc.2011.628 · Cited by 151 · see citing works

Critical role of PI3K signaling for NF-κB–dependent survival in a subset of activated B-cell–like diffuse large B-cell lymphoma cells

Kloo, B., Nagel, D., Pfeifer, M., Grau, M., Düwel, M., Vincendeau, M., Dörken, B., Lenz, P., Lenz, G., & Krappmann, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008969108 · Cited by 145 · see citing works

ARE- and TRE-mediated Regulation of Gene Expression

Xie, T., Belinsky, M. G., Xu, Y., & Jaiswal, A. K. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.12.6894 · Cited by 142 · see citing works

Global Downstream Pathway Analysis Reveals a Dependence of Oncogenic NF-E2–Related Factor 2 Mutation on the mTOR Growth Signaling Pathway

Shibata, T., Saito, S., Kokubu, A., Suzuki, T., Yamamoto, M. P., & Hirohashi, S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0384 · Cited by 128 · see citing works

AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules

Guichard, S. M., Curwen, J., Bihani, T., D’Cruz, C. M., Yates, J. W. T., Grondine, M. R., Howard, Z., Davies, B. R., Bigley, G., Klinowska, T. C. M., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0365 · Cited by 126 · see citing works

Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapy

Loignon, M., Miao, W., Hu, L., Bier, A., Bismar, T. A., Scrivens, P. J., Mann, K. K., Basik, M., Bouchard, A., Fiset, P., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-1186 · Cited by 99 · see citing works

Enhancing Endocrine Therapy for Hormone Receptor–Positive Advanced Breast Cancer: Cotargeting Signaling Pathways

Johnston, S. R. D. (2015) · Journal of the National Cancer Institute · doi:10.1093/jnci/djv212 · Cited by 92 · see citing works

Targeting the mTOR Signaling Pathway in Neuroendocrine Tumors

Chan, J. A., & Kulke, M. H. (2014) · Current Treatment Options in Oncology · doi:10.1007/s11864-014-0294-4 · Cited by 91 · see citing works

Phosphatidylinositol-3-Kinase Gamma Plays a Central Role in Blood–Brain Barrier Dysfunction in Acute Experimental Stroke

Jin, R., Song, Z., Yu, S., Piazza, A., Nanda, A., Penninger, J. M., Granger, D. N., & Li, G. (2011) · Stroke · doi:10.1161/strokeaha.110.601369 · Cited by 74 · see citing works

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma

Cescon, D. W., She, D., Sakashita, S., Zhu, C., Pintilie, M., Shepherd, F. A., & Tsao, M. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2206 · Cited by 61 · see citing works

Clinical development of mTOR inhibitors in breast cancer

Vicier, C., Dieci, M. V., Arnedos, M., Delaloge, S., Viens, P., & André, F. (2014) · Breast Cancer Research · doi:10.1186/bcr3618 · Cited by 61 · see citing works

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling

Shin, J., Kim, M. Y., Sohn, K., Jung, S.-Y., Lee, H.-E., Lim, J. W., Kim, S., Lee, Y., Im, M., Seo, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096035 · Cited by 60 · see citing works

Influence of Nrf2 genotype on pulmonary NF-kappaB activity and inflammatory response after traumatic brain injury.

Jin, W., Zhu, L., Guan, Q., Chen, G., Wang, Q. F., Yin, H. X., Hang, C. H., Shi, J. X., & Wang, H. D. (2008) · PubMed · Cited by 56 · see citing works

Isoniazid prevents Nrf2 translocation by inhibiting ERK1 phosphorylation and induces oxidative stress and apoptosis

Verma, A. K., Yadav, A., Dewangan, J., Singh, S. V., Mishra, M., Singh, P. K., & Rath, S. K. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.020 · Cited by 54 · see citing works

FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation

Chuang, J., Huang, J.-Y., Tsai, S., Sun, H. S., Yang, S., Chuang, P., Huang, B., & Ching, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.011 · Cited by 43 · see citing works

H2S mitigates severe acute pancreatitis through the PI3K/AKT-NF-κB pathwayin vivo

Rao, C.-Y., Lan-ying, F., Hu, C.-L., Chen, D.-X., Gan, T., Wang, Y., & Zhao, X. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i15.4555 · Cited by 38 · see citing works

Autophagy Deficiency Diminishes Indomethacin-Induced Intestinal Epithelial Cell Damage through Activation of the ERK/Nrf2/HO-1 Pathway

Harada, S., Nakagawa, T., Yokoe, S., Edogawa, S., Takeuchi, T., Inoue, T., Higuchi, K., & Asahi, M. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.226431 · Cited by 33 · see citing works

Independent role of phosphoinositol-3-kinase (PI3K) and casein kinase II (CK-2) in EGFR and Her-2-mediated constitutive NF-kappaB activation in prostate cancer cells

Page, C. L., Koumakpayi, I. H., Lessard, L., Fred Saad, C., & Mes‐Masson, A. (2005) · The Prostate · doi:10.1002/pros.20291 · Cited by 30 · see citing works

Novel role of NF-κB-p65 in antioxidant homeostasis in human kidney-2 cells

George, L. E., Lokhandwala, M. F., & Asghar, M. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00006.2012 · Cited by 27 · see citing works

RagD gene expression and NRF2 mutations in lung squamous cell carcinomas

Sasaki, H., Shitara, M., Yokota, K., Hikosaka, Y., Moriyama, S., Yano, M., & Fujii, Y. (2012) · Oncology Letters · doi:10.3892/ol.2012.938 · Cited by 21 · see citing works

T cell-to-T cell clustering enhances NF-κB activity by a PI3K signal mediated by Cbl-b and Rho

Herndon, T. M., Pirone, D. M., Tsokos, G. C., & Chen, C. S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.064 · Cited by 9 · see citing works

The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging

Yu, C., & Xiao, J.-H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6635460 · Cited by 537 · see citing works

Modulating NRF2 in Disease: Timing Is Everything

Dodson, M. B., de la Vega, M. R., Cholanians, A. B., Schmidlin, C. J., Chapman, E., & Zhang, D. D. (2018) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021856 · Cited by 540 · see citing works

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

Shaw, P., & Chattopadhyay, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29219 · Cited by 431 · see citing works

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

Wang, R., Yu, Z., Sunchu, B., Shoaf, J., Dang, I., Zhao, S., Caples, K., Bradley, L., Beaver, L. M., Ho, E., et al. (2017) · Aging Cell · doi:10.1111/acel.12587 · Cited by 360 · see citing works

Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle

Melnik, B. C. (2017) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2017.09.006 · Cited by 197 · see citing works

The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure

Galiè, M., Covi, V., Tabaracci, G., & Malatesta, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164009 · Cited by 177 · see citing works

Milk’s Role as an Epigenetic Regulator in Health and Disease

Melnik, B. C., & Schmitz, G. (2017) · Diseases · doi:10.3390/diseases5010012 · Cited by 113 · see citing works

The mTORC2 signaling network: targets and cross-talks

Ragupathi, A., Kim, C., & Jacinto, E. (2024) · Biochemical Journal · doi:10.1042/bcj20220325 · Cited by 113 · see citing works

Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies

the ARIA group, Bousquet, J., Cristol, J., Czarlewski, W., Antó, J. M., Martineau, A. R., Haahtela, T., Fonseca, S. C., Iaccarino, G., Blain, H., et al. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00362-7 · Cited by 80 · see citing works

Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection

Hiebert, P., & Werner, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163856 · Cited by 78 · see citing works

Normal and Pathological NRF2 Signalling in the Central Nervous System

Heurtaux, T., Bouvier, D. S., Bénani, A., Helgueta, S., Frauenknecht, K. B. M., Mittelbronn, M. G. A., & Sinkkonen, L. (2022) · Antioxidants · doi:10.3390/antiox11081426 · Cited by 76 · see citing works

Oxidative Stress-Driven Cellular Senescence: Mechanistic Crosstalk and Therapeutic Horizons

Stojanović, B., Jovanovic, I., Stojanovic, M. D., Stojanović, B., Kovačević, V., Radosavljević, I., Jovanović, D., Kovačević, M. M., Zornić, N., Arsić, A. A., et al. (2025) · Antioxidants · doi:10.3390/antiox14080987 · Cited by 83 · see citing works

Systems-Level Feedbacks of NRF2 Controlling Autophagy upon Oxidative Stress Response

Kapuy, O., Papp, D., Vellai, T., Bánhegyi, G., & Korcsmaros, T. D. (2018) · Antioxidants · doi:10.3390/antiox7030039 · Cited by 74 · see citing works

Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation

Gureev, A. P., Popov, V. N., & Starkov, A. A. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113285 · Cited by 73 · see citing works

NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells

Panieri, E., Pinho, S., Afonso, G. J. M., Oliveira, P. J., Cunha‐Oliveira, T., & Saso, L. (2022) · Cells · doi:10.3390/cells11152401 · Cited by 68 · see citing works

SIRT6 transcriptionally regulates global protein synthesis through transcription factor Sp1 independent of its deacetylase activity

Ravi, V., Jain, A., Khan, D., Ahamed, F., Mishra, S., Giri, M., Inbaraj, M., Krishna, S., Sarikhani, M., Maity, S., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz648 · Cited by 67 · see citing works

Neuroprotection during Thrombectomy for Acute Ischemic Stroke: A Review of Future Therapies

Dammavalam, V., Lin, S., Nessa, S., Daksla, N., Stefanowski, K., Costa, A., & Bergese, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020891 · Cited by 55 · see citing works

Nrf2 Is a Central Regulator of Metabolic Reprogramming of Myeloid-Derived Suppressor Cells in Steady State and Sepsis

Ohl, K., Fragoulis, A., Klemm, P., Baumeister, J., Klock, W., Verjans, E., Böll, S., Möllmann, J., Lehrke, M., Costa, I. G., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01552 · Cited by 55 · see citing works

Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease

Martín‐Montañez, E., Valverde, N., de Guevara‐Miranda, D. L., Lara, E., Romero‐Zerbo, S., Millón, C., Boraldi, F., Ávila‐Gámiz, F., Pérez-Cano, A. M., Garrido‐Gil, P., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102095 · Cited by 47 · see citing works

The NRF2 antagonist ML385 inhibits PI3K‐mTOR signaling and growth of lung squamous cell carcinoma cells

Ji, L., Moghal, N., Zou, X., Fang, Y., Hu, S., Wang, Y., & Tsao, M. (2022) · Cancer Medicine · doi:10.1002/cam4.5311 · Cited by 46 · see citing works

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration

Wang, S., Liu, C., Zhongyi, S., Yan, P., He, L., Huang, K., Li, C., & Tian, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-04384-3 · Cited by 46 · see citing works

Synergistic Effects of Milk-Derived Exosomes and Galactose on α-Synuclein Pathology in Parkinson’s Disease and Type 2 Diabetes Mellitus

Melnik, B. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031059 · Cited by 42 · see citing works

Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration

Melnik, B. C. (2021) · Biomolecules · doi:10.3390/biom11030404 · Cited by 42 · see citing works

Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells

Adinew, G. M., Messeha, S. S., Taka, E., Badisa, R. B., & Soliman, K. F. A. (2022) · Nutrients · doi:10.3390/nu14224787 · Cited by 41 · see citing works

Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury–A systematic review

Prem, P. N., Sivakumar, B., Boovarahan, S. R., & Kurian, G. A. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154123 · Cited by 36 · see citing works

A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants

Aboulkassim, T., Tian, X., Liu, Q., Qiu, D., Hancock, M. A., Wu, J. H., & Batist, G. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113104 · Cited by 35 · see citing works

An NRF2 Perspective on Stem Cells and Ageing

Dodson, M. B., Anandhan, A., Zhang, D. D., & Madhavan, L. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.690686 · Cited by 34 · see citing works

Emodin ameliorates antioxidant capacity and exerts neuroprotective effect via PKM2-mediated Nrf2 transactivation

Ding, Z., Da, H., Osama, A., Xi, J., Hou, Y., & Fang, J. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112790 · Cited by 34 · see citing works

Oxidative Stress, Inflammation, and Cellular Senescence in Neuropathic Pain: Mechanistic Crosstalk

Stojanović, B., Bevc, I. M., Stojanovic, M. D., Stojanović, B., Lazarević, T., Spasić, M., Petrovic, M., Stefanovic, I., Marković, M., Nešić, J., et al. (2025) · Antioxidants · doi:10.3390/antiox14101166 · Cited by 33 · see citing works

Lysosomes, Autophagy, and Hormesis in Cell Physiology, Pathology, and Age-Related Disease

Moore, M. N. (2020) · Dose-Response · doi:10.1177/1559325820934227 · Cited by 32 · see citing works

Pexophagy and Oxidative Stress: Focus on Peroxisomal Proteins and Reactive Oxygen Species (ROS) Signaling Pathways

Wei, X., Manandhar, L., Kim, H., Chhetri, A., Hwang, J., Jang, G., Park, C., & Park, R. (2025) · Antioxidants · doi:10.3390/antiox14020126 · Cited by 33 · see citing works

Features of increased malignancy in eosinophilic clear cell renal cell carcinoma

Nilsson, H., Lindgren, D., Axelson, H., Brueffer, C., Saal, L. H., Lundgren, J., & Johansson, M. (2020) · The Journal of Pathology · doi:10.1002/path.5532 · Cited by 32 · see citing works

SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas

Kim, A. L., Back, J. H., Chaudhary, S. C., Zhu, Y., Athar, M., & Bickers, D. R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.01.040 · Cited by 31 · see citing works

Antioxidant responses to salinity stress in an invasive species, the red-eared slider (Trachemys scripta elegans) and involvement of a TOR-Nrf2 signaling pathway

Ding, L., Li, W., Li, N., Liang, L., Zhang, X., Jin, H., Shi, H., Storey, K. B., & Hong, M. (2019) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2019.02.004 · Cited by 31 · see citing works

Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice

Abulizi, A., Ran, J., Ye, Y., An, Y., Zhang, Y., Huang, Z., Lin, S., Zhou, H., Lin, D., Wang, L., et al. (2021) · Food & Function · doi:10.1039/d1fo03055h · Cited by 30 · see citing works

Nrf2 expression driven by Foxp3 specific deletion of Keap1 results in loss of immune tolerance in mice

Klemm, P., Rajendiran, A., Fragoulis, A., Wruck, C. J., Schippers, A., Wagner, N., Bopp, T., Tenbrock, K., & Ohl, K. (2019) · European Journal of Immunology · doi:10.1002/eji.201948285 · Cited by 28 · see citing works

High amplitude and low frequency cyclic mechanical strain promotes degeneration of human nucleus pulposus cells via the NF‐κB p65 pathway

Wang, S., Li, J., Tian, J., Yu, Z., Gao, K., Shao, J., Li, A., Xing, S., Dong, Y., Li, Z., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26551 · Cited by 27 · see citing works

Age-Related Decline in Nrf2/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments

Gureev, A. P., Khorolskaya, V. G., Sadovnikova, I. S., Shaforostova, E. A., Cherednichenko, V. R., Burakova, I. Y., Plotnikov, E. Y., & Popov, V. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315197 · Cited by 26 · see citing works

Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes

Wu, J., Ni, Y., Yang, Q., Mao, J., Zhu, X., Tao, S., Kato, K., Zhang, J., Wang, D., Yamanaka, K., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139425 · Cited by 26 · see citing works

Beta-Hydroxybutyrate Mitigates Sensorimotor and Cognitive Impairments in a Photothrombosis-Induced Ischemic Stroke in Mice

Gureev, A. P., Sadovnikova, I. S., Chernyshova, E. V., Tsvetkova, A. D., Babenkova, P. I., Nesterova, V. V., Krutskikh, E. P., Volodina, D. E., Samoylova, N. A., Andrianova, N. V., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115710 · Cited by 22 · see citing works

Knockout of NRF2 triggers prostate cancer cells death through ROS modulation and sensitizes to cisplatin

Mancini, M. C. S., Morelli, A. P., Severino, M. B., Pavan, I. C. B., Zambalde, É. P., Góis, M. M., da Silva, L. G. S., Ruiz, N. Q., Romeiro, C. F., dos Santos, D. F. G., et al. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30333 · Cited by 21 · see citing works

The Roles of Oxidative Stress in Regulating Autophagy in Methylmercury-induced Neurotoxicity

Wei, Y., Ni, L., Pan, J., Li, X., Xu, B., Deng, Y. L., Yang, T., & Liu, W. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.06.026 · Cited by 20 · see citing works

The complex interplay between redox dysregulation and mTOR signaling pathway in cancer: A rationale for cancer treatment

Glorieux, C., Enriquez-Lara, C., & Calderón, P. B. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116729 · Cited by 18 · see citing works

Autophagy as a novel insight into mechanism of Danqi pill against post-acute myocardial infarction heart failure

Wang, X., Jiang, Y., Zhang, Q., Tian, X., Sun, Q., Guo, D., Wang, Q., Chai, X., Lei, P., Li, C., et al. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113404 · Cited by 18 · see citing works

Disease-Dependent Antiapoptotic Effects of Cannabidiol for Keratinocytes Observed upon UV Irradiation

Wójcik, P., Gęgotek, A., Žarković, N., & Skrzydlewska, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189956 · Cited by 18 · see citing works

Glucose deprivation triggers DCAF1-mediated inactivation of Rheb-mTORC1 and promotes cancer cell survival

Li, M., Huang, W., Zhang, Y., Du, Y., Zhao, S., Wang, L., Sun, Y., Sha, B., Yan, J., Ma, Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06808-1 · Cited by 17 · see citing works

Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Sparaneo, A., Fabrizio, F. P., la Torre, A., Graziano, P., Maïo, M. D., Fontana, A., Bisceglia, M., Rossi, A., Pizzolitto, S., Maglio, G. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102531 · Cited by 17 · see citing works

Discovery of New 2-Phenylamino-3-acyl-1,4-naphthoquinones as Inhibitors of Cancer Cells Proliferation: Searching for Intra-Cellular Targets Playing a Role in Cancer Cells Survival

Benites, J. F., Valderrama, J. A., Contreras, Á., Enriquez-Lara, C., Pino‐Rios, R., Yáñez, O., & Calderón, P. B. (2023) · Molecules · doi:10.3390/molecules28114323 · Cited by 15 · see citing works

Development of targeted therapy of NRF2high esophageal squamous cell carcinoma

Paiboonrungruang, C., Simpson, E., Xiong, Z., Huang, C. D., Li, J., Li, Y., & Chen, X. L. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110105 · Cited by 15 · see citing works

Intensity, Duration, and Context Dependency of the Responses to Nutrient Surplus and Deprivation Signaling in the Heart: Insights Into the Complexities of Cardioprotection

Packer, M. (2025) · Circulation · doi:10.1161/circulationaha.125.075568 · Cited by 15 · see citing works

Transcription Factor Nrf2 and Mitochondria – Friends or Foes in the Regulation of Aging Rate

Shilovsky, G. A., & Ashapkin, V. V. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922120057 · Cited by 13 · see citing works

Carvacrol attenuated myocardial infarction through NLRP3-mediated pyroptosis and mTOR/Nrf2/PPARγ-dependent autophagic signaling

Aslam, H., Albaqami, F. F., Rehman, N. U., & Shah, F. A. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117281 · Cited by 14 · see citing works

Dual mTOR1/2 Inhibitor Sapanisertib (FTH-003/TAK-228) in Combination With Weekly Paclitaxel in Patients With Previously Treated Metastatic Urothelial Carcinoma: A Phase II Open-Label Study

Joaquim Bellmunt, B., Maroto, P., Bonfill, T., Vazquez, F., Perez‐Gracia, J. L., Juanpere-Rodero, N., Hernández‐Prat, A., Hernández‐Llodrà, S., Rovira, A., Juan, O., et al. (2024) · Clinical Genitourinary Cancer · doi:10.1016/j.clgc.2024.102123 · Cited by 13 · see citing works

Rapid or Slow Time to Brain Death? Impact on Kidney Graft Injuries in an Allotransplantation Porcine Model

Kerforne, T., Giraud, S., Danion, J., Thuillier, R., Couturier, P., Hébrard, W., Mimoz, O., & Hauet, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153671 · Cited by 12 · see citing works

NRF2 and STAT3: friends or foes in carcinogenesis?

Arena, A., Romeo, M. A., Benedetti, R., Montani, M. S. G., Santarelli, R., Gonnella, R., D’Orazi, G., & Cirone, M. (2023) · Discover Oncology · doi:10.1007/s12672-023-00644-z · Cited by 12 · see citing works

TNFα enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy

Ahn, J., Jegal, H., Choi, M., Kim, S., Park, S., Ahn, J.-H., Han, H., Cho, H., Yoon, S., & Oh, J. (2021) · Toxicology Letters · doi:10.1016/j.toxlet.2021.02.009 · Cited by 10 · see citing works

Cancer Prevention and Therapy by Targeting Oxidative Stress Pathways

Saha, S., Saso, L., & Armağan, G. (2023) · Molecules · doi:10.3390/molecules28114293 · Cited by 10 · see citing works

Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

Hu, Z.-L., Lin, Z.-Y., Ren, W.-S., Liu, B., Zhao, H., & Qin, Q. (2024) · International Journal of Ophthalmology · doi:10.18240/ijo.2024.07.21 · Cited by 9 · see citing works

NRF2 signaling and amino acid metabolism in cancer

Ham, S., Choi, B.-H., & Kwak, M. (2024) · Free Radical Research · doi:10.1080/10715762.2024.2423690 · Cited by 9 · see citing works

Effects of hydrogen peroxide and l-tryptophan on antioxidative potential, apoptosis, and mammalian target of rapamycin signaling in bovine intestinal epithelial cells

Wei, X., Li, D., Feng, C., Mao, H., Zhu, J., Cui, Y., Yang, J., Gao, H., & Wang, C. (2022) · Journal of Dairy Science · doi:10.3168/jds.2022-21869 · Cited by 9 · see citing works

The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility

Zhang, S., Shi, W., Ramsay, E. S., Bliskovsky, V. V., Eiden, A. M., Connors, D. E., Steinsaltz, M., Dubois, W., & Mock, B. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009779 · Cited by 9 · see citing works

An integrative investigation on significant mutations and their down-stream pathways in lung squamous cell carcinoma reveals CUL3/KEAP1/NRF2 relevant subtypes

Liu, Z., Deng, M.-Y., Wu, L., & Zhang, S. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00166-2 · Cited by 9 · see citing works

Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling

Zhang, G., Liang, Z., Wang, Y., Zhang, Z., & Hoi, M. P. M. (2024) · Antioxidants · doi:10.3390/antiox13101272 · Cited by 8 · see citing works

Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus

Casanova-Maldonado, I., Arancibia, D., Lois, P., Peña‐Villalobos, I., & Palma, V. (2023) · Biological Research · doi:10.1186/s40659-023-00444-3 · Cited by 8 · see citing works

The molecular determinants regulating redox signaling in diabetic endothelial cells

Srivastava, S. P., Kopasz-Gemmen, O., Thurman, A., Rajendran, B. K., Selvam, M., Kumar, S., Srivastava, R., Suresh, M. X., Kumari, R., Goodwin, J. E., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1563047 · Cited by 9 · see citing works

Pre-imaginal exposure to mancozeb induces morphological and behavioral deficits and oxidative damage in Drosophila melanogaster

Ziech, C. C., Rodrigues, N. R., Macedo, G. E., Gomes, K. K., Martins, I. K., Franco, J. L., & Posser, T. (2022) · Drug and Chemical Toxicology · doi:10.1080/01480545.2022.2069802 · Cited by 7 · see citing works

Milk Exosomes and MicroRNAs: Potential Epigenetic Regulators

Melnik, B. C., & Kakulas, F. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_86 · Cited by 7 · see citing works

Immunoregulation: the interplay between metabolism and redox homeostasis

Perpiñán, E., Fueyo, A. S., & Safinia, N. (2023) · Frontiers in Transplantation · doi:10.3389/frtra.2023.1283275 · Cited by 6 · see citing works

Antioxidant and anti-inflammatory effects of Cinnamomum species and their bioactive compounds: An updated review of the molecular mechanisms

Davoudi, F., & Ramazani, E. (2024) · Physiology and Pharmacology · doi:10.61186/phypha.28.2.99 · Cited by 6 · see citing works

The endocrine and epigenetic impact of persistent cow milk consumption on prostate carcinogenesis

Melnik, B. C., John, S. M., Weiskirchen, R., & Schmitz, G. (2022) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2021.37 · Cited by 6 · see citing works

Folic Acid Alleviates Hydrogen Peroxide-Induced Oxidative Stress in Bovine Placental Trophoblast Cells by Regulating the NRF2/mTOR Signaling Pathway

Shi, L., Wang, Z., Xiao, J., Hu, R., Zou, H., Wang, J., Yue, Z., Peng, Q., Jiang, Y., Xue, B., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062818 · Cited by 6 · see citing works

Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133+ cells

Shrestha, S., Singhal, S. K., Sens, D. A., Somji, S., Davis, B., Guyer, R., Breen, S., Kalonick, M., & Garrett, S. H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248241 · Cited by 6 · see citing works

Origins and Timing of Emerging Lesions in Advanced Renal Cell Carcinoma

Wallace, A., Porten, S. P., Lo, A. A., Oreper, D., Lounsbury, N., Havnar, C., Pechuan-Jorge, X., Zill, O. A., & Meng, M. V. (2022) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-21-0590 · Cited by 5 · see citing works

Characterization of a Clinically and Biologically Defined Subgroup of Patients with Autism Spectrum Disorder and Identification of a Tailored Combination Treatment

Pérez‐Cano, L., Boccuto, L., Sirci, F., Hidalgo, J. M., Valentini, S., Bosio, M., D’ardhuy, X. L., Skinner, C. D., Cascio, L., Srikanth, S., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12050991 · Cited by 5 · see citing works

Molecular mechanism on autophagy associated cardiovascular dysfunction in Drosophila melanogaster

Zhang, W., Zhou, R., Lei, X., Wang, M., Duan, Q., Miao, Y., Zhang, T., Li, X., Zutong, Z., Wang, L., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1512341 · Cited by 5 · see citing works

Milk Exosomes and microRNAs: Potential Epigenetic Regulators

Melnik, B. C., & Kakulas, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_86-1 · Cited by 5 · see citing works

An Update on Role of Ionizing Radiation to Enhance Proliferation and Differentiation of Normal Stem Cells via Activation of NRF2 Pathway: Review

Moloudi, K., & Haghdoost, S. (2025) · Antioxidants · doi:10.3390/antiox14080986 · Cited by 4 · see citing works

CHML is an NRF2 target gene that regulates mTOR function

Dodson, M. B., Dai, W., Anandhan, A., Schmidlin, C. J., Liu, P., Wilson, N. C., Wei, Y., Kitamura, N., Galligan, J. J., Ooi, A., et al. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13194 · Cited by 4 · see citing works

Insights into Molecular Mediators of Oxidative Stress and Inflammation in Glioblastoma Multiforme

Anitha, T. S., Kuduvalli, S. S., Biswas, I., Mariappan, V., & Mangaiyarkarasi, N. (2020) · SBV Journal of Basic Clinical and Applied Health Science · doi:10.5005/jp-journals-10082-02274 · Cited by 4 · see citing works

Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine

Malarz, K., Zioła, P., Zych, D., Rurka, P., & Mrozek‐Wilczkiewicz, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-77575-4 · Cited by 3 · see citing works

UFMylation deficiency in hepatocytes activates the KEAP1-NRF2 pathway and contributes to hepatocarcinogenesis

Liang, Q., Xu, S., Fang, Y., Wang, X., Xiao, Y., Wang, Y., Li, S., Guo, Q., Cao, Y., Cao, Y., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104046 · Cited by 2 · see citing works

Bioactive peptides alleviating oxidative stress-associated diseases by targeting the Nrf2 signaling pathway

Qin, D., Hu, Z., Han, S., Luo, Y., Yang, F., Xie, T., & Luo, F. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250253 · Cited by 2 · see citing works

Association of polymorphisms in NFE2L2 gene encoding transcription factor Nrf2 with multifactorial diseases

Porokhovnik, L. N., & Писарев, В. М. (2017) · Russian Journal of Genetics · doi:10.1134/s1022795417080051 · Cited by 2 · see citing works

MYOD and HAND transcription factors have conserved recognition sites in mTOR promoter: insights from in silico analysis

Awasthi, A., Nain, V., & Puria, R. (2018) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-018-0284-5 · Cited by 2 · see citing works

The PI3K pathway is a downstream effector of NRF2 activation in the esophagus

Subramaniyan, B., Li, Y., Xiong, Z., Paiboonrungruang, C., Bui-Linh, C., Spitz, F. J., & Chen, X. L. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102629 · Cited by 1 · see citing works

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Porokhovnik, L. N., & Писарев, В. М. (2017) · Генетика · doi:10.7868/s0016675817080057

The Part Breast Milk Plays in Epigenetic Programming

Şahin, Ö. N. (2023) · Springer eBooks · doi:10.1007/978-3-031-33278-4_12

Canine prostate cancer cell transcriptome reveals important dysregulation in PI3K/AKT/mTOR pathway

Kobayashi, P. E., Lainetti, P. D. F., Leis‐Filho, A. F., Delella, F. K., Vicente, I. S. T., Fonseca‐Alves, C. E., & Amorim, R. L. (2025) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2025.03.190

Nrf2 modulates macrophage foam cells senescence and autophagy activation

Wai, K. W., Tang, Y.-Q., Foo, J. B., Goh, B. H., & Yap, W. H. (2025) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2025.2595439

Additional file 2 of Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus

Casanova-Maldonado, I., Arancibia, D., Lois, P., Peña‐Villalobos, I., & Palma, V. (2024) · Figshare · doi:10.6084/m9.figshare.26603869

Additional file 1 of Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus

Casanova-Maldonado, I., Arancibia, D., Lois, P., Peña‐Villalobos, I., & Palma, V. (2024) · Figshare · doi:10.6084/m9.figshare.26603866

Design, Synthesis, and Antitumor Activity of D‐13 Derivatives

Wang, X., Hao, H., Gao, Z., Wang, W., Ma, S., Zhao, Y., & Ji, J. (2026) · ChemistrySelect · doi:10.1002/slct.202506961

Le donneur de rein décédé, principes physiopathologiques et innovations thérapeutiques

Kerforne, T. (2018) · doi:10.70675/f25441cfz0e1bz40f5zbae0z0ea1d0037f9f

Isolation and characterization of Phanerochaete chrysosporium mutants resistant to antifungal compounds

Nguyen, D. V. (2020) · doi:10.70675/08063494zf72ez49d9z97cfz5c5d74d325a7

The antioxidant transcription factor NRF2 as a new regulator of the extracellular matrix in human skin fibroblasts

Salamito, M. (2020) · doi:10.70675/06c757bdz04c8z4119za1e4z46921f1528b1

mTOR transcriptional regulation by Nrf2

Bendavit, G. (2015) · eScholarship@McGill (McGill) · doi:10.82308/1214

Molecular Mechanism of Nrf2 Activation by Oxidative Stress

Kang, K. W., Lee, S. J., & Kim, S. G. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1664 · Cited by 361 · see citing works

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

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Regulation of Nrf2 Transactivation Domain Activity

Shen, G., Hebbar, V., Nair, S., Xu, C., Li, W., Lin, W., Keum, Y.-S., Han, J., Gallo, M. A., & Kong, A.-N. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401368200 · Cited by 194 · see citing works

Phosphatidylinositol 3-Kinase Regulates Nuclear Translocation of NF-E2-Related Factor 2 through Actin Rearrangement in Response to Oxidative Stress

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