The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structure of Formamidopyrimidine-DNA Glycosylase Covalently Complexed to DNA
Open accessAbstract
Formamidopyrimidine-DNA glycosylase (Fpg) is a DNA repair enzyme that excises oxidized purines from damaged DNA. The Schiff base intermediate formed during this reaction between Escherichia coli Fpg and DNA was trapped by reduction with sodium borohydride, and the structure of the resulting covalently cross-linked complex was determined at a 2.1-A resolution. Fpg is a bilobal protein with a wide, positively charged DNA-binding groove. It possesses a conserved zinc finger and a helix-two turn-helix motif that participate in DNA binding. The absolutely conserved residues Lys-56, His-70, Asn-168, and Arg-258 form hydrogen bonds to the phosphodiester backbone of DNA, which is sharply kinked at the lesion site. Residues Met-73, Arg-109, and Phe-110 are inserted into the DNA helix, filling the void created by nucleotide eversion. A deep hydrophobic pocket in the active site is positioned to accommodate an everted base. Structural analysis of the Fpg-DNA complex reveals essential features of damage recognition and the catalytic mechanism of Fpg.
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Citations
Cites
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
Self-citationOxidative Nucleobase Modifications Leading to Strand Scission
Burrows, C. J., & Muller, J. G. (1998) · Chemical Reviews · doi:10.1021/cr960421s · Cited by 1,736
Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation
Livingstone, C. D., & Barton, G. J. (1993) · Bioinformatics · doi:10.1093/bioinformatics/9.6.745 · Cited by 550
Cited by
A Mechanistic Perspective on the Chemistry of DNA Repair Glycosylases
Stivers, J. T., & Jiang, Y. L. (2003) · Chemical Reviews · doi:10.1021/cr010219b · Cited by 447
Zharkov, D. O. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7543-2 · Cited by 310
Self-citationHitomi, K., Iwai, S., & Tainer, J. A. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.10.004 · Cited by 220
Metadata
- Authors
- Gilboa, R., Zharkov, D. O., Golan, G., Fernandes, A. S., Gerchman, S. E., Matz, E., Kycia, J. H., Grollman, A. P., & Shoham, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-05
- Volume
- 277
- Issue
- 22
- Pages
- 19811-19816
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2042937673
- Cited by
- 248
- References
- 3
- FWCI
- 7.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gilboa, R., Zharkov, D. O., Golan, G., Fernandes, A. S., Gerchman, S. E., Matz, E., Kycia, J. H., Grollman, A. P., & Shoham, G. (2002). Structure of Formamidopyrimidine-DNA Glycosylase Covalently Complexed to DNA. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m202058200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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