Annexin XXI (ANX21) of Giardia lamblia Has Sequence Motifs Uniquely Shared by Giardial Annexins and Is Specifically Localized in the Flagella

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617 · see citing works

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

Guex, N., & Peitsch, M. (1997) · Electrophoresis · doi:10.1002/elps.1150181505 · Cited by 11,589 · see citing works

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

Matsudaira, P. T. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61070-1 · Cited by 4,951 · see citing works

Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G‐250 and R‐250

NEUHOFF, V., Arold, N., Taube, D., & Ehrhardt, W. (1988) · Electrophoresis · doi:10.1002/elps.1150090603 · Cited by 2,676 · see citing works

Biology of Giardia lamblia

Adam, R. D. (2001) · Clinical Microbiology Reviews · doi:10.1128/cmr.14.3.447-475.2001 · Cited by 1,218 · see citing works

Axenic culture of Giardia lamblia in TYI-S-33 medium supplemented with bile

Keister, D. B. (1983) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(83)90120-7 · Cited by 986 · see citing works

Annexins and membrane dynamics

Gerke, V., & Moss, S. E. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00038-4 · Cited by 347 · see citing works

Reconstructing Early Events in Eukaryotic Evolution

Roger, A. J. (1999) · The American Naturalist · doi:10.1086/303290 · Cited by 283 · see citing works

The Giardia genome project database

McArthur, A. G., Morrison, H. G., Nixon, J. E. J., Passamaneck, N. Q. E., Kim, U., Hinkle, G., Crocker, M. K., Holder, M., Farr, R. L., Reich, C. I., et al. (2000) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2000.tb09242.x · Cited by 170 · see citing works

[6] Analysis of products of mitochondrial protein synthesis in yeast: Genetic and biochemical aspects

Douglas, M. G., FINKELSTEIN, D. B., & Butow, R. A. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)56009-1 · Cited by 158 · see citing works

Characterisation and purification of pyruvate:ferredoxin oxidoreductase from Giardia duodenalis

Townson, S. M., Upcroft, J., & Upcroft, P. (1996) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(96)02661-8 · Cited by 141 · see citing works

Ultrastructural localization of giardins to the edges of disk microribbons of Giarida lamblia and the nucleotide and deduced protein sequence of alpha giardin.

Peattie, D. A., Alonso, R. A., Hein, A., & CAULFIELD, J. P. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.5.2323 · Cited by 132 · see citing works

The C Terminus of Annexin II Mediates Binding to F-actin

Filipenko, N. R., & Waisman, D. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009710200 · Cited by 128 · see citing works

Annexins : molecular structure to cellular function

Seaton, B. A. (1996) · Cited by 128 · see citing works

Identification and characterization of a novel type of annexin-membrane interaction: Ca2+ is not required for the association of annexin II with early endosomes

Jost, M., Zeuschner, D., Seemann, J., Weber, K. K., & Gerken, V. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.2.221 · Cited by 107 · see citing works

Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family.

Grundmann, U., Abel, K. J., Bohn, H., Löbermann, H., Lottspeich, F., & Küpper, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3708 · Cited by 78 · see citing works

Giardia in Humans and Animals

Kulda, J., & Nohýnková, E. (1995) · Elsevier eBooks · doi:10.1016/b978-0-12-426020-7.50008-6 · Cited by 77 · see citing works

Molecular phylogeny of annexins and identification of a primitive homologue in Giardia lamblia.

(1995) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040290 · Cited by 69 · see citing works

Distinct Annexin Subfamilies in Plants and Protists Diverged Prior to Animal Annexins and from a Common Ancestor

Morgan, R. O., & Fernández, M. P. (1997) · Journal of Molecular Evolution · doi:10.1007/pl00006134 · Cited by 67 · see citing works

Purification and characterization of annexin proteins from bovine lung

Khanna, N., Helwig, E. D., Ikebuchi, N. W., Fitzpatrick, S., Bajwa, R., & Waisman, D. M. (1990) · Biochemistry · doi:10.1021/bi00472a015 · Cited by 66 · see citing works

Assembly of 2·5 nm filaments from giardin, a protein associated with cytoskeletal microtubules in Giardia

Crossley, R., & Holberton, D. V. (1985) · Journal of Cell Science · doi:10.1242/jcs.78.1.205 · Cited by 63 · see citing works

Localization of gamma-tubulin in interphase and mitotic cells of a unicellular eukaryote, Giardia intestinalis

Nohýnková, E., Dráber, P., Reischig, J., & Kulda, J. (2000) · European Journal of Cell Biology · doi:10.1078/0171-9335-00066 · Cited by 53 · see citing works

Isolation and characterization of two novel calcium‐dependent phospholipid‐binding proteins from bovine lung

Boustead, C. M., Walker, J. H., & Geisow, M. J. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80433-2 · Cited by 44 · see citing works

Nucleotide sequence of a second alpha giardin gene and molecular analysis of the alpha giardin genes and transcripts in Giardia lamblia

Alonso, R. A., & Peattie, D. A. (1992) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(92)90247-h · Cited by 40 · see citing works

Calmodulin-binding properties of the paraflagellar rod complex from Trypanosoma brucei

Ridgley, E. L., Webster, P. C., Patton, C. L., & Ruben, L. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(00)00246-2 · Cited by 40 · see citing works

The Giardins of Giardia lamblia: Genes and proteins with promise

Peattie, D. A. (1990) · Parasitology Today · doi:10.1016/0169-4758(90)90070-k · Cited by 38 · see citing works

Functional identification of α1-giardin as an annexin ofGiardia lamblia

BAUER, B. E., Engelbrecht, S., Bakker-Grunwald, T., & Scholze, H. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb13496.x · Cited by 35 · see citing works

Triton-labile antigens in flagella isolated from Giardia lamblia

Clark, J. T., & Holberton, D. V. (1988) · Parasitology Research · doi:10.1007/bf00535140 · Cited by 32 · see citing works

The predominant calcimedins from Trypanosoma brucei comprise a family of flagellar EF-hand calcium-binding proteins

Wu, Y., Haghighat, N. G., & Ruben, L. (1992) · Biochemical Journal · doi:10.1042/bj2870187 · Cited by 32 · see citing works

Differential localization of annexins in ram germ cells: a biochemical and immunocytochemical study.

Feinberg, J. M., Rainteau, D. P., Kaetzel, M. A., Dacheux, J., Dedman, J. R., & Weinman, S. J. (1991) · Journal of Histochemistry & Cytochemistry · doi:10.1177/39.7.1830893 · Cited by 24 · see citing works

The cytoskeleton of Giardia lamblia

Elmendorf, H. G., Dawson, S. C., & McCaffery, J. M. (2003) · International Journal for Parasitology · doi:10.1016/s0020-7519(02)00228-x · Cited by 196 · see citing works

Annexin-like alpha giardins: a new cytoskeletal gene family in Giardia lamblia

Weiland, M. E.-L., McArthur, A. G., Morrison, H. G., Sogin, M. L., & Svärd, S. G. (2005) · International Journal for Parasitology · doi:10.1016/j.ijpara.2004.12.009 · Cited by 93 · see citing works

Life with eight flagella: flagellar assembly and division in Giardia

Dawson, S. C., & House, S. A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.014 · Cited by 59 · see citing works

An insider's guide to the microtubule cytoskeleton ofGiardia

Dawson, S. C. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01458.x · Cited by 57 · see citing works

High-resolution crystal structure and in vivo function of a kinesin-2 homologue in Giardia intestinalis.

Hoeng, J., Dawson, S., House, S. A., Sagolla, M., Pham, J. K., Mancuso, J., Löwe, J., & Cande, W. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-11-1156 · Cited by 62 · see citing works

Microtubule organelles in Giardia

Hagen, K. D., McInally, S. G., Hilton, N. A., & Dawson, S. C. (2020) · Advances in Parasitology/Advances in parasitology · doi:10.1016/bs.apar.2019.11.001 · Cited by 34 · see citing works

α14-Giardin (annexin E1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella

Vahrmann, A., Šarić, M., Scholze, H., & Koebsch, I. (2007) · Parasitology Research · doi:10.1007/s00436-007-0758-6 · Cited by 29 · see citing works

Dual Acylation Accounts for the Localization of α19-Giardin in the Ventral Flagellum Pair of <i>Giardia lamblia</i>

Šarić, M., Vahrmann, A., Niebur, D., Kluempers, V., Hehl, A. B., & Scholze, H. (2009) · Eukaryotic Cell · doi:10.1128/ec.00136-09 · Cited by 24 · see citing works

Apo and Calcium-Bound Crystal Structures of Cytoskeletal Protein Alpha-14 Giardin (Annexin E1) from the Intestinal Protozoan Parasite Giardia lamblia

Pathuri, P., Nguyen, E. T., Ozorowski, G., Svärd, S. G., & Luecke, H. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.11.012 · Cited by 19 · see citing works

Helix–helix interfaces and ligand binding

Kurochkina, N. A., & Choekyi, T. (2011) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2011.05.014 · Cited by 19 · see citing works

Comparative Cell Biology and Evolution of Annexins in Diplomonads

Einarsson, E., Ástvaldsson, Á., Hultenby, K., Andersson, J. O., Svärd, S. G., & Jerlström-Hultqvist, J. (2016) · mSphere · doi:10.1128/msphere.00032-15 · Cited by 15 · see citing works

Identification of α-11 giardin as a flagellar and surface component of Giardia lamblia

Kim, J., Lee, H. Y., Lee, M., Yong, T., Lee, K.-H., & Park, S. (2013) · Experimental Parasitology · doi:10.1016/j.exppara.2013.07.010 · Cited by 15 · see citing works

Role of gamma-giardin in ventral disc formation of Giardia lamblia

Kim, J., & Park, S. (2019) · Parasites & Vectors · doi:10.1186/s13071-019-3478-8 · Cited by 12 · see citing works

Cell Biology of the Life Cycle of Giardia intestinalis

Benchimol, M., Gadelha, A. P. R., & de Souza, W. (2022) · Microbiology monographs · doi:10.1007/978-3-030-80682-8_11 · Cited by 6 · see citing works

Interaction of Giardia with Host Cells

Ortega‐Pierres, G., Bazán‐Tejeda, M. L., Fonseca-Liñán, R., Bermúdez‐Cruz, R. M., & Argüello-García, R. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0198-8_17 · Cited by 4 · see citing works

Primary Microtubule Structures in Giardia

Dawson, S. C. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0198-8_18 · Cited by 3 · see citing works

Membrane dynamics in giardia: Structure, function, and host interactions

Vicente, B., Freitas, A. D., & Midlej, V. D. V. P. (2025) · Current topics in membranes · doi:10.1016/bs.ctm.2025.06.005

The N’ terminus of Alpha-1 Giardin, a parasitic annexin orthologue, is essential for oligomerization and lipid-binding activityPreprint

Warmus, D., Wirdnam, C. D., Balmer, E. A., Muronzi, T., Heller, M., Bishop, Ö. T., & Faso, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.09.697555

The N-terminus of alpha-1 giardin, a parasitic annexin orthologue, is essential for oligomerization and lipid-binding activity

Warmus, D., Wirdnam, C. D., Balmer, E. A., Muronzi, T., Heller, M., Bishop, Ö. T., & Faso, C. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014407

Functional identification of α1-giardin as an annexin ofGiardia lamblia

BAUER, B. E., Engelbrecht, S., Bakker-Grunwald, T., & Scholze, H. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb13496.x · Cited by 35 · see citing works

α14-Giardin (annexin E1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella

Vahrmann, A., Šarić, M., Scholze, H., & Koebsch, I. (2007) · Parasitology Research · doi:10.1007/s00436-007-0758-6 · Cited by 29 · see citing works

Structural characterization and localization of annexin E1 in trophozoites of Giardia lamblia

Vahrmann, A., Szkodowska, A., Linke, C., Mueller, M. C. M., Bakker-Grunwald, T., & Scholze, H. (2004) · GBM Annual Fall meeting M�nster 2004 · doi:10.1240/sav_gbm_2004_h_000755

Annexin homologues in Giardia lamblia

Fiedler, K., & Simons, K. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89001-5 · Cited by 17 · see citing works

Comparative Cell Biology and Evolution of Annexins in Diplomonads

Einarsson, E., Ástvaldsson, Á., Hultenby, K., Andersson, J. O., Svärd, S. G., & Jerlström-Hultqvist, J. (2016) · mSphere · doi:10.1128/msphere.00032-15 · Cited by 15 · see citing works