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Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids

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GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling

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APPL1 Potentiates Insulin-Mediated Inhibition of Hepatic Glucose Production and Alleviates Diabetes via Akt Activation in Mice

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APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

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Bax Mediates the Apoptosis-Sensitizing Effect of Maspin

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Human Follicle-Stimulating Hormone (FSH) Receptor Interacts with the Adaptor Protein APPL1 in HEK 293 Cells: Potential Involvement of the PI3K Pathway in FSH Signaling1

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APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex

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Filtering of Ineffective siRNAs and Improved siRNA Design Tool

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RNAi as a gene therapy approach

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Crystal Structures of the BAR-PH and PTB Domains of Human APPL1

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Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription

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Cdo Interacts with APPL1 and Activates AKT in Myoblast Differentiation

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Adaptor Protein APPL1 Couples Synaptic NMDA Receptor with Neuronal Prosurvival Phosphatidylinositol 3-Kinase/Akt Pathway

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Membrane Targeting by APPL1 and APPL2: Dynamic Scaffolds that Oligomerize and Bind Phosphoinositides

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Intranasal administration of recombinant Netrin-1 attenuates neuronal apoptosis by activating DCC/APPL-1/AKT signaling pathway after subarachnoid hemorrhage in rats

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An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons

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Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3τ interaction domain with a canonical G-protein interaction site

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RNA interference: gene silencing in the fast lane

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Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity

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Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats

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Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling

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Adiponectin as a Potential Therapeutic Target for Prostate Cancer

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APPLied mechanics: Uncovering how adiponectin modulates insulin action

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The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration

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Curcumin alleviates ischemia reperfusion‐induced late kidney fibrosis through the APPL1/Akt signaling pathway

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Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex

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Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment

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Netrin-1 in Post-stroke Neuroprotection: Beyond Axon Guidance Cue

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APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain

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Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway

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Introducing the CPL/MUW proteome database: Interpretation of human liver and liver cancer proteome profiles by referring to isolated primary cells

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The Melanosome: Dark Pigment Granule Shines Bright Light on Vesicle Biogenesis and More

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Serine 707 of APPL1 is Critical for the Synaptic NMDA Receptor-Mediated Akt Phosphorylation Signaling Pathway

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Use of the Gateway System for Protein Expression in Multiple Hosts

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Identification of Phosphorylation Sites within the Signaling Adaptor APPL1 by Mass Spectrometry

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APPL Proteins FRET at the BAR: Direct Observation of APPL1 and APPL2 BAR Domain-Mediated Interactions on Cell Membranes Using FRET Microscopy

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EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence

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Dependence Receptors: What Is the Mechanism?

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Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking

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Adaptor protein APPL1 interacts with EGFR to orchestrate EGF-stimulated signaling

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Apoptosis initiated by dependence receptors: a new paradigm for cell death?

Porter, A. G., & Dhakshinamoorthy, S. (2004) · BioEssays · doi:10.1002/bies.20037 · Cited by 17

Multifunctional protein APPL2 contributes to survival of human glioma cells

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Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells

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Single-cell SNP analyses and interpretations based on RNA-Seq data for colon cancer research

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α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration

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Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis

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Lost expression of DCC gene in ovarian cancer and its inhibition in ovarian cancer cells

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Netrin-1 inducing antiapoptotic effect of acute myeloid leukemia cells in a concentration-dependent manner through the Unc-5 netrin receptor B-focal adhesion kinase axis

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Dependence receptors: Mechanisms of an announced death

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Interactions between GIPC–APPL and GIPC–TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes

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Hypoxia leads to decreased autophosphorylation of the MET receptor but promotes its resistance to tyrosine kinase inhibitors

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Expression of APPL1 Is Correlated with Clinicopathologic Characteristics and Poor prognosis in Patients with Gastric Cancer

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Experimental verification of a predicted novel microRNA located in human PIK3CA gene with a potential oncogenic function in colorectal cancer

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Meeting Report: Cellular Dependence--Old Concept, New MechanismsA review of the meeting Dependence Receptors, Fondation des Treilles, France, 3 to 7 July 2003.

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Insulin and adipokine signaling and their cross-regulation in postmortem human brain

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Characterization and distribution of adaptor protein containing a PH domain, PTB domain and leucine zipper motif (APPL1) in Alzheimer’s disease hippocampus: an immunohistochemical study

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Resurgence of phosphotyrosine binding domains: Structural and functional properties essential for understanding disease pathogenesis

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Endosomal Protein Traffic Meets Nuclear Signal Transduction Head On

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Regulatory mechanisms of apoptosis in regularly dividing cells

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DCC (deleted in colorectal carcinoma)

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Role of the DIP Molecules in DCC Signaling

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The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

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Induction of apoptosis and G2/M cell cycle arrest by DCC

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DCC Functions as a Tumor Suppressor via Induction of Apoptosis

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DCC constrains tumour progression via its dependence receptor activity

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