The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer
Open accessAbstract
Quantitative bioluminescence resonance energy transfer (BRET) analysis was applied to the study of beta(1)- and beta(2)-adrenergic receptor homo- and heterodimerization. To assess the relative affinity between each of the protomers, BRET saturation experiments were carried out in HEK-293T cells. beta(1)- and beta(2)-adrenergic receptors were found to have similar propensity to engage in homo- and heterotropic interactions suggesting that, at equivalent expression levels of the two receptor subtypes, an equal proportion of homo- and heterodimers would form. Analysis of the data also revealed that, at equimolar expression levels of energy donor and acceptor, more than 80% of the receptor molecules exist as dimers and that this high incidence of receptor dimerization is insensitive to receptor density for expression levels varying between 1.4 and 26.9 pmol of receptor/mg of membrane protein. Taken together, these results indicate that most of the receptors expressed in cells exist as constitutive dimers and that, at least in undifferentiated fibroblasts, the proportion of homo- and heterodimers between the closely related beta(1)- and beta(2)-adrenergic receptors is determined by their relative levels of expression.
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Cites
Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
Bristow, M. R., Ginsburg, R., Minobe, W., Cubicciotti, R. S., Sageman, W. S., Lurie, K., Billingham, M. E., Harrison, D. C., & Stinson, E. B. (1982) · New England Journal of Medicine · doi:10.1056/nejm198207223070401 · Cited by 2,270
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,235
Bristow, M. R., Ginsburg, R., Umans, V, Fowler, M., Minobe, W., Rasmussen, R., Zera, P., Menlove, R., Shah, P., & Jamieson, S. (1986) · Circulation Research · doi:10.1161/01.res.59.3.297 · Cited by 1,327
GABAB-receptor subtypes assemble into functional heteromeric complexes
Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R., et al. (1998) · Nature · doi:10.1038/25360 · Cited by 1,195
Rocheville, M., Lange, D. C., Kumar, U., Patel, S. C., Patel, R. C., & Patel, Y. C. (2000) · Science · doi:10.1126/science.288.5463.154 · Cited by 888
Hebert, T. E., Moffett, S., Morello, J.-P., Loisel, T. P., Bichet, D. G., Barret, C., & Bouvier, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16384 · Cited by 775
Self-citationAdrenergic and Muscarinic Receptors in the Human Heart
Brodde, O.-E., & Michel, M. C. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01425-x · Cited by 673
Oligomerization of G-protein-coupled transmitter receptors
Bouvier, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35067575 · Cited by 669
Self-citationXu, Y., Piston, D. W., & Johnson, C. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.151 · Cited by 617
Mellon, P., Parker, V., Gluzman, Y., & Maniatis, T. (1981) · Cell · doi:10.1016/0092-8674(81)90411-6 · Cited by 598
Cited by
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Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G. F., Thian, F. S., Kobilka, T. S., Choi, H.-J., Kuhn, P., Weis, W. I., Kobilka, B. K., et al. (2007) · Science · doi:10.1126/science.1150577 · Cited by 3,264
Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J., Couturier, C., Delagrange, P., & Jockers, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601193 · Cited by 334
Doumazane, E., Scholler, P., Zwier, J. M., Trinquet, E., Rondard, P., & Pin, J. (2011) · The FASEB Journal · doi:10.1096/fj.10-163147 · Cited by 324
AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
Kalatskaya, I., Berchiche, Y. A., Gravel, S., Limberg, B. J., Rosenbaum, J. S., & Heveker, N. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.053389 · Cited by 309
Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity
Urizar, E., Montanelli, L., Loy, T., Bonomi, M., Swillens, S., Gales, C., Bouvier, M., Smits, G., Vassart, G., & Costagliola, S. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600686 · Cited by 295
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Metadata
- Authors
- Mercier, J.-F., Salahpour, A., Angers, S., Breit, A., & Bouvier, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 277
- Issue
- 47
- Pages
- 44925-44931
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2041138404
- Cited by
- 473
- References
- 34
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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