The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
pH-Dependent Intramolecular Binding and Structure Involving Cx43 Cytoplasmic Domains
Open accessAbstract
pH-induced closure of connexin43 (Cx43) channels involves interaction of the Cx43 carboxyl-terminal (Cx43CT) with a separate "receptor" domain. The receptor location and structure and whether the interaction is directly intramolecular are unknown. Here we show resonant mirror technology, enzyme-linked sorbent assays, and nuclear magnetic resonance (NMR) experiments demonstrating pH-dependent binding of Cx43CT to region 119-144 of Cx43 (Cx43L2), which we propose is the receptor. NMR showed that acidification induced alpha-helical order in Cx43L2, whereas only a minor modification in Cx43CT structure was detected. These data provide the first demonstration of chemically induced structural order and binding between cytoplasmic connexin domains.
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AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMR
Laskowski, R., Rullmann, J. A., MacArthur, M., Kaptein, R., & Thornton, J. (1996) · Journal of Biomolecular NMR · doi:10.1007/bf00228148 · Cited by 5,502
Protein backbone angle restraints from searching a database for chemical shift and sequence homology
Cornilescu, G., Delaglio, F., & Bax, A. (1999) · Journal of Biomolecular NMR · doi:10.1023/a:1008392405740 · Cited by 2,957
Cited by
Xie, H., Vucetic, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Obradovic, Z., & Uversky, V. N. (2007) · Journal of Proteome Research · doi:10.1021/pr060394e · Cited by 382
Glial Connexins and Pannexins in the Healthy and Diseased Brain
Giaume, C., Naus, C. C., Sáez, J. C., & Leybaert, L. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2018 · Cited by 154
Jović, M., Kieken, F., Naslavsky, N., Sorgen, P. L., & Caplan, S. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-11-1102 · Cited by 81
Self-citationBouvier, D., Kieken, F., Kellezi, A., & Sorgen, P. L. (2008) · Cell Communication & Adhesion · doi:10.1080/15419060802014347 · Cited by 29
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Metadata
- Authors
- Duffy, H. S., Sorgen, P. L., Girvin, M. E., O'Donnell, P., Coombs, W., Taffet, S. M., Delmar, M., & Spray, D. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 277
- Issue
- 39
- Pages
- 36706-36714
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2082553994
- Cited by
- 174
- References
- 2
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Duffy, H. S., Sorgen, P. L., Girvin, M. E., O'Donnell, P., Coombs, W., Taffet, S. M., Delmar, M., & Spray, D. C. (2002). pH-Dependent Intramolecular Binding and Structure Involving Cx43 Cytoplasmic Domains. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m207016200
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