Increased Protein Stability as a Mechanism That Enhances Nrf2-mediated Transcriptional Activation of the Antioxidant Response Element

Mdm2 promotes the rapid degradation of p53

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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Regulation of p53 stability by Mdm2

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

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The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

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Okadaic acid: a new probe for the study of cellular regulation

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Nrf2, a Cap'n'Collar Transcription Factor, Regulates Induction of the Heme Oxygenase-1 Gene

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Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

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Isovitexin Exerts Anti-Inflammatory and Anti-Oxidant Activities on Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting MAPK and NF-κB and Activating HO-1/Nrf2 Pathways

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Oncogenic functions of the transcription factor Nrf2

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Nrf2 as a target for cancer chemoprevention

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Regulation of Nrf2 Transactivation Domain Activity

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Pro-Oxidant Activity of Flavonoids Induces EpRE-Mediated Gene Expression

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Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals

Qin, S., & Hou, D. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201501017 · Cited by 191

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

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Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

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Potential Applications of NRF2 Inhibitors in Cancer Therapy

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Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR‐dependent motor neuron apoptosis

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Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes

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Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses

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Heme oxygenase–1 protects human melanocytes from H2O2–induced oxidative stress via the Nrf2–ARE pathway

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The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?

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Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Liu, T., Lv, Y., Zhao, J., You, Q., & Jiang, Z. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.034 · Cited by 177

Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages

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The role of phytochemicals in inhibition of cancer and inflammation: New directions and perspectives

Issa, A., Volate, S. R., & Wargovich, M. J. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2006.02.009 · Cited by 169

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

Battino, M. A., Giampieri, F., Pistollato, F., Sureda, A., de Oliveira, M. R., Pittalà, V., Fallarino, F., Nabavi, S. F., Atanasov, A. G., & Nabavi, S. M. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.012 · Cited by 170

NADPH Oxidase and ERK Signaling Regulates Hyperoxia-induced Nrf2-ARE Transcriptional Response in Pulmonary Epithelial Cells

Papaiahgari, S. R., Kleeberger, S. R., Cho, H., Kalvakolanu, D. V., & Reddy, S. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408275200 · Cited by 167

Identification of the Nrf2–Keap1 pathway in the European eel Anguilla anguilla: Role for a transcriptional regulation of antioxidant genes in aquatic organisms

Giuliani, M. E., & Regoli, F. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2014.03.003 · Cited by 166

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species

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Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells

Kesic, M. J., Simmons, S. O., Bauer, R. N., & Jaspers, I. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.027 · Cited by 171

Curcumin, Hormesis and the Nervous System

Scuto, M. C., Mancuso, C., Tomasello, B., Ontario, M. L., Cavallaro, A. S., Frasca, F., Maiolino, L., Salinaro, A. T., Calabrese, E. J., & Calabrese, V. (2019) · Nutrients · doi:10.3390/nu11102417 · Cited by 157

Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra

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Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

Uddin, M. S., Mamun, A. A., Jakaria, M., Thangapandiyan, S., Ahmad, J., Rahman, M. A., Mathew, B., Abdel-Daim, M. M., & Aleya, L. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135624 · Cited by 154

Antioxidant Functions of the Aryl Hydrocarbon Receptor

Dietrich, C. (2016) · Stem Cells International · doi:10.1155/2016/7943495 · Cited by 148

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

Wang, H., Sun, X.-B., Xu, Y.-X., Zhao, H., Zhu, Q.-Y., & Zhu, C.-Q. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.100 · Cited by 147

Reactive Oxygen Species and Oxidative Stress

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Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers

Holtzclaw, W. D., Dinkova‐Kostova, A. T., & Talalay, P. (2004) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2003.11.013 · Cited by 145

Fibroblast Growth Factor-1 Induces Heme Oxygenase-1 via Nuclear FactorErythroid 2-related Factor 2 (Nrf2) in Spinal Cord Astrocytes

Vargas, M. R., Pehar, M., Cassina, P., Palma, L. M., Thompson, J. A., Beckman, J. S., & Barbeito, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501920200 · Cited by 146

Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation

Danilov, C. A., Chandrasekaran, K., Racz, J. L., Soane, L., Zielke, C. L., & Fiskum, G. M. (2008) · Glia · doi:10.1002/glia.20793 · Cited by 141

Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells

Zhu, C., Dong, Y., Liu, H., Ren, H. N., & Cui, Z.-H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.11.089 · Cited by 141

Copper Modulates the Degradation of Copper Chaperone for Cu,Zn Superoxide Dismutase by the 26 S Proteosome

Bertinato, J., & L’Abbé, M. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302242200 · Cited by 143

Subcellular localization and cytoplasmic complex status of endogenous Keap1

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Identification of polymorphisms in the promoter region of the human NRF2 gene

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Increased expression of nuclear factor E2 p45‐related factor 2 (NRF2) in head and neck squamous cell carcinomas

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Dietary flavonoid genistein induces Nrf2 and phase II detoxification gene expression via ERKs and PKC pathways and protects against oxidative stress in Caco‐2 cells

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Downregulation of Nuclear Factor Erythroid 2–Related Factor and Associated Antioxidant Genes Contributes to Redox-Sensitive Vascular Dysfunction in Hypertension

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4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling

Chen, H., Chen, Y.-T., Huang, Y.-W., Tsai, H., & Kuo, C. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.12.012 · Cited by 133

Differential Expression and Stability of Endogenous Nuclear Factor E2-related Factor 2 (Nrf2) by Natural Chemopreventive Compounds in HepG2 Human Hepatoma Cells

Jeong, W., Keum, Y.-S., Chen, C., Jain, M. R., Shen, G., Kim, J. H., Li, W., & Kong, A. T. (2005) · BMB Reports · doi:10.5483/bmbrep.2005.38.2.167 · Cited by 133

Proteasome Inhibition Induces Glutathione Synthesis and Protects Cells from Oxidative Stress

Yamamoto, N., Sawada, H., Izumi, Y., Kume, T., Katsuki, H., Shimohama, S., & Akaike, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603712200 · Cited by 133

α-Melanocyte-Stimulating Hormone Counteracts the Suppressive Effect of UVB on Nrf2 and Nrf-Dependent Gene Expression in Human Skin

Kokot, A., Metze, D., Mouchet, N., Galibert, M.-D., Schiller, M., Luger, T. A., & Böhm, M. (2009) · Endocrinology · doi:10.1210/en.2008-1315 · Cited by 132

Antioxidant Responses and NRF2 in Synergistic Developmental Toxicity of PAHs in Zebrafish

Timme‐Laragy, A. R., Tiem, L. A. V., Linney, E. A., & Giulio, R. T. D. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp038 · Cited by 130

BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer

Liu, J., Hu, Y., Feng, Y., Jiang, Y., Guo, Y., Liu, Y., Chen, X., Yang, J., Chen, Y., Mao, Q.-S., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01620-z · Cited by 130

New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation

Zhang, L., Xu, L.-Y., Tang, F., Liu, D., Zhao, X.-L., Zhang, J.-N., Xia, J., Wu, J.-J., Yang, Y., Peng, C. Y., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.12.020 · Cited by 130

Interaction between Oxidative Stress Sensor Nrf2 and Xenobiotic-activated Aryl Hydrocarbon Receptor in the Regulation of the Human Phase II Detoxifying UDP-glucuronosyltransferase 1A10

Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P., & Strassburg, C. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.075770 · Cited by 129

NRF2, cancer and calorie restriction

Martín‐Montalvo, A., Villalba, J. M., Navas, P., & de Cabo, R. (2010) · Oncogene · doi:10.1038/onc.2010.492 · Cited by 129

Butylated hydroxyanisole regulates ARE‐mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells

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Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein

Camp, N. D., James, R. G., Dawson, D. W., Yan, F., Davison, J. M., Houck, S. A., Tang, X., Zheng, N., Major, M. B., & Moon, R. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316471 · Cited by 128

Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression

Liu, Y., Chan, F., Sun, H., Yan, J., Fan, D., Zhao, D., An, J., & Zhou, D. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.10.009 · Cited by 126

Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways

Truong, M., Kim, H. G., Khanal, T., Choi, J. H., Kim, D. H., Jeong, T. C., & Jeong, H. G. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.05.010 · Cited by 124

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels

Merchant, A. A., Singh, A., Matsui, W. H., & Biswal, S. S. (2011) · Blood · doi:10.1182/blood-2011-05-355362 · Cited by 123

Active defense under oxidative stress. The antioxidant responsive element

Lyakhovich, V. V., Андреевич, В. В., Зенков, Н. К., & Брониславовна, М. Е. (2006) · Biochemistry (Moscow) · doi:10.1134/s0006297906090033 · Cited by 123

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

Devling, T. W. P., LINDSAY, C. D., McLellan, L. I., McMahon, M. J., & Hayes, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501475102 · Cited by 122

Contribution of Nrf2 Modulation to the Mechanism of Action of Analgesic and Anti-inflammatory Drugs in Pre-clinical and Clinical Stages

Staurengo‐Ferrari, L., Badaro‐Garcia, S., Hohmann, M. S., Manchope, M. F., Zaninelli, T. H., Casagrande, R., & Verri, W. A., Jr. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01536 · Cited by 127

The Role of the Nrf2 Signaling in Obesity and Insulin Resistance

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Epicatechin induces NF-κB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells

Granado‐Serrano, A. B., Martín, M. Á., Haegeman, G., Goya, L., Bravo, L., & Ramos, S. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991747 · Cited by 115

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes

Keum, Y. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.2.144 · Cited by 114

Intracellular Signaling Pathways Modulated by Phenolic Compounds: Application for New Anti-Inflammatory Drugs Discovery

Costa, G., Francisco, V., Lopes, M. C., Cruz, M. T., & Batista, M. T. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800672049 · Cited by 113

NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

Kim, J.-H., Thimmulappa, R. K., Kumar, V., Cui, W., Kumar, S., Kombairaju, P., Zhang, H., Margolick, J. B., Matsui, W. H., MacVittie, T. J., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70812 · Cited by 114

Methylmercury Induces Acute Oxidative Stress, Altering Nrf2 Protein Level in Primary Microglial Cells

Ni, M., Li, X., Yin, Z., Jiang, H., Sidoryk‐Wȩgrzynowicz, M., Milatović, D., Cai, J., & Aschner, M. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq126 · Cited by 112

Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2

Beury, D. W., Carter, K. A., Nelson, C. E., Sinha, P., Hanson, E. M., Nyandjo, M., Fitzgerald, P., Majeed, A., Wali, N., & Ostrand‐Rosenberg, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501785 · Cited by 115

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death

Lv, H., Liu, Q., Zhou, J., Tan, G., Deng, X., & Ci, X. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.016 · Cited by 111

Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-κB Pathway in Macrophages and in Acute Lung Injury

Liu, Q., Lv, H., Wen, Z., Ci, X., & Peng, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01518 · Cited by 111

Anticarcinogenesis by dietary phytochemicals: Cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-κB and AP-1 in abnormal cancer cells

Gopalakrishnan, A., & Kong, A. T. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.082 · Cited by 110

Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress

Reuland, D. J., Khademi, S., Castle, C. J., Irwin, D. C., McCord, J. M., Miller, B. F., & Hamilton, K. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.016 · Cited by 110

Sinapic Acid Ameliorates the Progression of Streptozotocin (STZ)-Induced Diabetic Nephropathy in Rats via NRF2/HO-1 Mediated Pathways

Alaofi, A. L. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01119 · Cited by 109

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

Kim, J.-H., Yu, S., Chen, J. D., & Kong, A.-N. T. (2012) · Oncogene · doi:10.1038/onc.2012.59 · Cited by 110

Redox regulation of the transcriptional repressor Bach1

Ishikawa, M., Numazawa, S., & Yoshida, T. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.021 · Cited by 112

Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C δPreprint

Li, B., Wang, X., Rasheed, N., Hu, Y., Boast, S., Ishii, T., Nakayama, K., Nakayama, K., & Goff, S. P. (2004) · Genes & Development · doi:10.1101/gad.1223504 · Cited by 109

Molecular Mechanisms Involved in Enhancing HO-1 Expression: De-Repression by Heme and Activation by Nrf2, The "One-Two" Punch

Srisook, K., Kim, C., & Cha, Y. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1674 · Cited by 108

Epigallocatechin gallate induces expression of heme oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-α

Pullikotil, P., Chen, H., Muniyappa, R., Greenberg, C. C., Yang, S., Reiter, C. E. N., Lee, J.-W., Chung, J. H., & Quon, M. J. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.007 · Cited by 106

Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway

Zhang, L., Wang, H., Zhou, Y., Zhu, Y., & Fei, M. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.05.011 · Cited by 104

Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)

Hahn, M. E., Timme‐Laragy, A. R., Karchner, S. I., & Stegeman, J. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.022 · Cited by 106

Activation of the Nrf2/antioxidant response pathway increases IL-8 expression

Zhang, X., Chen, X., Song, H., Chen, H., & Rovin, B. H. (2005) · European Journal of Immunology · doi:10.1002/eji.200526116 · Cited by 103

Environmental sensing and response genes in cnidaria: the chemical defensome in the sea anemone Nematostella vectensis

Goldstone, J. V. (2008) · Cell Biology and Toxicology · doi:10.1007/s10565-008-9107-5 · Cited by 107

Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response

Du, Y., Villeneuve, N. F., Wang, X., Sun, Z., Chen, W., Li, J., Lou, H., Wong, P. K., & Zhang, D. D. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11464 · Cited by 99

Synthesis and anticancer activity of CDDO and CDDO-Me, two derivatives of natural triterpenoids

Borella, R., Forti, L., Gibellini, L., De Gaetano, A., De Biasi, S., Nasi, M., Cossarizza, A., & Pinti, M. (2019) · Molecules · doi:10.3390/molecules24224097 · Cited by 98

The KEAP1-NRF2 System in Healthy Aging and Longevity

Matsumaru, D., & Motohashi, H. (2021) · Antioxidants · doi:10.3390/antiox10121929 · Cited by 103

Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response

Shay, K. P., Michels, A. J., Li, W., Kong, A. T., & Hagen, T. M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.04.002 · Cited by 97

Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism

Smolková, K., Mikó, E., Kovàcs, T., Leguina‐Ruzzi, A., Sipos, A., & Bai, P. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8024 · Cited by 101

Nrf2 Possesses a Redox-insensitive Nuclear Export Signal Overlapping with the Leucine Zipper Motif

Li, W., Jain, M. R., Chen, C., Yue, X., Hebbar, V., Zhou, R., & Kong, A.-N. T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410601200 · Cited by 95

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment

Venkatraman, G., Benesch, M. G. K., Tang, X., Dewald, J. W., McMullen, T. P. W., & Brindley, D. N. (2014) · The FASEB Journal · doi:10.1096/fj.14-262659 · Cited by 95

The Role of Natural Products in Targeting Cardiovascular Diseases via Nrf2 Pathway: Novel Molecular Mechanisms and Therapeutic Approaches

Ooi, B. K., Chan, K., Goh, B. H., & Yap, W. H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01308 · Cited by 99

Regulating Nrf2 activity: ubiquitin ligases and signaling molecules in redox homeostasis

Hayes, J. D., Naidu, S. D., & Dinkova‐Kostova, A. T. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.12.010 · Cited by 103

Regulation of Nrf2, NF-κB, and AP-1 Signaling Pathways by Chemopreventive Agents

Shen, G., Jeong, W., Hu, R., & Kong, A. T. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1648 · Cited by 94

The Keap1-Nrf2 Cellular Defense Pathway: Mechanisms of Regulation and Role in Protection Against Drug-Induced Toxicity

Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-00663-0_9 · Cited by 98

Tanshinone IIA suppresses cholesterol accumulation in human macrophages: role of heme oxygenase-1

Liu, Z., Wang, J., Huang, E., Gao, S., Li, H., Lü, J., Tian, K., Little, P. J., Shen, X., Xu, S., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m040394 · Cited by 92

Failure of protein quality control in amyotrophic lateral sclerosis

Kabashi, E., & Durham, H. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.06.006 · Cited by 90

Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2

Dreger, H., Westphal, K., Wilck, N., Baumann, G., Stangl, V., Stangl, K., & Meiners, S. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp279 · Cited by 92

The Generation, Detection, and Effects of Reactive Drug Metabolites

Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D., Williams, D. P., Srivastava, A., Regan, S., Antoine, D. J., Goldring, C. E., et al. (2012) · Medicinal Research Reviews · doi:10.1002/med.21273 · Cited by 89

Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK

Wong, S. Y., Tan, M. G. K., Wong, P. T. ‐., Herr, D. R., & Lai, M. K. P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0723-3 · Cited by 86

Dietary flavonoid (−)epicatechin stimulates phosphatidylinositol 3‐kinase‐dependent anti‐oxidant response element activity and up‐regulates glutathione in cortical astrocytes

Bahia, P. K., Rattray, M., & Williams, R. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05542.x · Cited by 86

Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases

Sun, Y., Yang, T., Leak, R. K., Chen, J., & Zhang, F. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527316666170102120211 · Cited by 86

Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism

Gambari, L., Lisignoli, G., Cattini, L., Manferdini, C., Facchini, A., & Grassi, F. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.06.014 · Cited by 86

Acrylamide-Responsive Genes in the Nematode Caenorhabditis elegans

Hasegawa, K., Miwa, S., Isomura, K., Tsutsumiuchi, K., Taniguchi, H., & Miwa, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm276 · Cited by 85

Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity

Lv, H., Xiao, Q., Zhou, J., Feng, H., Liu, G., & Ci, X. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00147 · Cited by 83

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2

Apopa, P. L., Lin, G. X., He, X., & Ma, Q. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.5.a287-a

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

Nguyen, T. V. (2004) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(04)00379-x · Cited by 22

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR‐32 neuroblastoma cells

Apopa, P. L., He, X., & Ma, Q. (2008) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20212 · Cited by 230

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

Huang, H.-C., Nguyen, T., & Pickett, C. B. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220418997 · Cited by 539

Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2

Pi, J., Bai, Y., Reece, J. M., Williams, J. G., Liu, D., Freeman, M. L., Fahl, W. E., Shugar, D., Liu, J., Qu, W., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.001 · Cited by 217