CoChat
Sign Up
Cited by 154Genomics, phytochemicals, and oxidative stressNigella sativa pharmacological applicationsNeurological Disease Mechanisms and Treatments

Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders

Uddin, Md. Sahab, Mamun, Abdullah Al, Jakaria, Md., Thangapandiyan, Shanmugam, Ahmad, Jamil, Rahman, Md. Ataur, Mathew, Bijo, Abdel-Daim, Mohamed M. +1 more·2020·Science of The Total Environment
DOI 10.1016/j.scitotenv.2019.135624
Open this paper in CoChat — free account

Abstract

Neurological disorders represent a great challenge and are the leading cause of death and disability globally. Although numerous complicated mechanisms are involved in the progressions of chronic and acute neurodegenerative disorders, most of the diseases share mutual pathogenic features such as oxidative stress, mitochondrial dysfunction, neuroinflammation, protein misfolding, excitotoxicity, and neuronal damage, all of these are the common targets of nuclear factor erythroid 2 related factor 2 (Nrf2) signaling cascade. No cure has yet been discovered to tackle these disorders, so, intervention approaches targeting phytochemicals have been recommended as an alternative form of treatment. Sulforaphane is a sulfur-rich dietary phytochemical which has several activities such as antioxidant, anti-inflammatory, and anti-tumor via multiple targets and various mechanisms. Given its numerous actions, sulforaphane has drawn considerable attention for neurological disorders in recent years. Nrf2 is one of the most crucial targets of sulforaphane which has potential in regulating the series of cytoprotective enzyme expressions that have neuroprotective, antioxidative, and detoxification actions. Neurological disorders are auspicious candidates for Nrf2-targeted treatment strategy. Sulforaphane protects various neurological disorders by regulating the Nrf2 pathway. In this article, we recapitulate current studies of sulforaphane-mediated Nrf2 activation in the treatment of various neurological disorders.

Integrity signals

Registry

Crossref · 10.1016/j.scitotenv.2019.135624

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Sulforaphane can penetrate the blood brain barrier and induces the Nrf2 signaling cascade that stimulates the expression of more than 200 genes that are antioxidants and involved in detoxification and neuroprotection in the CNS.

    “Sulforaphane is a sulfur-rich dietary phytochemical which can penetrate the blood brain barrier, and it subsequently induces the nuclear factor erythroid 2 related factor 2 (Nrf2) signaling cascade that stimulates the expression of more than 200 genes that are antioxidants and involved in detoxification and neuroprotection in the CNS [67].”

    From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [67]

Cites

2 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Uddin, M. S., Mamun, A. A., Jakaria, M., Thangapandiyan, S., Ahmad, J., Rahman, M. A., Mathew, B., Abdel-Daim, M. M., & Aleya, L.
Affiliations
  • Southeast University (BD)
  • The University of Melbourne (AU)
  • Bharathiar University (IN)
  • The University of Agriculture, Peshawar (PK)
  • Korea Institute of Science and Technology (KR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Uddin, Md. Sahab
  • Aleya, Lotfi
ORCID
Venue
Science of The Total Environment
Publisher
Elsevier BV
Published
2020-03
Volume
707
Pages
135624
ISSN
0048-9697 (ISSN-L)
DOI
10.1016/j.scitotenv.2019.135624
OpenAlex
W2989772669
Cited by
154
References
144
Citations by year
2026: 6 · 2025: 17 · 2024: 20 · 2023: 23 · 2022: 24 · 2021: 22 · 2020: 42
FWCI
1.94
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The Science of The Total Environment (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion)
Funders
King Saud University, Deanship of Scientific Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Health Sciences › Medicine › Complementary and alternative medicine › Nigella sativa pharmacological applications
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
sulforaphane, Nrf2 signaling, neurological disorders, neurodegenerative diseases, neuroprotection, oxidative stress, mitochondrial dysfunction, neuroinflammation, excitotoxicity, protein misfolding, dietary phytochemicals, antioxidant activity, detoxification enzymes
MeSH terms
Humans, Nervous System Diseases, Sulfoxides, Signal Transduction, Isothiocyanates, Oxidative Stress, NF-E2-Related Factor 2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review