Cited by 640Chemokine receptors and signalingNF-κB Signaling PathwaysMechanisms of cancer metastasis

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NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

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Helbig, Gregory, Christopherson, Kent W., Bhat-Nakshatri, Poornima, Kumar, Suresh, Kishimoto, Hiromitsu, Miller, Kathy D., Broxmeyer, Hal E., Nakshatri, Harikrishna·2003·Journal of Biological Chemistry

DOI 10.1074/jbc.m300609200

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Abstract

Metastasis of cancer cells is a complex process involving multiple steps including invasion, angiogenesis, and trafficking of cancer cells through blood vessels, extravasations, organ-specific homing, and growth. While matrix metalloproteinases, urokinase-type plasminogen activator, and cytokines play a major role in invasion and angiogenesis, chemokines such as stromal derived factor-1alpha (SDF-1alpha) and their receptors such as CXCR4 are thought to play a critical role in motility, homing, and proliferation of cancer cells at specific metastatic sites. We and others have previously reported that the extracellular signal-activated transcription factor NF-kappaB up-regulates the expression of matrix metalloproteinases, urokinase-type plasminogen activator, and cytokines in highly metastatic breast cancer cell lines. In this report, we demonstrate that NF-kappaB regulates the motility of breast cancer cells by directly up-regulating the expression of CXCR4. Overexpression of the inhibitor of kappaB (IkappaB) in breast cancer cells with constitutive NF-kappaB activity resulted in reduced expression of CXCR4 and a corresponding loss of SDF-1alpha-mediated migration in vitro. Introduction of CXCR4 cDNA into IkappaB-expressing cells restored SDF-1alpha-mediated migration. Electrophoretic mobility shift assays and transient transfection assays revealed that the NF-kappaB subunits p65 and p50 bind directly to sequences within the -66 to +7 region of the CXCR4 promoter and activate transcription. We also show that the cell surface expression of CXCR4 and the SDF-1alpha-mediated migration are enhanced in breast cancer cells isolated from mammary fat pad xenografts compared with parental cells grown in culture. A further increase in CXCR4 cell surface expression and SDF-1alpha-mediated migration was observed with cancer cells that metastasized to the lungs. Taken together, these results implicate NF-kappaB in the migration and the organ-specific homing of metastatic breast cancer cells.

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Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Cellular survival: a play in three Akts
Datta, S. R., Brunet, A., & Greenberg, M. E. (1999) · Genes & Development · doi:10.1101/gad.13.22.2905 · Cited by 4,216
NF-κB in cancer: from innocent bystander to major culprit
Karin, M., Cao, Y., Greten, F. R., & Li, Z. (2002) · Nature reviews. Cancer · doi:10.1038/nrc780 · Cited by 2,476
Changing views of the role of matrix metalloproteinases in metastasis
Chambers, A. F., & Matrisian, L. M. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.17.1260 · Cited by 1,582
Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth
Nakshatri, H., Bhat‐Nakshatri, P., Martin, D. A., Goulet, R. J., & Sledge, G. W. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3629 · Cited by 818
Self-citation
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.
Bargou, R. C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M. Y., Arnold, W., Royer, H., Grinstein, E., Greiner, A., Scheidereit, C., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119849 · Cited by 757
Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.
Sovak, M. A., Bellas, R. E., Kim, D. W., Zanieski, G., Rogers, A. E., Traish, A. M., & Sonenshein, G. E. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119848 · Cited by 720
Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.
Sato, H., & Seiki, M. (1993) · PubMed · Cited by 695
The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways
Ganju, R. K., Brubaker, S. A., Meyer, J., Dutt, P., Yang, Y., Qin, S., Newman, W., & Groopman, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23169 · Cited by 614

Show all 42 references

Research works printed but not linked: 8

Sato, 1993, Oncogene, 8, 395
Andela, 2000, Cancer Res., 60, 6557
Dong, 1999, Cancer Res., 59, 3495
Shattuck-Brandt, 1997, Cancer Res., 57, 3032
Bachelder, 2002, Cancer Res., 62, 7203
Koshiba, 2000, Clin. Cancer Res., 6, 3530
Murakami, 2002, Cancer Res., 62, 7328
Scotton, 2002, Cancer Res., 62, 5930

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Liu, R., Fan, M., Candas, D., Qin, L., Zhang, X., Eldridge, A., Zou, J. X., Zhang, T., Juma, S., Jin, C., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0017 · Cited by 99
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To, S. Q., Dmello, R. S., Richards, A. K., Ernst, M., & Chand, A. L. (2022) · Cancers · doi:10.3390/cancers14020429 · Cited by 93
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Yadav, V. R., Sung, B., Prasad, S., Kannappan, R., Cho, S., Liu, M., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0669-3 · Cited by 88
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Harvey, J., Mellor, P., Eldaly, H., Lennard, T. W. J., Kirby, J. A., & Ali, S. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1987 · Cited by 82
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Goichberg, P., Kalinkovich, A., Borodovsky, N., Tesio, M., Petit, I., Nagler, A., Hardan, I., & Lapidot, T. (2005) · Blood · doi:10.1182/blood-2005-03-0941 · Cited by 81
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Arya, M., Ahmed, H. U., Silhi, N., Williamson, M. P., & Patel, H. (2007) · Tumor Biology · doi:10.1159/000102979 · Cited by 84
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Cabıoğlu, N., Şahin, A. A., Morandi, P., Meric‐Bernstam, F., Islam, R., Lin, H. Y., Bucana, C. D., Gonzalez-Angulo, A. M., Hortobágyi, G. N., & Cristofanilli, M. (2009) · Annals of Oncology · doi:10.1093/annonc/mdn740 · Cited by 80
Epidermal Growth Factor (EGF)-induced Corneal Epithelial Wound Healing through Nuclear Factor κB Subtype-regulated CCCTC Binding Factor (CTCF) Activation
Wang, L., Wu, X., Shi, T., & Luo, L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458141 · Cited by 80
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Yasuoka, H., Tsujimoto, M., Yoshidome, K., Nakahara, M., Kodama, R., Sanke, T., & Nakamura, Y. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-340 · Cited by 78
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Kumar, S., Kishimoto, H., Chua, H. L., Badve, S., Miller, K. D., Bigsby, R. M., & Nakshatri, H. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63608-5 · Cited by 78
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Tarnowski, M., Grymuła, K., Reca, R., Jankowski, K., Maksym, R., Tarnowska, J., Przybylski, G. K., Barr, F. G., Kucia, M., & Ratajczak, M. Z. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0259 · Cited by 78
Up‐regulation of the interferon γ (IFN‐γ)‐inducible chemokines IFN‐inducible T‐cell α chemoattractant and monokine induced by IFN‐γ and of their receptor CXC receptor 3 in human renal cell carcinoma
Suyama, T., Furuya, M., Nishiyama, M., Kasuya, Y., Kimura, S., Ichikawa, T., Ueda, T., Nikaido, T., Itô, H., & Ishikura, H. (2004) · Cancer · doi:10.1002/cncr.20747 · Cited by 79
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Arora, R., Yates, C. C., Gary, B. D., McClellan, S. B., Tan, M., Xi, Y., Reed, E., Piazza, G. A., Owen, L. B., & Dean-Colomb, W. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098370 · Cited by 77
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Jiang, L., Yu, L., Zhang, X., Lei, F., Wang, L., Liu, X., Wu, S., Zhu, J., Wu, G., Cao, L., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1770 · Cited by 76
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Shanmugam, R., Kusumanchi, P., Appaiah, H. N., Liang Cheng, C., Crooks, P. A., Neelakantan, S., Peat, T. J., Klaunig, J. E., Matthews, W., Nakshatri, H., et al. (2010) · International Journal of Cancer · doi:10.1002/ijc.25587 · Cited by 75
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Kim, M. J., Kim, W., Kim, D., Byun, J.-E., Huy, H., Lee, S.-Y., Song, H., Park, Y.-J., Kim, T.-D., Yoon, S., et al. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.03.007 · Cited by 63
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Jacobson, O., Weiss, I. D., Szajek, L. P., Niu, G., Ma, Y., Kiesewetter, D. O., Farber, J. M., & Chen, X. S. (2011) · Theranostics · doi:10.7150/thno/v01p0251 · Cited by 76
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Sukumaran, B. O., Ramadas, K., Sebastian, P., & Pillai, M. R. (2006) · Head & Neck · doi:10.1002/hed.20437 · Cited by 75
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Schmid, B. C., Rudas, M., Rezniczek, G. A., Leodolter, S., & Zeillinger, R. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000019962.18922.87 · Cited by 73
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Zhao, B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i19.2389 · Cited by 72
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Colavito, S. A., Zou, M. R., Yan, Q., Nguyen, D. X., & Stern, D. F. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0444-4 · Cited by 71
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Cho, H. H., Kyoung, K. M., Seo, M. J., Kim, Y. J., Bae, Y. C., & Jung, J. S. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.853 · Cited by 71
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Manu, K. A., Shanmugam, M. K., Ong, T. H., Subramaniam, A., Siveen, K. S., Perumal, E., Samy, R. P., Bist, P., Lim, L. H. K., Kumar, A. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057015 · Cited by 72
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O’Malley, G., Heijltjes, M. T., Houston, A. M., Rani, S., Ritter, T., Egan, L. J., & Ryan, A. E. (2016) · Oncotarget · doi:10.18632/oncotarget.11354 · Cited by 72
The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines
Opdenakker, G., & Damme, J. V. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041796go · Cited by 71
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Hu, J., Deng, X., Bian, X., Li, G., Tong, Y., Li, Y., Wang, Q., Xin, R., He, X., Zhou, G., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1798 · Cited by 70
Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells
Sierra, M. D. L. L., Gasperini, P., McCormick, P. J., Zhu, J., & Tosato, G. (2007) · Blood · doi:10.1182/blood-2007-03-081448 · Cited by 69
Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model
Rahman, K. W., Sarkar, F. H., Banerjee, S., Wang, Z. P., Liao, D. J., Hong, X., & Sarkar, N. H. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0221 · Cited by 69
Retracted
Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells
Altenburg, J. D., & Siddiqui, R. A. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0385 · Cited by 67
Extracellular calcium increases CXCR4 expression on bone marrow‐derived cells and enhances pro‐angiogenesis therapy
Wu, Q., Shao, H., Eton, D., Li, J., Li, J., Yang, B., Webster, K. A., & Yu, H. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00691.x · Cited by 67
Immunoimaging of CXCR4 Expression in Brain Tumor Xenografts Using SPECT/CT
Nimmagadda, S., Pullambhatla, M., & Pomper, M. G. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.061325 · Cited by 67
Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway
Lee, C., Lee, M., Yoo, S.-M., Choi, K.-I., Song, J.-H., Jang, J., Oh, S., Ryu, H. W., Lee, H.-S., Surh, Y., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1580-7 · Cited by 65

Authors: Helbig, G., Christopherson, K. W., Bhat-Nakshatri, P., Kumar, S., Kishimoto, H., Miller, K. D., Broxmeyer, H. E., & Nakshatri, H.
Affiliations: Indiana University Indianapolis (US)
Walther Cancer Foundation (US)
Corresponding author: Nakshatri, Harikrishna
ORCID: Kumar, Suresh
Kishimoto, Hiromitsu
Miller, Kathy D.
Broxmeyer, Hal E.
Nakshatri, Harikrishna
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2003-06
Volume: 278
Issue: 24
Pages: 21631-21638
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m300609200
OpenAlex: W1980790180
Cited by: 639
References: 42
Citations by year: 2026: 6 · 2025: 12 · 2024: 15 · 2023: 12 · 2022: 19 · 2021: 14 · 2020: 23 · 2019: 18 · 2018: 33 · 2017: 28 · 2016: 34 · 2015: 30 · 2014: 35 · 2013: 42 · 2012: 18
FWCI: 16.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6323 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institutes of Health (5r21ca082208-02)
National Heart, Lung, and Blood Institute (HL67384, R01HL067384)
National Cancer Institute (CA82208)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK053674, DK53674, T32DK007519)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords: NF-κB, breast cancer, metastasis, cell migration, CXCR4, chemokine receptors, SDF-1α, chemokine signaling, IκB, transcriptional regulation, lung metastasis
MeSH terms: Animals, Breast Neoplasms, Cell Movement, Chemotaxis, Flow Cytometry, Genetic Vectors, Humans, Neoplasm Metastasis, Neoplasm Transplantation, Plasmids, Promoter Regions, Genetic, Ribonucleases, RNA, Messenger, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Up-Regulation, Gene Expression Regulation, Neoplastic, NF-kappa B, DNA, Complementary, COS Cells, Receptors, CXCR4, Matrix Metalloproteinases, Mitogen-Activated Protein Kinases, Transcription Factor RelA, NF-kappa B p50 Subunit

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NF-κ B Promotes Breast Cancer Cell Migration and Metastasis by Inducing the Expression of the Chemokine Receptor CXCR4

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