The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Secretory IgA N- and O-Glycans Provide a Link between the Innate and Adaptive Immune Systems
Open accessAbstract
Secretory IgA (SIgA) is a multi-polypeptide complex consisting of a secretory component (SC) covalently attached to dimeric IgA containing one joining (J) chain. We present the analysis of both the N- and O-glycans on the individual peptides from this complex. Based on these data, we have constructed a molecular model of SIgA1 with all its glycans, in which the Fab arms form a T shape and the SC is wrapped around the heavy chains. The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids. These glycan epitopes provide SIgA with further bacteria-binding sites in addition to the four Fab-binding sites, thus enabling SIgA to participate in both innate and adaptive immunity. We also show that the N-glycans on the H chains of both SIgA1 and SIgA2 present terminal GlcNAc and mannose residues that are normally masked by SC, but that can be unmasked and recognized by mannose-binding lectin, by disrupting the SC-H chain noncovalent interactions.
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Glycosylation in health and disease
Reily, C., Stewart, T. J., Renfrow, M. B., & Novak, J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0129-4 · Cited by 2,075
The Impact of Glycosylation on the Biological Function and Structure of Human Immunoglobulins
Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141702 · Cited by 1,307
Self-citationSecretory IgA's complex roles in immunity and mucosal homeostasis in the gut
Mantis, N. J., Rol, N., & Corthésy, B. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.41 · Cited by 1,283
Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces
Corthésy, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00185 · Cited by 674
Yel, L. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9357-x · Cited by 580
Metadata
- Authors
- Royle, L., Roos, A., Harvey, D. J., Wormald, M. R., Van Gijlswijk-Janssen, D., Redwan, E.-R. M., Wilson, I. A., Daha, M. R., Dwek, R. A., & Rudd, P. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 278
- Issue
- 22
- Pages
- 20140-20153
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1973283944
- Cited by
- 335
- References
- 58
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Royle, L., Roos, A., Harvey, D. J., Wormald, M. R., Van Gijlswijk-Janssen, D., Redwan, E.-R. M., Wilson, I. A., Daha, M. R., Dwek, R. A., & Rudd, P. M. (2003). Secretory IgA N- and O-Glycans Provide a Link between the Innate and Adaptive Immune Systems. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m301436200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
