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Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens
Abstract
Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis b (Le b ) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Le b antigen or antibodies to the Le b antigen inhibited bacterial binding. Gastric tissue lacking Le b expression did not bind H. pylori . Bacteria did not bind to Le b antigen substituted with a terminal GalNAcα1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.
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Citations
Cited by
The complete genome sequence of the gastric pathogen Helicobacter pylori
Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., et al. (1997) · Nature · doi:10.1038/41483 · Cited by 3,529
Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635
“Among the numerous examples that can be cited for bacterial adhesins (223, 712), the example of Helicobacter recognition of gastric sialoglycans is particularly interesting, given its role in pathogenesis of gastric ulcers and cancers (713) (714) (715) (716) (717) (718) (719) .”
BackgroundPathogenesis of Helicobacter pylori Infection
Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526
Exploitation of Mammalian Host Cell Functions by Bacterial Pathogens
Finlay, B. B., & Cossart, P. (1997) · Science · doi:10.1126/science.276.5313.718 · Cited by 746
Human milk glycobiome and its impact on the infant gastrointestinal microbiota
Zivkovic, A. M., German, J. B., Lebrilla, C. B., & Mills, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000083107 · Cited by 679
Metadata
- Authors
- Borén, T., Falk, P., Roth, K. A., Larson, G., & Normark, S.
- Venue
- Science
- Published
- 1993-12-17
- Volume
- 262
- Issue
- 5141
- Pages
- 1892-1895
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030336958
- Cited by
- 1,188
- References
- 0
- FWCI
- 62.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens. https://app.cochat.ai/papers/10.1126/science.8018146
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- Borén, T., Falk, P., Roth, K. A., Larson, G., & Normark, S. (1993). Attachment of Helicobacter pylori to Human Gastric Epithelium Mediated by Blood Group Antigens. Science. https://doi.org/10.1126/science.8018146
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
