Identification of a Novel Integrin αMβ2 Binding Site in CCN1 (CYR61), a Matricellular Protein Expressed in Healing Wounds and Atherosclerotic Lesions
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CCN1 (cysteine-rich 61) and CCN2 (connective tissue growth factor) are growth factor-inducible immediate-early gene products found in atherosclerotic lesions, restenosed blood vessels, and healing cutaneous wounds. Both CCN proteins have been shown to support cell adhesion and induce cell migration through interaction with integrin receptors. Recently, we have identified integrin alphaMbeta2 as the major adhesion receptor mediating monocyte adhesion to CCN1 and CCN2 and have shown that the alphaMI domain binds specifically to both proteins. In the present study, we demonstrated that activated monocytes adhered to a synthetic peptide (CCN1-H2, SSVKKYRPKYCGS) derived from a conserved region within the CCN1 C-terminal domain, and this process was blocked by the anti-alphaM monoclonal antibody 2LPM19c. Consistently, a glutathione S-transferase (GST) fusion protein containing the alphaMI domain (GST-alphaMI) bound to immobilized CCN1-H2 as well as to the corresponding H2 sequence in CCN2 (CCN2-H2, TSVKTYRAKFCGV). By contrast, a scrambled CCN1-H2 peptide and an 18-residue peptide derived from an adjacent sequence of CCN1-H2 failed to support monocyte adhesion or alphaMI domain binding. To confirm that the CCN1-H2 sequence within the CCN1 protein mediates alphaMbeta2 interaction, we developed an anti-peptide antibody against CCN1-H2 and showed that it specifically blocked GST-alphaMI binding to intact CCN1. Collectively, these results identify the H2 sequence in CCN1 and CCN2 as a novel integrin alphaMbeta2 binding motif that bears no apparent homology to any alphaMbeta2 binding sequence reported to date.
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CCN1 lacks the canonical RGD sequence that binds many integrins; instead, specific non-canonical binding sites for several integrins have been identified.
“CCN1 does not contain the canonical RGD sequence that can bind a number of integrins [54]. Instead, specific non-canonical binding sites of CCN1 for several integrins have been identified (Fig. 1) [63–66].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [63]
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Cites
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009 · see citing works
Molecular modeling of protein-glycosaminoglycan interactions.
Cardin, A. D., & Weintraub, H. J. R. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.1.21 · Cited by 1,301 · see citing works
Igarashi, A., Okochi, H., Bradham, D. M., & Grotendorst, G. R. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.6.637 · Cited by 699 · see citing works
The CCN Family of Angiogenic Regulators: The Integrin Connection
Lau, L. F., & Lam, S. C.-T. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4456 · Cited by 645 · see citing works
Self-citationPeer Bork, B. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80155-n · Cited by 623 · see citing works
The Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family
Brigstock, D. R. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.2.0360 · Cited by 588 · see citing works
Babic, A. M., Kireeva, M. L., Kolesnikova, T. V., & Lau, L. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6355 · Cited by 495 · see citing works
Self-citationBabic, A. M., Chen, C.-C., & Lau, L. F. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2958 · Cited by 445 · see citing works
Self-citationCYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity
Mo, F.-E., Muntean, A. G., Chen, C.-C., Stolz, D. B., Watkins, S. C., & Lau, L. F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8709-8720.2002 · Cited by 416 · see citing works
Self-citationThe Connective Tissue Growth Factor/Cysteine- Rich 61/Nephroblastoma Overexpressed (CCN) Family
Brigstock, D. R. (1999) · Endocrine Reviews · doi:10.1210/er.20.2.189 · Cited by 370 · see citing works
NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues
Perbal, B. (2001) · Molecular Pathology · doi:10.1136/mp.54.2.57 · Cited by 345 · see citing works
Kireeva, M. L., Mo, F.-E., Yang, G. P., & Lau, L. F. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1326 · Cited by 341 · see citing works
Self-citationWoods, A., & Couchman, J. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.2.183 · Cited by 333 · see citing works
Chen, C.-C., Chen, N., & Lau, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008087200 · Cited by 305 · see citing works
Self-citationThe Angiogenic Factor Cyr61 Activates a Genetic Program for Wound Healing in Human Skin Fibroblasts
Chen, C.-C., Mo, F.-E., & Lau, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107666200 · Cited by 300 · see citing works
Self-citationHuman Connective Tissue Growth Factor Is Expressed in Advanced Atherosclerotic Lesions
Oemar, B. S., Werner, A., Garnier, J., Do, D.-D., Godoy, N., Nauck, M., März, W., Rupp, J., Pech, M., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.95.4.831 · Cited by 295 · see citing works
Leu, S.-J., Lam, S. C.-T., & Lau, L. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209288200 · Cited by 247 · see citing works
Self-citationSchober, J. M., Chen, N., Grzeszkiewicz, T. M., Jovanovic, I., Emeson, E. E., Ugarova, T. P., Ye, R. D., Lau, L. F., & Lam, S. C.-T. (2002) · Blood · doi:10.1182/blood.v99.12.4457 · Cited by 242 · see citing works
Self-citationKireeva, M. L., Latinkic, B., Kolesnikova, T. V., Chen, C.-C., Yang, G. P., Abler, A. S., & Lau, L. F. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3548 · Cited by 236 · see citing works
Self-citationJedsadayanmata, A., Chen, C.-C., Kireeva, M. L., Lau, L. F., & Lam, S. C.-T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24321 · Cited by 204 · see citing works
Self-citationDetermination of the number of endothelial cells in culture using an acid phosphatase assay
Connolly, D. T., Knight, M. B., Harakas, N. K., Wittwer, A. J., & Feder, J. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90131-4 · Cited by 204 · see citing works
Connective Tissue Growth Factor
Oemar, B. S., & Lüscher, T. F. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.8.1483 · Cited by 204 · see citing works
Kireeva, M. L., Lam, S. C.-T., & Lau, L. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.3090 · Cited by 203 · see citing works
Self-citationChen, N., Chen, C.-C., & Lau, L. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003040200 · Cited by 195 · see citing works
Self-citationAltieri, D. C., Plescia, J., & Plow, E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53932-6 · Cited by 186 · see citing works
Grzeszkiewicz, T. M., Kirschling, D. J., Chen, N., & Lau, L. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100978200 · Cited by 162 · see citing works
Self-citationIdentification of a Novel Recognition Sequence for Integrin αMβ2 within the γ-chain of Fibrinogen
Ugarova, T. P., Solovjov, D. A., Zhang, L., Loukinov, D., Yee, V. C., Medved, L. V., & Plow, E. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22519 · Cited by 148 · see citing works
Self-citationIUPAC-IUB Commission on Biochemical Nomenclature A One-Letter Notation for Amino Acid Sequences1–3
(1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)34176-6 · Cited by 139 · see citing works
Li, R., Rieu, P., Griffith, D. L., Scott, D., & Arnaout, M. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.6.1523 · Cited by 127 · see citing works
A Molecular Basis for Integrin αMβ2 Ligand Binding Promiscuity
Yakubenko, V. P., Lishko, V. K., Lam, S. C.-T., & Ugarova, T. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208877200 · Cited by 119 · see citing works
Self-citationHilfiker, A., Hilfiker-Kleiner, D., Fuchs, M., Kaminski, K., Lichtenberg, A., Rothkötter, H.-J., Schieffer, B., & Drexler, H. (2002) · Circulation · doi:10.1161/01.cir.0000021426.87274.62 · Cited by 114 · see citing works
Li, R. Q., Nortamo, P., Valmu, L., Tolvanen, M. E. E., Huuskonen, J., Kantor, C., & Gahmberg, C. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85363-2 · Cited by 68 · see citing works
Koivunen, E., Ranta, T.-M., Annila, A., Taube, S., Uppala, A., Jokinen, M., van WILLIGEN, G., Ihanus, E., & Gahmberg, C. G. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.5.905 · Cited by 67 · see citing works
Latinkic, B. V. (2001) · Endocrinology · doi:10.1210/en.142.6.2549 · Cited by 61 · see citing works
Yakubenko, V. P., Solovjov, D. A., Zhang, L., Yee, V. C., Plow, E. F., & Ugarova, T. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010174200 · Cited by 60 · see citing works
Self-citationNielsen, P. K., & Yamada, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008743200 · Cited by 56 · see citing works
Li, R., Xie, J., Kantor, C., Koistinen, V., Altieri, D. C., Nortamo, P., & Gahmberg, C. G. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.4.1143 · Cited by 55 · see citing works
Moyano, J. V., Carnemolla, B., Albar, J. P., Leprini, A., Gaggero, B., Zardi, L., & Garcı́a-Pardo, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.135 · Cited by 45 · see citing works
Dual Regulation of Ligand Binding by CD11b I Domain
Mesri, M., Plescia, J., & Altieri, D. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.2.744 · Cited by 28 · see citing works
Acuña-Cueva, E. R., Hueso‐Ureña, F., Jiménez‐Pulido, S. B., & Moreno‐Carretero, M. N. (2000) · Journal of Molecular Modeling · doi:10.1007/s0089400060433 · Cited by 27 · see citing works
Wu, K., Yee, A., Zhu, N. L., Gordon, E. M., & Hall, F. L. (2000) · International Journal of Molecular Medicine · doi:10.3892/ijmm.6.4.433 · Cited by 24 · see citing works
Grzeszkiewicz, T. M. (2002) · Endocrinology · doi:10.1210/en.143.4.1441 · Cited by 23 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Babic, A. M., Kireeva, M. L., Kolesnikova, T. V., and Lau, L. F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6355-6360
- Springer, T. A. (1994) Cell 76, 301-314
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CCN proteins: multifunctional signalling regulators
Perbal, B. (2004) · The Lancet · doi:10.1016/s0140-6736(03)15172-0 · Cited by 704 · see citing works
All in the CCN family: essential matricellular signaling modulators emerge from the bunker
Leask, A., & Abraham, D. (2006) · Journal of Cell Science · doi:10.1242/jcs.03270 · Cited by 653 · see citing works
CCN1/CYR61: the very model of a modern matricellular protein
Lau, L. F. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0778-3 · Cited by 338 · see citing works
Self-citationPiccaluga, P. P., Agostinelli, C., Califano, A., Rossi, M., Basso, K., Zupo, S., Went, P., Klein, U., Zinzani, P. L., Baccarani, M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26833 · Cited by 303 · see citing works
Lin, M.-T., Chang, C.-C., Chen, S.-T., Chang, H.-L., Su, J.-L., Chau, Y.-P., & Kuo, M.-L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402305200 · Cited by 194 · see citing works
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Bai, T., Chen, C.-C., & Lau, L. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902792 · Cited by 173 · see citing works
Self-citationStructural and Functional Properties of CCN Proteins
Rachfal, A. W., & Brigstock, D. R. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)70003-0 · Cited by 162 · see citing works
Chen, N., Leu, S.-J., Todorović, V., Lam, S. C.-T., & Lau, L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406813200 · Cited by 132 · see citing works
Self-citationWang, X., Hamza, M., Wu, T., & Dionne, R. A. (2009) · Pain · doi:10.1016/j.pain.2009.02.001 · Cited by 130 · see citing works
Multiple Binding Sites in Fibrinogen for Integrin αMβ2 (Mac-1)
Lishko, V. K., Podolnikova, N. P., Yakubenko, V. P., Yakovlev, S., Medved, L. V., Yadav, S. P., & Ugarova, T. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408012200 · Cited by 112 · see citing works
Self-citationGao, R., & Brigstock, D. R. (2005) · Gut · doi:10.1136/gut.2005.079178 · Cited by 112 · see citing works
CCN proteins and cancer: two to tango
Bleau, A. (2005) · Frontiers in bioscience · doi:10.2741/1594 · Cited by 97 · see citing works
Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking
Emre, Y., & Imhof, B. A. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0420-1 · Cited by 95 · see citing works
Quan, T., Qin, Z., Xu, Y., He, T., Kang, S., Voorhees, J. J., & Fisher, G. J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.29 · Cited by 90 · see citing works
Chen, L., & Brigstock, D. R. (2016) · FEBS Letters · doi:10.1002/1873-3468.12448 · Cited by 89 · see citing works
Mechanoregulation of Wound Healing and Skin Homeostasis
Rosińćzuk, J., Taradaj, J., Dymarek, R., & Sopel, M. (2016) · BioMed Research International · doi:10.1155/2016/3943481 · Cited by 87 · see citing works
Podolnikova, N. P., Podolnikov, A. V., Haas, T. A., Lishko, V. K., & Ugarova, T. P. (2015) · Biochemistry · doi:10.1021/bi5013782 · Cited by 83 · see citing works
Self-citationPathobiology of neutrophil–epithelial interactions
Brazil, J. C., & Parkos, C. A. (2016) · Immunological Reviews · doi:10.1111/imr.12446 · Cited by 81 · see citing works
Shome, D., von Woedtke, T., Riedel, K., & Masur, K. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4910280 · Cited by 80 · see citing works
Lamers, C., Plüss, C. J., & Ricklin, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662164 · Cited by 74 · see citing works
Yakubenko, V. P., Yadav, S. P., & Ugarova, T. P. (2005) · Blood · doi:10.1182/blood-2005-06-2509 · Cited by 72 · see citing works
Self-citationTargeted Mutagenesis of the Angiogenic Protein CCN1 (CYR61)
Leu, S.-J., Chen, N., Chen, C.-C., Todorović, V., Bai, T., Juric, V., Liu, Y., Yan, G., Lam, S. C.-T., & Lau, L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407850200 · Cited by 72 · see citing works
Self-citationCCN1/CYR61-mediated meticulous patrolling by Ly6C low monocytes fuels vascular inflammation
Imhof, B. A., Jemelin, S., Ballet, R., Vesin, C., Schapira, M., Karaca, M., & Emre, Y. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607710113 · Cited by 70 · see citing works
CCN1: a novel inflammation-regulated biphasic immune cell migration modulator
Löbel, M., Bauer, S., Meisel, C., Eisenreich, A., Kudernatsch, R., Tank, J., Rauch, U., Kühl, U., Schultheiß, H., Volk, H., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0981-x · Cited by 68 · see citing works
McCallum, L. M. R., Price, S., Planque, N., Perbal, B., Pierce, A., Whetton, A. D., & Irvine, A. E. (2006) · Blood · doi:10.1182/blood-2006-04-016113 · Cited by 66 · see citing works
Quan, T., Qin, Z., Robichaud, P., Voorhees, J. J., & Fisher, G. J. (2011) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-011-0144-0 · Cited by 67 · see citing works
Stefanidakis, M., Björklund, M., Ihanus, E., Gahmberg, C. G., & Koivunen, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302288200 · Cited by 65 · see citing works
Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies
Agostinelli, C., Piccaluga, P. P., Went, P., Rossi, M., Gazzola, A., Righi, S., Sista, T., Campidelli, C., Zinzani, P. L., Falini, B., et al. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.055335 · Cited by 63 · see citing works
The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6
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Matsumae, H., Yoshida, Y., Ono, K., Togi, K., Inoue, K., Furukawa, Y., Nakashima, Y., Kojima, Y., Nobuyoshi, M., Kita, T., et al. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.162362 · Cited by 59 · see citing works
Chai, J., Norng, M., Tarnawski, A. S., & Chow, J. (2006) · Gut · doi:10.1136/gut.2006.106674 · Cited by 53 · see citing works
Rother, M., Krohn, S., Kania, G., Vanhoutte, D., Eisenreich, A., Wang, X., Westermann, D., Savvatis, K., Dannemann, N., Skurk, C., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.945261 · Cited by 52 · see citing works
Chai, J., Baatar, D., & Tarnawski, A. S. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.021 · Cited by 50 · see citing works
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Walsh, C. T., Radeff‐Huang, J., Matteo, R., Hsiao, A., Subramaniam, S., Stupack, D., & Brown, J. H. (2008) · The FASEB Journal · doi:10.1096/fj.08-113266 · Cited by 47 · see citing works
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Lin, J., Huo, R., Wang, L., Zhou, Z., Sun, Y., Shen, B., Wang, R., & Li, N. (2011) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-011-1135-y · Cited by 47 · see citing works
Thorne, A. H., Meisen, W. H., Russell, L., Yoo, J. Y., Bolyard, C. M., Lathia, J. D., Rich, J. N., Puduvalli, V. K., Mao, H. C., Yu, J., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.101 · Cited by 43 · see citing works
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Walsh, C. T., Stupack, D., & Brown, J. H. (2008) · Molecular Interventions · doi:10.1124/mi.8.4.8 · Cited by 40 · see citing works
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Pileri, S. A., & Piccaluga, P. P. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61205 · Cited by 41 · see citing works
Podolnikova, N. P., Gorkun, O. V., Loreth, R. M., Yee, V. C., Lord, S. T., & Ugarova, T. P. (2005) · Biochemistry · doi:10.1021/bi051581d · Cited by 39 · see citing works
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Einarson, M. B., Pugacheva, E. N., & Orlinick, J. R. (2007) · Cold Spring Harbor Protocols · doi:10.1101/pdb.top11 · Cited by 33 · see citing works
Delayed wound healing in Mac‐1–deficient mice is associated with normal monocyte recruitment
Sisco, M., Chao, J. D., Kim, I., Mogford, J. E., Mayadas, T. N., & Mustoe, T. A. (2007) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2007.00264.x · Cited by 28 · see citing works
Podolnikova, N. P., Hlaváčková, M., Wu, Y., Yakubenko, V. P., Faust, J. J., Balabiyev, A., Wang, X., & Ugarova, T. P. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006314 · Cited by 26 · see citing works
Self-citationLi, T., Qian, Y., Li, H., Wang, T., Jiang, Q., Wang, Y., Zhu, Y., Li, S., He, X., Shi, G., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01653-3 · Cited by 22 · see citing works
Schütze, N., Jüngel, E., Blaheta, R. A., Naggi, A., Torri, G., Schmitz, P., Gerber, U., & Bendas, G. (2013) · Thrombosis and Haemostasis · doi:10.1160/th13-02-0158 · Cited by 20 · see citing works
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Self-citationBorland, G., Edkins, A. L., Acharya, M., Matheson, J., White, L. J., Allen, J. M., Bonnefoy, J., Ozanne, B. W., & Cushley, W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609335200 · Cited by 17 · see citing works
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Wang, G., Zhang, W., Meng, W., Liu, J., Wang, P., Lin, S., Xu, L., Li, E., & Chen, G. (2013) · Journal of International Medical Research · doi:10.1177/0300060513476595 · Cited by 16 · see citing works
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Mechanoregulation of Wound Healing and Skin Homeostasis
Rosińćzuk, J., Taradaj, J., Dymarek, R., & Sopel, M. (2018) · Recent clinical techniques, results, and research in wounds · doi:10.1007/15695_2017_107 · Cited by 8 · see citing works
Correlations Between CCN1 Immunoexpression and Myocardial Histologic Lesions in Sudden Cardiac Death
Papetta, A., Gakiopoulou, H., Agapitos, E. B., Patsouris, E., & Lazaris, A. C. (2013) · American Journal of Forensic Medicine & Pathology · doi:10.1097/paf.0b013e31828d69b5 · Cited by 8 · see citing works
αMI-domain of integrin Mac-1 binds the cytokine pleiotrophin using multiple mechanisms
Nguyen, H., Podolnikova, N. P., Ugarova, T. P., & Wang, X. (2024) · Structure · doi:10.1016/j.str.2024.04.013 · Cited by 7 · see citing works
Self-citationFeng, W., Nguyen, H., Shen, D., Deng, H., Jiang, Z., Podolnikova, N. P., Ugarova, T. P., & Wang, X. (2021) · Biochemistry · doi:10.1021/acs.biochem.0c00700 · Cited by 6 · see citing works
Self-citationMa, Y., Duan, L., Reisch, B., Kimmig, R., Iannaccone, A., & Gellhaus, A. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040221 · Cited by 5 · see citing works
Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23
Edkins, A. L., Borland, G., Acharya, M., Cogdell, R. J., Ozanne, B. W., & Cushley, W. (2012) · Immunology · doi:10.1111/j.1365-2567.2012.03576.x · Cited by 5 · see citing works
Analysis of novel targets in the pathobiology of prostate cancer
D'Antonio, K. B. (2009) · Cited by 2 · see citing works
REGULATION OF CCN PROTEINS BY ALTERATIONS OF THE CYTOSKELETON
Chaqour, B., & Goppelt‐Struebe, M. (2005) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781860946899_0010 · Cited by 2 · see citing works
Gene expression profiling of peripheral T-cell lymphoma: from bench to bedside
Piccaluga, P. P., Rossi, M., Gazzola, A., Sapienza, M. R., Mannu, C., Righi, S., Agostinelli, C., Sista, M. T., & Pileri, S. A. (2009) · Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) · doi:10.4081/hmr.v3i1.528 · Cited by 1 · see citing works
Will o’ the WISP1: A novel mediator of Ang-II induced cardiomyocyte hypertrophy
Martin, E. D., & Marber, M. S. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.03.006 · Cited by 1 · see citing works
Construction and Analysis of an Allelic Series of Ccn1 Knockin Mice
Monzon, R. I., Kim, K., & Lau, L. F. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6430-7_30 · Cited by 1 · see citing works
Self-citationMolecular Profiling of Peripheral T-Cell Lymphomas
Piccaluga, P. P., & Pileri, S. A. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-408-1_3 · Cited by 1 · see citing works
The Aspects of CCN Protein Family on Breast CancerPreprint
Saikat, A. S. M., Ahmed, K. A., Saddam, M., Mimi, A., Hasib, T. A., Paul, S. K., Faruque, H.-A., Uddin, M. J., & Rahman, M. A. (2021) · Preprints.org · doi:10.20944/preprints202101.0582.v1 · Cited by 1 · see citing works
Schütze, N., Wagemanns, R., Schilling, T., & Jakob, F. J. (2006) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a003362.01 · Cited by 1 · see citing works
Li, T., Qian, Y., Li, H., Wang, T., Jiang, Q., Wang, Y., Zhu, Y., Li, S., He, X., Shi, G., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3845429/v1 · Cited by 1 · see citing works
Molecular Profiling and Prognosis in T-Cell Lymphomas
Piccaluga, P. P., & Pileri, S. A. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-170-7_3
Tian, Y., & Guo, S. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.09.019
Recombinant elastin analogues as cell-adhesive matrices for vascular tissue engineering
Ravi, S. (2010) · SMARTech Repository (Georgia Institute of Technology)
Shi, W., Chen, B., Yang, W., Yang, F., Wang, X., Li, J., Yang, Y., Sun, Y., & Li, H. (2023) · Research Square · doi:10.21203/rs.3.rs-3161076/v1
Li, T., Qian, Y., Li, H., Wang, T., Jiang, Q., Wang, Y., Zhu, Y., Li, S., He, X., Shi, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25844531
Li, T., Qian, Y., Li, H., Wang, T., Jiang, Q., Wang, Y., Zhu, Y., Li, S., He, X., Shi, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25844429
- Authors
- Schober, J. M., Lau, L. F., Ugarova, T. P., & Lam, S. C.-T.
- Affiliations
- University of Illinois Chicago (US)
- Cleveland Clinic (US)
- Corresponding author
- Lam, Stephen C.-T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 278
- Issue
- 28
- Pages
- 25808-25815
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2087823284
- Cited by
- 76
- References
- 41
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 2 · 2016: 5 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 5
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health (5r01ca080080-05)
- National Heart, Lung, and Blood Institute (HL07829, HL41793, HL 63199, R01HL063199)
- National Cancer Institute (CA-80080, R01CA046565, CA-46565)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
- Keywords
- CYR61, connective tissue growth factor, Mac-1, integrin-binding motif, monocyte adhesion, matricellular proteins, wound healing, atherosclerosis, cell adhesion, cell migration, peptide binding
- MeSH terms
- Amino Acid Sequence, Arteriosclerosis, Binding Sites, Cell Adhesion, Dose-Response Relationship, Drug, Glutathione Transferase, Humans, Manganese, Molecular Sequence Data, Monocytes, Peptides, Protein Binding, Recombinant Fusion Proteins, Wound Healing, Macrophage-1 Antigen, Protein Structure, Tertiary, Immediate-Early Proteins, Amino Acid Motifs, Intercellular Signaling Peptides and Proteins, Cysteine-Rich Protein 61
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