The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury
Open accessAbstract
Carbon monoxide is protective in ischemia-reperfusion organ injury, but the precise mechanisms remain elusive. We have recently shown that low levels of exogenous carbon monoxide (CO) utilize p38 MAPK and attenuate caspase 3 activity to exert an antiapoptotic effect during lung ischemia-reperfusion injury. Our current data demonstrate that CO activates the p38alpha MAPK isoform and the upstream MAPK kinase MKK3 to modulate Fas/Fas ligand expression; caspases 3, 8, and 9; mitochondrial cytochrome c release; Bcl-2 proteins; and poly(ADP-ribose) polymerase cleavage. We correlate our in vitro findings with in vivo studies using MKK3-deficient and Fas-deficient mice. Taken together, our data are the first to demonstrate that CO has an antiapoptotic effect by inhibiting Fas/Fas ligand, caspases, proapoptotic Bcl-2 proteins, and cytochrome c release via the MKK3/p38alpha MAPK pathway.
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Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626
Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis
Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M. K., & Soares, M. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1015 · Cited by 984
The Fas Signaling Pathway: More Than a Paradigm
Wajant, H. (2002) · Science · doi:10.1126/science.1071553 · Cited by 957
Zhang, X., Shan, P., Otterbein, L. E., Alam, J., Flavell, R. A., Davis, R. J., Choi, A. M. K., & Lee, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208419200 · Cited by 288
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Cited by
Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications
Ryter, S. W., Alam, J., & Choi, A. M. K. (2006) · Physiological Reviews · doi:10.1152/physrev.00011.2005 · Cited by 2,307
Self-citationThe therapeutic potential of carbon monoxide
Motterlini, R., & Otterbein, L. E. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3228 · Cited by 1,638
CO AS A CELLULAR SIGNALING MOLECULE
Kim, H. P., Ryter, S. W., & Choi, A. M. K. (2006) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141053 · Cited by 426
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Ryter, S. W., & Choi, A. M. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.011 · Cited by 362
Zhang, X., Shan, P., Alam, J., Fu, X.-Y., & Lee, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408092200 · Cited by 198
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Metadata
- Authors
- Zhang, X., Shan, P., Alam, J., Davis, R. J., Flavell, R. A., & Lee, P. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 278
- Issue
- 24
- Pages
- 22061-22070
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1997849875
- Cited by
- 171
- References
- 4
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zhang, X., Shan, P., Alam, J., Davis, R. J., Flavell, R. A., & Lee, P. J. (2003). Carbon Monoxide Modulates Fas/Fas Ligand, Caspases, and Bcl-2 Family Proteins via the p38α Mitogen-activated Protein Kinase Pathway during Ischemia-Reperfusion Lung Injury. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m301858200
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